Background
Methods
Study populations
Evaluation
Definitions and diagnostic criteria
Ethical considerations
Statistical analysis
Results
Characteristics of patients with TIA and controls
Sex | Age interval | |||||||
---|---|---|---|---|---|---|---|---|
15–25 | 26–35 | 36–45 | 46–55 | 56–65 | 66–75 | 76–90 | Mean age | |
Male TIA patinets (n = 55) | 3 (5.5%) | 4 (7.3%) | 5 (9.1%) | 7 (12.7%) | 22 (40%) | 10 (18.2%) | 4 (7.3%) | 56.5 |
Male controls (n = 69) | 0 (0.0%) | 2 (2.9%) | 11 (15.9%) | 24 (34.8%) | 17 (24.6%) | 9 (13.0%) | 6 (8.7%) | 56.5 |
Female TIA patients (n = 65) | 5 (7.7%) | 7 (10.8%) | 7 (10.8%) | 9 (13.8%) | 16 (24.6%) | 11 (16.9%) | 10 (15.4%) | 55.7 |
Female controls (n = 123) | 0 (0.0%) | 5 (4.1%) | 11 (8.9%) | 25 (20.3%) | 41 (33.3%) | 26 (21.1%) | 15 (12.2%) | 59.9 |
All TIA patients (n = 120) | 8 (6.7%) | 11 (9.2%) | 12 (10.0%) | 16 (13.3%) | 38 (31.7%) | 21 (17.5%) | 14 (11.7%) | 56,1 |
All control patients (n = 192) | 0 (0.0%) | 7 (3.6%) | 22 (11.5%) | 49 (25.5%) | 58 (30.2%) | 35 (18.2%) | 21 (10.9%) | 58.7 |
Characteristics | Patients with TIA (n = 120) | Controls (n = 192) | Р value |
---|---|---|---|
Mean age | 56.1 | 58.7 | 0.1 |
Male, n (%) | 55 (45.8%) | 69 (35.9%) | 0.1 |
Current smoker, n (%) | 38 (31.7%) | 45 (23.4%) | 0.1 |
Consumption of light alcoholic beverages, n (%) | 5 (4.2%) | 11 (5.7%) | 0.7 |
Consumption of strong alcoholic beverages, n (%) | 23 (19.2%) | 18 (9.4%) | 0.02 |
Arterial hypertension, n (%) | 94 (78.3%) | 108 (56.3%) | < 0.001 |
Diabetes mellitus, n (%) | 10 (8.3%) | 14 (7.3%) | 0.9 |
Hyperglycemia n (%) | 23 (19.2%) | 26 (13.5%) | 0.2 |
Atrial fibrillation, n (%) | 14 (11.6%) | 7 (3.6%) | 0.01 |
Body mass index > 25, n (%) | 68 (56.7%) | 118 (61.5%) | 0.5 |
Low physical activity, n (%) | 45 (37.5%) | 28 (14.6%) | < 0.001 |
Family history of stroke in first degree relatives, n (%) | 53 (44.2%) | 48(25.0%) | 0.001 |
Peripheral artery disease, n (%) | 2 (1.7%) | 1 (0.5%) | 0.7 |
Hypercholesterolemia, n (%) | 56 (46.7%) | 55 (28.6%) | 0.002 |
Angina pectoris, n (%) | 32 (26.7%) | 18 (9.4%) | < 0.001 |
Myocardial infarction, n (%) | 11 (9.2%) | 7 (3.6%) | 0.07 |
Headache within last year (excepting last week) before TIA
Type of headaches | Males with TIA (n = 55) | Male controls (n = 69) | Р, ОR (95% CI) | Females with TIA (n = 65) | Female controls (n = 123) | Р, ОR (95% CI) | All patients with TIA (n = 120) | All controls (n = 192) | Р, ОR (95% CI) |
---|---|---|---|---|---|---|---|---|---|
Migraine without aura | 3 (5.5%)b | 1 (1.4%) | 0.5 | 22 (33.8%) | 14 (11.4%) | < 0.001, 4.0; 1.9–8.5 | 25 (20.8%) | 15 (7.8%) | 0.002, 3.1; 1.6–6.2 |
Migraine with aura | 0 | 0 | – | 1 (1.5%) | 1 (0.8%) | 0.8 | 1 (0.8%) | 1 (0.52%) | 0.7 |
Chronic migraine | 0 | 0 | – | 1 (1.5%) | 1 (0.8%) | 0.8 | 1 (0.8%) | 1 (0.52%) | 0.7 |
Episodic TTHc | 40 (72.7%) | 48 (69%) | 0.9 | 46 (70.8%) | 84 (68.3%) | 0.9 | 86 (71.7%) | 132 (68.7%) | 0.6 |
Chronic TTH | 0 | 0 | – | 4 (6.2%) | 3 (2.4%) | 0.4 | 4 (3.3%) | 3 (1.6%) | 0.5 |
Cluster headache | 1 (1.8%) | 0 | 0.9 | 0 | 1 (0.81%) | 0.7 | 1 (0.8%) | 1 (0.52%) | 0.7 |
Medication overuse headache (analgesics) | 0 | 0 | – | 2 (3.1%) | 0 | 0.2 | 2 (1.7%) | 0 | 0.3 |
Absence of headache | 11 (20%) | 20 (29%) | 0.3 | 9 (13.8%) | 14 (11.4%) | 0.8 | 20 (16.6%) | 34 (17.7%) | 0.9 |
Headache within the last week before TIA
Type of headache | Previous headache without changes in patients with TIA | Previous headache without changes in controls | Р, ОR (95% CI) | Previous headache with changes in patients with TIA | Previous headache with changes in controls | Р, ОR (95% CI) | New type of headache in patients with TIA | New type of headache in controls | Р, ОR (95% CI) |
---|---|---|---|---|---|---|---|---|---|
Migraine without auraa | 2(1.6%) | 0 (0%) | 0.07 | 4 (3.3%) | 0 | 0.01 | 2 (1.6%) | 0 | 0.07 |
Migraine with auraa | 0 | 0 | – | 0 | 0 | – | 1 (0.8%) | 0 | 0.2 |
TTHa | 2 (1.6%) | 10 (5.2%) | 0.1 | 12 (10%) | 2 (1.0%) | 0.0002 | 2 (1.6%) | 0 | 0.01 |
Cluster headache | 0 | 0 | – | 0 | 0 | – | 0 | 0 | – |
Thunderclap headache | N/Ab | N/A | – | N/A | – | 1 (0.8%) | 0 | 0.2 | |
All headaches | 4 (3.3%) | 10 (5.2%) | 0.4 | 16 (13.3%) | 2 (1.0%) | 0.00001 | 6 (5%) | 0 | 0.0003 |
Headache at the time of TIA
Type of headache | Headaches at the time of development of TIA | ||||||||
---|---|---|---|---|---|---|---|---|---|
Previous headache without changes in patients with TIA | Previous headache without changes in controls | Р, ОR (95% CI) | Previous headache with changes in patients with TIA | Previous headache with changes in controls | Р, ОR (95% CI) | New type of headache in patients with TIA | New type of headache in patients with controls | Р, ОR (95% CI) | |
Migraine without aura | 2 (1.6%) | 5 (4.1%) | 0.6 | 4 (3.3%) | 0 | 0.01 | 11 (9.1%) | 0 | 0.00001 |
Migraine with aura | 0 | 0 | – | 0 | 0 | – | 1 (0.83%) | 0 | 0.2 |
TTH | 6 (5%) | 4 (3.3%) | 0.1 | 5 (4.1%) | 0 | 0.004 | 3 (2.5%) | 0 | 0.02 |
Cluster headache | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 0 |
Thunderclap headache | N/A | N/A | – | N/A | N/A | – | 1 (0.83%) | 0 | 0.2 |
All headaches | 8 (6.6%) | 9 (4.6%) | 0.4 | 9 (7.5%) | 0 | 0.0001 | 16 (13.3%) | 0 | 0.00001 |