Erschienen in:
01.12.2001 | Paper Report
BLys expression and function in Lupus
verfasst von:
Sylvie Fournel
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
B lymphocyte stimulator (BLyS), also called BAFF, TALL-1 and zTNF4, is a newly identified member in the tumor necrosis factor (TNF) family that exhibits a strong costimulatory function for B cell activation in vitro. BLyS-transgenic mice develop severe B cell hyperplasia and autoimmune lupus-like disease. Moreover, in two murine models of human systemic lupus erythematosus (SLE), MRL/Mp-lpr/lpr and NZB/W F1 mice, increased serum levels of BLyS seem to correlate with autoimmune kidney damage. Knowing that treatment with the soluble BLyS receptor significantly improves the survival of lupus mice, the authors examined the serum level and function of BLyS in the patients with SLE. …