Erschienen in:
25.01.2021
Biliary inflammation scoring for immunoglobulin G4-related sclerosing cholangitis: an endoscopic approach with endoscopic ultrasound
verfasst von:
Yunlu Feng, Shengyu Zhang, Zehui Zheng, Xi Wu, Tao Guo, Qingwei Jiang, Qiang Wang, Dongsheng Wu, Aiming Yang
Erschienen in:
Surgical Endoscopy
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Ausgabe 12/2021
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Abstract
Background and Aims
The differential diagnosis of immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) and cholangiocarcinoma (CC) remains a clinical challenge. Imaging modalities play critical roles in the diagnosis of IgG4-SC. The present study aimed to evaluate the differential diagnosis of IgG4-SC and CC based on images of endoscopic ultrasound (EUS).
Methods
The biliary inflammation scoring (BIS) method for EUS was developed based on the comparison between images of IgG4-SC and that of cholangiocarcinoma (CC) and other acute or chronic cholangitis. In the BIS diagnostic phase, the EUS images from 66 IgG4-SC patients and 44 CC patients were blindly evaluated using the BIS methods.
Results
The sensitivity, specificity, and accuracy of the newly established BIS in distinguishing IgG4-SC from CC were 86% [95% confidence interval (CI) 75–93%], 95% (95% CI 83–99%), and 90% (95% CI 83–94%), respectively.
Conclusion
EUS should be considered to be added to the workup algorithm in patients with suspected IgG4-SC as a useful diagnostic procedure. BIS is a promising diagnostic method to discriminate IgG4-SC during the ongoing endoscopy.