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04.07.2015 | Educational Review

Autophagy in renal diseases

verfasst von: Stéphanie De Rechter, Jean-Paul Decuypere, Ekaterina Ivanova, Lambertus P. van den Heuvel, Humbert De Smedt, Elena Levtchenko, Djalila Mekahli

Erschienen in: Pediatric Nephrology | Ausgabe 5/2016

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Abstract

Autophagy is the cell biology process in which cytoplasmic components are degraded in lysosomes to maintain cellular homeostasis and energy production. In the healthy kidney, autophagy plays an important role in the homeostasis and viability of renal cells such as podocytes and tubular epithelial cells and of immune cells. Recently, evidence is mounting that (dys)regulation of autophagy is implicated in the pathogenesis of various renal diseases, and might be an attractive target for new renoprotective therapies. In this review, we provide an overview of the role of autophagy in kidney physiology and kidney diseases.

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Titel: Autophagy in renal diseases
verfasst von: Stéphanie De Rechter
Jean-Paul Decuypere
Ekaterina Ivanova
Lambertus P. van den Heuvel
Humbert De Smedt
Elena Levtchenko
Djalila Mekahli
Publikationsdatum: 04.07.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 5/2016
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-015-3134-2

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