Skip to main content
Erschienen in: Archives of Gynecology and Obstetrics 5/2007

01.05.2007 | Case Report

Bilateral micropapillary serous carcinoma of the ovary: a case report

verfasst von: Ruchika Gupta, Sompal Singh, Sonu Nigam

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2007

Einloggen, um Zugang zu erhalten

Abstract

Background

Micropapillary serous carcinoma (MPSC), a recently described entity in the group of serous borderline tumor, needs to be recognized and separated from serous borderline tumor of usual type (SBT) as MPSC has a worse prognosis.

Case report

We report the case of a 21-year-old female with gradually increasing lump abdomen for 6 months. Ultrasonography showed bilateral ovarian enlargement with cysts. Laparotomy revealed both ovaries to be enlarged and right ovary showed capsular breach. With a per-operative diagnosis of bilateral malignant ovarian tumor, total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Multiple sections from both ovaries showed non-invasive micropapillary serous carcinoma with right ovary showing surface growth but no definite capsular breach. The final histological diagnosis was bilateral micropapillary serous carcinoma. The patient has been asymptomatic in 10-month follow-up.

Conclusion

MPSC, classified as serous borderline tumor, needs to be differentiated from APST as well as conventional serous carcinoma. It is diagnosed according to strict criteria laid down. Multiple sections should be studied to exclude invasion. Adequate peritoneal sampling should be performed to look for implants, which is of prognostic significance.
Literatur
1.
Zurück zum Zitat Burks RT, Sherman ME, Kurman RJ (1996) Micropapillary serous carcinoma of the ovary: a distinctive low-grade carcinoma related to serous borderline tumors. Am J Surg Pathol 20:1319–1330PubMedCrossRef Burks RT, Sherman ME, Kurman RJ (1996) Micropapillary serous carcinoma of the ovary: a distinctive low-grade carcinoma related to serous borderline tumors. Am J Surg Pathol 20:1319–1330PubMedCrossRef
2.
Zurück zum Zitat Bell KA, Sehdev AES, Kurman RJ (2001) Refined diagnostic criteria for implants associated with ovarian atypical proliferative serous tumors (borderline) and micropapillary serous carcinomas. Am J Surg Pathol 25:419–432PubMedCrossRef Bell KA, Sehdev AES, Kurman RJ (2001) Refined diagnostic criteria for implants associated with ovarian atypical proliferative serous tumors (borderline) and micropapillary serous carcinomas. Am J Surg Pathol 25:419–432PubMedCrossRef
3.
Zurück zum Zitat Seidman JD, Kurman RJ (1996) Sub-classification of serous borderline tumors of the ovary into benign and malignant types: a clinico-pathologic study of 65 advanced stage cases. Am J Surg Pathol 20:1331–1345PubMedCrossRef Seidman JD, Kurman RJ (1996) Sub-classification of serous borderline tumors of the ovary into benign and malignant types: a clinico-pathologic study of 65 advanced stage cases. Am J Surg Pathol 20:1331–1345PubMedCrossRef
4.
Zurück zum Zitat Eichhorn JH, Bell DA, Young RH, Scully RL (1999) Ovarian serous borderline tumors with micropapillary and cribriform patterns: a study of 40 cases and comparison with 44 cases without these patterns. Am J Surg Pathol 23:397–409PubMedCrossRef Eichhorn JH, Bell DA, Young RH, Scully RL (1999) Ovarian serous borderline tumors with micropapillary and cribriform patterns: a study of 40 cases and comparison with 44 cases without these patterns. Am J Surg Pathol 23:397–409PubMedCrossRef
5.
Zurück zum Zitat Sehdev AES, Sehdev PS, Kurman RJ (2003) Noninvasive and invasive micopapillary (low-grade) serous carcinoma of the ovary: a clinicopathologic analysis of 135 cases. Am J Surg Pathol 27:725–736PubMedCrossRef Sehdev AES, Sehdev PS, Kurman RJ (2003) Noninvasive and invasive micopapillary (low-grade) serous carcinoma of the ovary: a clinicopathologic analysis of 135 cases. Am J Surg Pathol 27:725–736PubMedCrossRef
6.
Zurück zum Zitat Prat J, de Nictolis M (2002) Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion. Am J Surg Pathol 26:1111–1128PubMedCrossRef Prat J, de Nictolis M (2002) Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion. Am J Surg Pathol 26:1111–1128PubMedCrossRef
7.
Zurück zum Zitat Singer G, Stohr R, Cope L, Dehari R, Hartmann A, Cao DF, Wang TL, Kurman RJ, Shih IeM (2005) Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinoma and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation. Am J Surg Pathol 29:218–224PubMedCrossRef Singer G, Stohr R, Cope L, Dehari R, Hartmann A, Cao DF, Wang TL, Kurman RJ, Shih IeM (2005) Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinoma and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation. Am J Surg Pathol 29:218–224PubMedCrossRef
8.
Zurück zum Zitat Shih IeM, Kurman RJ (2004) Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol 164:1511–1518PubMed Shih IeM, Kurman RJ (2004) Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol 164:1511–1518PubMed
Metadaten
Titel
Bilateral micropapillary serous carcinoma of the ovary: a case report
verfasst von
Ruchika Gupta
Sompal Singh
Sonu Nigam
Publikationsdatum
01.05.2007
Verlag
Springer-Verlag
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 5/2007
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-006-0255-7

Weitere Artikel der Ausgabe 5/2007

Archives of Gynecology and Obstetrics 5/2007 Zur Ausgabe

Alter der Mutter beeinflusst Risiko für kongenitale Anomalie

28.05.2024 Kinder- und Jugendgynäkologie Nachrichten

Welchen Einfluss das Alter ihrer Mutter auf das Risiko hat, dass Kinder mit nicht chromosomal bedingter Malformation zur Welt kommen, hat eine ungarische Studie untersucht. Sie zeigt: Nicht nur fortgeschrittenes Alter ist riskant.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Fehlerkultur Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mammakarzinom: Brustdichte beeinflusst rezidivfreies Überleben

26.05.2024 Mammakarzinom Nachrichten

Frauen, die zum Zeitpunkt der Brustkrebsdiagnose eine hohe mammografische Brustdichte aufweisen, haben ein erhöhtes Risiko für ein baldiges Rezidiv, legen neue Daten nahe.

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.