Introduction
Materials and methods
Clinical and gene expression data
Combined microarray dataset
Statistical analyses
Results
Outcome prediction
Variables | Univariate analysis | Multivariate analysis | ||||||
---|---|---|---|---|---|---|---|---|
HR | Lower 95 % | Upper 95 % |
p Value | HR | Lower 95 % | Upper 95 % |
p Value | |
Age (cont. variable) | 0.989 | 0.983 | 0.996 | 0.003 | 0.996 | 0.988 | 1.003 | 0.257 |
Node status | 1.176 | 0.851 | 0.992 | 0.063 | 1.695 | 1.315 | 2.184 | <0.001 |
Tumor size T2–T4 versus T0–T1 | 1.305 | 1.104 | 1.541 | 0.002 | 1.242 | 1.042 | 1.480 | 0.015 |
Treatment (yes vs. no) | 0.973 | 0.845 | 1.121 | 0.707 | 0.547 | 0.428 | 0.700 | <0.001 |
PAM50 | ||||||||
Luminal A | 1.0 | – | – | – | 1.0 | – | – | – |
Luminal B | 1.797 | 1.503 | 2.149 | <0.001 | 2.041 | 1.578 | 2.641 | <0.001 |
HER2-E | 2.677 | 2.120 | 3.380 | <0.001 | 1.648 | 1.073 | 2.530 | 0.023 |
Basal-like | 2.144 | 1.737 | 2.647 | <0.001 | 1.312 | 0.812 | 2.121 | 0.268 |
Normal-like | 1.073 | 0.670 | 1.718 | 0.769 | 1.024 | 0.572 | 1.835 | 0.936 |
Three-gene signature | ||||||||
ER+/HER2−/Low Prolif | 1.0 | – | – | – | 1.0 | – | – | – |
ER+/HER2−/High Prolif | 1.852 | 1.531 | 2.241 | <0.001 | 1.153 | 0.882 | 1.508 | 0.297 |
HER2+ | 2.785 | 2.196 | 3.533 | <0.001 | 1.588 | 1.053 | 2.395 | 0.028 |
ER−/HER2− | 2.536 | 2.041 | 3.150 | <0.001 | 1.762 | 1.095 | 2.835 | 0.020 |
Chemotherapy response prediction
Variables |
N
| pCR rate (%) | Univariate analysis | Multivariate analysis | ||||||
---|---|---|---|---|---|---|---|---|---|---|
OR | Lower 95 % | Upper 95 % |
p Value | OR | Lower 95 % | Upper 95 % |
p Value | |||
Age (cont. variable) | – | – | 1.0 | 0.95 | 1.01 | 0.169 | – | – | – | – |
Tumor size | ||||||||||
T0–T1 | 23 | 35 | 1.0 | – | – | – | 1.0 | – | – | – |
T2–T4 | 203 | 19 | 2.3 | 0.92 | 5.86 | 0.076 | 0.4 | 0.13 | 1.23 | 0.111 |
PAM50 | ||||||||||
Luminal A | 66 | 3 | 1.0 | – | – | – | 1.0 | – | – | – |
Luminal B | 66 | 9 | 3.2 | 0.62 | 16.47 | 0.164 | 5.2 | 0.68 | 37.97 | 0.108 |
HER2-E | 28 | 46 | 23.5 | 5.25 | 105.36 | <0.001 | 12.5 | 1.46 | 145.68 | 0.030 |
Basal-like | 59 | 42 | 27.7 | 5.65 | 136.18 | <0.001 | 25.3 | 2.64 | 255.95 | 0.005 |
Normal-like | 7 | 0 | 0.0 | 0.00 | – | 0.988 | 0.0 | 0.00 | – | 0.988 |
Three-gene signature | ||||||||||
ER+/HER2−/Low Prolif | 52 | 4 | 1.0 | – | – | – | 1.0 | – | – | – |
ER+/HER2−/High Prolif | 85 | 8 | 2.2 | 0.45 | 11.23 | 0.325 | 0.6 | 0.08 | 4.62 | 0.633 |
HER2+ | 24 | 50 | 25.0 | 4.93 | 126.80 | <0.001 | 3.9 | 0.34 | 46.46 | 0.275 |
ER−/HER2− | 65 | 38 | 15.6 | 3.49 | 69.93 | <0.001 | 0.9 | 0.09 | 9.97 | 0.954 |