nach oben

Journal of Clinical Immunology

Erschienen in:

01.01.2007

Anti-Tac (daclizumab, Zenapax) in the Treatment of Leukemia, Autoimmune Diseases, and in the Prevention of Allograft Rejection: A 25-Year Personal Odyssey

verfasst von: Thomas A. Waldmann

Erschienen in: Journal of Clinical Immunology | Ausgabe 1/2007

Einloggen, um Zugang zu erhalten

Abstract

Twenty-five years ago, we reported the production of the monoclonal antibody, anti-Tac that identifies the IL-2 receptor alpha subunit and blocks the interaction of IL-2 with this growth factor receptor. In 1997, daclizumab (Zenapax^®), the humanized form of this antibody, was approved by the FDA for use in the prevention of renal allograft rejection. In addition, we demonstrated that daclizumab is of value in the treatment of patients with noninfectious uveitis, multiple sclerosis, and the neurological disease human T-cell lymphotropic virus I associated myelopathy/tropical spastic paraparesis (HAM/TSP). Others demonstrated therapeutic efficacy with daclizumab in patients with pure red cell aplasia, aplastic anemia, and psoriasis. Thus, translation of basic insights concerning the IL-2/IL-2 receptor system obtained using the monoclonal antibody daclizumab provided a useful strategy for the prevention of organ allograft rejection and the treatment of patients with select autoimmune diseases or T-cell leukemia/lymphoma.

Uchiyama T, Broder S, Waldmann TA: A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T-cells I production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J Immunol 126:1393–1397, 1981 PubMed

Uchiyama T, Nelson DL, Fleisher TA, Waldmann TA: A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T-cells II expression of Tac antigen on activated cytotoxic killer T-cells suppressor cells and on one of two types of helper T-cells. J Immunol 126:1398–1403, 1981 PubMed

Wiseman LR, Faulds D: Daclizumab: A review of its use in the prevention of acute rejection in renal transplant recipients. Drugs 58:1029–1042, 1999 PubMedCrossRef

Waldmann TA: The multi-subunit interleukin-2 receptor. Annu Rev Biochem 58:875–911, 1989 PubMedCrossRef

Waldmann TA: The IL-2/IL-2 receptor system: A target for rational immune intervention. Immunol Today 14:264–270, 1993 PubMedCrossRef

Foss FM, Waldmann TA: Interleukin-2 receptor-directed therapies for cutaneous lymphomas. Hematol Oncol Clin N Am 17:1449–1458, 2003 CrossRef

Waldmann TA, Goldman CK, Bongiovanni KF, Sharrow SO, Davey MP, Cease KB, Greenberg SJ, Longo DL: Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac a monoclonal antibody to the receptor for interleukin-2. Blood 72:1805–1816, 1988 PubMed

Waldmann TA, White JD, Carrasquillo JA, Reynolds JC, Paik CH, Gansow OA, Brechbiel MW, Jaffe ES, Fleisher TA, Goldman CK, Top LE, Bamford R, Zaknoen E, Roessler E, Kasten-Sportes C, England R, Litou H, Johnson JA, Jackson-White T, Manns A, Hanchard B, Junghans RP, Nelson DL: Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac. Blood 86:4063–4075, 1995 PubMed

Morris JC, Waldmann TA: Advances in interleukin 2 receptor targeted treatment. Ann Rheum Dis 59(Suppl 1):i109–i114, 2000 PubMedCrossRef

10.

Vincenti F, Kirkman R, Light S, Bumgardner G, Pescovitz M, Halloran P, Neylan J, Wilkinson A, Ekberg H, Gaston R, Backman L, Burdick J: Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation Daclizumab triple therapy study group. N Engl J Med 338:161–165, 1998 PubMedCrossRef

11.

Waldmann TA, O’Shea J: The use of antibodies against the IL-2 receptor in transplantation. Curr Opin Immunol 10:507–512, 1998 PubMedCrossRef

12.

Nussenblatt RB, Fortin E, Schiffman R, Rizzo L, Smith J, Van VP, Sran P, Yaffe A, Goldman CK, Waldmann TA, Whitcup SM: Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: A phase I/II clinical trial. Proc Natl Acad Sci USA 96:7462–7466, 1999 PubMedCrossRef

13.

Nussenblatt RB, Thompson DJ, Li Z, Chan CC, Peterson JS, Robinson RR, Shames RS, Nagarajan S, Tang MT, Mailman M, Velez G, Roy C, Levy-Clarke GA, Suhler EB, Djalilian A, Sen HN, Al-Khatib S, Ursea R, Srivastava S, Bamji A, Mellow S, Sran P, Waldmann TA, Buggage RR: Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: Long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration. J Autoimmun 21:283–293, 2003 PubMedCrossRef

14.

Bielekova B, Richert N, Howard T, Blevins G, Markovic-Plese S, McCartin J, Frank JA, Wurfel J, Ohayon J, Waldmann TA, McFarland HF, Martin R: Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta. Proc Natl Acad Sci USA 101:8705–8708, 2004 PubMedCrossRef

15.

Lehky TJ, Levin MC, Kubota R, Bamford RN, Flerlage AN, Soldan SS, Leist TP, Xavier A, White JD, Brown M, Fleisher TA, Top LE, Light S, McFarland HF, Waldmann TA, Jacobson S: Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac. Ann Neurol 44:942–947, 1998 PubMedCrossRef

16.

O’Mahony D, Morris JC, Carrasquillo JA, Le N, Paik CH, Whatley M, Pittaluga S, Fleisher TA, Lee C, Gao W, O’Hagan D, Brechbiel M, Waldmann TA, Janik JE: Phase I/II study of Yttrium-90 labeled humanized anti-Tac (HAT) monoclonal antibody and calcium DTPA in CD25-expressing malignanices. J Nucl Med 47:98P, 2006

17.

Köhler G, Milstein C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–497, 1975 PubMedCrossRef

18.

Ehrlich P: On immunity with special reference to cell life: Croonian lecture. In The Collected Papers of Paul Ehrlich, B Himmelweir (ed). London, Pergammon, 1956, pp 148–192

19.

Schwartz RH: T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol 3:237–261, 1985 PubMedCrossRef

20.

Robb RJ, Munck A, Smith KA: T-cell growth factor receptors quantitation specificity and biological relevance. J Exp Med 154:1455–1474, 1981 PubMedCrossRef

21.

Waldmann TA: The meandering 45-year odyssey of a clinical immunologist. Annu Rev Immunol 21:1–27, 2003 PubMedCrossRef

22.

Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC: A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature 300:267–269, 1982 PubMedCrossRef

23.

Leonard WJ, Depper JM, Kronke M, Robb RJ, Waldmann TA, Greene WC: The human receptor for T-cell growth factor evidence for variable post-translational processing phosphorylation sulfation and the ability of precursor forms of the receptor to bind T-cell growth factor. J Biol Chem 260:1872–1880, 1985 PubMed

24.

Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Kronke M, Svetlik PB, Peffer NJ, Waldmann TA, Greene WC: Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 311:626–631, 1984 PubMedCrossRef

25.

Leonard WJ, Depper JM, Kanehisa M, Kronke M, Peffer NJ, Svetlik PB, Sullivan M, Greene WC: Structure of the human interleukin-2 receptor gene. Science 230:633–639, 1985 PubMedCrossRef

26.

Tsudo M, Kozak RW, Goldman CK, Waldmann TA: Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex. Proc Natl Acad Sci USA 83:9694–9698, 1986 PubMedCrossRef

27.

Sharon M, Klausner RD, Cullen BR, Chizzonite R, Leonard WJ: Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science 234:859–863, 1986 PubMedCrossRef

28.

Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Ohbo K, Nakamura M, Takeshita T: The interleukin-2 receptor gamma chain: Its role in the multiple cytokine receptor complexes and T-cell development in XSCID. Annu Rev Immunol 14:179–205, 1996 PubMedCrossRef

29.

Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ: Interleukin-2 receptor gamma chain: A functional component of the interleukin-7 receptor. Science 262:1877–1880, 1993 PubMedCrossRef

30.

Sakaguchi S: Naturally arising CD4+ regulatory T-cells for immunologic self-tolerance and negative control of immune responses. Annu Rev.Immunol 22:531–562, 2004 PubMedCrossRef

31.

Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA: Human natural killer cells: A unique innate immunoregulatory role for the CD56(bright) subset. Blood 97:3146–3151, 2001 PubMedCrossRef

32.

Depper JM, Leonard WJ, Robb RJ, Waldmann TA, Greene WC: Blockade of the interleukin-2 receptor by anti-Tac antibody: Inhibition of human lymphocyte activation. J Immunol 131:690–696, 1983 PubMed

33.

Korsmeyer SJ, Greene WC, Cossman J, Hsu SM, Jensen JP, Neckers LM, Marshall SL, Bakhshi A, Depper JM, Leonard WJ, Jaffe ES, Waldmann TA: Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. Proc Natl Acad Sci USA 80:4522–4526, 1983 PubMedCrossRef

34.

Holter W, Goldman CK, Casabo L, Nelson DL, Greene WC, Waldmann TA: Expression of functional IL 2 receptors by lipopolysaccharide and interferon-gamma stimulated human monocytes. J Immunol 138:2917–2922, 1987 PubMed

35.

Herrmann F, Cannistra SA, Levine H, Griffin JD: Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells. J Exp Med 162:1111–1116, 1985 PubMedCrossRef

36.

Waldmann TA: The structure function and expression of interleukin-2 receptors on normal and malignant lymphocytes. Science 232:727–732, 1986 PubMedCrossRef

37.

Depper JM, Leonard WJ, Kronke M, Noguchi PD, Cunningham RE, Waldmann TA, Greene WC: Regulation of interleukin 2 receptor expression: Effects of phorbol diester phospholipase C and reexposure to lectin or antigen. J Immunol 133:3054–3061, 1984 PubMed

38.

Reem GH, Yeh NH: Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes. Science 225:429–430, 1984 PubMedCrossRef

39.

Cantrell DA, Smith KA: Transient expression of interleukin 2 receptors Consequences for T-cell growth. J Exp Med 158:1895–1911, 1983 PubMedCrossRef

40.

Rubin LA, Nelson DL: The soluble interleukin-2 receptor: Biology function and clinical application. Ann Intern Med 113:619–627, 1990 PubMed

41.

Waldmann TA, Goldman CK, Robb RJ, Depper JM, Leonard WJ, Sharrow SO, Bongiovanni KF, Korsmeyer SJ, Greene WC: Expression of interleukin 2 receptors on activated human B cells. J Exp Med 160:1450–1466, 1984 PubMedCrossRef

42.

Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I: Development and function of T-cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621–624, 1991 PubMedCrossRef

43.

Sadlack B, Kuhn R, Schorle H, Rajewsky K, Muller W, Horak I: Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Eur J Immunol 24:281–284, 1994 PubMed

44.

Waldmann TA, Dubois S, Tagaya Y: Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 14:105–110, 2001 PubMed

45.

Zhang X, Sun S, Hwang I, Tough DF, Sprent J: Potent and selective stimulation of memory-phenotype CD8+ T-cells in vivo by IL-15. Immunity 8:591–599, 1998 PubMedCrossRef

46.

Ku CC, Murakami M, Sakamoto A, Kappler J, Marrack P: Control of homeostasis of CD8+ memory T-cells by opposing cytokines. Science 288:675–678, 2000 PubMedCrossRef

47.

Marks-Konczalik J, Dubois S, Losi JM, Sabzevari H, Yamada N, Feigenbaum L, Waldmann TA, Tagaya Y: IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc Natl Acad Sci USA 97:11445–11450, 2000 PubMedCrossRef

48.

Waldmann TA: The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design. Nat Rev Immunol 6:595–601, 2006 PubMedCrossRef

49.

Sakaguchi S: Naturally arising CD4+ regulatory T-cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22:531–562, 2004 PubMedCrossRef

50.

Lenardo MJ: Fas and the art of lymphocyte maintenance. J Exp Med 183:721–724, 1996 PubMedCrossRef

51.

Roifman CM: Human IL-2 receptor alpha chain deficiency. Pediatr Res 48(1):6–11, 2000 PubMed

52.

Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, Trettin S, Ma A: IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669–676, 1998 PubMedCrossRef

53.

Kennedy MK, Glaccum M, Brown SN, Butz EA, Viney JL, Embers M, Matsuki N, Charrier K, Sedger L, Willis CR, Brasel K, Morrissey PJ, Stocking K, Schuh JC, Joyce S, Peschon JJ: Reversible defects in natural killer and memory CD8 T-cell lineages in interleukin 15-deficient mice. J Exp Med 191:771–780, 2000 PubMedCrossRef

54.

Kirkman RL, Shapiro ME, Carpenter CB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmerman CE, Strom TB: Early experience with anti-Tac in clinical renal transplantation. Transplant Proc 21:1766–1768, 1989 PubMed

55.

Tinubu SA, Hakimi J, Kondas JA, Bailon P, Familletti PC, Spence C, Crittenden MD, Parenteau GL, Dirbas FM, Tsudo M, Bacher JD, Kastensprtes C, Waviucci JL, Gddman CK Clark Re Waldman TA: Humanized antibody directed to the IL-2 receptor beta-chain prolongs primate cardiac allograft survival. J Immunol 153:4330–4338, 1994 PubMed

56.

Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H: Adult T-cell leukemia: Clinical and hematologic features of 16 cases. Blood 50:481–492, 1977 PubMed

57.

Shimoyama M: Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma A report from the Lymphoma study group (1984–87). Br J Haematol 79:428–437, 1991 PubMed

58.

Jeang KT: Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B. Cytokine Growth Factor Rev 12:207–217, 2001 PubMedCrossRef

59.

Uchiyama T: Human T-cell leukemia virus type I (HTLV-I) and human diseases. Annu Rev Immunol 15:15–37, 1997 PubMedCrossRef

60.

Kirkman RL, Shapiro ME, Carpenter CB, McKay DB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmerman CE, Strom TB: A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation. Transplant Proc 23:1066–1067, 1991 PubMed

61.

Queen C, Schneider WP, Selick HE, Payne PW, Landolfi NF, Duncan JF, Avdalovic NM, Levitt M, Junghans RP, Waldmann TA: A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci USA 86:10029–10033, 1989 PubMedCrossRef

62.

Junghans RP, Waldmann TA, Landolfi NF, Avdalovic NM, Schneider WP, Queen C: Anti-Tac-H a humanized antibody to the interleukin 2 receptor with new features for immunotherapy in malignant and immune disorders. Cancer Res 50:1495–1502, 1990 PubMed

63.

Jones PT, Dear PH, Foote J, Neuberger MS, Winter G: Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 321:522–525, 1986 PubMedCrossRef

64.

Nashan B, Light S, Hardie IR, Lin A, Johnson JR: Reduction of acute renal allograft rejection by daclizumab. Daclizumab Double Therapy Study Group. Transplantation 67:110–115, 1999

65.

Carswell CI, Plosker GL, Wagstaff AJ: Daclizumab: A review of its use in the management of organ transplantation. BioDrugs 15:745–773, 2001 PubMedCrossRef

66.

Beniaminovitz A, Itescu S, Lietz K, Donovan M, Burke EM, Groff BD, Edwards N, Mancini DM: Prevention of rejection in cardiac transplantation by blockade of the interleukin-2 receptor with a monoclonal antibody. N Engl J Med 342:613–619, 2000 PubMedCrossRef

67.

Kobashigawa J, David K, Morris J, Chu AH, Steffen BJ, Gotz VP, Gordon RD: Daclizumab is associated with decreased rejection and no increased mortality in cardiac transplant patients receiving MMF cyclosporine and corticosteroids. Transplant Proc 37:1333–1339, 2005 PubMedCrossRef

68.

Eckhoff DE, McGuire B, Sellers M, Contreras J, Frenette L, Young C, Hudson S, Bynon JS: The safety and efficacy of a two-dose daclizumab (Zenapax) induction therapy in liver transplant recipients. Transplantation 69:1867–1872, 2000 PubMedCrossRef

69.

Niemeyer G, Koch M, Light S, Kuse ER, Nashan B: Long-term safety tolerability and efficacy of daclizumab (Zenapax) in a two-dose regimen in liver transplant recipients. Am J Transplant 2:454–460, 2002 PubMedCrossRef

70.

Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230–238, 2000 PubMedCrossRef

71.

Phillips KE, Herring B, Wilson LA, Rickford MS, Zhang M, Goldman CK, Tso JY, Waldmann TA: IL-2R alpha directed monoclonal antibodies provide effective therapy in a murine model of adult T-cell leukemia by a mechanism other than blockade of IL-2/IL-2R alpha interaction. Cancer Res 60:6977–6984, 2000 PubMed

72.

Zhang M, Zhang Z, Garmestani K, Goldman CK, Ravetch JV, Brechbiel MW, Carrasquillo JA, Waldmann TA: Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult T-cell leukemia. Cancer Res 64:5825–5829, 2004 PubMedCrossRef

73.

Tan C, Waldmann TA: Proteasome inhibitor PS-341 a potential therapeutic agent for adult T-cell leukemia. Cancer Res 62:1083–1086, 2002 PubMed

74.

Zhang M, Zhang Z, Goldman CK, Janik J, Waldmann TA: Combination therapy for adult T-cell leukemia-xenografted mice: Flavopiridol and anti-CD25 monoclonal antibody. Blood 105:1231–1236, 2005 PubMedCrossRef

75.

Kreitman RJ, Wilson WH, White JD, Stetler-Stevenson M, Jaffe ES, Giardina S, Waldmann TA, Pastan I: Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J Clin Oncol 18:1622–1636, 2000 PubMed

76.

Axworthy DB, Reno JM, Hylarides MD, Mallett RW, Theodore LJ, Gustavson LM, Su F, Hobson LJ, Beaumier PL, Fritzberg AR: Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity. Proc Natl Acad Sci USA 97:1802–1807, 2000 PubMedCrossRef

77.

Zhang M, Yao Z, Garmestani K, Axworthy DB, Zhang Z, Mallett RW, Theodore LJ, Goldman CK, Brechbiel MW, Carrasquillo JA, Waldmann TA: Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide bismuth. Blood 100:208–216, 2002 PubMedCrossRef

78.

Zhang M, Zhang Z, Garmestani K, Schultz J, Axworthy DB, Goldman CK, Brechbiel MW, Carrasquillo JA, Waldmann TA: Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts. Proc Natl Acad Sci USA 100:1891–1895, 2003 PubMedCrossRef

79.

Zhang M, Yao Z, Zhang Z, Garmestani K, Talanov VS, Plascjak PS, Yu S, Kim HS, Goldman CK, Paik CH, Brechbiel MW, Carrasquillo JA, Waldmann TA: The Anti-CD25 monoclonal antibody 7G7/B6 armed with the {alpha}-emitter 211At provides effective radioimmunotherapy for a murine model of leukemia. Cancer Res 66:8227–8232, 2006 PubMedCrossRef

80.

Sloand EM, Scheinberg P, Maciejewski J, Young NS: Brief communication: Successful treatment of pure red-cell aplasia with an anti-interleukin-2 receptor antibody (daclizumab). Ann Intern Med 144:181–185, 2006 PubMed

81.

Maciejewski JP, Sloand EM, Nunez O, Boss C, Young NS: Recombinant humanized anti-IL-2 receptor antibody (daclizumab) produces responses in patients with moderate aplastic anemia. Blood 102:3584–3586, 2003 PubMedCrossRef

82.

Guex-Crosier Y, Raber J, Chan CC, Kriete MS, Benichou J, Pilson RS, Kerwin JA, Waldmann TA, Hakimi J, Roberge FG: Humanized antibodies against the alpha-chain of the IL-2 receptor and against the beta-chain shared by the IL-2 and IL-15 receptors in a monkey uveitis model of autoimmune diseases. J Immunol 158:452–458, 1997 PubMed

83.

Krueger JG, Walters IB, Miyazawa M, Gilleaudeau P, Hakimi J, Light S, Sherr A, Gottlieb AB: Successful in vivo blockade of CD25 (high-affinity interleukin-2 receptor) on T-cells by administration of humanized anti-Tac antibody to patients with psoriasis. J Am Acad Dermatol 43:448–458, 2000 PubMedCrossRef

84.

Rose JW, Watt HE, White AT, Carlson NG: Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody. Ann Neurol 56:864–867, 2004 PubMedCrossRef

85.

Bielekova B, Howard T, Packer A, Richert N, Blevins G, O’Hayon J, Waldmann TA, McFarland HF, Martin R: Daclizumab inhibits inflammation and stabilizes disease progression in multiple sclerosis. Ann Neurol, in press

86.

Tendler CL, Greenberg SJ, Blattner WA, Manns A, Murphy E, Fleisher T, Hanchard B, Morgan O, Burton JD, Nelson DL, Waldmann TA: Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. Proc Natl Acad Sci USA 87:5218–5222, 1990 PubMedCrossRef

87.

Azimi N, Brown K, Bamford RN, Tagaya Y, Siebenlist U, Waldmann TA: Human T-cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site. Proc Natl Acad Sci USA 95:2452–2457, 1998 PubMedCrossRef

88.

Azimi N, Nagai M, Jacobson S, Waldmann TA: IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients. Proc Natl Acad Sci USA 98:14559–14564, 2001 PubMedCrossRef

89.

Tkaczuk J, Yu CL, Baksh S, Milford EL, Carpenter CB, Burakoff SJ, McKay DB: Effect of anti-IL-2Ralpha antibody on IL-2-induced Jak/STAT signaling. Am J Transplant 2:31–40, 2002 PubMedCrossRef

90.

Goebel J, Stevens E, Forrest K, Roszman TL: Daclizumab (Zenapax) inhibits early interleukin-2 receptor signal transduction events. Transpl Immunol 8:153–159, 2000 PubMedCrossRef

91.

Bielekova B, Catalfamo M, Reichert-Scrivner S, Packer A, Cerna M, Waldmann TA, McFarland H, Henkart PA, Martin R: Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2R alpha-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci USA 103:5941–5946, 2006 PubMedCrossRef

92.

Li Z, Lim WK, Mahesh SP, Liu B, Nussenblatt RB: Cutting edge: In vivo blockade of human IL-2 receptor induces expansion of CD56(bright) regulatory NK cells in patients with active uveitis. J Immunol 174:5187–5191, 2005 PubMed

93.

Zhang B, Yamamura T, Kondo T, Fujiwara M, Tabira T: Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J Exp Med 186:1677–1687, 1997 PubMedCrossRef

94.

Brok HP, Tekoppele JM, Hakimi J, Kerwin JA, Nijenhuis EM, De Groot CW, Bontrop RE, Hart BA: Prophylactic and therapeutic effects of a humanized monoclonal antibody against the IL-2 receptor (DACLIZUMAB) on collagen-induced arthritis (CIA) in rhesus monkeys. Clin Exp Immunol 124:134–141, 2001

Titel: Anti-Tac (daclizumab, Zenapax) in the Treatment of Leukemia, Autoimmune Diseases, and in the Prevention of Allograft Rejection: A 25-Year Personal Odyssey
verfasst von: Thomas A. Waldmann
Publikationsdatum: 01.01.2007
Verlag: Kluwer Academic Publishers-Plenum Publishers
Erschienen in: Journal of Clinical Immunology / Ausgabe 1/2007
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-006-9060-0

Neu im Fachgebiet Innere Medizin

27.05.2023 | DDG-Jahrestagung 2023 | Kongressbericht | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Hauptrubriken

Service

Fachgebiete

Themen

Sammlungen

Springer Medizin

Anti-Tac (daclizumab, Zenapax) in the Treatment of Leukemia, Autoimmune Diseases, and in the Prevention of Allograft Rejection: A 25-Year Personal Odyssey

Abstract

Neu im Fachgebiet Innere Medizin

Was bringen Omega-3-Fettsäuren und Fibrate?

Klonale hämatologische Prämalignome sind nicht assoziiert

Valve-in-Valve-TAVI so sicher wie TAVI in nativer Klappe

Ernährungsempfehlungen für Menschen mit Diabetes

Update Innere Medizin

Hauptrubriken Chevron down icon Chevron up icon

Service Chevron down icon Chevron up icon

Fachgebiete Chevron down icon Chevron up icon

Themen Chevron down icon Chevron up icon

Sammlungen Chevron down icon Chevron up icon

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2007

Rosmarinic Acid Induces Apoptosis of Activated T Cells from Rheumatoid Arthritis Patients via Mitochondrial Pathway

Novel Analysis of Clonal Diversification in Blood B Cell and Bone Marrow Plasma Cell Clones in Immunoglobulin Light Chain Amyloidosis

The Expression of Retinoic Acid Receptors in Lymph Nodes of Young Children and the Effect of All-trans-Retinoic Acid on the B Cells from Lymph Nodes

Primary Immunodeficiency Diseases in Latin America: The Second Report of the LAGID Registry

Gene Polymorphisms in CCR5, CCR2, CX3CR1, SDF-1 and RANTES in Exposed but Uninfected Partners of HIV-1 Infected Individuals in North India

The Effect of Natural Killer Cell Killer Ig-Like Receptor Alloreactivity on the Outcome of Bone Marrow Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID)

Neu im Fachgebiet Innere Medizin

Was bringen Omega-3-Fettsäuren und Fibrate?

Klonale hämatologische Prämalignome sind nicht assoziiert

Valve-in-Valve-TAVI so sicher wie TAVI in nativer Klappe

Ernährungsempfehlungen für Menschen mit Diabetes

Update Innere Medizin

Hauptrubriken

Service

Fachgebiete

Themen

Sammlungen