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Erschienen in: Heart and Vessels 5/2015

01.09.2015 | Case Report

Black hole restenosis after drug-eluting stent implantation for in-stent restenosis: potential mechanism and optimal strategy

verfasst von: Yoritaka Otsuka, Takashi Murata, Michiaki Kono, Hiroki Imoto, Taku Koyama, Keita Nakamura, Sunao Kadama, Hiroo Noguchi, Taro Saito

Erschienen in: Heart and Vessels | Ausgabe 5/2015

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Abstract

In-stent restenosis (ISR) has long remained as the major limitation of coronary stenting. The use of drug-eluting stent (DES) reduces the risk of repeat revascularization without an increase of death and myocardial infarction, compared to the standard bare metal stents. DES has also demonstrated markedly to reduce ISR for complex lesions. However, ISR after DES implantation still occurs and optimal treatment for ISR after DES has not been established. Herein, we report 3 cases with black hole restenosis confirmed by intravascular ultrasound at the site of overlapped DES and discuss potential mechanism and optimal strategy for this phenomenon.
Literatur
1.
Zurück zum Zitat Morice MC, Serruys PW, Sousa JE, Fajadet J, BanHayashi E, Perin M, Colombo A, Schuler G, Barragan P, Guagliumi G, Molnàr F, Falotico R, RAVEL Study Group (2002) A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med 346:1773–1780CrossRefPubMed Morice MC, Serruys PW, Sousa JE, Fajadet J, BanHayashi E, Perin M, Colombo A, Schuler G, Barragan P, Guagliumi G, Molnàr F, Falotico R, RAVEL Study Group (2002) A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med 346:1773–1780CrossRefPubMed
2.
Zurück zum Zitat Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O’Shaughnessy C, Caputo RP, Kereiakes DJ, Williams DO, Teirstein PS, Jaeger JL, Kuntz RE, SIRIUS Investigators (2003) Sirolimus-eluting stents versus standard stents in patientswith stenosis in a native coronary artery. N Engl J Med 349:1315–1323CrossRefPubMed Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O’Shaughnessy C, Caputo RP, Kereiakes DJ, Williams DO, Teirstein PS, Jaeger JL, Kuntz RE, SIRIUS Investigators (2003) Sirolimus-eluting stents versus standard stents in patientswith stenosis in a native coronary artery. N Engl J Med 349:1315–1323CrossRefPubMed
3.
Zurück zum Zitat Dangas GD, Claessen BE, Caixeta A, Sanidas EA, Mintz GS, Mehran R (2010) In-stent restenosis in the drug-eluting stent era. J Am Coll Cardiol 56:1897–1907CrossRefPubMed Dangas GD, Claessen BE, Caixeta A, Sanidas EA, Mintz GS, Mehran R (2010) In-stent restenosis in the drug-eluting stent era. J Am Coll Cardiol 56:1897–1907CrossRefPubMed
4.
Zurück zum Zitat Farooq V, Gogas BD, Serruys PW (2011) Restenosis: delineating the numerous causes of drug-eluting stent restenosis. Circ Cardiovasc Interv 4:195–205CrossRefPubMed Farooq V, Gogas BD, Serruys PW (2011) Restenosis: delineating the numerous causes of drug-eluting stent restenosis. Circ Cardiovasc Interv 4:195–205CrossRefPubMed
5.
Zurück zum Zitat Abe M, Kimura T, Morimoto T, Taniguchi T, Yamanaka F, Nakao K, Yagi N, Kokubu N, Kasahara Y, Kataoka Y, Otsuka Y, Kawamura A, Miyazaki S, Nakao K, Horiuchi K, Ito A, Hoshizaki H, Kawaguchi R, Setoguchi M, Inada T, Kishi K, Sakamoto H, Morioka N, Imai M, Shiomi H, Nonogi H, Mitsudo K, j-Cypher Registry Investigators (2010) Sirolimus-eluting stent versus balloon angioplasty for sirolimus-eluting stent restenosis: Insights from the j-Cypher Registry. Circulation 122:42–51CrossRefPubMed Abe M, Kimura T, Morimoto T, Taniguchi T, Yamanaka F, Nakao K, Yagi N, Kokubu N, Kasahara Y, Kataoka Y, Otsuka Y, Kawamura A, Miyazaki S, Nakao K, Horiuchi K, Ito A, Hoshizaki H, Kawaguchi R, Setoguchi M, Inada T, Kishi K, Sakamoto H, Morioka N, Imai M, Shiomi H, Nonogi H, Mitsudo K, j-Cypher Registry Investigators (2010) Sirolimus-eluting stent versus balloon angioplasty for sirolimus-eluting stent restenosis: Insights from the j-Cypher Registry. Circulation 122:42–51CrossRefPubMed
6.
Zurück zum Zitat Habara S, Mitsudo K, Kadota K, Goto T, Fujii S, Yamamoto H, Katoh H, Oka N, Fuku Y, Hosogi S, Hirono A, Maruo T, Tanaka H, Shigemoto Y, Hasegawa D, Tasaka H, Kusunose M, Otsuru S, Okamoto Y, Saito N, Tsujimoto Y, Eguchi H, Miyake K, Yoshino M (2011) Effectiveness of paclitaxel-eluting balloon catheter in patients with sirolimus-eluting stent restenosis. JACC Cardiovasc Interv 4:149–154CrossRefPubMed Habara S, Mitsudo K, Kadota K, Goto T, Fujii S, Yamamoto H, Katoh H, Oka N, Fuku Y, Hosogi S, Hirono A, Maruo T, Tanaka H, Shigemoto Y, Hasegawa D, Tasaka H, Kusunose M, Otsuru S, Okamoto Y, Saito N, Tsujimoto Y, Eguchi H, Miyake K, Yoshino M (2011) Effectiveness of paclitaxel-eluting balloon catheter in patients with sirolimus-eluting stent restenosis. JACC Cardiovasc Interv 4:149–154CrossRefPubMed
7.
Zurück zum Zitat Habara S, Iwabuchi M, Inoue N, Nakamura S, Asano R, Nanto S, Hayashi Y, Shiode N, Saito S, Ikari Y, Kimura T, Hosokawa J, Nakamura M, Kotani J, Kozuma K, Mitsudo K (2013) A multicenter randomized comparison of paclitaxel-coated balloon catheter with conventional balloon angioplasty in patients with bare-metal stent restenosis and drug-eluting stent restenosis. Am Heart J 166:527–533CrossRefPubMed Habara S, Iwabuchi M, Inoue N, Nakamura S, Asano R, Nanto S, Hayashi Y, Shiode N, Saito S, Ikari Y, Kimura T, Hosokawa J, Nakamura M, Kotani J, Kozuma K, Mitsudo K (2013) A multicenter randomized comparison of paclitaxel-coated balloon catheter with conventional balloon angioplasty in patients with bare-metal stent restenosis and drug-eluting stent restenosis. Am Heart J 166:527–533CrossRefPubMed
8.
Zurück zum Zitat Nakano M, Otsuka F, Yahagi K, Sakakura K, Kutys R, Ladich ER, Finn AV, Kolodgie FD, Virmani R (2013) Human autopsy study of drug-eluting stents restenosis: histomorphological predictors and neointimal characteristics. Eur Heart J 34:3304–3313CrossRefPubMedCentralPubMed Nakano M, Otsuka F, Yahagi K, Sakakura K, Kutys R, Ladich ER, Finn AV, Kolodgie FD, Virmani R (2013) Human autopsy study of drug-eluting stents restenosis: histomorphological predictors and neointimal characteristics. Eur Heart J 34:3304–3313CrossRefPubMedCentralPubMed
9.
Zurück zum Zitat Koshy SK, Kleiman NS, George LK, Misra V, Hillegass WB, Brott BC (2008) Vascular changes and black hole phenomenon after coronary brachytherapy: a pathologically distinct entity. J Invasive Cardiol 20:560–562PubMed Koshy SK, Kleiman NS, George LK, Misra V, Hillegass WB, Brott BC (2008) Vascular changes and black hole phenomenon after coronary brachytherapy: a pathologically distinct entity. J Invasive Cardiol 20:560–562PubMed
10.
Zurück zum Zitat Costa MA, Simon DI (2005) Molecular basis of restenosis and drug-eluting stents. Circulation 111:2257–2273CrossRefPubMed Costa MA, Simon DI (2005) Molecular basis of restenosis and drug-eluting stents. Circulation 111:2257–2273CrossRefPubMed
11.
Zurück zum Zitat Costa MA, Sabate M, Angiolillo DJ, Jimenez-Quevedo P, Teirstein P, Carter A, Leon MB, Moses J, Zenni M, Yakubov S, Guzman LA, Gilmore P, Macaya C, Bass TA (2006) Intravascular ultrasound characterization of the “black hole” phenomenon after drug-eluting stent implantation. Am J Cardiol 97:203–206CrossRefPubMed Costa MA, Sabate M, Angiolillo DJ, Jimenez-Quevedo P, Teirstein P, Carter A, Leon MB, Moses J, Zenni M, Yakubov S, Guzman LA, Gilmore P, Macaya C, Bass TA (2006) Intravascular ultrasound characterization of the “black hole” phenomenon after drug-eluting stent implantation. Am J Cardiol 97:203–206CrossRefPubMed
12.
Zurück zum Zitat Daemen J, Wenaweser P, Tsuchida K, Abrecht L, Vaina S, Morger C, Kukreja N, Jüni P, Sianos G, Hellige G, van Domburg RT, Hess OM, Boersma E, Meier B, Windecker S, Serruys PW (2007) Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study. Lancet 369:667–678CrossRefPubMed Daemen J, Wenaweser P, Tsuchida K, Abrecht L, Vaina S, Morger C, Kukreja N, Jüni P, Sianos G, Hellige G, van Domburg RT, Hess OM, Boersma E, Meier B, Windecker S, Serruys PW (2007) Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study. Lancet 369:667–678CrossRefPubMed
13.
Zurück zum Zitat Kimura T, Morimoto T, Nakagawa Y, Kawai K, Miyazaki S, Muramatsu T, Shiode N, Namura M, Sone T, Oshima S, Nishikawa H, Hiasa Y, Hayashi Y, Nobuyoshi M, Mitudo K, j-Cypher Registry Investigators (2012) Very late stent thrombosis and late target lesion revascularization after sirolimus-eluting stent implantation: five-year outcome of the j-Cypher Registry. Circulation 125:584–591CrossRefPubMed Kimura T, Morimoto T, Nakagawa Y, Kawai K, Miyazaki S, Muramatsu T, Shiode N, Namura M, Sone T, Oshima S, Nishikawa H, Hiasa Y, Hayashi Y, Nobuyoshi M, Mitudo K, j-Cypher Registry Investigators (2012) Very late stent thrombosis and late target lesion revascularization after sirolimus-eluting stent implantation: five-year outcome of the j-Cypher Registry. Circulation 125:584–591CrossRefPubMed
14.
Zurück zum Zitat Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, Kutys R, Skorija K, Gold HK, Virmani R (2006) Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 48:193–202CrossRefPubMed Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, Kutys R, Skorija K, Gold HK, Virmani R (2006) Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 48:193–202CrossRefPubMed
15.
Zurück zum Zitat Finn AV, Joner M, Nakazawa G, Kolodgie F, Newell J, John MC, Gold HK, Virmani R (2007) Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization. Circulation 115:2435–2441CrossRefPubMed Finn AV, Joner M, Nakazawa G, Kolodgie F, Newell J, John MC, Gold HK, Virmani R (2007) Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization. Circulation 115:2435–2441CrossRefPubMed
16.
Zurück zum Zitat Virmani R, Guagliumi G, Farb A, Musumeci G, Grieco N, Motta T, Mihalcsik L, Tespili M, Valsecchi O, Kolodgie FD (2004) Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation 109:701–705CrossRefPubMed Virmani R, Guagliumi G, Farb A, Musumeci G, Grieco N, Motta T, Mihalcsik L, Tespili M, Valsecchi O, Kolodgie FD (2004) Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation 109:701–705CrossRefPubMed
17.
Zurück zum Zitat Carter AJ, Aggarwal M, Kopia GA, Tio F, Tsao PS, Kolata R, Yeung AC, Llanos G, Dooley J, Falotico R (2004) Long-term effects of polymer-based, slow-release, sirolimus-eluting stents in a porcine coronary model. Cardiovasc Res 63:617–624CrossRefPubMed Carter AJ, Aggarwal M, Kopia GA, Tio F, Tsao PS, Kolata R, Yeung AC, Llanos G, Dooley J, Falotico R (2004) Long-term effects of polymer-based, slow-release, sirolimus-eluting stents in a porcine coronary model. Cardiovasc Res 63:617–624CrossRefPubMed
18.
Zurück zum Zitat Otsuka Y, Nakamura M, Kokubu N, Tonooka A, Inoue K, Higami T (2012) Diffuse in-stent restenosis of CYPHER® stent due to hypersensitivity reaction confirmed by pathohistological findings. Heart Vessels 27:110–113CrossRefPubMed Otsuka Y, Nakamura M, Kokubu N, Tonooka A, Inoue K, Higami T (2012) Diffuse in-stent restenosis of CYPHER® stent due to hypersensitivity reaction confirmed by pathohistological findings. Heart Vessels 27:110–113CrossRefPubMed
19.
Zurück zum Zitat Oikawa Y, Yajima J, Costa MA, Matsuno S, Akabane M, Funada R, Inaba T, Nakagawa Y, Nakamura M, Nagashima K, Kirigaya H, Ogasawara K, Sawada H, Aizawa T (2010) Intravascular ultrasound, angioscopic and histopathological characterisation of heterogeneous patterns of restenosis after sirolimus-eluting stent implantation: insights into potential “thromborestenosis” phenomenon. EuroIntervention 6:380–387CrossRefPubMed Oikawa Y, Yajima J, Costa MA, Matsuno S, Akabane M, Funada R, Inaba T, Nakagawa Y, Nakamura M, Nagashima K, Kirigaya H, Ogasawara K, Sawada H, Aizawa T (2010) Intravascular ultrasound, angioscopic and histopathological characterisation of heterogeneous patterns of restenosis after sirolimus-eluting stent implantation: insights into potential “thromborestenosis” phenomenon. EuroIntervention 6:380–387CrossRefPubMed
20.
Zurück zum Zitat Goto K, Shiode N, Shirota K, Fukuda Y, Kitamura F, Tominaga K, Kato Y, Miura H, Inoue K, Nobuyoshi M (2009) Pathological finding of sirolimus-eluting stent (SES) restenosis lesion with black hole appearance on intravascular ultrasound. Circ J 73:1969–1971CrossRefPubMed Goto K, Shiode N, Shirota K, Fukuda Y, Kitamura F, Tominaga K, Kato Y, Miura H, Inoue K, Nobuyoshi M (2009) Pathological finding of sirolimus-eluting stent (SES) restenosis lesion with black hole appearance on intravascular ultrasound. Circ J 73:1969–1971CrossRefPubMed
21.
Zurück zum Zitat Linares Vicente JA, Lukic A, Gonzalo López N, Ruiz Arroyo JR (2012) Atypical “black hole” phenomenon after treatment of sirolimus stent restenosis with a paclitaxel-coated balloon. EuroIntervention 7:1479CrossRefPubMed Linares Vicente JA, Lukic A, Gonzalo López N, Ruiz Arroyo JR (2012) Atypical “black hole” phenomenon after treatment of sirolimus stent restenosis with a paclitaxel-coated balloon. EuroIntervention 7:1479CrossRefPubMed
22.
Zurück zum Zitat Kurita T, Terashima M, Suzuki T (2012) Serial optical coherence tomography imaging of the “black-hole” phenomenon by intravascular ultrasound following sirolimus-eluting stent implantation. EuroIntervention 7:1480–1481CrossRefPubMed Kurita T, Terashima M, Suzuki T (2012) Serial optical coherence tomography imaging of the “black-hole” phenomenon by intravascular ultrasound following sirolimus-eluting stent implantation. EuroIntervention 7:1480–1481CrossRefPubMed
23.
Zurück zum Zitat Landmesser U (2012) Optical coherence tomography (OCT) evaluation after coronary stenting: the “black hole” and other low OCT signal-intensity areas. EuroIntervention 7:1367–1371CrossRefPubMed Landmesser U (2012) Optical coherence tomography (OCT) evaluation after coronary stenting: the “black hole” and other low OCT signal-intensity areas. EuroIntervention 7:1367–1371CrossRefPubMed
24.
Zurück zum Zitat Farb A, Kolodgie FD, Hwang JY, Burke AP, Tefera K, Weber DK, Wight TN, Virmani R (2004) Extracellular matrix changes in stented human coronary arteries. Circulation 110:940–947CrossRefPubMed Farb A, Kolodgie FD, Hwang JY, Burke AP, Tefera K, Weber DK, Wight TN, Virmani R (2004) Extracellular matrix changes in stented human coronary arteries. Circulation 110:940–947CrossRefPubMed
25.
Metadaten
Titel
Black hole restenosis after drug-eluting stent implantation for in-stent restenosis: potential mechanism and optimal strategy
verfasst von
Yoritaka Otsuka
Takashi Murata
Michiaki Kono
Hiroki Imoto
Taku Koyama
Keita Nakamura
Sunao Kadama
Hiroo Noguchi
Taro Saito
Publikationsdatum
01.09.2015
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 5/2015
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-014-0528-1

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