The online version of this article (doi:10.1186/ar3401) contains supplementary material, which is available to authorized users.
Miguel A González-Gay and Javier Martin contributed equally to this work.
The authors declare that they have no competing interests.
MT, JEM, NB and JM made substantial contributions to the conception and design of the study, and the interpretation of data. MT carried out genotyping, analysis of data and drafted the manuscript. JEM carried out genotyping. CGJ, RLM, JAMF, RB, AB, DPS, LRR, BFG, AMO, IGA and CGV were involved in the acquisition of cardiovascular data in the different Spanish hospitals included in this study. JL carried out the analysis and interpretation of the data. JM and MAGG were involved in revising the manuscript and gave final approval of the version to be published.
Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACP1 polymorphisms to susceptibility to rheumatoid arthritis (RA), as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease (CV) observed in RA patients.
A set of 1,603 Spanish RA patients and 1,877 healthy controls were included in the study. Information related to the presence/absence of CV events was obtained from 1,284 of these participants. All individuals were genotyped for four ACP1 single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247, and rs3828329, using a predesigned TaqMan SNP genotyping assay. Classical ACP1 alleles (*A, *B and *C) were imputed with SNP data.
No association between ACP1 gene polymorphisms and susceptibility to RA was observed. However, when RA patients were stratified according to the presence or absence of CV events, an association between rs11553742*T and CV events was found (P = 0.012, odds ratio (OR) = 2.62 (1.24 to 5.53)). Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA (P = 0.024, OR = 2.43).
Our data show that the ACP1*C allele influences the risk of CV events in patients with RA.
Additional file 1: Genotype and allele distribution of ACP1 polymorphisms in Spanish RA patients and healthy subjects. Supplementary table S1 shows the genotype and allele frequencies of ACP1 polymorphisms in Spanish RA patients and healthy controls. That table also shows the lack of association among cases and controls. (DOC 51 KB)13075_2011_3153_MOESM1_ESM.DOC
Additional file 2: Distribution of ACP1 alleles in Spanish RA patients and healthy controls. Supplementary table S2 shows the frequencies of ACP1 alleles in Spanish RA patients and individuals controls. No association was observed. (DOC 44 KB)13075_2011_3153_MOESM2_ESM.DOC
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- Association of acid phosphatase locus 1*Callele with the risk of cardiovascular events in rheumatoid arthritis patients
Jose A Miranda-Filloy
Ana M Ortiz
Miguel A González-Gay
- BioMed Central
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