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01.01.2007 | Original Paper

Similar CD19 Dysregulation in Two Autoantibody-Associated Autoimmune Diseases Suggests a Shared Mechanism of B-Cell Tolerance Loss

verfasst von: DONNA A. CULTON, MATILDA W. NICHOLAS, DONNA O. BUNCH, QUAN LI ZHEN, THOMAS B. KEPLER, MARY ANNE DOOLEY, CHANDRA MOHAN, PATRICK H. NACHMAN, STEPHEN H. CLARKE

Erschienen in: Journal of Clinical Immunology | Ausgabe 1/2007

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We report here that dysregulation of CD19, a coreceptor that augments B-cell receptor (BCR) signaling, occurs at two B-cell differentiative stages in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic autoantibody (ANCA) associated small vessel vasculitis (SVV). The naïve B cells of nearly all SLE and ANCA-SVV patients express ∼20% less CD19 than healthy control (HC) B cells. In contrast, a subset of memory B cells of some SLE and ANCA-SVV Pts (25–35%) express two to fourfold more CD19 than HC B cells. These CD19^hi memory B cells are activated and exhibit evidence of antigen selection. Proteome array analysis of 67 autoantigens indicates that CD19^hi SLE Pts exhibit a distinct autoantibody profile characterized by high levels of antibodies to small nuclear ribonucleoproteins and low levels of antiglomerular autoantibodies. These findings have implications for autoreactive B-cell activation and suggest a shared mechanism of B-cell tolerance loss in these two diseases.

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Titel: Similar CD19 Dysregulation in Two Autoantibody-Associated Autoimmune Diseases Suggests a Shared Mechanism of B-Cell Tolerance Loss
verfasst von: DONNA A. CULTON
MATILDA W. NICHOLAS
DONNA O. BUNCH
QUAN LI ZHEN
THOMAS B. KEPLER
MARY ANNE DOOLEY
CHANDRA MOHAN
PATRICK H. NACHMAN
STEPHEN H. CLARKE
Publikationsdatum: 01.01.2007
Verlag: Kluwer Academic Publishers-Plenum Publishers
Erschienen in: Journal of Clinical Immunology / Ausgabe 1/2007
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-006-9051-1

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