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01.04.2011 | Magnetic Resonance

Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: a quantitative comparison with spectroscopic findings

verfasst von: Fabian Springer, Stefan Ehehalt, Julia Sommer, Verena Ballweg, Jürgen Machann, Gerhard Binder, Claus D. Claussen, Fritz Schick, for the DISKUS-Study Group

Erschienen in: European Radiology | Ausgabe 4/2011

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Abstract

Objective

To test the feasibility of fat-selective GRE imaging using a spectral-spatial excitation technique for determination of intrahepatic lipid content (IHL) in obese adolescents.

Methods

Fat-selective MR imaging (1.5 T) was applied to record a single axial slice through a representative liver region within a single breath-hold. The sequence uses six equidistant slice-selective excitation pulses with binomial amplitude ratios to achieve high selectivity for lipid signals after appropriate shimming. IHL_MRI content was quantified using signal intensity of adjacent subcutaneous adipose tissue. As the gold standard for IHL quantification, single-voxel stimulated echo magnetic resonance spectroscopy (MRS) was applied. IHL_MRS was quantified using the water peak as a reference.

Results

Forty-five MR examinations could be performed, and IHL_MRS content ranged from 0.7% to 19.1%. Results from MRS and fat-selective imaging correlated well with Spearman coefficients between r = 0.78 and r = 0.86. There were no relevant regional differences in IHL within the liver parenchyma (p > 0.6359). Fat-selective imaging was able to reliably identify patients with IHL content above 5% with positive/negative likelihood ratio of 11.8 and 0.05, respectively.

Conclusion

Fat-selective MR imaging provides both a reliable and a convenient method of rapidly quantifying IHL content in obese adolescents.

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Titel: Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: a quantitative comparison with spectroscopic findings
verfasst von: Fabian Springer
Stefan Ehehalt
Julia Sommer
Verena Ballweg
Jürgen Machann
Gerhard Binder
Claus D. Claussen
Fritz Schick
for the DISKUS-Study Group
Publikationsdatum: 01.04.2011
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 4/2011
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1975-4

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Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: a quantitative comparison with spectroscopic findings