BMC Medicine

Individual and neighborhood risk factors of hospital admission and death during the COVID-19 pandemic: a population-based cohort study

Max Bell, Maria-Pia Hergens, Stefan Fors, Per Tynelius, Antonio Ponce de Leon, Anton Lager

First-in-human phase I dose-escalation and dose-expansion trial of the selective MEK inhibitor HL-085 in patients with advanced melanoma harboring NRAS mutations

Xuan Wang, Zhiguo Luo, Jing Chen, Yu Chen, Dongmei Ji, Li Fan, Ling Chen, Qian Zhao, Pei Hu, Peng Sun, Zhongwei Jia, Jun Guo, Lu Si

Survival outcomes of stage I colorectal cancer: development and validation of the ACEPLY model using two prospective cohorts

Qingbin Wu, Pengju Chen, Chi Shu, Lin Chen, Zechuan Jin, Jun Huang, Xin Wang, Xue Li, Mingtian Wei, Tinghan Yang, Xiangbing Deng, Aiwen Wu, Yazhou He, Ziqiang Wang

Lean or diabetic subtypes predict increased all-cause and disease-specific mortality in metabolic-associated fatty liver disease

Goh Eun Chung, Su Jong Yu, Jeong-Ju Yoo, Yuri Cho, Kyu-na Lee, Dong Wook Shin, Donghee Kim, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Eun Ju Cho

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study

Nikos Papadimitriou, Caroline J. Bull, Mazda Jenab, David J. Hughes, Joshua A. Bell, Eleanor Sanderson, Nicholas J. Timpson, George Davey Smith, Demetrius Albanes, Peter T. Campbell, Sébastien Küry, Loic Le Marchand, Cornelia M. Ulrich, Kala Visvanathan, Jane C. Figueiredo, Polly A. Newcomb, Rish K. Pai, Ulrike Peters, Kostas K. Tsilidis, Jolanda M. A. Boer, Emma E. Vincent, Daniela Mariosa, Marc J. Gunter, Tom G. Richardson, Neil Murphy

Interstitial pneumonitis associated with combined regimen of immunotherapy and conventional therapies—pharmacovigilance database analysis with real-world data validation

Xue-Jun Guo, Xiao-Ting Cai, Zi-Xuan Rong, Yan-Pei Zhang, Yu-Xiang Wen, Xue Bai, Jian Wang, Qiang John Fu, Ze-Qin Guo, Li-Li Long, Si-Cong Ma, Xin-Ran Tang, Li Liu, Jian Guan, Zhong-Yi Dong, De-Hua Wu

Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors

Feng Xu, Linlin Han, Yafeng Wang, Daling Deng, Yuanyuan Ding, Shuai Zhao, Qingtong Zhang, Lulin Ma, Xiangdong Chen

Bereavement in childhood and young adulthood and the risk of atrial fibrillation: a population-based cohort study from Denmark and Sweden

Hua Chen, Imre Janszky, Mikael Rostila, Dang Wei, Fen Yang, Jiong Li, Krisztina D. László

Chronic pain conditions and risk of suicidal behavior: a 10-year longitudinal co-twin control study

C. Chen, E. Pettersson, A. G. Summit, K. Boersma, Z. Chang, R. Kuja-Halkola, P. Lichtenstein, P. D. Quinn

Predicting mortality in acutely hospitalised older patients: the impact of model dimensionality

Alex Tsui, Petru-Daniel Tudosiu, Mikael Brudfors, Ashwani Jha, Jorge Cardoso, Sebastien Ourselin, John Ashburner, Geraint Rees, Daniel Davis, Parashkev Nachev

Results of the phase IIa study to evaluate the efficacy and safety of rezivertinib (BPI-7711) for the first-line treatment of locally advanced or metastatic/recurrent NSCLC patients with EGFR mutation from a phase I/IIa study

Yuankai Shi, Jianying Zhou, Yanqiu Zhao, Bo Zhu, Liangming Zhang, Xingya Li, Jian Fang, Jianhua Shi, Zhixiang Zhuang, Sheng Yang, Donglin Wang, Huiqing Yu, Longzhen Zhang, Rongsheng Zheng, Michael Greco, Tingting Wang

Prenatal social support in low-risk pregnancy shapes placental epigenome

Markos Tesfaye, Jing Wu, Richard J. Biedrzycki, Katherine L. Grantz, Paule Joseph, Fasil Tekola-Ayele

Ethnic differences in COVID-19 mortality in the second and third waves of the pandemic in England during the vaccine rollout: a retrospective, population-based cohort study

Matthew L. Bosworth, Tamanna Ahmed, Tim Larsen, Luke Lorenzi, Jasper Morgan, Raghib Ali, Peter Goldblatt, Nazrul Islam, Kamlesh Khunti, Veena Raleigh, Daniel Ayoubkhani, Neil Bannister, Myer Glickman, Vahé Nafilyan

Recommendations for robust and reproducible preclinical research in personalised medicine

Vibeke Fosse, Emanuela Oldoni, Florence Bietrix, Alfredo Budillon, Evangelos P. Daskalopoulos, Maddalena Fratelli, Björn Gerlach, Peter M. A. Groenen, Sabine M. Hölter, Julia M. L. Menon, Ali Mobasheri, Nikki Osborne, Merel Ritskes-Hoitinga, Bettina Ryll, Elmar Schmitt, Anton Ussi, Antonio L. Andreu, Emmet McCormack, Rita Banzi, Jacques Demotes, Paula Garcia, Chiara Gerardi, Enrico Glaab, Josep Maria Haro, Frank Hulstaert, Lorena San Miguel, Judit Subirana Mirete, Albert Sanchez Niubo, Raphaël Porcher, Armin Rauschenberger, Montserrat Carmona Rodriguez, Cecilia Superchi, Teresa Torres

Correction: Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)

Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou, Likun Chen

Identification of genetic variants associated with diabetic kidney disease in multiple Korean cohorts via a genome-wide association study mega-analysis

Heejin Jin, Ye An Kim, Young Lee, Seung-hyun Kwon, Ah Ra Do, Sujin Seo, Sungho Won, Je Hyun Seo

Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth

Rossella Alfano, Daniela Zugna, Henrique Barros, Mariona Bustamante, Leda Chatzi, Akram Ghantous, Zdenko Herceg, Pekka Keski-Rahkonen, Theo M. de Kok, Tim S Nawrot, Caroline L Relton, Oliver Robinson, Theano Roumeliotaki, Augustin Scalbert, Martine Vrijheid, Paolo Vineis, Lorenzo Richiardi, Michelle Plusquin

Thyroid dysfunction in Chinese nasopharyngeal carcinoma after anti-PD-1 therapy and its association with treatment response

Zi-Hang Chen, Wei-Hong Zheng, Chen-Fei Wu, Jia Kou, Xing-Li Yang, Li Lin, Jia-Wei Lv, Ying Sun, Guan-Qun Zhou

Real-time forecasting the trajectory of monkeypox outbreaks at the national and global levels, July–October 2022

Amanda Bleichrodt, Sushma Dahal, Kevin Maloney, Lisa Casanova, Ruiyan Luo, Gerardo Chowell

Long-term variability in physiological measures in relation to mortality and epigenetic aging: prospective studies in the USA and China

Hui Chen, Tianjing Zhou, Shaowei Wu, Yaying Cao, Geng Zong, Changzheng Yuan

Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019

Anuradhaa Subramanian, Amaya Azcoaga-Lorenzo, Astha Anand, Katherine Phillips, Siang Ing Lee, Neil Cockburn, Adeniyi Francis Fagbamigbe, Christine Damase-Michel, Christopher Yau, Colin McCowan, Dermot O’Reilly, Gillian Santorelli, Holly Hope, Jonathan I. Kennedy, Kathryn M. Abel, Kelly-Ann Eastwood, Louise Locock, Mairead Black, Maria Loane, Ngawai Moss, Rachel Plachcinski, Shakila Thangaratinam, Sinead Brophy, Utkarsh Agrawal, Zoe Vowles, Peter Brocklehurst, Helen Dolk, Catherine Nelson-Piercy, Krishnarajah Nirantharakumar

The impact of alcohol taxation increase on all-cause mortality inequalities in Lithuania: an interrupted time series analysis

Jakob Manthey, Domantas Jasilionis, Huan Jiang, Olga Meščeriakova, Janina Petkevičienė, Ričardas Radišauskas, Mindaugas Štelemėkas, Jürgen Rehm

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study

Ahmed Elhakeem, Justiina Ronkainen, Toby Mansell, Katherine Lange, Tuija M. Mikkola, Binisha H. Mishra, Rama J. Wahab, Tim Cadman, Tiffany Yang, David Burgner, Johan G. Eriksson, Marjo-Riitta Järvelin, Romy Gaillard, Vincent W. V. Jaddoe, Terho Lehtimäki, Olli T. Raitakari, Richard Saffery, Melissa Wake, John Wright, Sylvain Sebert, Deborah A. Lawlor

Retinal nerve fiber layer thinning as a novel fingerprint for cardiovascular events: results from the prospective cohorts in UK and China

Yanping Chen, Yixiong Yuan, Shiran Zhang, Shaopeng Yang, Junyao Zhang, Xiao Guo, Wenyong Huang, Zhuoting Zhu, Mingguang He, Wei Wang

Voluntary risk mitigation behaviour can reduce impact of SARS-CoV-2: a real-time modelling study of the January 2022 Omicron wave in England

Ellen Brooks-Pollock, Kate Northstone, Lorenzo Pellis, Francesca Scarabel, Amy Thomas, Emily Nixon, David A. Matthews, Vicky Bowyer, Maria Paz Garcia, Claire J. Steves, Nicholas J. Timpson, Leon Danon

Ethnic inequalities in the impact of COVID-19 on primary care consultations: a time series analysis of 460,084 individuals with multimorbidity in South London

Alice McGreevy, Marina Soley-Bori, Mark Ashworth, Yanzhong Wang, Emma Rezel-Potts, Stevo Durbaba, Hiten Dodhia, Julia Fox-Rushby

Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality

Huiping Li, Yan Borné, Yaogang Wang, Emily Sonestedt

Validation of a deep-learning-based retinal biomarker (Reti-CVD) in the prediction of cardiovascular disease: data from UK Biobank

Rachel Marjorie Wei Wen Tseng, Tyler Hyungtaek Rim, Eduard Shantsila, Joseph K. Yi, Sungha Park, Sung Soo Kim, Chan Joo Lee, Sahil Thakur, Simon Nusinovici, Qingsheng Peng, Hyeonmin Kim, Geunyoung Lee, Marco Yu, Yih-Chung Tham, Ameet Bakhai, Paul Leeson, Gregory Y.H. Lip, Tien Yin Wong, Ching-Yu Cheng

Faecal haemoglobin concentrations are associated with all-cause mortality and cause of death in colorectal cancer screening

Lasse Kaalby, Ulrik Deding, Issam Al-Najami, Gabriele Berg-Beckhoff, Thomas Bjørsum-Meyer, Tinne Laurberg, Aasma Shaukat, Robert J. C. Steele, Anastasios Koulaouzidis, Morten Rasmussen, Morten Kobaek-Larsen, Gunnar Baatrup

Diabetes education for better personalized management in pediatric patients

Temporal relationship between atherogenic dyslipidemia and inflammation and their joint cumulative effect on type 2 diabetes onset: a longitudinal cohort study

Yulong Lan, Guanzhi Chen, Dan Wu, Xiong Ding, Zegui Huang, Xianxuan Wang, Lois Balmer, Xingang Li, Manshu Song, Wei Wang, Shouling Wu, Youren Chen

Short-term air pollution exposure associated with death from kidney diseases: a nationwide time-stratified case-crossover study in China from 2015 to 2019

Miao Cai, Jing Wei, Shiyu Zhang, Wei Liu, Lijun Wang, Zhengmin Qian, Hualiang Lin, Echu Liu, Stephen Edward McMillin, Yu Cao, Peng Yin

UK government’s new placement legislation is a ‘good first step’: a rapid qualitative analysis of consumer, business, enforcement and health stakeholder perspectives

Sarah Muir, Preeti Dhuria, Emma Roe, Wendy Lawrence, Janis Baird, Christina Vogel

Associations between types and sources of dietary carbohydrates and cardiovascular disease risk: a prospective cohort study of UK Biobank participants

Rebecca K. Kelly, Tammy Y. N. Tong, Cody Z. Watling, Andrew Reynolds, Carmen Piernas, Julie A. Schmidt, Keren Papier, Jennifer L. Carter, Timothy J. Key, Aurora Perez-Cornago

The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study

Kurt Taylor, Robyn E. Wootton, Qian Yang, Sam Oddie, John Wright, Tiffany C. Yang, Maria Magnus, Ole A. Andreassen, Maria Carolina Borges, Massimo Caputo, Deborah A. Lawlor

In silico formulation of a next-generation multiepitope vaccine for use as a prophylactic candidate against Crimean-Congo hemorrhagic fever

Rahat Alam, Abdus Samad, Foysal Ahammad, Suza Mohammad Nur, Ahad Amer Alsaiari, Raihan Rahman Imon, Md. Enamul Kabir Talukder, Zulkar Nain, Md. Mashiar Rahman, Farhan Mohammad, Tomasz M. Karpiński

Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality

Jessica O’Loughlin, Francesco Casanova, Zammy Fairhurst-Hunter, Amanda Hughes, Jack Bowden, Edward R. Watkins, Rachel M. Freathy, Iona Y. Millwood, Kuang Lin, Zhengming Chen, Liming Li, Jun Lv, Robin G. Walters, Laura D. Howe, Karoline Kuchenbaecker, Jessica Tyrrell

PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models

Ki Cheong Park, Jung Min Kim, Sang Yong Kim, Seok-Mo Kim, Jin Hong Lim, Min Ki Kim, Sungsoon Fang, Yonjung Kim, Gordon B. Mills, Sung Hoon Noh, Jae-Ho Cheong

Associations of the circulating levels of cytokines with risk of amyotrophic lateral sclerosis: a Mendelian randomization study

Bin Liu, Linshuoshuo Lyu, Wenkai Zhou, Jie Song, Ding Ye, Yingying Mao, Guo-Bo Chen, Xiaohui Sun

Glucagon-like peptide-1 receptor agonists and diabetic retinopathy: nationwide cohort and Mendelian randomization studies

Deqiang Zheng, Ning Li, Rui Hou, Xiaoyu Zhang, Lijuan Wu, Jan Sundquist, Kristina Sundquist, Jianguang Ji

Association of intellectual disability with overall and type-specific cardiovascular diseases: a population-based cohort study in Denmark

Hui Wang, Priscilla Ming Yi Lee, Jun Zhang, Katrine Svendsen, Fei Li, Jiong Li

Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond LDL cholesterol

Zhiyuan Wu, Jinqi Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Yue Liu, Xinlei Miao, Ze Han, Xiaoping Kang, Xia Li, Xiuhua Guo, Lixin Tao, Wei Wang

Maternal prenatal cholesterol levels predict offspring weight trajectories during childhood in the Norwegian Mother, Father and Child Cohort Study

Linn K. L. Øyri, Jacob J. Christensen, Sylvain Sebert, Magne Thoresen, Trond M. Michelsen, Stine M. Ulven, Hilde K. Brekke, Kjetil Retterstøl, Anne Lise Brantsæter, Per Magnus, Martin P. Bogsrud, Kirsten B. Holven

Neonatal intensive care admission for term neonates and subsequent childhood mortality: a retrospective linkage study

Shahar Talisman, Joshua Guedalia, Rivka Farkash, Tehila Avitan, Naama Srebnik, Yair Kasirer, Michael S. Schimmel, Donia Ghanem, Ron Unger, Sorina Grisaru Granovsky

A modified renal risk score for Chinese patients with antineutrophil cytoplasmic antibody-associated vasculitis

Rui-Xue Wang, Jin-Wei Wang, Zhi-Ying Li, Su-Fang Chen, Xiao-Juan Yu, Su-Xia Wang, Fan Zhang, Zu-Ying Xiong, Shu-Hong Bi, Yue Wang, Ming-Hui Zhao, Min Chen

Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis

Ming-Han Chen, Huai-Chia Chuang, Yi-Chen Yeh, Chung-Tei Chou, Tse-Hua Tan

Association of adverse respiratory events with sodium-glucose cotransporter 2 inhibitors versus dipeptidyl peptidase 4 inhibitors among patients with type 2 diabetes in South Korea: a nationwide cohort study

Han Eol Jeong, Sohee Park, Yunha Noh, Sungho Bea, Kristian B. Filion, Oriana H. Y. Yu, Seung Hun Jang, Young Min Cho, Dong Keon Yon, Ju-Young Shin

Maximizing the cost-effectiveness of cervical screening in the context of routine HPV vaccination by optimizing screening strategies with respect to vaccine uptake: a modeling analysis

Horace C. W. Choi, Kathy Leung, Karen K. L. Chan, Yuan Bai, Mark Jit, Joseph T. Wu

Simultaneous attenuation of hyperglycemic memory-induced retinal, pulmonary, and glomerular dysfunctions by proinsulin C-peptide in diabetes

Hye-Yoon Jeon, Chan-Hee Moon, Eun-Bin Kim, Nilofar Danishmalik Sayyed, Ah-Jun Lee, Kwon-Soo Ha

Maternal obesity and programming of metabolic syndrome in the offspring: searching for mechanisms in the adipocyte progenitor pool

Taylor B. Scheidl, Amy L. Brightwell, Sarah H. Easson, Jennifer A. Thompson

Postoperative Supplemental Oxygen in Liver Transplantation (PSOLT) does not reduce the rate of infections: results of a randomized controlled trial

Wojciech Figiel, Grzegorz Niewiński, Michał Grąt, Marek Krawczyk, Jan Stypułkowski, Zbigniew Lewandowski, Maciej Krasnodębski, Waldemar Patkowski, Krzysztof Zieniewicz

Oxygen “therapy” for infection in liver transplant surgery: less is more, enough is enough

Cheng-Maw Ho, Hsin-Yun Sun

Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study

Li Chen, Sartaj Ahmad Mir, Anne K. Bendt, Esther W. L. Chua, Kothandaraman Narasimhan, Karen Mei-Ling Tan, See Ling Loy, Kok Hian Tan, Lynette P. Shek, Jerry Chan, Fabian Yap, Michael J. Meaney, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Neerja Karnani, Markus R. Wenk

Heart failure with preserved ejection fraction and atrial fibrillation: recent advances and open questions

Laurent Fauchier, Arnaud Bisson, Alexandre Bodin

Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease

Peter C. Taylor, Ayman Askari, Ernest Choy, Michael R. Ehrenstein, Sara Else, Muhammad K. Nisar

Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest

Kei Hayashida, Ryosuke Takegawa, Yusuke Endo, Tai Yin, Rishabh C. Choudhary, Tomoaki Aoki, Mitsuaki Nishikimi, Atsushi Murao, Eriko Nakamura, Muhammad Shoaib, Cyrus Kuschner, Santiago J. Miyara, Junhwan Kim, Koichiro Shinozaki, Ping Wang, Lance B. Becker

Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study

Jerod M. Rasmussen, Jetro J. Tuulari, Saara Nolvi, Paul M. Thompson, Harri Merisaari, Maria Lavonius, Linnea Karlsson, Sonja Entringer, Pathik D. Wadhwa, Hasse Karlsson, Claudia Buss

Coding long COVID: characterizing a new disease through an ICD-10 lens

Emily R. Pfaff, Charisse Madlock-Brown, John M. Baratta, Abhishek Bhatia, Hannah Davis, Andrew Girvin, Elaine Hill, Elizabeth Kelly, Kristin Kostka, Johanna Loomba, Julie A. McMurry, Rachel Wong, Tellen D. Bennett, Richard Moffitt, Christopher G. Chute, Melissa Haendel

Maternal hypertensive disorders during pregnancy and the risk of offspring diabetes mellitus in childhood, adolescence, and early adulthood: a nationwide population-based cohort study

Liu Yang, Chen Huang, Min Zhao, Priscilla M. Y. Lee, Cheng Zhang, Yongfu Yu, Bo Xi, Jiong Li

Correction: Prednisolone does not improve olfactory function after COVID-19: a randomized, double-blind, placebo-controlled trial

Emma J. A. Schepens, Esther E. Blijleven, Wilbert M. Boek, Sanne Boesveldt, Robert J. Stokroos, Inge Stegeman, Digna M. A. Kamalski

Variety and quantity of dietary insoluble fiber intake from different sources and risk of new-onset hypertension

Ziliang Ye, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chun Zhou, Mengyi Liu, Zhuxian Zhang, Panpan He, Yuanyuan Zhang, Rui Li, Huan Li, Chengzhang Liu, Jing Nie, Fan Fan Hou, Xianhui Qin

The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome

Dong Liu, Xue Gao, Xiong-Fei Pan, Tao Zhou, Cairong Zhu, Fei Li, Jian-Gao Fan, Giovanni Targher, Jian Zhao

Prediction models of colorectal cancer prognosis incorporating perioperative longitudinal serum tumor markers: a retrospective longitudinal cohort study

Chunxia Li, Ke Zhao, Dafu Zhang, Xiaolin Pang, Hongjiang Pu, Ming Lei, Bingbing Fan, Jiali Lv, Dingyun You, Zhenhui Li, Tao Zhang

Associations of reproductive factors with incidence of myocardial infarction and ischemic stroke in postmenopausal women: a cohort study

Su-Min Jeong, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Heesun Lee, Dong-Yun Lee, Dong Wook Shin

Monocyte, neutrophil, and whole blood transcriptome dynamics following ischemic stroke

Paulina Carmona-Mora, Bodie Knepp, Glen C. Jickling, Xinhua Zhan, Marisa Hakoupian, Heather Hull, Noor Alomar, Hajar Amini, Frank R. Sharp, Boryana Stamova, Bradley P. Ander

Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study

Yiwen Long, Lanhua Tang, Yangying Zhou, Shushan Zhao, Hong Zhu

Genetic susceptibility and lifestyle modify the association of long-term air pollution exposure on major depressive disorder: a prospective study in UK Biobank

Dankang Li, Junqing Xie, Lulin Wang, Yu Sun, Yonghua Hu, Yaohua Tian

Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer

Qingqing Huang, Mingcheng Liu, Duo Zhang, Bing-Biao Lin, Xing Fu, Zhiqian Zhang, Baotong Zhang, Jin-Tang Dong

Assessment of redundant randomized clinical trials among patients with ST segment elevation myocardial infarction

Yuanxi Jia, Jun Liang, Wenyao Wang, Xin Wei, Shaoming Xiao, Karen A. Robinson

There is no such thing as a validated prediction model

Ben Van Calster, Ewout W. Steyerberg, Laure Wynants, Maarten van Smeden

SGLT-2 inhibitors and in-stent restenosis-related events after acute myocardial infarction: an observational study in patients with type 2 diabetes

Raffaele Marfella, Celestino Sardu, Nunzia D’Onofrio, Carlo Fumagalli, Lucia Scisciola, Ferdinando Carlo Sasso, Mario Siniscalchi, Ludovica Vittoria Marfella, Davide D’Andrea, Fabio Minicucci, Giuseppe Signoriello, Arturo Cesaro, Maria Consiglia Trotta, Chiara Frigé, Francesco Prattichizzo, Maria Luisa Balestrieri, Antonio Ceriello, Paolo Calabrò, Ciro Mauro, Luca del Viscovo, Giuseppe Paolisso

Efficacy and safety of iruplinalkib (WX-0593) in ALK-positive crizotinib-resistant advanced non-small cell lung cancer patients: a single-arm, multicenter phase II study (INTELLECT)

Yuankai Shi, Jianhua Chen, Helong Zhang, Zhihong Zhang, Yiping Zhang, Zhehai Wang, Shucai Zhang, Jian Zhao, Chunling Liu, Xiuwen Wang, Yanqiu Zhao, Changlu Hu, Lei Yang, Xuezhi Hao, Lin Wang, Yunpeng Liu, Yan Yu, Jun Zhao, Mengzhao Wang, Liangming Zhang, Sanyuan Sun, Yanping Hu, Kangsheng Gu, Xiaosheng Hang, Jinlu Shan, Yu Zhang, Bangxian Tan, Weihua Yang, Runxiang Yang, Meimei Si, Huaize Geng, Hui Li, Xiaoyan Kang

Rare mutation-dominant compound EGFR-positive NSCLC is associated with enriched kinase domain-resided variants of uncertain significance and poor clinical outcomes

Weixin Zhao, Ailing Song, Yang Xu, Qian Wu, Cuicui Liu, Jiani C. Yin, Qiuxiang Ou, Xue Wu, Yang Shao, Xinmin Zhao

Association of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study

Xingqi Cao, Zhenqing Yang, Xueqin Li, Chen Chen, Emiel O. Hoogendijk, Jingyun Zhang, Nengliang Aaron Yao, Lina Ma, Yawei Zhang, Yong Zhu, Xuehong Zhang, Yuxian Du, Xiaofeng Wang, Xifeng Wu, Thomas M. Gill, Zuyun Liu

Influence of poor sleep on cardiovascular disease-free life expectancy: a multi-resource-based population cohort study

Bo-Huei Huang, Borja del Pozo Cruz, Armando Teixeira-Pinto, Peter A. Cistulli, Emmanuel Stamatakis

Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort

Xiaorong Yang, Shaohua Zhao, Shaohua Wang, Xuelei Cao, Yue Xu, Meichen Yan, Mingmin Pang, Fan Yi, Hao Wang

Efficacy and safety of tafolecimab in Chinese patients with heterozygous familial hypercholesterolemia: a randomized, double-blind, placebo-controlled phase 3 trial (CREDIT-2)

Meng Chai, Yongming He, Wang Zhao, Xuebin Han, Guoyan Zhao, Xueping Ma, Ping Qiao, Dongmei Shi, Yuyang Liu, Wei Han, Pei An, Haoyu Li, Shuling Yan, Qingyang Ma, Huan Deng, Lei Qian, Yujie Zhou

Comparative effectiveness of BNT162b2 and ChAdOx1 nCoV-19 vaccines against COVID-19

Jie Wei, Weiya Zhang, Michael Doherty, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Xiaoxiao Li, Chao Zeng, Guanghua Lei, Yuqing Zhang

Low serum anti-Müllerian hormone is associated with semen quality in infertile men and not influenced by vitamin D supplementation

Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Christine Hjorth Andreassen, Anna-Maria Andersson, Anders Juul, Niels Jørgensen, Martin Blomberg Jensen

Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Joseph A. Rothwell, Jelena Bešević, Niki Dimou, Marie Breeur, Neil Murphy, Mazda Jenab, Roland Wedekind, Vivian Viallon, Pietro Ferrari, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Augustin Scalbert, Inge Huybrechts, Cornelia Prehn, Jerzy Adamski, Amanda J. Cross, Hector Keun, Marc Chadeau-Hyam, Marie-Christine Boutron-Ruault, Kim Overvad, Christina C. Dahm, Therese Haugdahl Nøst, Torkjel M. Sandanger, Guri Skeie, Raul Zamora-Ros, Kostas K. Tsilidis, Fabian Eichelmann, Matthias B. Schulze, Bethany van Guelpen, Linda Vidman, Maria-José Sánchez, Pilar Amiano, Eva Ardanaz, Karl Smith-Byrne, Ruth Travis, Verena Katzke, Rudolf Kaaks, Jeroen W. G. Derksen, Sandra Colorado-Yohar, Rosario Tumino, Bas Bueno-de-Mesquita, Paolo Vineis, Domenico Palli, Fabrizio Pasanisi, Anne Kirstine Eriksen, Anne Tjønneland, Gianluca Severi, Marc J. Gunter

Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study

Oliver M. Shannon, Janice M. Ranson, Sarah Gregory, Helen Macpherson, Catherine Milte, Marleen Lentjes, Angela Mulligan, Claire McEvoy, Alex Griffiths, Jamie Matu, Tom R. Hill, Ashley Adamson, Mario Siervo, Anne Marie Minihane, Graciela Muniz-Tererra, Craig Ritchie, John C. Mathers, David J. Llewellyn, Emma Stevenson

Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study

Stephanie K. Nishi, Nancy Babio, Indira Paz-Graniel, Lluís Serra-Majem, Jesús Vioque, Montserrat Fitó, Dolores Corella, Xavier Pintó, Aurora Bueno-Cavanillas, Josep A. Tur, Laura Diez-Ricote, J. Alfredo Martinez, Carlos Gómez-Martínez, Andrés González-Botella, Olga Castañer, Andrea Alvarez-Sala, Cristina Montesdeoca-Mendoza, Marta Fanlo-Maresma, Naomi Cano-Ibáñez, Cristina Bouzas, Lidia Daimiel, María Ángeles Zulet, John L. Sievenpiper, Kelly L. Rodriguez, Zenaida Vázquez-Ruiz, Jordi Salas-Salvadó

The long-term and short-term effects of ambient air pollutants on sleep characteristics in the Chinese population: big data analysis from real world by sleep records of consumer wearable devices

Peining Zhou, Jing Ma, Xueying Li, Yixue Zhao, Kunyao Yu, Rui Su, Rui Zhou, Hui Wang, Guangfa Wang

Circulating levels of micronutrients and risk of infections: a Mendelian randomization study

Helene M. Flatby, Anuradha Ravi, Jan K. Damås, Erik Solligård, Tormod Rogne

Assessing the impacts of COVID-19 vaccination programme’s timing and speed on health benefits, cost-effectiveness, and relative affordability in 27 African countries

Yang Liu, Simon R. Procter, Carl A. B. Pearson, Andrés Madriz Montero, Sergio Torres-Rueda, Elias Asfaw, Benjamin Uzochukwu, Tom Drake, Eleanor Bergren, Rosalind M. Eggo, Francis Ruiz, Nicaise Ndembi, Justice Nonvignon, Mark Jit, Anna Vassall

Comparing a PD-L1 inhibitor plus chemotherapy to chemotherapy alone in neoadjuvant therapy for locally advanced ESCC: a randomized Phase II clinical trial

Yong Li, Aiping Zhou, Shuoyan Liu, Ming He, Keneng Chen, Ziqiang Tian, Yin Li, Jianjun Qin, Zhen Wang, Haiquan Chen, Hui Tian, Yue Yu, Wang Qu, Liyan Xue, Shun He, Shuhang Wang, Fenglong Bie, Guangyu Bai, Bolun Zhou, Zhaoyang Yang, Huiyao Huang, Yan Fang, Benjamin Li, Xiangrong Dai, Shugeng Gao, Jie He

Association between progression-free survival and overall survival in women receiving first-line treatment for metastatic breast cancer: evidence from the ESME real-world database

Coralie Courtinard, Sophie Gourgou, William Jacot, Matthieu Carton, Olivier Guérin, Laure Vacher, Aurélie Bertaut, Marie-Cécile Le Deley, David Pérol, Patricia Marino, Christelle Levy, Lionel Uwer, Geneviève Perrocheau, Renaud Schiappa, Florence Bachelot, Damien Parent, Mathias Breton, Thierry Petit, Thomas Filleron, Agnès Loeb, Simone Mathoulin Pélissier, Mathieu Robain, Suzette Delaloge, Carine Bellera

Associations of risk factor burden and genetic predisposition with the 10-year risk of atrial fibrillation: observations from a large prospective study of 348,904 participants

Junguo Zhang, Ge Chen, ChongJian Wang, Xiaojie Wang, Zhengmin (Min) Qian, Miao Cai, Michael G. Vaughn, Elizabeth Bingheim, Haitao Li, Yanhui Gao, Gregory Y. H. Lip, Hualiang Lin

‘Willpower’ is not enough: time for a new approach to public health policy to prevent obesity

Susan A. Jebb, Paul Aveyard

Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis

Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li, Xuesong Yang

Unravelling the potential of social prescribing in individual-level type 2 diabetes prevention: a mixed-methods realist evaluation

Sara Calderón-Larrañaga, Trish Greenhalgh, Megan Clinch, John Robson, Isabel Dostal, Fabiola Eto, Sarah Finer

Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis

Luiz Gustavo dos Anjos Borges, Jana Pastuschek, Yvonne Heimann, Kristin Dawczynski, Michael Bergner, Roland Haase, Johannes Stubert, Dirk Olbertz, Iris Plumeier, Silke Kahl, Ann Kathrin Heroven, Ekkehard Schleußner, Dietmar H. Pieper, Janine Zöllkau

Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants

Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke, Charlotte A. M. Cecil, Janine F. Felix, Hans J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton, Brenda W. J. H. Penninx

The efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial

Lin-Quan Tang, Xiao-Yun Li, Zhi-Ming Li, Zhi-Gang Liu, Miao-Zhen Lin, Huan Zhou, Qi-Wen Yu, Jian Zhou, Chong Zhao, Ze-Bin Chen, Xi-Cheng Wang, Jia-Yu Peng, Qiu-Yan Chen, Wen-Feng Fang, Yun-Peng Yang, Bei Zhang, Liang-Ping Xia, Pi-Li Hu, Wei-Han Hu, Yi-Jie Li, Hai-Qiang Mai, Xiu-Yu Cai

Light at night and cause-specific mortality risk in Mainland China: a nationwide observational study

Yao Lu, Peng Yin, Jie Wang, Yiping Yang, Fei Li, Hong Yuan, Shenxin Li, Zheng Long, Maigeng Zhou

Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway

Yu Ning, Peisen Huang, Guihao Chen, Yuyan Xiong, Zhaoting Gong, Chunxiao Wu, Junyan Xu, Wenyang Jiang, Xiaosong Li, Ruijie Tang, Lili Zhang, Mengjin Hu, Jing Xu, Jun Xu, Haiyan Qian, Chen Jin, Yuejin Yang

Relative role of border restrictions, case finding and contact tracing in controlling SARS-CoV-2 in the presence of undetected transmission: a mathematical modelling study

Rachael Pung, Hannah E. Clapham, Timothy W. Russell, Vernon J. Lee, Adam J. Kucharski

Safety, tolerability, pharmacokinetics, and antiviral activity of the novel core protein allosteric modulator ZM-H1505R (Canocapavir) in chronic hepatitis B patients: a randomized multiple-dose escalation trial

Haiyan Jia, Jiajia Mai, Min Wu, Hong Chen, Xiaojiao Li, Cuiyun Li, Jingrui Liu, Chengjiao Liu, Yue Hu, Xiaoxue Zhu, Xiuhong Jiang, Bo Hua, Tian Xia, Gang Liu, Aiyun Deng, Bo Liang, Ruoling Guo, Hui Lu, Zhe Wang, Huanming Chen, Zhijun Zhang, Hong Zhang, Junqi Niu, Yanhua Ding

Exploring preconception signatures of metabolites in mothers with gestational diabetes mellitus using a non-targeted approach

Ling-Jun Li, Ximeng Wang, Yap Seng Chong, Jerry Kok Yen Chan, Kok Hian Tan, Johan G. Eriksson, Zhongwei Huang, Mohammad L. Rahman, Liang Cui, Cuilin Zhang

Strategies to inTerrupt RAbies Transmission for the Elimination Goal by 2030 In China (STRATEGIC): a modelling study

Qiulan Chen, Qiuping Liu, Chao Gong, Wenwu Yin, Di Mu, Yu Li, Shujun Ding, Yifang Liu, Hao Yang, Shuwu Zhou, Sa Chen, Zhongfa Tao, Yanping Zhang, Xun Tang

Life expectancy among older adults with or without frailty in China: multistate modelling of a national longitudinal cohort study

Junling Gao, Yujie Wang, Jixiang Xu, Junjia Jiang, Shitong Yang, Qianyi Xiao

One size does not fit all: working towards increasing participation of minority groups in cancer screening programmes

The association of gestational age and birthweight with blood pressure, cardiac structure, and function in 4 years old: a prospective birth cohort study

Bowen Du, Hualin Wang, Yujian Wu, Zhuoyan Li, Yiwei Niu, Qianchuo Wang, Lin Zhang, Sun Chen, Yurong Wu, Jihong Huang, Kun Sun, Jian Wang

The association between menstrual cycle characteristics and cardiometabolic outcomes in later life: a retrospective matched cohort study of 704,743 women from the UK

Kelvin Okoth, William Parry Smith, G. Neil Thomas, Krishnarajah Nirantharakumar, Nicola J. Adderley

Bayesian network modelling to identify on-ramps to childhood obesity

Wanchuang Zhu, Roman Marchant, Richard W. Morris, Louise A. Baur, Stephen J. Simpson, Sally Cripps

Potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya: a modelling study

Naomi R. Waterlow, Sreejith Radhakrishnan, Jeanette Dawa, Edwin van Leeuwen, Simon R. Procter, Philipp Lambach, Joseph Bresee, Marie Mazur, Rosalind M. Eggo, Mark Jit

Shining a light on endometriosis: time to listen and take action

Rates of maternal weight gain over the course of pregnancy and offspring risk of neurodevelopmental disorders

Shuyun Chen, Mengyu Fan, Brian K. Lee, Christina Dalman, Håkan Karlsson, Renee M. Gardner

Navigating the complexities of mobile medical app development from idea to launch, a guide for clinicians and biomedical researchers

Robert G. Mannino, Santiago J. Arconada Alvarez, Morgan Greenleaf, Maren Parsell, Comfort Mwalija, Wilbur A. Lam

Rapid antigen-based and rapid molecular tests for the detection of SARS-CoV-2: a rapid review with network meta-analysis of diagnostic test accuracy studies

Areti Angeliki Veroniki, Andrea C. Tricco, Jennifer Watt, Sofia Tsokani, Paul A. Khan, Charlene Soobiah, Ahmed Negm, Amanda Doherty-Kirby, Paul Taylor, Carole Lunny, Jessie McGowan, Julian Little, Patrick Mallon, David Moher, Sabrina Wong, Jacqueline Dinnes, Yemisi Takwoingi, Lynora Saxinger, Adrienne Chan, Wanrudee Isaranuwatchai, Bryn Lander, Adrienne Meyers, Guillaume Poliquin, Sharon E. Straus

Ethnic minority representation in UK COVID-19 trials: systematic review and meta-analysis

Mayur Murali, Leher Gumber, Hannah Jethwa, Divolka Ganesh, Jamie Hartmann-Boyce, Harpreet Sood, Francesco Zaccardi, Kamlesh Khunti

The normality assumption on between-study random effects was questionable in a considerable number of Cochrane meta-analyses

Ziyu Liu, Fahad M. Al Amer, Mengli Xiao, Chang Xu, Luis Furuya-Kanamori, Hwanhee Hong, Lianne Siegel, Lifeng Lin

Correction: Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder

Shile Qi, Vince D. Calhoun, Daoqiang Zhang, Jeremy Miller, Zhi-De Deng, Katherine L. Narr, Yvette Sheline, Shawn M. McClintock, Rongtao Jiang, Xiao Yang, Joel Upston, Tom Jones, Jing Sui, Christopher C. Abbott

Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study

Jiazhen Zheng, Can Ni, Yingchai Zhang, Jinghan Huang, Daniel Nyarko Hukportie, Buwen Liang, Shaojun Tang

NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer

Shunyi Wang, Yihe Kuai, Simin Lin, Li Li, Quliang Gu, Xiaohan Zhang, Xiaoming Li, Yajun He, Sishuo Chen, Xiaoru Xia, Zhang Ruan, Caixia Lin, Yi Ding, Qianqian Zhang, Cuiling Qi, Jiangchao Li, Xiaodong He, Janak L. Pathak, Weijie Zhou, Side Liu, Lijing Wang, Lingyun Zheng

Association of the American Heart Association’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality: prospective cohort study

Jiahong Sun, Yanzhi Li, Min Zhao, Xiao Yu, Cheng Zhang, Costan G. Magnussen, Bo Xi

Association between epicardial adipose tissue and incident heart failure mediating by alteration of natriuretic peptide and myocardial strain

Manting Choy, Yuwen Huang, Yang Peng, Weihao Liang, Xin He, Chen Chen, Jiayong Li, Wengen Zhu, Fang-fei Wei, Yugang Dong, Chen Liu, Yuzhong Wu

The CARAMAL study could not assess the effectiveness of rectal artesunate in treating suspected severe malaria

James A. Watson, Thomas J. Peto, Nicholas J. White

Pre-referral rectal artesunate is no “magic bullet” in weak health systems

Manuel W. Hetzel, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Phyllis Awor, Aita Signorell, Marek Kwiatkowski, Mark J. Lambiris, Theodoor Visser, Justin M. Cohen, Valentina Buj, Christian Burri, Christian Lengeler

Estimating the cost-effectiveness of maternal vaccination and monoclonal antibodies for respiratory syncytial virus in Kenya and South Africa

Mihaly Koltai, Jocelyn Moyes, Bryan Nyawanda, Joyce Nyiro, Patrick K. Munywoki, Stefano Tempia, Xiao Li, Marina Antillon, Joke Bilcke, Stefan Flasche, Philippe Beutels, D. James Nokes, Cheryl Cohen, Mark Jit

Cost of childhood RSV management and cost-effectiveness of RSV interventions: a systematic review from a low- and middle-income country perspective

Rachel Wittenauer, Clint Pecenka, Ranju Baral

Estimates of the national burden of respiratory syncytial virus in Kenyan children aged under 5 years, 2010–2018

Bryan O. Nyawanda, Nickson Murunga, Nancy A. Otieno, Godfrey Bigogo, Joyce U. Nyiro, Elisabeth Vodicka, Marc Bulterys, D. James Nokes, Patrick K. Munywoki, Gideon O. Emukule

Associations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK Biobank participants

Fanny Petermann-Rocha, Michael D. Wirth, Jirapitcha Boonpor, Solange Parra-Soto, Ziyi Zhou, John C. Mathers, Katherine Livingstone, Ewan Forrest, Jill P. Pell, Frederick K. Ho, James R. Hébert, Carlos Celis-Morales

Maternal metabolic syndrome in pregnancy and child development at age 5: exploring mediating mechanisms using cord blood markers

Janell Kwok, Lydia Gabriela Speyer, Georgia Soursou, Aja Louise Murray, Kostas A. Fanti, Bonnie Auyeung

Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)

Robyn E. Wootton, Rebecca B. Lawn, Maria C. Magnus, Jorien L. Treur, Elizabeth C. Corfield, Pål R. Njølstad, Ole A. Andreassen, Deborah A. Lawlor, Marcus R. Munafò, Siri E. Håberg, George Davey Smith, Ted Reichborn-Kjennerud, Per Magnus, Alexandra Havdahl

Rheumatoid arthritis and the risk of postpartum psychiatric disorders: a Nordic population-based cohort study

Min Luan, Fen Yang, Maohua Miao, Wei Yuan, Mika Gissler, Elizabeth V. Arkema, Donghao Lu, Jiong Li, Krisztina D. László

Identifying the causal effects of long-term exposure to PM2.5 and ground surface ozone on individual medical costs in China—evidence from a representative longitudinal nationwide cohort

Ke Ju, Liyong Lu, Jingguo Yang, Ting Chen, Tianjiao Lan, Zhongxin Duan, Zongyou Xu, En Zhang, Wen Wang, Jay Pan

Identifying the potential causal role of insomnia symptoms on 11,409 health-related outcomes: a phenome-wide Mendelian randomisation analysis in UK Biobank

Mark J. Gibson, Deborah A. Lawlor, Louise A. C. Millard

Safety, pharmacokinetics, and pharmacodynamics of SHR7280, an oral gonadotropin-releasing hormone receptor antagonist, in healthy men: a randomized, double-blind, placebo-controlled phase 1 study

Xin Li, Feifei Sun, Xiaolei Zhang, Pingping Lin, Kai Shen, Yu Shen, Lingyu Ma, Yu Cao, Chenjing Wang

Food insecurity: a neglected public health issue requiring multisectoral action

Interventions to improve well-being among children and youth aged 6–17 years during the COVID-19 pandemic: a systematic review

Stephana J. Moss, Sara J. Mizen, Maia Stelfox, Rebecca Brundin Mather, Emily A. FitzGerald, Perri Tutelman, Nicole Racine, Kathryn A. Birnie, Kirsten M. Fiest, Henry T. Stelfox, Jeanna Parsons Leigh

Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis

Zhijian Zheng, Ming Wu, Hongyan Li, Wenxia Xu, Mengxiang Yang, Kailing Pan, Yuqi Ni, Ting Jiang, Hongjuan Zheng, Xiayun Jin, Yanfei Zhang, Linchao Ding, Jianfei Fu

Comprehensive proteomics and platform validation of urinary biomarkers for bladder cancer diagnosis and staging

Kamala Vanarsa, Jessica Castillo, Long Wang, Kyung Hyun Lee, Claudia Pedroza, Yair Lotan, Chandra Mohan

Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo–YAP1 pathway

Duanrui Liu, Yunyun Liu, Wenshuai Zhu, Yi Lu, Jingyu Zhu, Xiaoli Ma, Yuanxin Xing, Mingjie Yuan, Bin Ning, Yunshan Wang, Yanfei Jia

Preserved vegetable consumption and its association with mortality among 440,415 people in the China Kadoorie Biobank

Pan Zhuang, Fei Wu, Xiaohui Liu, Fanghuan Zhu, Yin Li, Jingjing Jiao, Yu Zhang

Increased iron deposition in nucleus accumbens associated with disease progression and chronicity in migraine

Xiaopei Xu, Mengting Zhou, Xiao Wu, Fangling Zhao, Xiao Luo, Kaicheng Li, Qingze Zeng, Jiahui He, Hongrong Cheng, Xiaojun Guan, Peiyu Huang, Minming Zhang, Kaiming Liu

Whole sporozoite immunization with Plasmodium falciparum strain NF135 in a randomized trial

Saskia C. van der Boor, Manon Alkema, Geert-Jan van Gemert, Karina Teelen, Marga van de Vegte-Bolmer, Jona Walk, Reinout van Crevel, Quirijn de Mast, Christian F. Ockenhouse, Robert W. Sauerwein, Matthew B. B. McCall

Cost-effectiveness of pharmaceutical strategies to prevent respiratory syncytial virus disease in young children: a decision-support model for use in low-income and middle-income countries

Sarwat Mahmud, Ranju Baral, Colin Sanderson, Clint Pecenka, Mark Jit, You Li, Andrew Clark

The burden of RSV-associated illness in children aged < 5 years, South Africa, 2011 to 2016

Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen

Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study

Line Riis Jølving, Jan Nielsen, Mette Louise Andersen, Sonia Friedman, Bente Mertz Nørgård

Associations of bullying perpetration and peer victimization subtypes with preadolescent’s suicidality, non-suicidal self-injury, neurocognition, and brain development

Xue Wen, Yinuo Shu, Diyang Qu, Yinzhe Wang, Zaixu Cui, Xiaoqian Zhang, Runsen Chen

Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment

Alejandro Cáceres, Natàlia Carreras-Gallo, Sandra Andrusaityte, Mariona Bustamante, Ángel Carracedo, Leda Chatzi, Varun B. Dwaraka, Regina Grazuleviciene, Kristine Bjerve Gutzkow, Johanna Lepeule, Léa Maitre, Tavis L. Mendez, Mark Nieuwenhuijsen, Remy Slama, Ryan Smith, Nikos Stratakis, Cathrine Thomsen, Jose Urquiza, Hannah Went, John Wright, Tiffany Yang, Maribel Casas, Martine Vrijheid, Juan R. González

Exploring the causal role of the immune response to varicella-zoster virus on multiple traits: a phenome-wide Mendelian randomization study

Xinzhu Yu, Artitaya Lophatananon, Krisztina Mekli, Kenneth R. Muir, Hui Guo

Sudan Ebola virus (SUDV) outbreak in Uganda, 2022: lessons learnt and future priorities for sub-Saharan Africa

Godfrey Bwire, Benn Sartorius, Philippe Guerin, Merawi Aragaw Tegegne, Sam I. Okware, Ambrose O. Talisuna

Previous BCG vaccination is associated with less severe clinical progression of COVID-19

Susan Martins Pereira, Florisneide Rodrigues Barreto, Ramon Andrade de Souza, Carlos Antonio de Souza Teles Santos, Marcos Pereira, Enny Santos da Paixão, Carla Cristina Oliveira de Jesus Lima, Marcio Santos da Natividade, Ana Angélica Bulcão Portela Lindoso, Eder Gatti Fernandes, Evonio Barros Campelo Junior, Julia Moreira Pescarini, Kaio Vinicius Freitas de Andrade, Fernanda Mattos de Souza, Elisangela Alves de Britto, Ceuci Nunes, Maria Yuri Ichihara, Margareth Dalcolmo, Anete Trajman, Manoel Barral-Netto, Ibrahim Abubakar, Mauricio Lima Barreto, Ricardo Arraes de Alencar Ximenes, Laura Cunha Rodrigues

The economic burden of RSV-associated illness in children aged < 5 years, South Africa 2011–2016

Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen

Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes

Huan Wang, Yiming Wang, Jiongyuan Li, Ziyi He, Sarah A. Boswell, Mirra Chung, Fuping You, Sen Han

Validation of patient- and GP-reported core sets of quality indicators for older adults with multimorbidity in primary care: results of the cross-sectional observational MULTIqual validation study

Ingmar Schäfer, Josefine Schulze, Katharina Glassen, Amanda Breckner, Heike Hansen, Anja Rakebrandt, Jessica Berg, Eva Blozik, Joachim Szecsenyi, Dagmar Lühmann, Martin Scherer

Cost-effectiveness of the screen-and-treat strategies using HPV test linked to thermal ablation for cervical cancer prevention in China: a modeling study

Xue-Lian Zhao, Shuang Zhao, Chang-Fa Xia, Shang-Ying Hu, Xian-Zhi Duan, Zhi-Hua Liu, Yue-Yun Wang, Ting-Ting You, Meng Gao, You-Lin Qiao, Partha Basu, Fang-Hui Zhao

Liver biomarkers, lipid metabolites, and risk of gestational diabetes mellitus in a prospective study among Chinese pregnant women

Ping Wu, Yi Wang, Yi Ye, Xue Yang, Yichao Huang, Yixiang Ye, Yuwei Lai, Jing Ouyang, Linjing Wu, Jianguo Xu, Jiaying Yuan, Yayi Hu, Yi-Xin Wang, Gang Liu, Da Chen, An Pan, Xiong-Fei Pan

Clinical prediction models for serious infections in children: external validation in ambulatory care

David A. G. Bos, Tine De Burghgraeve, An De Sutter, Frank Buntinx, Jan Y. Verbakel

Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature

Anita Semertzidou, Harriet Grout-Smith, Ilkka Kalliala, Akanksha Garg, Vasso Terzidou, Julian Marchesi, David MacIntyre, Phillip Bennett, Konstantinos Tsilidis, Maria Kyrgiou

Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population

Zhu Zhang, Haobo Li, Haoyi Weng, Geyu Zhou, Hong Chen, Guoru Yang, Ping Zhang, Xiangyan Zhang, Yingqun Ji, Kejing Ying, Bo Liu, Qixia Xu, Yongjun Tang, Guangfa Zhu, Zhihong Liu, Shuyue Xia, Xiaohong Yang, Lixia Dong, Ling Zhu, Mian Zeng, Yadong Yuan, Yuanhua Yang, Nuofu Zhang, Xiaomao Xu, Wenyi Pang, Meng Zhang, Yu Zhang, Kaiyuan Zhen, Dingyi Wang, Jieping Lei, Sinan Wu, Shi Shu, Yunxia Zhang, Shuai Zhang, Qian Gao, Qiang Huang, Chao Deng, Xi Fu, Gang Chen, Wenxin Duan, Jun Wan, Wanmu Xie, Peng Zhang, Shengfeng Wang, Peiran Yang, Xianbo Zuo, Zhenguo Zhai, Chen Wang

The impact of metabolic endotoxaemia on the browning process in human adipocytes

Farah Omran, Alice M. Murphy, Awais Z. Younis, Ioannis Kyrou, Jana Vrbikova, Vojtech Hainer, Petra Sramkova, Martin Fried, Graham Ball, Gyanendra Tripathi, Sudhesh Kumar, Philip G. McTernan, Mark Christian

MECP2 germline mosaicism plays an important part in the inheritance of Rett syndrome: a study of MECP2 germline mosaicism in males

Yongxin Wen, Jiaping Wang, Qingping Zhang, Xiaoxu Yang, Liping Wei, Xinhua Bao

NREM sleep as a novel protective cognitive reserve factor in the face of Alzheimer's disease pathology

Zsófia Zavecz, Vyoma D. Shah, Olivia G. Murillo, Raphael Vallat, Bryce A. Mander, Joseph R. Winer, William J. Jagust, Matthew P. Walker

Third dose mRNA vaccination against SARS-CoV-2 reduces medical complaints seen in primary care: a matched cohort study

Fredrik Methi, Jon Michael Gran, Morten Valberg, Jonas Minet Kinge, Kjetil Telle, Karin Magnusson

Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study

Héléne T. Cronjé, Ville Karhunen, G. Kees Hovingh, Ken Coppieters, Jens O. Lagerstedt, Michael Nyberg, Dipender Gill

Development, validation, and evaluation of a risk assessment tool for personalized screening of gastric cancer in Chinese populations

Xia Zhu, Jun Lv, Meng Zhu, Caiwang Yan, Bin Deng, Canqing Yu, Yu Guo, Jing Ni, Qiang She, Tianpei Wang, Jiayu Wang, Yue Jiang, Jiaping Chen, Dong Hang, Ci Song, Xuefeng Gao, Jian Wu, Juncheng Dai, Hongxia Ma, Ling Yang, Yiping Chen, Mingyang Song, Qingyi Wei, Zhengming Chen, Zhibin Hu, Hongbing Shen, Yanbing Ding, Liming Li, Guangfu Jin

Real-world effectiveness and factors associated with effectiveness of inactivated SARS-CoV-2 vaccines: a systematic review and meta-regression analysis

Shiyao Xu, Jincheng Li, Hongyuan Wang, Fuzhen Wang, Zundong Yin, Zhifeng Wang

Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability

Tao Wu, Xuan Zhang, Xinxing Liu, Xinyi Cai, Tao Shen, Dingguo Pan, Rui Liang, Rong Ding, Ruixi Hu, Jianhua Dong, Furong Li, Jinsha Li, Lin Xie, Chunlong Wang, Shilei Geng, Zhaoyu Yang, Lu Xing, YunFeng Li

Impact of oral intervention on the oral and overall health of children living with HIV in Cambodia: a randomized controlled trial

Kimiyo Kikuchi, Sovannary Tuot, Junko Yasuoka, Makoto Murayama, Sumiyo Okawa, Akira Shibanuma, Keiko Nanishi, Sothearith Eng, Chantheany Huot, Siyan Yi

Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study

Jiayao Fan, Yuan Zhou, Ran Meng, Jinsong Tang, Jiahao Zhu, Melinda C. Aldrich, Nancy J. Cox, Yimin Zhu, Yingjun Li, Dan Zhou

Central nervous system efficacy of furmonertinib (AST2818) in patients with EGFR T790M mutated non-small cell lung cancer: a pooled analysis from two phase 2 studies

Xingsheng Hu, Shucai Zhang, Zhiyong Ma, Jifeng Feng, Lin Wu, Dongqing Lv, Jianying Zhou, Xiaodong Zhang, Li Liu, Qitao Yu, Wangjun Liao, Yiping Zhang, Xiang Wang, Ying Cheng, Hongrui Niu, Ziping Wang, Dong Wang, Cheng Huang, Chunling Liu, Hui Zhao, Jian Feng, Jingzhang Li, Kejing Ying, Nong Yang, Shukui Qin, Jie Hu, Fei Liu, Yong Jiang, Nan Ge, Yuankai Shi

Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation

Woo-Jeong Shon, Jae Won Song, Seung Hoon Oh, Keon-Hee Lee, Hobin Seong, Hyun Ju You, Je Kyung Seong, Dong-Mi Shin

Retraction Note: Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis

Amir Abbas Momtazi-Borojeni, Mahmoud Reza Jaafari, Ali Badiee, Maciej Banach, Amirhossein Sahebkar

Differentiation between fetal and postnatal iron deficiency in altering brain substrates of cognitive control in pre-adolescence

Mengdi Hua, Donglin Shi, Wenwen Xu, Liuyan Zhu, Xiaoxin Hao, Bingquan Zhu, Qiang Shu, Betsy Lozoff, Fengji Geng, Jie Shao

Housing modification for malaria control: impact of a “lethal house lure” intervention on malaria infection prevalence in a cluster randomised control trial in Côte d’Ivoire

Jackie Cook, Eleanore Sternberg, Carine J. Aoura, Raphael N’Guessan, Immo Kleinschmidt, Alphonsine A. Koffi, Matthew B. Thomas, Serge-Brice Assi

Association between chronic pain and risk of incident dementia: findings from a prospective cohort

Jing Tian, Graeme Jones, Xin Lin, Yuan Zhou, Anna King, James Vickers, Feng Pan

Investigating the relationship between depression and breast cancer: observational and genetic analyses

Xueyao Wu, Wenqiang Zhang, Xunying Zhao, Li Zhang, Minghan Xu, Yu Hao, Jinyu Xiao, Ben Zhang, Jiayuan Li, Peter Kraft, Jordan W. Smoller, Xia Jiang

Combination therapies for cancer: challenges and opportunities

Zhijun Zhou, Barish H. Edil, Min Li

Saving time and money in biomedical publishing: the case for free-format submissions with minimal requirements

Amy Clotworthy, Megan Davies, Timothy J. Cadman, Jessica Bengtsson, Thea O. Andersen, Manik Kadawathagedara, Johan L. Vinther, Tri-Long Nguyen, Tibor V. Varga

Safety and efficacy of apatinib in patients with advanced gastric or gastroesophageal junction adenocarcinoma after the failure of two or more lines of chemotherapy (AHEAD): a prospective, single-arm, multicenter, phase IV study

Jin Li, Shukui Qin, Lu Wen, Junsheng Wang, Wenying Deng, Weijian Guo, Tongfu Jia, Da Jiang, Guifang Zhang, Yifu He, Yi Ba, Haijun Zhong, Lin Wang, Xiaoyan Lin, Jianwei Yang, Jun Zhao, Yuxian Bai, Xiangyuan Wu, Feng Gao, Guogui Sun, Yongjuan Wu, Feng Ye, Qiong Wang, Zhong Xie, Tienan Yi, Yong Huang, Guohua Yu, Lin Lu, Ying Yuan, Wei Li, Likun Liu, Yuping Sun, Ying Sun, Lifeng Yin, Zhiguo Hou

Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites

Yuntao Zhang, Lin Liu, Chunbo Wei, Xuanyang Wang, Ran Li, Xiaoqing Xu, Yingfeng Zhang, Guannan Geng, Keke Dang, Zhu Ming, Xinmiao Tao, Huan Xu, Xuemin Yan, Jia Zhang, Jinxia Hu, Ying Li

Correction: Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study

Jiazhen Zheng, Can Ni, Yingchai Zhang, Jinghan Huang, Daniel Nyarko Hukportie, Buwen Liang, Shaojun Tang

Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis

Sandi M Azab, Meera Shanmuganathan, Russell J de Souza, Zachary Kroezen, Dipika Desai, Natalie C Williams, Katherine M Morrison, Stephanie A Atkinson, Koon K Teo, Meghan B Azad, Elinor Simons, Theo J Moraes, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Philip Britz-McKibbin, Sonia S Anand

New respiratory syncytial virus immunization products in low- and middle-income countries: potential for cost-effective impact on a high burden of disease in young infants

Padmini Srikantiah, Keith P. Klugman

Chemotherapy-induced weight gain in early-stage breast cancer: a prospective matched cohort study reveals associations with inflammation and gut dysbiosis

John Walker, Anil Abraham Joy, Larissa J. Vos, Trevor H. Stenson, John R. Mackey, Juan Jovel, Dina Kao, Karen L. Madsen, Gane Ka-Shu Wong

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

Shu Xu, Xiaozhi Li, Shenghong Zhang, Cancan Qi, Zhenhua Zhang, Ruiqi Ma, Liyuan Xiang, Lianmin Chen, Yijun Zhu, Ce Tang, Arno R. Bourgonje, Miaoxin Li, Yao He, Zhirong Zeng, Shixian Hu, Rui Feng, Minhu Chen

Accuracy of minimal residual disease detection by circulating tumor DNA profiling in lung cancer: a meta-analysis

Ran Zhong, Rui Gao, Wenhai Fu, Caichen Li, Zhenyu Huo, Yuewen Gao, Yi Lu, Feng Li, Fan Ge, Hengjia Tu, Zhixuan You, Jianxing He, Wenhua Liang

Change in habitual intakes of flavonoid-rich foods and mortality in US males and females

Nicola P. Bondonno, Yan Lydia Liu, Yan Zheng, Kerry Ivey, Walter C. Willett, Meir J. Stampfer, Eric B. Rimm, Aedín Cassidy

Statistical analysis of high-dimensional biomedical data: a gentle introduction to analytical goals, common approaches and challenges

Jörg Rahnenführer, Riccardo De Bin, Axel Benner, Federico Ambrogi, Lara Lusa, Anne-Laure Boulesteix, Eugenia Migliavacca, Harald Binder, Stefan Michiels, Willi Sauerbrei, Lisa McShane

Unexpectedly higher levels of anti-orthopoxvirus neutralizing antibodies are observed among gay men than general adult population

Yanmeng Feng, Yifan Zhang, Shengya Liu, Meng Guo, Haojie Huang, Cuiyuan Guo, Wanhai Wang, Wenhong Zhang, Heng Tang, Yanmin Wan

Increasing emergency number utilisation is not driven by low-acuity calls: an observational study of 1.5 million emergency calls (2018–2021) from Berlin

David Herr, Sangeeta Bhatia, Florian Breuer, Stefan Poloczek, Christopher Pommerenke, Janosch Dahmen

The impact of non-alcoholic fatty liver disease and liver fibrosis on adverse clinical outcomes and mortality in patients with chronic kidney disease: a prospective cohort study using the UK Biobank

Theresa J. Hydes, Oliver J. Kennedy, Ryan Buchanan, Daniel J. Cuthbertson, Julie Parkes, Simon D. S. Fraser, Paul Roderick

Autophagy-related genes analysis reveals potential biomarkers for prediction of the impaired walking capacity of peripheral arterial disease

Mengjun Dai, Kangbo Li, Mesud Sacirovic, Claudia Zemmrich, Eva Buschmann, Oliver Ritter, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann, Philipp Hillmeister

Standardizing the reporting of Mendelian randomization studies

Shiu Lun Au Yeung, Dipender Gill

Putting Chagas disease on the global health agenda

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review

Rebekah Maksoud, Chandi Magawa, Natalie Eaton-Fitch, Kiran Thapaliya, Sonya Marshall-Gradisnik

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes

Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Mohammad Alhadj Ali, Colin Dayan, Bart Keymeulen, Katharine R. Owen, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Roxana R. Ahangarani, Evelien Gebruers, Nicolas Bovy, Luc Vanderelst, Marcelle Van Mechelen, Pierre Vandepapelière, Christian Boitard

Dose–response relationship between device-measured physical activity and incident type 2 diabetes: findings from the UK Biobank prospective cohort study

Jirapitcha Boonpor, Solange Parra-Soto, Fanny Petermann-Rocha, Nathan Lynskey, Verónica Cabanas-Sánchez, Naveed Sattar, Jason M. R. Gill, Paul Welsh, Jill P. Pell, Stuart R. Gray, Frederick K. Ho, Carlos Celis-Morales

The effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial

Jia Sun, Yuting Ruan, Ningning Xu, Peili Wu, Nie Lin, Kun Yuan, Shengli An, Pei Kang, Shu Li, Qiya Huang, Yingzhang, Yuzhong Li, Jialin Su, Wenjun Ma, Bo Chen, Xiuwei Zhang, Xiaoming Chen, Yongqian Liang, Zeyuan Lu, Guobao Deng, Zhen Zhang, Yuqin Wang, Weiheng Wen, Huijie Zhang, Hong Chen

A combination of genetically engineered oncolytic virus and melittin-CpG for cancer viro-chemo-immunotherapy

Amirhossein Bahreyni, Huitao Liu, Yasir Mohamud, Yuan Chao Xue, Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Honglin Luo

Cancer risk following surgical removal of tonsils and adenoids — a population-based, sibling-controlled cohort study in Sweden

Jinfeng Liang, Yi Huang, Li Yin, Fatemeh Sadeghi, Yanping Yang, Xue Xiao, Hans-Olov Adami, Weimin Ye, Zhe Zhang, Fang Fang

The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study

Yan Li, Hongyan Liu, Shuting Ye, Bumei Zhang, Xiaopei Li, Jiapei Yuan, Yongrui Du, Jianmei Wang, Yang Yang

Effects of ketogenic diet on health outcomes: an umbrella review of meta-analyses of randomized clinical trials

Chanthawat Patikorn, Pantakarn Saidoung, Tuan Pham, Pochamana Phisalprapa, Yeong Yeh Lee, Krista A. Varady, Sajesh K. Veettil, Nathorn Chaiyakunapruk

Adipsin alleviates cardiac microvascular injury in diabetic cardiomyopathy through Csk-dependent signaling mechanism

Xuebin Zhang, Yu Duan, Xiao Zhang, Mengyuan Jiang, Wanrong Man, Yan Zhang, Dexi Wu, Jiye Zhang, Xinglong Song, Congye Li, Jie Lin, Dongdong Sun

Multimodal-based machine learning strategy for accurate and non-invasive prediction of intramedullary glioma grade and mutation status of molecular markers: a retrospective study

Chao Ma, Liyang Wang, Dengpan Song, Chuntian Gao, Linkai Jing, Yang Lu, Dongkang Liu, Weitao Man, Kaiyuan Yang, Zhe Meng, Huifang Zhang, Ping Xue, Yupeng Zhang, Fuyou Guo, Guihuai Wang

MPC-n (IgG) improves long-term cognitive impairment in the mouse model of repetitive mild traumatic brain injury

Chaonan Zhang, Cheng Wei, Xingqi Huang, Changxin Hou, Chuan Liu, Shu Zhang, Zilong Zhao, Yafan Liu, Ruiguang Zhang, Lei Zhou, Ying Li, Xubo Yuan, Jianning Zhang

Correction: Childhood diabetes mellitus and early-onset kidney diseases later in life: a nationwide population-based matched cohort study

Jiahong Sun, Ce Wang, Min Zhao, Priscilla M. Y. Lee, Bo Xi, Yongfu Yu, Jiong Li

Disease-specific health spending by age, sex, and type of care in Norway: a national health registry study

Jonas Minet Kinge, Joseph L. Dieleman, Øystein Karlstad, Ann Kristin Knudsen, Søren Toksvig Klitkou, Simon I. Hay, Theo Vos, Christopher J. L. Murray, Stein Emil Vollset

What effect have commissioners’ policies for body mass index had on hip replacement surgery?: an interrupted time series analysis from the National Joint Registry for England

Joanna McLaughlin, Ruth Kipping, Amanda Owen-Smith, Hugh McLeod, Samuel Hawley, J. Mark Wilkinson, Andrew Judge

Shared genetic correlation and causal association between major depressive disorder and breast cancer

Kazutaka Ohi

Trends in cognitive function before and after stroke in China

Jianian Hua, Jianye Dong, Guo-Chong Chen, Yueping Shen

Neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementia

Lin Sun, Jie Zhang, Wei Li, Jianhua Sheng, Shifu Xiao

miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis

Genpeng Li, Linye He, Jing Huang, Jiaye Liu, Wenjie Chen, Jinjing Zhong, Tao Wei, Zhihui Li, Jingqiang Zhu, Jianyong Lei

Correction: Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients

Flávio de Azevedo Figueiredo, Lucas Emanuel Ferreira Ramos, Rafael Tavares Silva, Daniela Ponce, Rafael Lima Rodrigues de Carvalho, Alexandre Vargas Schwarzbold, Amanda de Oliveira Maurílio, Ana Luiza Bahia Alves Scotton, Andresa Fontoura Garbini, Bárbara Lopes Farace, Bárbara Machado Garcia, Carla Thais Cândida Alves da Silva, Christiane Corrêa Rodrigues Cimini, Cíntia Alcantara de Carvalho, Cristiane dos Santos Dias, Daniel Vitório Silveira, Euler Roberto Fernandes Manenti, Evelin Paola de Almeida Cenci, Fernando Anschau, Fernando Graça Aranha, Filipe Carrilho de Aguiar, Frederico Bartolazzi, Giovanna Grunewald Vietta, Guilherme Fagundes Nascimento, Helena Carolina Noal, Helena Duani, Heloisa Reniers Vianna, Henrique Cerqueira Guimarães, Joice Coutinho de Alvarenga, José Miguel Chatkin, Júlia Drumond Parreiras de Morais, Juliana Machado-Rugolo, Karen Brasil Ruschel, Karina Paula Medeiros Prado Martins, Luanna Silva Monteiro Menezes, Luciana Siuves Ferreira Couto, Luís César de Castro, Luiz Antônio Nasi, Máderson Alvares de Souza Cabral, Maiara Anschau Floriani, Maíra Dias Souza, Maira Viana Rego Souza-Silva, Marcelo Carneiro, Mariana Frizzo de Godoy, Maria Aparecida Camargos Bicalho, Maria Clara Pontello Barbosa Lima, Márlon Juliano Romero Aliberti, Matheus Carvalho Alves Nogueira, Matheus Fernandes Lopes Martins, Milton Henriques Guimarães-Júnior, Natália da Cunha Severino Sampaio, Neimy Ramos de Oliveira, Patricia Klarmann Ziegelmann, Pedro Guido Soares Andrade, Pedro Ledic Assaf, Petrônio José de Lima Martelli, Polianna Delfino-Pereira, Raphael Castro Martins, Rochele Mosmann Menezes, Saionara Cristina Francisco, Silvia Ferreira Araújo, Talita Fischer Oliveira, Thainara Conceição de Oliveira, Thaís Lorenna Souza Sales, Thiago Junqueira Avelino-Silva, Yuri Carlotto Ramires, Magda Carvalho Pires, Milena Soriano Marcolino

Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study

Yalan Tian, Jiahui Liu, Yue Zhao, Nana Jiang, Xiao Liu, Gang Zhao, Xia Wang

Antidepressant drug prescription and incidence of COVID-19 in mental health outpatients: a retrospective cohort study

Oleg O. Glebov, Christoph Mueller, Robert Stewart, Dag Aarsland, Gayan Perera

Efficacy of COVID-19 mRNA vaccination in patients with autoimmune disorders: humoral and cellular immune response

Federica Filippini, Mauro Giacomelli, Chiara Bazzani, Micaela Fredi, Paolo Semeraro, Cesare Tomasi, Franco Franceschini, Arnaldo Caruso, Ilaria Cavazzana, Cinzia Giagulli

Associations between smoking and vaping prevalence, product use characteristics, and mental health diagnoses in Great Britain: a population survey

Eve Taylor, Leonie S Brose, Ann McNeill, Jamie Brown, Loren Kock, Debbie Robson

A multicentre, prospective, non-interventional study evaluating the safety of dapagliflozin in patients with type 2 diabetes in routine clinical practice in China (DONATE)

Lixin Guo, Jing Wang, Li Li, Lin Yuan, Sheng Chen, Hui Wang, Tonghuan Li, Lin Qi, Hong Yang

Exploring the depth and breadth of the genomics toolbox during the COVID-19 pandemic: insights from Aotearoa New Zealand

Michael Bunce, Jemma L. Geoghegan, David Winter, Joep de Ligt, Siouxsie Wiles

Workplace-based primary prevention intervention reduces incidence of hypertension: a post hoc analysis of cluster randomized controlled study

Zhen Hu, Xin Wang, Conglin Hong, Congyi Zheng, Linfeng Zhang, Zuo Chen, Haoqi Zhou, Yixin Tian, Xue Cao, Jiayin Cai, Runqing Gu, Ye Tian, Lan Shao, Zengwu Wang

Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis

Mengqiang Fan, Peijian Tong, Li Yan, Ting Li, Jiadan Ren, Jiefeng Huang, Wenxi Du, Li Zhou, Letian Shan

Trajectories of cardiac troponin in the decades before cardiovascular death: a longitudinal cohort study

Dorien M. Kimenai, Atul Anand, Marie de Bakker, Martin Shipley, Takeshi Fujisawa, Magnus N. Lyngbakken, Kristian Hveem, Torbjørn Omland, Carlos A. Valencia-Hernández, Joni V. Lindbohm, Mika Kivimaki, Archana Singh-Manoux, Fiona E. Strachan, Anoop S. V. Shah, Isabella Kardys, Eric Boersma, Eric J. Brunner, Nicholas L. Mills

Balancing access to ADHD medication

Reactogenicity and safety of COVID-19 primary immunisation and booster vaccination regimens: a comparative observational cohort study

Lisette Warkentin, Felix Werner, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla, Isabelle Kaiser, Maria Sebastião, Susann Hueber

Expression of the endocannabinoid system and response to cannabinoid components by the human fetal testis

J. Dochez-Arnault, C. Desdoits-Lethimonier, I. Matias, B. Evrard, M. Lagarrigue, M. Toupin, A. Lardenois, F. Chalmel, S. Mazaud-Guittot, N. Dejucq-Rainsford, A. Gely-Pernot

Varenicline and counseling for vaping cessation: a double-blind, randomized, parallel-group, placebo-controlled trial

Pasquale Caponnetto, Davide Campagna, Jasjit S. Ahluwalia, Christopher Russell, Marilena Maglia, Paolo Marco Riela, Carmelo Fabio Longo, Barbara Busa, Riccardo Polosa

Effectiveness of mHealth consultation services for preventing postpartum depressive symptoms: a randomized clinical trial

Yuki Arakawa, Maho Haseda, Kosuke Inoue, Daisuke Nishioka, Shiho Kino, Daisuke Nishi, Hideki Hashimoto, Naoki Kondo

Global, regional, and national burden of cardiovascular diseases in youths and young adults aged 15–39 years in 204 countries/territories, 1990–2019: a systematic analysis of Global Burden of Disease Study 2019

Jiahong Sun, Yanan Qiao, Min Zhao, Costan G. Magnussen, Bo Xi

Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease

Wenwen Li, Yana Pang, Yan Wang, Fan Mei, Mengmeng Guo, Yiping Wei, Xinyue Li, Wei Qin, Wei Wang, Longfei Jia, Jianping Jia

Understanding the age spectrum of respiratory syncytial virus associated hospitalisation and mortality burden based on statistical modelling methods: a systematic analysis

Bingbing Cong, Izzie Dighero, Tiantian Zhang, Alexandria Chung, Harish Nair, You Li

Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries: results from the EPIC cohort study

Carlota Castro-Espin, Catalina Bonet, Marta Crous-Bou, Núria Nadal-Zaragoza, Anne Tjønneland, Lene Mellemkjær, Mariem Hajji-Louati, Thérèse Truong, Verena Katzke, Charlotte Le Cornet, Matthias B. Schulze, Franziska Jannasch, Giovanna Masala, Sabina Sieri, Salvatore Panico, Chiara Di Girolamo, Guri Skeie, Kristin Benjaminsen Borch, Karina Standahl Olsen, Maria-Jose Sánchez, Pilar Amiano, María-Dolores Chirlaque, Marcela Guevara, Malin Sund, Stina Bodén, Marc J. Gunter, Esther M. Gonzalez-Gil, Elisabete Weiderpass, Inmaculada Aguilera-Buenosvinos, Kostas K. Tsilidis, Alicia K. Heath, Dagfinn Aune, Laure Dossus, Antonio Agudo

Pyrotinib in combination with letrozole for hormone receptor-positive, human epidermal growth factor receptor 2-positive metastatic breast cancer (PLEHERM): a multicenter, single-arm, phase II trial

Zhe-Yu Hu, Min Yan, Huihua Xiong, Li Ran, Jincai Zhong, Ting Luo, Tao Sun, Ning Xie, Liping Liu, Xiaohong Yang, Huawu Xiao, Jing Li, Binliang Liu, Quchang Ouyang

Prevalence, risk factors, impact and management of pneumonia among preschool children in Chinese seven cities: a cross-sectional study with interrupted time series analysis

Haonan Shi, Tingting Wang, Zhuohui Zhao, Dan Norback, Xiaowei Wang, Yongsheng Li, Qihong Deng, Chan Lu, Xin Zhang, Xiaohong Zheng, Hua Qian, Ling Zhang, Wei Yu, Yuqing Shi, Tianyi Chen, Huaijiang Yu, Huizhen Qi, Ye Yang, Lan Jiang, Yuting Lin, Jian Yao, Junwen Lu, Qi Yan

The relationship between alcohol consumption and health: J-shaped or less is more?

Min-Kuang Tsai, Wayne Gao, Chi-Pang Wen

The Full Value of Vaccine Assessments (FVVA): a framework for assessing and communicating the value of vaccines for investment and introduction decision-making

Raymond Hutubessy, Jeremy A. Lauer, Birgitte Giersing, So Yoon Sim, Mark Jit, David Kaslow, Siobhan Botwright

Phase 1 dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and anti-tumor activity of FCN-159 in adults with neurofibromatosis type 1-related unresectable plexiform neurofibromas

Xiaojie Hu, Wenbin Li, Kang Zeng, Zhongyuan Xu, Changxing Li, Zhuang Kang, Shenglan Li, Xin Huang, Pu Han, Hongmei Lin, Ai-Min Hui, Yan Tan, Lei Diao, Ben Li, Xingli Wang, Zhuli Wu, Xiaoxi Lin

Plasma protein N-glycome composition associates with postprandial lipaemic response

Panayiotis Louca, Tamara Štambuk, Azra Frkatović-Hodžić, Ana Nogal, Massimo Mangino, Sarah E. Berry, Helena Deriš, George Hadjigeorgiou, Jonathan Wolf, Martina Vinicki, Paul W. Franks, Ana M. Valdes, Tim D. Spector, Gordan Lauc, Cristina Menni

Evaluation of post-acute care and one-year outcomes among Medicare beneficiaries with hip fractures: a retrospective cohort study

Melissa R. Riester, Francesca L. Beaudoin, Richa Joshi, Kaleen N. Hayes, Meghan A. Cupp, Sarah D. Berry, Andrew R. Zullo

Neutralizing antibody levels associated with injectable and aerosolized Ad5-nCoV boosters and BA.2 infection

Fuzhen Wang, Baoying Huang, Yao Deng, Shaobai Zhang, Xiaoqiang Liu, Lei Wang, Qianqian Liu, Li Zhao, Lin Tang, Wenling Wang, Xiaoqi Wang, Fei Ye, Weijun Hu, Haitao Yang, Siquan Wang, Jiao Ren, Xiaoyu Liu, Cangning Wang, Xuhua Guan, Ruize Wang, Yan Zheng, Xianfeng Zhang, Hui Zheng, Dan Wu, Zhijie An, Wenbo Xu, Lawrence E. Rodewald, George F. Gao, Zundong Yin, Wenjie Tan

Analysis of phase III clinical trials in metastatic NSCLC to assess the correlation between QoL results and survival outcomes

Alberto Servetto, Massimo Di Maio, Fabio Salomone, Fabiana Napolitano, Chiara Paratore, Fabrizio Di Costanzo, Giuseppe Viscardi, Antonio Santaniello, Luigi Formisano, Roberto Bianco

Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study

Guoyi Yang, C. Mary Schooling

The usage of data in NHS primary care commissioning: a realist review

Alexandra Jager, Geoff Wong, Chrysanthi Papoutsi, Nia Roberts

Progressive trajectories of schizophrenia across symptoms, genes, and the brain

Sisi Jiang, Huan Huang, Jingyu Zhou, Hechun Li, Mingjun Duan, Dezhong Yao, Cheng Luo

Dobutamine-induced alternations in cerebral blood flow of healthy adults: a 3D pseudocontinuous arterial spin labeling study

Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang

Family history and breast cancer risk for Asian women: a systematic review and meta-analysis

Heran Wang, Robert J. MacInnis, Shuai Li

Eligibility criteria in clinical trials in breast cancer: a cohort study

Katarzyna Szlezinger, Katarzyna Pogoda, Agnieszka Jagiełło-Gruszfeld, Danuta Kłosowska, Andrzej Górski, Jan Borysowski

Sampling inequalities affect generalization of neuroimaging-based diagnostic classifiers in psychiatry

Zhiyi Chen, Bowen Hu, Xuerong Liu, Benjamin Becker, Simon B. Eickhoff, Kuan Miao, Xingmei Gu, Yancheng Tang, Xin Dai, Chao Li, Artemiy Leonov, Zhibing Xiao, Zhengzhi Feng, Ji Chen, Hu Chuan-Peng

Adherence to healthy diet and risk of cardiovascular disease in adult survivors of childhood cancer in the St. Jude Lifetime Cohort: a cross-sectional study

Tuo Lan, Mei Wang, Matthew J. Ehrhardt, Shu Jiang, Jennifer Q. Lanctot, Gregory T. Armstrong, Melissa M. Hudson, Graham A. Colditz, Leslie L. Robison, Yikyung Park

Informing a target product profile for rapid tests to identify HBV-infected pregnant women with high viral loads: a discrete choice experiment with African healthcare workers

Yasir Shitu Isa, Jonathan Sicsic, Henry Njuguna, John Ward, Mohamed Chakroun, Mohamed El-Kassas, Rado Ramanampamonjy, Salim Chalal, Jeanne Perpétue Vincent, Monique Andersson, Hailemichael Desalegn, Fatou Fall, Asgeir Johannessen, Philippa C. Matthews, Gibril Ndow, Edith Okeke, Nicholas Riches, Moussa Seydi, Edford Sinkala, C. Wendy Spearman, Alexander Stockdale, Michael J. Vinikoor, Gilles Wandeler, Roger Sombié, Maud Lemoine, Judith E. Mueller, Yusuke Shimakawa

Providing multimedia information to children and young people increases recruitment to trials: pre-planned meta-analysis of SWATs

Peter Knapp, Thirimon Moe-Byrne, Jacqueline Martin-Kerry, Rebecca Sheridan, Jenny Roche, Elizabeth Coleman, Peter Bower, Steven Higgins, Catherine Stones, Jonathan Graffy, Jenny Preston, Carrol Gamble, Bridget Young, Daniel Perry, Annegret Dahlmann-Noor, Mohamed Abbas, Payal Khandelwal, Siobhan Ludden, Augusto Azuara-Blanco, Emma McConnell, Nicky Mandall, Anna Lawson, Chris A. Rogers, Helena J. M. Smartt, Rachael Heys, Simon R. Stones, Danielle Horton Taylor, Sophie Ainsworth, Jenny Ainsworth

Proteomic profiling of longitudinal changes in kidney function among middle-aged and older men and women: the KORA S4/F4/FF4 study

Jie-sheng Lin, Jana Nano, Agnese Petrera, Stefanie M. Hauck, Tanja Zeller, Wolfgang Koenig, Christian L. Müller, Annette Peters, Barbara Thorand

Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study

Olga Solovyeva, Munyaradzi Dimairo, Christopher J. Weir, Siew Wan Hee, Aude Espinasse, Moreno Ursino, Dhrusti Patel, Andrew Kightley, Sarah Hughes, Thomas Jaki, Adrian Mander, Thomas R. Jeffry Evans, Shing Lee, Sally Hopewell, Khadija Rerhou Rantell, An-Wen Chan, Alun Bedding, Richard Stephens, Dawn Richards, Lesley Roberts, John Kirkpatrick, Johann de Bono, Christina Yap

Caregiver burden in Parkinson’s disease: a mixed-methods study

Angelika D. Geerlings, Willanka M. Kapelle, Charlotte J. Sederel, Emma Tenison, Hilde Wijngaards-Berenbroek, Marjan J. Meinders, Marten Munneke, Yoav Ben-Shlomo, Bastiaan R. Bloem, Sirwan K. L. Darweesh

Estimating the delivery costs of COVID-19 vaccination using the COVID-19 Vaccine Introduction and deployment Costing (CVIC) tool: the Lao People’s Democratic Republic experience

Karene Hoi Ting Yeung, Eunkyoung Kim, Wei Aun Yap, Chansay Pathammavong, Lauren Franzel, Yu Lee Park, Peter Cowley, Ulla Kou Griffiths, Raymond Christiaan W. Hutubessy

Investigating the risk of metabolic and cardiovascular comorbidities among patients with parathyroid cancer: a nationwide representative cohort study in Taiwan

Ming-Chieh Tsai, Min-Shu Hsu, Hsin-Yin Hsu, Tzu-Lin Yeh, Chun-Ju Chiang, Wen-Chung Lee, Jing-Rong Jhuang, Shih-Ping Cheng, Po-Jung Tseng, Kuo-Liong Chien

Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia

Long-Biao Cui, Xian-Yang Wang, Yu-Fei Fu, Xiao-Fan Liu, Yongbin Wei, Shu-Wan Zhao, Yue-Wen Gu, Jing-Wen Fan, Wen-Jun Wu, Hengfen Gong, Bochao Danae Lin, Hong Yin, Fanglin Guan, Xiao Chang

Associations between an obesity-related dietary pattern and incidence of overall and site-specific cancers: a prospective cohort study

Maiwulamujiang Maimaitiyiming, Hongxi Yang, Lihui Zhou, Xinyu Zhang, Qiliang Cai, Yaogang Wang

Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice

Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu, Qingchun Zeng

PARP inhibitor exerts an anti-tumor effect via LMO2 and synergizes with cisplatin in natural killer/T cell lymphoma

Jiazhuo Wu, Cunzhen Shi, Hongwen Li, Wenting Song, Shuo Huang, Jianxiang Zhang, Wencai Li, Zhaoming Li, Mingzhi Zhang

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang, Xiao Xiao

Individualized dynamic methylation-based analysis of cell-free DNA in postoperative monitoring of lung cancer

Kezhong Chen, Guannan Kang, Zhihong Zhang, Analyn Lizaso, Stephan Beck, Iben Lyskjær, Olga Chervova, Bingsi Li, Haifeng Shen, Chenyang Wang, Bing Li, Heng Zhao, Xi Li, Fan Yang, Nnennaya Kanu, Jun Wang

Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice

Mei-Yu Yin, Lei Guo, Li-Juan Zhao, Chen Zhang, Wei-Peng Liu, Chu-Yi Zhang, Jin-Hua Huo, Lu Wang, Shi-Wu Li, Chang-Bo Zheng, Xiao Xiao, Ming Li, Chuang Wang, Hong Chang

Assessment of cardio-renal-hepatic function in patients with valvular heart disease: a multi-biomarker approach—the cardio-renal-hepatic score

Junxing Lv, Bin Zhang, Yunqing Ye, Zhe Li, Weiwei Wang, Qinghao Zhao, Qingrong Liu, Zhenyan Zhao, Haitong Zhang, Bincheng Wang, Zikai Yu, Zhenya Duan, Shuai Guo, Yanyan Zhao, Runlin Gao, Haiyan Xu, Yongjian Wu

A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth

Li Wang, Robert M. Rossi, Xiaoting Chen, Jing Chen, Jilian Runyon, Mehak Chawla, Daniel Miller, Carmy Forney, Arthur Lynch, Xuzhe Zhang, Fansheng Kong, Bo Jacobsson, Leah C. Kottyan, Matthew T. Weirauch, Ge Zhang, Louis J. Muglia

Healthcare use attributable to COVID-19: a propensity-matched national electronic health records cohort study of 249,390 people in Wales, UK

J Kennedy , M Parker, M Seaborne, M Mhereeg , A Walker , V Walker, S Denaxas, N Kennedy, S. V Katikireddi, S Brophy

Random capillary glucose levels throughout pregnancy, obstetric and neonatal outcomes, and long-term neurodevelopmental conditions in children: a group-based trajectory analysis

Shuyun Chen, Margareta Persson, Rui Wang, Christina Dalman, Brian K. Lee, Håkan Karlsson, Renee M. Gardner

Causal effects of COVID-19 on structural changes in specific brain regions: a Mendelian randomization study

Shaojiong Zhou, Tao Wei, Xiaoduo Liu, Yufei Liu, Weiyi Song, Xinwei Que, Yi Xing, Zhibin Wang, Yi Tang

Probiotic supplementation during antibiotic treatment is unjustified in maintaining the gut microbiome diversity: a systematic review and meta-analysis

Anna Júlia Éliás, Viktória Barna, Cristina Patoni, Dóra Demeter, Dániel Sándor Veres, Stefania Bunduc, Bálint Erőss, Péter Hegyi, László Földvári-Nagy, Katalin Lenti

Early non-response as a predictor of later non-response to antipsychotics in schizophrenia: a randomized trial

Yujun Long, Qiongqiong Wu, Ye Yang, Jingda Cai, Jingmei Xiao, Zhaoqian Liu, Yifeng Xu, Ying Chen, Manli Huang, Ruiguo Zhang, Xijia Xu, Jian Hu, Zhifen Liu, Fang Liu, Yingjun Zheng, Huaqing Meng, Zhimin Wang, Yanqing Tang, Xueqin Song, Yunchun Chen, Xueyi Wang, Tiebang Liu, Xiaoli Wu, Maosheng Fang, Chunling Wan, Jingping Zhao, Renrong Wu

Gastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites

Deyu Zhang, Siyuan Weng, Chuanchao Xia, Yuqing Ren, Zaoqu Liu, Yudi Xu, Xiaoli Yang, Ruhao Wu, Lisi Peng, Liqi Sun, Jiaqi Zhu, Xuesong Liang, Yin Jia, Huaizhou Wang, Qian Chen, Dongtian Liu, Yi Chen, Honglei Guo, Xinwei Han, Zhendong Jin, Cui Chen, Xia Yang, Zhaoshen Li, Haojie Huang

Cost-effectiveness of prehabilitation prior to elective surgery: a systematic review of economic evaluations

Tanja Rombey, Helene Eckhardt, Jörn Kiselev, Julia Silzle, Tim Mathes, Wilm Quentin

Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants

Yisen Shi, Fabin Lin, Yueping Li, Yingqing Wang, Xiaochun Chen, Fangang Meng, Qinyong Ye, Guoen Cai

A network medicine approach to study comorbidities in heart failure with preserved ejection fraction

Jan D. Lanzer, Alberto Valdeolivas, Mark Pepin, Hauke Hund, Johannes Backs, Norbert Frey, Hans-Christoph Friederich, Jobst-Hendrik Schultz, Julio Saez-Rodriguez, Rebecca T. Levinson

The expression profiles of signature genes from CD103+LAG3+ tumour-infiltrating lymphocyte subsets predict breast cancer survival

Zi-An Xia, Can Lu, Can Pan, Jia Li, Jun Li, Yitao Mao, Lunquan Sun, Jiang He

Efficacy of sustained knowledge translation (KT) interventions in chronic disease management in older adults: systematic review and meta-analysis of complex interventions

Areti Angeliki Veroniki, Charlene Soobiah, Vera Nincic, Yonda Lai, Patricia Rios, Heather MacDonald, Paul A. Khan, Marco Ghassemi, Fatemeh Yazdi, Ross C. Brownson, David A. Chambers, Lisa R. Dolovich, Annemarie Edwards, Paul P. Glasziou, Ian D. Graham, Brenda R. Hemmelgarn, Bev J. Holmes, Wanrudee Isaranuwatchai, France Legare, Jessie McGowan, Justin Presseau, Janet E. Squires, Henry T. Stelfox, Lisa Strifler, Trudy Van der Weijden, Christine Fahim, Andrea C. Tricco, Sharon E. Straus

Artificial intelligence for the diagnosis of clinically significant prostate cancer based on multimodal data: a multicenter study

Huiyong Zhang, Jin Ji, Zhe Liu, Huiru Lu, Chong Qian, Chunmeng Wei, Shaohua Chen, Wenhao Lu, Chengbang Wang, Huan Xu, Yalong Xu, Xi Chen, Xing He, Zuheng Wang, Xiaodong Zhao, Wen Cheng, Xingfa Chen, Guijian Pang, Guopeng Yu, Yue Gu, Kangxian Jiang, Bin Xu, Junyi Chen, Bin Xu, Xuedong Wei, Ming Chen, Rui Chen, Jiwen Cheng, Fubo Wang

Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study

Ke Yu, Xiao-Feng Chen, Jing Guo, Sen Wang, Xiao-Ting Huang, Yan Guo, Shan-Shan Dong, Tie-Lin Yang

Current coffee consumption is associated with decreased striatal dopamine transporter availability in Parkinson’s disease patients and healthy controls

Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang

Estimating the full health and economic benefits of current and future influenza vaccines

K. E. Lafond, R. Gharpure, V. G. Dugan, E. Azziz-Baumgartner

Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies

Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou

Metabolic systems approaches update molecular insights of clinical phenotypes and cardiovascular risk in patients with homozygous familial hypercholesterolemia

Zhiyong Du, Fan Li, Long Jiang, Linyi Li, Yunhui Du, Huahui Yu, Yan Luo, Yu Wang, Haili Sun, Chaowei Hu, Jianping Li, Ya Yang, Xiaolu Jiao, Luya Wang, Yanwen Qin

Why estimands are needed to define treatment effects in clinical trials

Oliver N. Keene, Helle Lynggaard, Stefan Englert, Vivian Lanius, David Wright

Estimated projection of incidence and mortality of alcohol-related liver disease in China from 2022 to 2040: a modeling study

Meiyu Wu, Shuxia Qin, Chongqing Tan, Sini Li, Ouyang Xie, Xiaomin Wan

Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: a prospective cohort study of 413,914 UK Biobank participants

James Webster, Darren C. Greenwood, Janet E. Cade

Expanding hepatitis C virus test uptake using self-testing among men who have sex with men in China: two parallel randomized controlled trials

Cheng Wang, Peizhen Zhao, Ann Marie Weideman, Wenqian Xu, Jason J. Ong, Muhammad S. Jamil, Bin Yang, Joseph D. Tucker

The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort

Shunming Zhang, Anna Stubbendorff, Ulrika Ericson, Per Wändell, Kaijun Niu, Lu Qi, Yan Borné, Emily Sonestedt

Diabetes and climate change: breaking the vicious cycle

A culturally adapted manual-assisted problem-solving intervention (CMAP) for adults with a history of self-harm: a multi-centre randomised controlled trial

Nusrat Husain, Tayyeba Kiran, Imran Bashir Chaudhry, Christopher Williams, Richard Emsley, Usman Arshad, Moin Ahmed Ansari, Paul Bassett, Penny Bee, Moti Ram Bhatia, Carolyn Chew-Graham, Muhammad Omair Husain, Muhammad Irfan, Ayesha Khaliq, Fareed A. Minhas, Farooq Naeem, Haider Naqvi, Asad Tamizuddin Nizami, Amna Noureen, Maria Panagioti, Ghulam Rasool, Sofiya Saeed, Sumira Qambar Bukhari, Sehrish Tofique, Zainab F. Zadeh, Shehla Naeem Zafar, Nasim Chaudhry

Ageing as risk factor for tinnitus and its complex interplay with hearing loss—evidence from online and NHANES data

Lisa Reisinger, Fabian Schmidt, Kaja Benz, Lorenzo Vignali, Sebastian Roesch, Martin Kronbichler, Nathan Weisz

Safeguarding mothers and newborns: the urgent need to address hepatitis during pregnancy

Common mental health disorders in adults with inflammatory skin conditions: nationwide population-based matched cohort studies in the UK

Alasdair D. Henderson, Elizabeth Adesanya, Amy Mulick, Julian Matthewman, Nhung Vu, Firoza Davies, Catherine H. Smith, Joseph Hayes, Kathryn E. Mansfield, Sinéad M. Langan

CSF1R regulates schizophrenia-related stress response and vascular association of microglia/macrophages

Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L. Elliot Hong, Yunlong Tan, Li Tian

Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn’s disease

Longyuan Zhou, Liguo Zhu, Xiaomin Wu, Shixian Hu, Shenghong Zhang, Min Ning, Jun Yu, Minhu Chen

New tuberculosis vaccines in India: modelling the potential health and economic impacts of adolescent/adult vaccination with M72/AS01E and BCG-revaccination

Rebecca A. Clark, Chathika K. Weerasuriya, Allison Portnoy, Christinah Mukandavire, Matthew Quaife, Roel Bakker, Danny Scarponi, Rebecca C. Harris, Kirankumar Rade, Sanjay Kumar Mattoo, Dheeraj Tumu, Nicolas A. Menzies, Richard G. White

Racial differences in long-term social, physical, and psychological health among adolescent and young adult cancer survivors

Sooyeon Kim, Juhee Cho, Dong Wook Shin, Su-Min Jeong, Danbee Kang

Early neuro-rehabilitation in traumatic brain injury: the need for an African perspective

Franklin Chu Buh, Peter J. A. Hutchinson, Fahim Anwar

Neurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study

Nanyu Kuang, Zhaowen Liu, Gechang Yu, Xinran Wu, Benjamin Becker, Huaxin Fan, Songjun Peng, Kai Zhang, Jiajia Zhao, Jujiao Kang, Guiying Dong, Xingming Zhao, Barbara J. Sahakian, Trevor W. Robbins, Wei Cheng, Jianfeng Feng, Gunter Schumann, Lena Palaniyappan, Jie Zhang

Initiation and duration of folic acid supplementation in preventing congenital malformations

Jing Dong, Lin-Liang Yin, Xue-Dong Deng, Chun-Ya Ji, Qi Pan, Zhong Yang, Ting Peng, Jiang-Nan Wu, Gui-Hua Wu, Liu-Ying Zhou, Mei Li, Yue-Qin Chen, Jia-Xiang Yang, Bai-Song Liang, Tong Ru, Chun-Li Jing, Weng-Rong Zhou, Li Cao, Qin Li, Gui-Ping Li, Tai-Zhu Yang, Xin-Ru Gao, Li-Ling Shi, Yu-Qing Zhou, Xue-Qin Ji, Bo Liang, Qing Han, Ling Ren, Wen-Rong Wang, Guo-Wei Tao

Effect of home-based online training and activity feedback on oxygen uptake in patients after surgical cancer therapy: a randomized controlled trial

Roberto Falz, Christian Bischoff, René Thieme, Uwe Tegtbur, Peter Hillemanns, Jens-Uwe Stolzenburg, Bahriye Aktas, Ulrich Bork, Jürgen Weitz, Johannes Lässing, Christian Leps, Johannes Voß, Florian Lordick, Antina Schulze, Ines Gockel, Martin Busse

Identification of a novel bile marker clusterin and a public online prediction platform based on deep learning for cholangiocarcinoma

Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung, Shun He, Jinqiu Yuan, Wenbo Meng, Xun Li

NICE and NHS England leads the way to improve diabetes care with access to continuous glucose monitoring for people with type 1 diabetes

Sze May Ng

Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization

Benjamin Woolf, Héléne T. Cronjé, Loukas Zagkos, Stephen Burgess, Dipender Gill, Susanna C. Larsson

Adverse childhood and adulthood experiences and risk of new-onset cardiovascular disease with consideration of social support: a prospective cohort study

Wanxin Wang, Yifeng Liu, Yuwei Yang, Weiqing Jiang, Yanyan Ni, Xue Han, Ciyong Lu, Lan Guo

Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM

Annelieke R. Müller, Michiel A. J. Luijten, Lotte Haverman, Wendela L. de Ranitz-Greven, Peter Janssens, André B. Rietman, Leontine W. ten Hoopen, Laura C. G. de Graaff, Marie-Claire de Wit, Anna C. Jansen, Tanjala Gipson, Jamie K. Capal, Petrus J. de Vries, Agnies M. van Eeghen

Estimating disparities in breast cancer screening programs towards mortality, case fatality, and DALYs across BRICS-plus

Sumaira Mubarik, Saima Shakil Malik, Zhang Yanran, Eelko Hak, Nawsherwan, Fang Wang, Chuanhua Yu

Pyrotinib plus capecitabine for trastuzumab-resistant, HER2-positive advanced breast cancer (PICTURE): a single-arm, multicenter phase 2 trial

Jun Cao, Yuee Teng, Huiping Li, Lili Zhang, Quchang Ouyang, Weimin Xie, Yueyin Pan, Zhenchuan Song, Xiaoling Ling, Xiaohong Wu, Jingwei Xu, Li Li, Liping Ren, Hong Wang, Dongxian Zhou, Jing Luo, Xichun Hu

Correspondence to: Estimating the full health and economic benefits of current and future influenza vaccines

Naomi R. Waterlow, Simon R. Procter, Rosalind M. Eggo, Mark Jit

Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Pan Li, Ping Shuai, Sj Shen, Huimin Zheng, Ping Sun, Renfang Zhang, Shanwei Lan, Zixin Lan, Thisun Jayawardana, Yumei Yang, Jianhui Zhao, Yuping Liu, Xia Chen, Emad M. El-Omar, Zhengwei Wan

Intensive community care services for children and young people in psychiatric crisis: an expert opinion

Eleanor Keiller, Saba Masood, Ben Hoi-ching Wong, Cerian Avent, Kofi Bediako, Rebecca Margaret Bird, Isabel Boege, Marta Casanovas, Veronika Beatrice Dobler, Maya James, Jane Kiernan, Maria Martinez-Herves, Thinh Vinh Thanh Ngo, Ana Pascual-Sanchez, Izabela Pilecka, Paul L Plener, Karin Prillinger, Isabelle Sabbah Lim, Tania Saour, Nidhita Singh, Eirini Skouta, Mariana Steffen, Jovanka Tolmac, Hemma Velani, Ruth Woolhouse, Toby Zundel, Dennis Ougrin

Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population

Aravind Lathika Rajendrakumar, Simona M. Hapca, Anand Thakarakkattil Narayanan Nair, Yu Huang, Mehul Kumar Chourasia, Ryan Shun-Yuen Kwan, Charvi Nangia, Moneeza K. Siddiqui, Prathiba Vijayaraghavan, Shona Z. Matthew, Graham P. Leese, Viswanathan Mohan, Ewan R. Pearson, Alexander S. F. Doney, Colin N. A. Palmer

Healthcare fragmentation, multimorbidity, potentially inappropriate medication, and mortality: a Danish nationwide cohort study

Anders Prior, Claus Høstrup Vestergaard, Peter Vedsted, Susan M. Smith, Line Flytkjær Virgilsen, Linda Aagaard Rasmussen, Morten Fenger-Grøn

Potential value of ctDNA monitoring in metastatic HR + /HER2 − breast cancer: longitudinal ctDNA analysis in the phase Ib MONALEESASIA trial

Joanne Chiu, Fei Su, Mukta Joshi, Norikazu Masuda, Takashi Ishikawa, Tomoyuki Aruga, Juan Pablo Zarate, Naveen Babbar, O. Alejandro Balbin, Yoon-Sim Yap

The associations of dietary patterns with depressive and anxiety symptoms: a prospective study

Han Chen, Zhi Cao, Yabing Hou, Hongxi Yang, Xiaohe Wang, Chenjie Xu

Underrepresentation of ethnic minorities in UK COVID-19 trials: comment on a recent systematic review and meta-analysis

Zeynep Ersoy Guller, Frederick Green, Anna L. Goodman

Impact of data source choice on multimorbidity measurement: a comparison study of 2.3 million individuals in the Welsh National Health Service

Clare MacRae, Daniel Morales, Stewart W. Mercer, Nazir Lone, Andrew Lawson, Emily Jefferson, David McAllister, Marjan van den Akker, Alan Marshall, Sohan Seth, Anna Rawlings, Jane Lyons, Ronan A. Lyons, Amy Mizen, Eleojo Abubakar, Chris Dibben, Bruce Guthrie

Association between plant-based dietary pattern and biological aging trajectory in a large prospective cohort

Sicong Wang, Wenyuan Li, Shu Li, Huakang Tu, Junlin Jia, Wenting Zhao, Andi Xu, Wenxin Xu, Min Kuang Tsai, David Ta-Wei Chu, Chi Pang Wen, Xifeng Wu

Correction: Socioeconomic position and prognosis in premenopausal breast cancer: a population-based cohort study in Denmark

Cathrine Fonnesbech Hjorth, Per Damkier, Bent Ejlertsen, Timothy Lash, Henrik Toft Sørensen, Deirdre Cronin-Fenton

Inappropriate hospital admission as a risk factor for the subsequent development of adverse events: a cross-sectional study

Diego San Jose-Saras, Jorge Vicente-Guijarro, Paulo Sousa, Paloma Moreno-Nunez, Jesús María Aranaz-Andres, Cristina Díaz-Agero Pérez, Miguel Ignacio Cuchi Alfaro, Juan Manuel Ramos López, Mercedes García Haro, Abelardo Claudio Fernández Chávez, Cornelia Bischofberger Valdés, Amaranta Mcgee Laso, Carmen Garrote Liarte, Gerardo Gómez Montero, Juan Daniel Miranda Cortes, Gema Nieto Gomez, Jessica Alia Herrero, Sara de la Hoz San Clemente, Marta Gonzalez Touya, Moisés David Espejo Mambié, Diana Carretero Gomez, Manuela Serrano Pareja, Marco Antonio Espinel Ruiz, Raquel Gutierrez Gallardo, Eva Elisa Álvarez León, Paloma Navas Gutiérrez, Nerea Armenteros Arzá, Francisco Bolumar Montrull, Ana García de la Santa Viñuela, Raquel Arguedas Sanz, Miriam Roncal Redín

Global impact and cost-effectiveness of one-dose versus two-dose human papillomavirus vaccination schedules: a comparative modelling analysis

Kiesha Prem, Yoon Hong Choi, Élodie Bénard, Emily A. Burger, Liza Hadley, Jean-François Laprise, Mary Caroline Regan, Mélanie Drolet, Stephen Sy, Kaja Abbas, Allison Portnoy, Jane J. Kim, Marc Brisson, Mark Jit

The development of a core outcome set for studies of pregnant women with multimorbidity

Siang Ing Lee, Stephanie Hanley, Zoe Vowles, Rachel Plachcinski, Ngawai Moss, Megha Singh, Chris Gale, Adeniyi Francis Fagbamigbe, Amaya Azcoaga-Lorenzo, Anuradhaa Subramanian, Beck Taylor, Catherine Nelson-Piercy, Christine Damase-Michel, Christopher Yau, Colin McCowan, Dermot O’Reilly, Gillian Santorelli, Helen Dolk, Holly Hope, Katherine Phillips, Kathryn M. Abel, Kelly-Ann Eastwood, Lisa Kent, Louise Locock, Maria Loane, Mohamed Mhereeg, Peter Brocklehurst, Sharon McCann, Sinead Brophy, Steven Wambua, Sudasing Pathirannehelage Buddhika Hemali Sudasinghe, Shakila Thangaratinam, Krishnarajah Nirantharakumar, Mairead Black

Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8+ T cells to demote the antitumor immunity

Ruochan Zhang, Kun Chen, Caifeng Gong, Zhiyuan Wu, Chungui Xu, Xing-Ning Li, Fei Zhao, Dongmei Wang, Jianqiang Cai, Aiping Zhou, Chunfeng Qu

An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses

Jong Yeob Kim, Minku Song, Min Seo Kim, Pradeep Natarajan, Ron Do, Woojae Myung, Hong-Hee Won

Maternal pre-pregnancy BMI, offspring epigenome-wide DNA methylation, and childhood obesity: findings from the Boston Birth Cohort

Jiahui Si, Anat Yaskolka Meir, Xiumei Hong, Guoying Wang, Wanyu Huang, Colleen Pearson, William G. Adams, Xiaobin Wang, Liming Liang

Alcohol exposure before and during pregnancy is associated with reduced fetal growth: the Safe Passage Study

Marin Pielage, Hanan El Marroun, Hein J. Odendaal, Sten P. Willemsen, Manon H. J. Hillegers, Eric A. P. Steegers, Melek Rousian

Understanding primary care transformation and implications for ageing populations and health inequalities: a systematic scoping review of new models of primary health care in OECD countries and China

D. A. G Henderson, E Donaghy, M Dozier, B Guthrie, H Huang, M Pickersgill, E Stewart, A Thompson, H. H. X Wang, S. W Mercer

Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study

Makoto Saito, Aung Pyae Phyo, Cindy Chu, Stephane Proux, Marcus J. Rijken, Candy Beau, Htun Htun Win, Laypaw Archasuksan, Jacher Wiladphaingern, Nguyen H. Phu, Tran T. Hien, Nick P. Day, Arjen M. Dondorp, Nicholas J. White, François Nosten, Rose McGready

Benefits of near-universal vaccination and treatment access to manage COVID-19 burden in the United States

Fuhan Yang, Thu Nguyen-Anh Tran, Emily Howerton, Maciej F. Boni, Joseph L. Servadio

Vestibular rehabilitation therapy on balance and gait in patients after stroke: a systematic review and meta-analysis

Lijiao Meng, Qiu Liang, Jianrong Yuan, Siyi Li, Yanlei Ge, Jingyi Yang, Raymond C C Tsang, Quan Wei

Metabolic characteristics and pathogenesis of precocious puberty in girls: the role of perfluorinated compounds

Jinxia Wu, Jing Chen, Rong Huang, Hongwei Zhu, Lin Che, Yanyan Lin, Yajie Chang, Guiping Shen, Jianghua Feng

Chronic remote ischemic conditioning treatment in patients with chronic stable angina (EARLY-MYO-CSA): a randomized, controlled proof-of-concept trial

Quan Guo, Zhenzhou Zhao, Fan Yang, Zhiwen Zhang, Xiaoyu Rao, Jing Cui, Qingbo Shi, Kaiyuan Liu, Kang Zhao, Haiyu Tang, Liang Peng, Cao Ma, Jun Pu, Muwei Li

Sustainability of knowledge translation interventions: the evidence lacks evidence

Alexis Descatha, Marc Fadel

Identification and prediction model of placenta-brain axis genes associated with neurodevelopmental delay in moderate and late preterm children

Yumin Zhu, Yimin Zhang, Yunfan Jin, Heyue Jin, Kun Huang, Juan Tong, Hong Gan, Chen Rui, Jia Lv, Xianyan Wang, Qu’nan Wang, Fangbiao Tao

Targeted delivery of a PD-1-blocking scFv by CD133-specific CAR-T cells using nonviral Sleeping Beauty transposition shows enhanced antitumour efficacy for advanced hepatocellular carcinoma

Chaopin Yang, Jinqi You, Qiuzhong Pan, Yan Tang, Liming Cai, Yue Huang, Jiamei Gu, Yizhi Wang, Xinyi Yang, Yufei Du, Dijun Ouyang, Hao Chen, Haoran Zhong, Yongqiang Li, Jieying Yang, Yulong Han, Fengze Sun, Yuanyuan Chen, Qijing Wang, Desheng Weng, Zhongqiu Liu, Tong Xiang, Jianchuan Xia

Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China

Tianqi Tan, Tingting Chen, Wenwen Zhu, Lin Gong, Yizhong Yan, Qian Li, Li Chen, Yiling Li, Jialin Liu, Yanan Li, Xuefeng Yang, Liping Hao, Huaiji Wang, Nianhong Yang, Sheng Wei

Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases

Qi Zhou, Xufeng Tao, Fangyue Guo, Yu Wu, Dawei Deng, Linlin Lv, Deshi Dong, Dong Shang, Hong Xiang

CAR-T cells targeting CD38 and LMP1 exhibit robust antitumour activity against NK/T cell lymphoma

Hongwen Li, Wenting Song, Jiazhuo Wu, Zhuangzhuang Shi, Yuyang Gao, Jiwei Li, Lijuan Han, Jianxiang Zhang, Zhaoming Li, Yong Li, Mingzhi Zhang

Tabby2: a user-friendly web tool for forecasting state-level TB outcomes in the United States

Nicole A. Swartwood, Christian Testa, Ted Cohen, Suzanne M. Marks, Andrew N. Hill, Garrett Beeler Asay, Jennifer Cochran, Kevin Cranston, Liisa M. Randall, Andrew Tibbs, C. Robert Horsburgh Jr, Joshua A. Salomon, Nicolas A. Menzies

Telehealth in antenatal care: recent insights and advances

Jessica Atkinson, Roxanne Hastie, Susan Walker, Anthea Lindquist, Stephen Tong

Psychobiotics and the need for better interventional data

The write algorithm: promoting responsible artificial intelligence usage and accountability in academic writing

Steven Bell

Fluorescence-tagged salivary small extracellular vesicles as a nanotool in early diagnosis of Parkinson’s disease

Simran Rastogi, Komal Rani, Sanskriti Rai, Rishabh Singh, Prahalad Singh Bharti, Vaibhav Sharma, Jyoti Sahu, Vrinda Kapoor, Poorvi Vishwakarma, Sumit Garg, Shivajirao Lahu Gholap, Krishna Kishore Inampudi, Gyan Prakash Modi, Neerja Rani, Madhavi Tripathi, Achal Srivastava, Roopa Rajan, Fredrik Nikolajeff, Saroj Kumar

Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening

Zhongguang Luo, Bangting Wang, Feifei Luo, Yumeng Guo, Ning Jiang, Jinsong Wei, Xin Wang, Yujen Tseng, Jian Chen, Bing Zhao, Jie Liu

Exogenous female sex steroid hormones and new-onset asthma in women: a matched case–control study

Guoqiang Zhang, Rani Basna, Maya B. Mathur, Cecilia Lässer, Roxana Mincheva, Linda Ekerljung, Göran Wennergren, Madeleine Rådinger, Bo Lundbäck, Hannu Kankaanranta, Bright I. Nwaru

Effect of chimeric antigen receptor T cells against protease-activated receptor 1 for treating pancreatic cancer

Hao-Chien Hung, Ming-Huei Fan, Daniel Wang, Carol H. Miao, Pong Su, Chao-Lien Liu

Evidence of questionable research practices in clinical prediction models

Nicole White, Rex Parsons, Gary Collins, Adrian Barnett

Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance

Wichanon Sae-jie, Suangsuda Supasai, Mika Kivimaki, Jackie F. Price, Andrew Wong, Meena Kumari, Jorgen Engmann, Tina Shah, Amand F. Schmidt, Tom R. Gaunt, Aroon Hingorani, Pimphen Charoen

Prenatal ambient air pollution exposure and child weight trajectories from the 3rd trimester of pregnancy to 2 years of age: a cohort study

Nan Ji, Mark Johnson, Sandrah P. Eckel, William J. Gauderman, Thomas A. Chavez, Kiros Berhane, Dema Faham, Fred Lurmann, Nathan R. Pavlovic, Brendan H. Grubbs, Deborah Lerner, Rima Habre, Shohreh F. Farzan, Theresa M. Bastain, Carrie V. Breton

Detection of diabetic patients in people with normal fasting glucose using machine learning

Kun Lv, Chunmei Cui, Rui Fan, Xiaojuan Zha, Pengyu Wang, Jun Zhang, Lina Zhang, Jing Ke, Dong Zhao, Qinghua Cui, Liming Yang

Re: Molecular testing to deliver personalised chemotherapy recommendations

Peter Gibbs, Wei Hong, Jeanne Tie

Additional considerations before using a ctDNA-guided approach for informing adjuvant chemotherapy in colorectal cancer

Timothée Olivier, Alyson Haslam, Vinay Prasad

Substantially more children receiving antidepressants see a specialist than reported by Jack et al.

Vicky P. Taxiarchi, Carolyn A. Chew-Graham, Matthias Pierce

Importance of accurate and accessible recording of healthcare contacts in mental health

Ruth H. Jack, Carol A. C. Coupland, Rebecca M. Joseph, Chris Hollis, Richard Morriss, Roger David Knaggs, Andrea Cipriani, Samuele Cortese, Julia Hippisley-Cox

Integrated epigenome, whole genome sequence and metabolome analyses identify novel multi-omics pathways in type 2 diabetes: a Middle Eastern study

Noha A. Yousri, Omar M. E. Albagha, Steven C. Hunt

Association of caesarean delivery with offspring health outcomes in full-cohort versus sibling-comparison studies: a comparative meta-analysis and simulation study

Hong-zhao Yu, Xiao-wei Wang, Zhen-yu Guo, Zhi Lin, Yu-bo Zhou, Hong-tian Li, Jian-meng Liu

Integrated unbiased multiomics defines disease-independent placental clusters in common obstetrical syndromes

Oren Barak, Tyler Lovelace, Samantha Piekos, Tianjiao Chu, Zhishen Cao, Elena Sadovsky, Jean-Francois Mouillet, Yingshi Ouyang, W. Tony Parks, Leroy Hood, Nathan D. Price, Panayiotis V. Benos, Yoel Sadovsky

Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysis

Claire Prince, Laura D. Howe, Gemma C. Sharp, Abigail Fraser, Rebecca C. Richmond

Plant-based diets, genetic predisposition and risk of non-alcoholic fatty liver disease

Yanling Lv, Shuang Rong, Yan Deng, Wei Bao, Yang Xia, Liangkai Chen

Maternal multimorbidity and preterm birth in Scotland: an observational record-linkage study

Amaya Azcoaga-Lorenzo, Adeniyi Francis Fagbamigbe, Utkarsh Agrawal , Mairead Black, Muhammad Usman, Siang Ing Lee, Kelly-Ann Eastwood, Ngawai Moss, Rachel Plachcinski, Catherine Nelson-Piercy, Sinead Brophy, Dermot O’Reilly, Krishnarajah Nirantharakumar, Colin McCowan

Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses

Li Zhang, Wenqiang Zhang, Lin He, Huijie Cui, Yutong Wang, Xueyao Wu, Xunying Zhao, Peijing Yan, Chao Yang, Changfeng Xiao, Mingshuang Tang, Lin Chen, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Yanfang Yang, Ling Zhang, Yuqin Yao, Jiayuan Li, Zhenmi Liu, Chunxia Yang, Xia Jiang, Ben Zhang

A roadmap for sex- and gender-disaggregated health research

Sanne A. E. Peters, Mark Woodward

Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study

Vasilios Karageorgiou, Francesco Casanova, Jessica O’Loughlin, Harry Green, Trevelyan J. McKinley, Jack Bowden, Jessica Tyrrell

Financial hardship associated with catastrophic out-of-pocket spending tied to primary care services in low- and lower-middle-income countries: findings from a modeling study

Sarah Bolongaita, Yeeun Lee, Kjell Arne Johansson, Øystein A. Haaland, Mieraf Taddesse Tolla, Jongwook Lee, Stéphane Verguet

A urinary assay for mutation and methylation biomarkers in the diagnosis and recurrence prediction of non-muscle invasive bladder cancer patients

Hai Huang, Ao Liu, Yiming Liang, Yaqun Xin, Jiacheng Liu, Yining Hao, Da Huang, Lu Chen, Wei Li, Guangliang Jiang, Yuhua Huang, Yaoting Xu, Jie Zhang, Tonghui Ma, Danfeng Xu, Yi Gao

Patient-reported reactogenicity and safety of COVID-19 vaccinations vs. comparator vaccinations: a comparative observational cohort study

Felix Werner, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla, Isabelle Kaiser, Maria Sebastião, Susann Hueber, Lisette Warkentin

The influence of explainable vs non-explainable clinical decision support systems on rapid triage decisions: a mixed methods study

Daniel Laxar, Magdalena Eitenberger, Mathias Maleczek, Alexandra Kaider, Fabian Peter Hammerle, Oliver Kimberger

Small volume bone marrow aspirates with high progenitor cell concentrations maximize cell therapy dose manufacture and substantially reduce donor hemoglobin loss

Jeremy Epah, Gabriele Spohn, Kathrin Preiß, Markus M. Müller, Johanna Dörr, Rainer Bauer, Shabnam Daqiq-Mirdad, Joachim Schwäble, Stefanie N. Bernas, Alexander H. Schmidt, Erhard Seifried, Richard Schäfer

Larval therapy vs conventional silver dressings for full-thickness burns: a randomized controlled trial

Jasem Gaffari, Kamran Akbarzadeh, Mozhgan Baniardalani, Reza Hosseini, Safdar Masoumi, Zahra Sadat Amiri, Razieh Shabani Kordshouli, Javad Rafinejad, Mostafa Dahmardehei

Evidencing general acceptability of open-label placebo use for tackling overtreatment in primary care: a mixed methods study

E. M. Krockow, T. Emerson, E. Youssef, S. Scott, S. Tromans

Incidence of immune-mediated inflammatory diseases following COVID-19: a matched cohort study in UK primary care

Umer Syed, Anuradhaa Subramanian, David C. Wraith, Janet M. Lord, Kirsty McGee, Krishna Ghokale, Krishnarajah Nirantharakumar, Shamil Haroon

The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial

Anat Yaskolka Meir, Maria Keller, Anne Hoffmann, Ehud Rinott, Gal Tsaban, Alon Kaplan, Hila Zelicha, Tobias Hagemann, Uta Ceglarek, Berend Isermann, Ilan Shelef, Matthias Blüher, Michael Stumvoll, Jun Li, Sven-Bastian Haange, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Martin von Bergen, Frank B. Hu, Meir J. Stampfer, Peter Kovacs, Liming Liang, Iris Shai

Diagnostic and societal impact of implementing the syncope guidelines of the European Society of Cardiology (SYNERGY study)

M. Ghariq, W. B. van den Hout, O. M. Dekkers, M. Bootsma, B. de Groot, J. G. J. Groothuis, M. P. M. Harms, M. E. W. Hemels, E. C. A. Kaal, E. M. Koomen, F. J. de Lange, S. Y. G. Peeters, I. A. van Rossum, J. H. W. Rutten, E. W. van Zwet, J. G. van Dijk, R. D. Thijs, R. M. Tuinema, W. Voet, D. B. Boerman, M. Firouzi, C. Fokke

ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization

Xiaolin Lu, Ruiqi Liu, Yuanyu Liao, Luying Cui, Haoxiu Sun, Dongzhi Zhang, Bojun Wang, Lin Fang, Xin Guan, Yuanfei Yao, Chao Liu, Yanqiao Zhang

What is the impact of one’s chronic illness on his or her spouse’s future chronic illness: a community-based prospective cohort study

Hoyoung An, Hee Won Yang, Dae Jong Oh, Eunji Lim, Jin Shin, Dong Gyu Moon, Seung Wan Suh, Seonjeong Byun, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Jong Bin Bae, Ji Won Han, Ki Woong Kim

Correction: Identification of a novel bile marker clusterin and a public online prediction platform based on deep learning for cholangiocarcinoma

Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung, Shun He, Jinqiu Yuan, Wenbo Meng, Xun Li

Correction: Multiplex immunohistochemistry defines the tumor immune microenvironment and immunotherapeutic outcome in CLDN18.2-positive gastric cancer

Keren Jia, Yang Chen, Yu Sun, Yajie Hu, Lei Jiao, Jie Ma, Jiajia Yuan, Changsong Qi, Yanyan Li, Jifang Gong, Jing Gao, Xiaotian Zhang, Jian Li, Cheng Zhang, Lin Shen

Healthcare professionals’ views on the accessibility and acceptability of perinatal mental health services for South Asian and Black women: a qualitative study

Kiren Bains, Sarah Bicknell, Nikolina Jovanović, Maev Conneely, Rosemarie McCabe, Alex Copello, Jessica Fletcher-Rogers, Stefan Priebe, Jelena Janković

Perinatal mental health services for women from minority ethnic groups: why patient-centred approach matter

Shanquan Chen, Huyang Zhang, Hannah Kuper

Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress

Yu Shi, Wen Wu

Five-year results of a treatment program for chronic hepatitis B in Ethiopia

Hailemichael Desalegn, Stian Magnus Staurung Orlien, Hanna Aberra, Eyerusalem Mamo, Sine Grude, Kristina Hommersand, Nega Berhe, Svein Gunnar Gundersen, Asgeir Johannessen

Assessing changes in incubation period, serial interval, and generation time of SARS-CoV-2 variants of concern: a systematic review and meta-analysis

Xiangyanyu Xu, Yanpeng Wu, Allisandra G. Kummer, Yuchen Zhao, Zexin Hu, Yan Wang, Hengcong Liu, Marco Ajelli, Hongjie Yu

Real-world data emulating randomized controlled trials of non-vitamin K antagonist oral anticoagulants in patients with venous thromboembolism

Dongwon Yoon, Han Eol Jeong, Sohee Park, Seng Chan You, Soo-Mee Bang, Ju-Young Shin

A phase 1 trial of fuzuloparib in combination with apatinib for advanced ovarian and triple-negative breast cancer: efficacy, safety, pharmacokinetics and germline BRCA mutation analysis

Yaxin Liu, Wei Wang, Rutie Yin, Youzhong Zhang, Yu Zhang, Keqiang Zhang, Hongming Pan, Ke Wang, Ge Lou, Guiling Li, Ruyan Zhang, Kun Li, Jing Rao, Ben Zhang, Yuting Wang, Quanren Wang, Yunong Gao, Huiping Li

Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma

Qiangsheng Wang, Qiqin Shi, Zhenqian Wang, Jiawen Lu, Jian Hou

Non-pharmacological interventions for smoking cessation: analysis of systematic reviews and meta-analyses

Tao Nian, Kangle Guo, Wendi Liu, Xinxin Deng, Xiaoye Hu, Meng Xu, Fenfen E, Ziyi Wang, Guihang Song, Kehu Yang, Xiuxia Li, Wenru Shang

Effect of provision of non-alcoholic beverages on alcohol consumption: a randomized controlled study

Hisashi Yoshimoto, Kyoko Kawaida, Shohei Dobashi, Go Saito, Yukiko Owaki

Return to work and health-related quality of life up to 1 year in patients hospitalized for COVID-19: the CO-FLOW study

L. M. Bek, J. C. Berentschot, M. E. Hellemons, S. C. Remerie, J. van Bommel, J. G. J. V. Aerts, G. M. Ribbers, H. J. G. van den Berg-Emons, M. H. Heijenbrok-Kal, Michel E. van Genderen, Diederik A. M. P. J. Gommers, Erwin Ista, Robert van der Stoep, Rutger Osterthun, Markus P. J. M. Wijffels, Marieke M. Visser, Janette J. Tazmi-Staal, Eva G. Willems, Roxane Heller, Shai A. Gajadin, Wouter J. B. Blox, Laurien Oswald, Sieshem Bindraban, Herbert J. van de Sande, Ronald N. van Rossem, Stephanie van Loon-Kooij

Impacts of performance-based financing on health system performance: evidence from the Democratic Republic of Congo

Gil Shapira, Emma Clarke-Deelder, Baudouin Makuma Booto, Hadia Samaha, György Bèla Fritsche, Michel Muvudi, Dominique Baabo, Delphin Antwisi, Didier Ramanana, Saloua Benami, Günther Fink

Effects of a text messaging smoking cessation intervention amongst online help-seekers and primary health care visitors: findings from a randomised controlled trial

Jenny Blomqvist, Katarina Ulfsdotter Gunnarsson, Preben Bendtsen, Marcus Bendtsen

The Biomarker Toolkit — an evidence-based guideline to predict cancer biomarker success and guide development

Katerina-Vanessa Savva, Michal Kawka, Bhamini Vadhwana, Rahul Penumaka, Imogen Patton, Komal Khan, Claire Perrott, Saranya Das, Maxime Giot, Stella Mavroveli, George B. Hanna, Melody Zhifang Ni, Christopher J. Peters

Social connection and mortality in UK Biobank: a prospective cohort analysis

Hamish M. E. Foster, Jason M. R. Gill, Frances S. Mair, Carlos A. Celis-Morales, Bhautesh D. Jani, Barbara I. Nicholl, Duncan Lee, Catherine A. O’Donnell

Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study

Nikhil Arora, Laxmi Bhatta, Eivind Schjelderup Skarpsno, Håvard Dalen, Bjørn Olav Åsvold, Ben Michael Brumpton, Rebecca Claire Richmond, Linn Beate Strand

Phase III clinical trial of autologous CD34 + cell transplantation to accelerate fracture nonunion repair

Ryosuke Kuroda, Takahiro Niikura, Tomoyuki Matsumoto, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Hironobu Minami, Hiroshi Matsuoka, Kimikazu Yakushijin, Yoshiharu Miyata, Shinichiro Kawamoto, Tatsuo Kagimura, Yasuyuki Fujita, Atsuhiko Kawamoto

The one-dose schedule opens the door to rapid scale-up of HPV vaccination

Zhuoru Zou, Lei Zhang

Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial

Mingtong Xu, Kan Sun, Wenjie Xu, Chuan Wang, Dewen Yan, Shu Li, Li Cong, Yinzhen Pi, Weihong Song, Qingyuan Sun, Rijun Xiao, Weixia Peng, Jianping Wang, Hui Peng, Yawei Zhang, Peng Duan, Meiying Zhang, Jianying Liu, Qingmei Huang, Xuefeng Li, Yan Bao, Tianshu Zeng, Kun Wang, Li Qin, Chaoming Wu, Chunying Deng, Chenghu Huang, Shuang Yan, Wei Zhang, Meizi Li, Li Sun, Yanjun Wang, HongMei Li, Guang Wang, Shuguang Pang, Xianling Zheng, Haifang Wang, Fujun Wang, Xiuhai Su, Yujin Ma, Wei Zhang, Ziling Li, Zuoling Xie, Ning Xu, Lin Ni, Li Zhang, Xiangqun Deng, Tianrong Pan, Qijuan Dong, Xiaohong Wu, Xingping Shen, Xin Zhang, Qijing Zou, Chengxia Jiang, Jue Xi, Jianhua Ma, Jingchao Sun, Li Yan

Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study

Hui Gao, Shuhao Zheng, Xin Yuan, Jiarong Xie, Lei Xu

Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Sangeetha Shyam, Jesús Francisco García-Gavilán, Indira Paz-Graniel, José J. Gaforio, Miguel Ángel Martínez-González, Dolores Corella, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, J. Luís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martín Sánchez, Xavier Pintó, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia-Regata, Estefania Toledo, Eva M. Asensio, Olga Castañer, Antonio Garcia-Rios, Laura Torres-Collado, Enrique Gómez-Gracia, M. Angeles Zulet, Nuria Goñi Ruiz, Rosa Casas, Naomi Cano-Ibáñez, Lucas Tojal-Sierra, A. M. Gómez-Perez, Jose V. Sorlí, Sergio Cinza-Sanjurjo, Sandra Martín-Peláez, Patricia J. Peña-Orihuela, Alejandro Oncina-Canovas, Rafael Perez-Araluce, María Dolores Zomeño, Alice Chaplin, Miguel Delgado-Rodríguez, Nancy Babio, Montserrat Fitó, Jordi Salas-Salvadó

Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer

Katharina Nimptsch, Krasimira Aleksandrova, Thu Thi Pham, Nikos Papadimitriou, Jürgen Janke, Sofia Christakoudi, Alicia Heath, Anja Olsen, Anne Tjønneland, Matthias B. Schulze, Verena Katzke, Rudolf Kaaks, Bethany van Guelpen, Justin Harbs, Domenico Palli, Alessandra Macciotta, Fabrizio Pasanisi, Sandra Milena Colorado Yohar, Marcela Guevara, Pilar Amiano, Sara Grioni, Paula Gabriela Jakszyn, Jane C. Figueiredo, N. Jewel Samadder, Christopher I. Li, Victor Moreno, John D. Potter, Robert E. Schoen, Caroline Y. Um, Elisabete Weiderpass, Mazda Jenab, Marc J. Gunter, Tobias Pischon

Beneficial effects of recombinant CER-001 high-density lipoprotein infusion in sepsis: results from a bench to bedside translational research project

Alessandra Stasi, Marco Fiorentino, Rossana Franzin, Francesco Staffieri, Sabrina Carparelli, Rosa Losapio, Alberto Crovace, Luca Lacitignola, Maria Teresa Cimmarusti, Francesco Murgolo, Monica Stufano, Cesira Cafiero, Giuseppe Castellano, Fabio Sallustio, Chiara Ferrari, Mario Ribezzi, Nicola Brienza, Annalisa Schirinzi, Francesca Di Serio, Salvatore Grasso, Paola Pontrelli, Cyrille Tupin, Ronald Barbaras, Constance Keyserling-Peyrottes, Antonio Crovace, Loreto Gesualdo

Association of breastfeeding with mental disorders in mother and child: a systematic review and meta-analysis

Polina Bugaeva, Inna Arkusha, Rinat Bikaev, Igor Kamenskiy, Aleksandra Pokrovskaya, Yasmin El-Taravi, Valeria Caso, Alla Avedisova, Derek K. Chu, Jon Genuneit, Gabriel Torbahn, Timothy R. Nicholson, Dina Baimukhambetova, Aigun Mursalova, Anastasia Kolotilina, Svetlana Gadetskaya, Elena Kondrikova, Mikhail Zinchuk, Renat Akzhigitov, Robert J. Boyle, Alla Guekht, Daniel Munblit

Cardiovascular outcomes between COVID-19 and non-COVID-19 pneumonia: a nationwide cohort study

Min-Taek Lee, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung, Won-Young Kim

Combination of GT90001 and nivolumab in patients with advanced hepatocellular carcinoma: a multicenter, single-arm, phase 1b/2 study

Chiun Hsu, Yi-Fang Chang, Chia-Jui Yen, Yu-Wei Xu, Min Dong, You-Zhi Tong

Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection

Yixuan Sheng, Liying Wu, Yuan Chang, Wendao Liu, Menghao Tao, Xiao Chen, Xiong Zhang, Bin Li, Ningning Zhang, Dongting Ye, Chunxi Zhang, Daliang Zhu, Haisen Zhao, Aijun Chen, Haisheng Chen, Jiangping Song

Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo

Marie A. Onyamboko, Peter Olupot-Olupot, Winifred Were, Cate Namayanja, Peter Onyas, Harriet Titin, Joy Baseke, Rita Muhindo, Daddy K. Kayembe, Pauline O. Ndjowo, Benjamin B. Basara, Charles B. Okalebo, Thomas N. Williams, Sophie Uyoga, Chiraporn Taya, Adeola Bamisaiye, Caterina Fanello, Kathryn Maitland, Nicholas P. J. Day, Walter R. J. Taylor, Mavuto Mukaka

Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank

Yu Jia, Dongze Li, Yi You, Jing Yu, Wenli Jiang, Yi Liu, Rui Zeng, Zhi Wan, Yi Lei, Xiaoyang Liao

Racial differences in healthcare expenditures for prevalent multimorbidity combinations in the USA: a cross-sectional study

Manal Alshakhs, Patricia J. Goedecke, James E. Bailey, Charisse Madlock-Brown

A 10-year update to the principles for clinical trial data sharing by pharmaceutical companies: perspectives based on a decade of literature and policies

Natansh D. Modi, Ganessan Kichenadasse, Tammy C. Hoffmann, Mark Haseloff, Jessica M. Logan, Areti A. Veroniki, Rebecca L. Venchiarutti, Amelia K. Smit, Haitham Tuffaha, Harindra Jayasekara, Arkady Manning-Bennet, Erin Morton, Ross A. McKinnon, Andrew Rowland, Michael J. Sorich, Ashley M. Hopkins

Correction: Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM

Annelieke R. Müller, Michiel A. J. Luijten, Lotte Haverman, Wendela L. de Ranitz-Greven, Peter Janssens, André B. Rietman, Leontine W.ten Hoopen, Laura C. G. de Graaff, Marie-Claire de Wit, Anna C. Jansen, Tanjala Gipson, Jamie K. Capal, Petrus J. de Vries, Agnies M. van Eeghen

A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy

Zude Chen, Xiaoshuang Yang, Zugen Chen, Minzhao Li, Wei Wang, Riwei Yang, Zuomin Wang, Yuxiang Ma, Yulong Xu, Shan Ao, Leqi Liang, Chao Cai, Changning Wang, Tuo Deng, Di Gu, Hongqing Zhou, Guohua Zeng

Interventions to address unprofessional behaviours between staff in acute care: what works for whom and why? A realist review

Jill Maben, Justin Avery Aunger, Ruth Abrams, Judy M. Wright, Mark Pearson, Johanna I. Westbrook, Aled Jones, Russell Mannion

Substitution of animal-based with plant-based foods on cardiometabolic health and all-cause mortality: a systematic review and meta-analysis of prospective studies

Manuela Neuenschwander, Julia Stadelmaier, Julian Eble, Kathrin Grummich, Edyta Szczerba, Eva Kiesswetter, Sabrina Schlesinger, Lukas Schwingshackl

Deep learning models of ultrasonography significantly improved the differential diagnosis performance for superficial soft-tissue masses: a retrospective multicenter study

Bin Long, Haoyan Zhang, Han Zhang, Wen Chen, Yang Sun, Rui Tang, Yuxuan Lin, Qiang Fu, Xin Yang, Ligang Cui, Kun Wang

Shoulder replacement surgery’s rising demand, inequality of provision, and variation in outcomes: cohort study using Hospital Episode Statistics for England

Epaminondas Markos Valsamis, Rafael Pinedo-Villanueva, Adrian Sayers, Gary S. Collins, Jonathan L. Rees

Adherence to the 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations and risk of 14 lifestyle-related cancers in the UK Biobank prospective cohort study

Fiona C. Malcomson, Solange Parra-Soto, Frederick K. Ho, Liya Lu, Carlos Celis-Morales, Linda Sharp, John C. Mathers

Plasma metabolomics profiles in Black and White participants of the Adventist Health Study-2 cohort

Fayth M. Butler, Jason Utt, Roy O. Mathew, Carlos A. Casiano, Suzanne Montgomery, Seth A. Wiafe, Johanna W. Lampe, Gary E. Fraser

Gut mycobiome as a potential non-invasive tool in early detection of lung adenocarcinoma: a cross-sectional study

Qingyan Liu, Weidong Zhang, Yanbin Pei, Haitao Tao, Junxun Ma, Rong Li, Fan Zhang, Lijie Wang, Leilei Shen, Yang Liu, Xiaodong Jia, Yi Hu

Assessing the safety of lipid-modifying medications among Chinese adolescents: a drug-target Mendelian randomization study

Shan Luo, Hugh Simon Lam, Yap Hang Chan, Clara Sze Man Tang, Baoting He, Man Ki Kwok, Gabriel M. Leung, C Mary Schooling, Shiu Lun Au Yeung

Joint association of sedentary behavior and vitamin D status with mortality among cancer survivors

Yu Yu, Sijing Cheng, Hao Huang, Yu Deng, Chi Cai, Min Gu, Xuhua Chen, Hongxia Niu, Wei Hua

Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis

Milena Paw, Agnieszka A. Kusiak, Kinga Nit, Jacek J. Litewka, Marcin Piejko, Dawid Wnuk, Michał Sarna, Kinga Fic, Kinga B. Stopa, Ruba Hammad, Olga Barczyk-Woznicka, Toni Cathomen, Ewa Zuba-Surma, Zbigniew Madeja, Paweł E. Ferdek, Sylwia Bobis-Wozowicz

Association between antenatal corticosteroid treatment and severe adverse events in pregnant women

Hui-Ju Tsai, Beth I. Wallace, Akbar K. Waljee, Xiumei Hong, Sheng-Mao Chang, Yi-Fen Tsai, Mei-Leng Cheong, Ann Chen Wu, Tsung-Chieh Yao

Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies

Wanglong Gou, Huijun Wang, Xin-yi Tang, Yan He, Chang Su, Jiguo Zhang, Ting-yu Sun, Zengliang Jiang, Zelei Miao, Yuanqing Fu, Hui Zhao, Yu-ming Chen, Bing Zhang, Hongwei Zhou, Ju-Sheng Zheng

Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease

Huiping Li, Yaogang Wang, Emily Sonestedt, Yan Borné

Experience with 2 years’ intervention to progressively reduce salt supply to kitchens in elderly care facilities—challenges and further research: post hoc analysis of the DECIDE-Salt randomized clinical trial

Yifang Yuan, Aoming Jin, Peifen Duan, La’e Cao, Hongxia Wang, Senke Hu, Jiayu Li, Xiangxian Feng, Qianku Qiao, Hui Zhang, Ruijuan Zhang, Huijuan Li, Pei Gao, Gaoqiang Xie, Jianhui Yuan, Lili Cheng, Sujuan Wang, Wenyi Niu, Paul Elliott, Runlin Gao, Darwin Labarthe, Yangfeng Wu

Six-hour time-restricted feeding inhibits lung cancer progression and reshapes circadian metabolism

Dan Shi, Gaofeng Fang, Qianyao Chen, Jianling Li, Xiongzhong Ruan, Xuemei Lian

Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies

Emma Fontvieille, Vivian Viallon, Martina Recalde, Reynalda Cordova, Anna Jansana, Laia Peruchet-Noray, Hannah Lennon, Alicia K. Heath, Dagfinn Aune, Sofia Christakoudi, Verena Katzke, Rudolf Kaaks, Elif Inan-Eroglu, Matthias B. Schulze, Lene Mellemkjær, Anne Tjønneland, Kim Overvad, Marta Farràs, Dafina Petrova, Pilar Amiano, María-Dolores Chirlaque, Conchi Moreno-Iribas, Sandar Tin Tin, Giovanna Masala, Sabina Sieri, Fulvio Ricceri, Salvatore Panico, Anne M. May, Evelyn M. Monninkhof, Elisabete Weiderpass, Marc J. Gunter, Pietro Ferrari, Heinz Freisling

Does disease incite a stronger moral appeal than health?

Bjørn Hofmann

Plasma glial fibrillary acidic protein as a biomarker of disease progression in Parkinson’s disease: a prospective cohort study

Junyu Lin, Ruwei Ou, Chunyu Li, Yanbing Hou, Lingyu Zhang, Qianqian Wei, Dejiang Pang, Kuncheng Liu, Qirui Jiang, Tianmi Yang, Yi Xiao, Bi Zhao, Xueping Chen, Wei Song, Jing Yang, Ying Wu, Huifang Shang

Malnutrition-related mortality trends in older adults in the United States from 1999 to 2020

Naydeen Mostafa, Ahmed Sayed, Omar Rashad, Omar Baqal

Associations between maternal metabolic conditions and neurodevelopmental conditions in offspring: the mediating effects of obstetric and neonatal complications

Shuyun Chen, Xi Wang, Brian K. Lee, Renee M. Gardner

Anlotinib as a third-line or further treatment for recurrent or metastatic nasopharyngeal carcinoma: a single-arm, phase 2 clinical trial

Yu Fang, Ning Su, Qihua Zou, Yi Cao, Yi Xia, Linquan Tang, Xiaopeng Tian, Panpan Liu, Qingqing Cai

Real-world outcomes of concomitant antidepressant and statin use in primary care patients with depression: a population-based cohort study

Riccardo De Giorgi, Franco De Crescenzo, Philip J. Cowen, Catherine J. Harmer, Andrea Cipriani

Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of ‘studies within a trial’ (SWATs)

Vichithranie W. Madurasinghe, Peter Knapp, Sandra Eldridge, David Collier, Shaun Treweek, Jo Rick, Jonathan Graffy, Adwoa Parker, Chris Salisbury, David Torgerson, Kate Jolly, Manbinder S. Sidhu, Christopher Fife-Schaw, Mark A. Hull, Kirsty Sprange, Elizabeth Brettell, Sunil Bhandari, Alan Montgomery, Peter Bower

Impact of vaccination against severe COVID-19 in the French population aged 50 years and above: a retrospective population-based study

Laetitia Tan-Lhernould, Cynthia Tamandjou, Guilhem Deschamps, Johnny Platon, Cécile Sommen, Fanny Chereau, Isabelle Parent du Châtelet, Simon Cauchemez, Sophie Vaux, Juliette Paireau

The association between telomere length and non-alcoholic fatty liver disease: a prospective study

Linxi Tang, Dankang Li, Yudiyang Ma, Feipeng Cui, Jianing Wang, Yaohua Tian

The case for better governance to mitigate against childhood obesity: the UK experience

A quantitative evaluation of the impact of vaccine roll-out rate and coverage on reducing deaths: insights from the first 2 years of COVID-19 epidemic in Iran

Mahan Ghafari, Sepanta Hosseinpour, Mohammad Saeid Rezaee-Zavareh, Stefan Dascalu, Somayeh Rostamian, Kiarash Aramesh, Kaveh Madani, Shahram Kordasti

Periodontitis and systemic inflammation as independent and interacting risk factors for mortality: evidence from a prospective cohort study

Christiane Pink, Birte Holtfreter, Henry Völzke, Matthias Nauck, Marcus Dörr, Thomas Kocher

Cardiovascular events and venous thromboembolism after primary malignant or non-malignant brain tumour diagnosis: a population matched cohort study in Wales (United Kingdom)

Michael T. C. Poon, Paul M. Brennan, Kai Jin, Cathie L. M. Sudlow, Jonine D. Figueroa

Advancing the communication of genetic risk for cardiometabolic diseases: a critical interpretive synthesis

Jing Hui Law, Najia Sultan, Sarah Finer, Nina Fudge

Association between ethnicity and migration status with the prevalence of single and multiple long-term conditions in UK healthcare workers

Winifred Ekezie, Christopher A. Martin, Rebecca F. Baggaley, Lucy Teece, Joshua Nazareth, Daniel Pan, Shirley Sze, Luke Bryant, Katherine Woolf, Laura J. Gray, Kamlesh Khunti, Manish Pareek, Laura Nellums, Anna L. Guyatt, Catherine John, I Chris McManus, Ibrahim Abubakar, Amit Gupta, Keith R. Abrams, Martin D. Tobin, Louise Wain, Sue Carr, Edward Dove, David Ford, Robert Free

Trends in the ability of socioeconomic position to predict individual body mass index: an analysis of repeated cross-sectional data, 1991–2019

Liam Wright, Charis Bridger Staatz, Richard J. Silverwood, David Bann

Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits

Kevin M. Cook, Josepheen De Asis-Cruz, Jung-Hoon Kim, Sudeepta K. Basu, Nickie Andescavage, Jonathan Murnick, Emma Spoehr, Melissa Liggett, Adré J. du Plessis, Catherine Limperopoulos

Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study

Marcos D. Machado-Fragua, Séverine Sabia, Aurore Fayosse, Céline Ben Hassen, Frank van der Heide, Mika Kivimaki, Archana Singh-Manoux

Nonselective beta-adrenoceptor blocker use and risk of Parkinson’s disease: from multiple real-world evidence

Zeying Feng, Qiuping Zhao, Jingjing Wu, Yiping Yang, Xinru Jia, Junlong Ma, Haibo Tang, Hong Yuan, Guoping Yang, Yao Lu

Circulating oxysterols and prognosis among women with a breast cancer diagnosis: results from the MARIE patient cohort

Nina Sophia Decker, Theron Johnson, Johannes A. Vey, Charlotte Le Cornet, Sabine Behrens, Nadia Obi, Rudolf Kaaks, Jenny Chang-Claude, Renée Turzanski Fortner

A mathematical model of Marburg virus disease outbreaks and the potential role of vaccination in control

George Y. Qian, W. John Edmunds, Daniel G. Bausch, Thibaut Jombart

Transient increased risk of influenza infection following RSV infection in South Africa: findings from the PHIRST study, South Africa, 2016–2018

Naomi R. Waterlow, Jackie Kleynhans, Nicole Wolter, Stefano Tempia, Rosalind M. Eggo, Orienka Hellferscee, Limakatso Lebina, Neil Martinson, Ryan G. Wagner, Jocelyn Moyes, Anne von Gottberg, Cheryl Cohen, Stefan Flasche

The effects of creatine supplementation on cognitive performance—a randomised controlled study

Julia Fabienne Sandkühler, Xenia Kersting, Annika Faust, Eva Kathrin Königs, George Altman, Ulrich Ettinger, Silke Lux, Alexandra Philipsen, Helge Müller, Jan Brauner

Establishing international optimal cut-offs of waist-to-height ratio for predicting cardiometabolic risk in children and adolescents aged 6–18 years

Xin’nan Zong, Roya Kelishadi, Young Mi Hong, Peter Schwandt, Tandi E. Matsha, Jose G. Mill, Peter H. Whincup, Lucia Pacifico, Abel López-Bermejo, Carmelo Antonio Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Mostafa Qorbani, Fariborz Sharifian Jazi, Gerda-Maria Haas, Rafael de Oliveira Alvim, Divanei Zaniqueli, Claudio Chiesa, Judit Bassols, Elisabetta Lucia Romeo, Danielle Franklin de Carvalho, Mônica Oliveira da Silva Simões, George S. Stergiou, Evangelos Grammatikos, Min Zhao, Costan G. Magnussen, Bo Xi

Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease

Yi Li, Mengyao Wang, Xue Liu, Jian Rong, Patricia Emogene Miller, Roby Joehanes, Tianxiao Huan, Xiuqing Guo, Jerome I. Rotter, Jennifer A. Smith, Bing Yu, Matthew Nayor, Daniel Levy, Chunyu Liu, Jiantao Ma

Associations between types and sources of dietary carbohydrates and liver fat: a UK Biobank study

Josefina Orliacq, Aurora Pérez-Cornago, Siôn A Parry, Rebecca K Kelly, Dimitrios A Koutoukidis, Jennifer L Carter

Mood, Activity Participation, and Leisure Engagement Satisfaction (MAPLES): results from a randomised controlled pilot feasibility trial for low mood in acquired brain injury

Andrea Kusec, Fionnuala C. Murphy, Polly V. Peers, Ron Bennett, Estela Carmona, Aleksandra Korbacz, Cara Lawrence, Emma Cameron, Andrew Bateman, Peter Watson, Judith Allanson, Pieter duToit, Tom Manly

The association between cognitive ability and opioid prescribing in vulnerable older adults with chronic pain in ambulatory care: a secondary data analysis using the Medical Expenditure Panel Survey

Ulrike Muench, Kyung Mi Kim, Zachary Zimmer, Todd B. Monroe

Comparative effectiveness of multiple different treatment regimens for nonalcoholic fatty liver disease with type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis of randomised controlled trials

Manjun Deng, Yonghao Wen, JingXin Yan, Yichen Fan, Zhixin Wang, Ruixia Zhang, Li Ren, Yinggui Ba, Haijiu Wang, Qian Lu, Haining Fan

The psychological legacy of past obesity and early mortality: evidence from two longitudinal studies

I Gusti Ngurah Edi Putra, Michael Daly, Angelina Sutin, Andrew Steptoe, Eric Robinson

Placental inflammatory cytokines mRNA expression and preschool children’s cognitive performance: a birth cohort study in China

Jixing Zhou, Juan Tong, Xue Ru, Yuzhu Teng, Menglong Geng, Shuangqin Yan, Fangbiao Tao, Kun Huang

Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study

Unnur Jakobsdottir Smari, Unnur Anna Valdimarsdottir, Thor Aspelund, Arna Hauksdottir, Edda Bjork Thordardottir, Catharina A. Hartman, Pontus Andell, Henrik Larsson, Helga Zoega

Comparing associations of handgrip strength and chair stand performance with all-cause mortality—implications for defining probable sarcopenia: the Tromsø Study 2015–2020

Jonas Johansson, Sameline Grimsgaard, Bjørn Heine Strand, Avan A. Sayer, Rachel Cooper

Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction

Zhuoyao Ma, Jinyu Li, Li Fu, Rong Fu, Ningyuan Tang, Yanmei Quan, Zhixiang Xin, Zhide Ding, Yue Liu

Attention-deficit/hyperactivity disorder symptoms and subsequent cardiometabolic disorders in adults: investigating underlying mechanisms using a longitudinal twin study

Maja Dobrosavljevic, Ralf Kuja-Halkola, Lin Li, Zheng Chang, Henrik Larsson, Ebba Du Rietz

Longitudinal evolution of sleep disturbances in early multiple system atrophy: a 2‐year prospective cohort study

Lingyu Zhang, Yanbing Hou, Chunyu Li, Qianqian Wei, Ruwei Ou, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Qirui Jiang, Bi Zhao, Huifang Shang

Metabolic dynamics and prediction of sFGR and adverse fetal outcomes: a prospective longitudinal cohort study

Nana Huang, Wei Chen, Hai Jiang, Jing Yang, Youzhen Zhang, Huifeng Shi, Ying Wang, Pengbo Yuan, Jie Qiao, Yuan Wei, Yangyu Zhao

The impact of the new acute respiratory distress syndrome (ARDS) criteria on Berlin criteria ARDS patients: a multicenter cohort study

Lina Zhao, Fuhong Su, Nannan Zhang, Hening Wu, Yuehao Shen, Haiying Liu, Xuguang Li, Yun Li, Keliang Xie

Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis

Shuang-Ling Han, De-Chun Liu, Chen-Chen Tan, Lan Tan, Wei Xu

Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia—an exploratory study

Tove Lekva, Arvind Y.FM. Sundaram, Marie Cecilie Paasche Roland, June Åsheim, Annika E. Michelsen, Errol R. Norwitz, Pål Aukrust, Gregor D. Gilfillan, Thor Ueland

Safety, tolerability, pharmacokinetics and effects of diet on AD16, a novel neuroinflammatory inhibitor for Alzheimer’s disease: a randomized phase 1 study

Daizhuang Peng, Sumei Xu, Ting Zou, Yahui Wang, Wenjuan Ouyang, Yalan Zhang, Chengmei Dong, Dai Li, Jie Guo, Qiuying Shen, Xiaolei Hu, Wenzhi Zhou, Xiaomin Li, Qun Qin

Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression

Sushma Marla, Sally Mortlock, Taija Heinosalo, Matti Poutanen, Grant W. Montgomery, Brett David McKinnon

Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study

Wei-Jie Chen, Chun-Xia Gan, Yang-Wei Cai, Yang-Yang Liu, Pei-Lin Xiao, Li-Li Zou, Qing-Song Xiong, Fang Qin, Xie-Xin Tao, Ran Li, Hua-An Du, Zeng-Zhang Liu, Yue-Hui Yin, Zhi-Yu Ling

Why diversity among participants in clinical studies is not always preferable: the case for small, exploratory studies

Anne-Marie Ellegaard, Filip Krag Knop

Are breast cancer patients with suboptimal adherence to cardiovascular treatment more likely to discontinue adjuvant endocrine therapy? Competing risk survival analysis in a nationwide cohort of postmenopausal women

Juliette Artignan, Perrine Capmas, Henri Panjo, Panayotis Constantinou, Nathalie Pelletier-Fleury

Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study

Ting Liu, Di Dong, Xun Zhao, Xiao-Min Ou, Jun-Lin Yi, Jian Guan, Ye Zhang, Lv Xiao-Fei, Chuan-Miao Xie, Dong-Hua Luo, Rui Sun, Qiu-Yan Chen, Lv Xing, Shan-Shan Guo, Li-Ting Liu, Da-Feng Lin, Yan-Zhou Chen, Jie-Yi Lin, Mei-Juan Luo, Wen-Bin Yan, Mei-Lin He, Meng-Yuan Mao, Man-Yi Zhu, Wen-Hui Chen, Bo-Wen Shen, Shi-Qian Wang, Hai-Lin Li, Lian-Zhen Zhong, Chao-Su Hu, De-Hua Wu, Hai-Qiang Mai, Jie Tian, Lin-Quan Tang

Radiomics in precision oncology: hype or ludum mutante

Shi Hui Tay, Xin Zhang, Melvin L. K. Chua

A novel approach to risk exposure and epigenetics—the use of multidimensional context to gain insights into the early origins of cardiometabolic and neurocognitive health

Jane W. Y. Ng, Janine F. Felix, David M. Olson

Prognostic value of circulating tumor DNA in operable non-small cell lung cancer: a systematic review and reconstructed individual patient-data based meta-analysis

Dali Chen, Jinbao Guo, Hao Huang, Lei Tian, Yunbo Xie, Qingchen Wu

Identifying patterns of reported findings on long-term cardiac complications of COVID-19: a systematic review and meta-analysis

Boya Guo, Chenya Zhao, Mike Z. He, Camilla Senter, Zhenwei Zhou, Jin Peng, Song Li, Annette L. Fitzpatrick, Sara Lindström, Rebecca C. Stebbins, Grace A. Noppert, Chihua Li

Genetically predicted plasma levels of amino acids and metabolic dysfunction-associated fatty liver disease risk: a Mendelian randomization study

Jian Zhao, Jing Zeng, Cairong Zhu, Xuechao Li, Dong Liu, Jun Zhang, Fei Li, Giovanni Targher, Jian-Gao Fan

A pilot study of multi-antigen stimulated cell therapy-I plus camrelizumab and apatinib in patients with advanced bone and soft-tissue sarcomas

Yan Zhou, Mei Li, Bing Zhang, Cheng Yang, Yaling Wang, Shuier Zheng, Lina Tang, Chenliang Zhou, Guowei Qian, Yujing Huang, Wenxi Yu, Hongtao Li, Yonggang Wang, Aina He, Zan Shen, Jianjun Zhang, Xiaoshuang Li, Qingcheng Yang, Haiyan Hu, Yang Yao

Representativeness in health research studies: an audit of Greater Manchester Clinical Research Network studies between 2016 and 2021

Kathryn M. Abel, Maja R. Radojčić, Archie Rayner, Rabia Butt, Pauline Whelan, Isaac Parr, Lauren F. Gledhill, Ashley Minchin, Peter Bower, Holly Hope

Maternal glycemic status during pregnancy and mid-childhood plasma amino acid profiles: findings from a multi-ethnic Asian birth cohort

Mengjiao Liu, Shiao-Yng Chan, Johan G. Eriksson, Yap Seng Chong, Yung Seng Lee, Fabian Yap, Mary Foong-Fong Chong, Mya Thway Tint, Jiaxi Yang, David Burgner, Cuilin Zhang, Ling-Jun Li

Clinical efficacy of sodium bicarbonate in treating pediatric metabolic acidosis with varying level of acid–base balance parameters: a real-world study

Huaqing Liu, Yanmei Cao, Xiaoyan Xue, Zhenjiang Bai, Shuiyan Wu

Have there been sustained impacts of the COVID-19 pandemic on trends in smoking prevalence, uptake, quitting, use of treatment, and relapse? A monthly population study in England, 2017–2022

Sarah E. Jackson, Harry Tattan-Birch, Lion Shahab, Emma Beard, Jamie Brown

Dissemination of Registered COVID-19 Clinical Trials (DIRECCT): a cross-sectional study

Maia Salholz-Hillel, Molly Pugh-Jones, Nicole Hildebrand, Tjada A. Schult, Johannes Schwietering, Peter Grabitz, Benjamin Gregory Carlisle, Ben Goldacre, Daniel Strech, Nicholas J. DeVito

Predicting drug response from single-cell expression profiles of tumours

Simona Pellecchia, Gaetano Viscido, Melania Franchini, Gennaro Gambardella

Coronary microvascular function in male physicians with burnout and job stress: an observational study

Roland von Känel, Mary Princip, Sarah A. Holzgang, Chrysoula Garefa, Alexia Rossi, Dominik C. Benz, Andreas A. Giannopoulos, Philipp A. Kaufmann, Ronny R. Buechel, Claudia Zuccarella-Hackl, Aju P. Pazhenkottil

Change of the vaginal microbiome with oral contraceptive therapy in women with polycystic ovary syndrome: a 6-month longitudinal cohort study

Xiang Hong, Pengfei Qin, Liting Gao, Lingling Huang, Yong Shi, Danhong Peng, Bei Wang

Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns

Guanqun Yao, Ting Zou, Jing Luo, Shuang Hu, Langxiong Yang, Jing Li, Xinrong Li, Yuqi Zhang, Kun Feng, Yong Xu, Pozi Liu

Comparison of post-acute sequelae following hospitalization for COVID-19 and influenza

Ting-Hui Liu, Po-Yu Huang, Jheng-Yan Wu, Min-Hsiang Chuang, Wan-Hsuan Hsu, Ya-Wen Tsai, Chih-Cheng Lai

Noninvasive urinary protein signatures combined clinical information associated with microvascular invasion risk in HCC patients

Yaru Wang, Bo Meng, Xijun Wang, Anke Wu, Xiaoyu Li, Xiaohong Qian, Jianxiong Wu, Wantao Ying, Ting Xiao, Weiqi Rong

Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

Isabelle M. McGrath, Grant W. Montgomery, Sally Mortlock

A low-inflammatory diet is associated with a lower incidence of diabetes: role of diabetes-related genetic risk

Rongrong Yang, Jing Lin, Hongxi Yang, Michelle M. Dunk, Jiao Wang, Weili Xu, Yaogang Wang

Performance of a safe and dignified burial intervention during an Ebola epidemic in the eastern Democratic Republic of the Congo, 2018–2019

Abdihamid Warsame, Gwendolen Eamer, Alaria Kai, Lucia Robles Dios, Hana Rohan, Patrick Keating, Jacques Katshishi, Francesco Checchi

Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease

Fangkun Yang, Fengzhe Xu, Han Zhang, Dipender Gill, Susanna C. Larsson, Xue Li, Hanbin Cui, Shuai Yuan

Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis

Yan Wang, Chu Xu, Zongxin Zhang

Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis

Sheng Zhong, Wenzhuo Yang, Zhiyun Zhang, Yangyiran Xie, Lin Pan, Jiaxin Ren, Fei Ren, Yifan Li, Haoqun Xie, Hongyu Chen, Davy Deng, Jie Lu, Hui Li, Bo Wu, Youqi Chen, Fei Peng, Vinay K. Puduvalli, Ke Sai, Yunqian Li, Ye Cheng, Yonggao Mou

Association between menstrual cycle phase and metabolites in healthy, regularly menstruating women in UK Biobank, and effect modification by inflammatory markers and risk factors for metabolic disease

Kirstin A. MacGregor, Frederick K. Ho, Carlos A. Celis-Morales, Jill P. Pell, Iain J. Gallagher, Colin N. Moran

Association of genetic risk and lifestyle with pancreatic cancer and their age dependency: a large prospective cohort study in the UK Biobank

Liangtang Zeng, Zhuo Wu, Jiabin Yang, Yu Zhou, Rufu Chen

One-year psychophysical evaluation of COVID-19-induced olfactory disorders: a prospective cohort study

Emma J. A. Schepens, Wilbert M. Boek, Sanne Boesveldt, Robert J. Stokroos, Inge Stegeman, Digna M. A. Kamalski

Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders

Junping Ye, Zhanwang Huang, Qiyang Li, Zhongwei Li, Yuting Lan, Zhongju Wang, Chaoying Ni, Xiaohui Wu, Tingyun Jiang, Yujing Li, Qiong Yang, Junghwa Lim, Cun-Yan Ren, Meijun Jiang, Shufen Li, Peng Jin, Jian-Huan Chen, Cunyou Zhao

Model-based evaluation of admission screening strategies for the detection and control of carbapenemase-producing Enterobacterales in the English hospital setting

Diane Pople, Theodore Kypraios, Tjibbe Donker, Nicole Stoesser, Anna C. Seale, Ryan George, Andrew Dodgson, Rachel Freeman, Russell Hope, Ann Sarah Walker, Susan Hopkins, Julie Robotham

Construction of a risk stratification model integrating ctDNA to predict response and survival in neoadjuvant-treated breast cancer

Zhaoyun Liu, Bo Yu, Mu Su, Chenxi Yuan, Cuicui Liu, Xinzhao Wang, Xiang Song, Chao Li, Fukai Wang, Jianli Ma, Meng Wu, Dawei Chen, Jinming Yu, Zhiyong Yu

Risk factors for preterm birth: an umbrella review of meta-analyses of observational studies

Ioannis Mitrogiannis, Evangelos Evangelou, Athina Efthymiou, Theofilos Kanavos, Effrosyni Birbas, George Makrydimas, Stefania Papatheodorou

Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom

Yining Bao, Pengyi Lu, Mengjie Wang, Xueli Zhang, Aowei Song, Xiaoyun Gu, Ting Ma, Shu Su, Lin Wang, Xianwen Shang, Zhuoting Zhu, Yuhang Zhai, Mingguang He, Zengbin Li, Hanting Liu, Christopher K. Fairley, Jiangcun Yang, Lei Zhang

Functional connectivity of cognition-related brain networks in adults with fetal alcohol syndrome

Benedikt Sundermann, Reinhold Feldmann, Christian Mathys, Johanna M. H. Rau, Stefan Garde, Anna Braje, Josef Weglage, Bettina Pfleiderer

Performance measures of 8,169,869 examinations in the National Breast Cancer Screening Program in Taiwan, 2004–2020

Melissa Min-Szu Yao, Vu Pham Thao Vy, Tony Hsiu-Hsi Chen, Hsian-He Hsu, Giu-Cheng Hsu, Cindy S. Lee, Li-Ju Lin, Shu-Li Chia, Chao-Chun Wu, Wing P. Chan, Amy Ming-Fang Yen

Self-collection of samples for group B streptococcus testing during pregnancy: a systematic review and meta-analysis

Sarah A. Borg, Jenny Cao, Phi-Yen Nguyen, Samia Aziz, Joshua P. Vogel

Impact of maternal age and body mass index on the structure and function of the heart in newborns: a Copenhagen Baby Heart Study

Mette Marie Olsen Nørregaard, Saima Basit, Anne-Sophie Sillesen, Anna Axelsson Raja, Finn Stener Jørgensen, Kasper Karmark Iversen, Henning Bundgaard, Heather Allison Boyd, Ruth Ottilia Birgitta Vøgg

Predictive model for epileptogenic tubers from all tubers in patients with tuberous sclerosis complex based on 18F-FDG PET: an 8-year single-centre study

Zhongke Wang, Yang Li, Zeng He, Shujing Li, Kaixuan Huang, Xianjun Shi, Xiaoqin Sun, Ruotong Ruan, Chun Cui, Ruodan Wang, Li Wang, Shengqing Lv, Chunqing Zhang, Zhonghong Liu, Hui Yang, Xiaolin Yang, Shiyong Liu

Effects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study

Francesco Casanova, Jessica O’Loughlin, Vasilis Karageorgiou, Robin N. Beaumont, Jack Bowden, Andrew R. Wood, Jessica Tyrrell

Clinical prediction models and the multiverse of madness

Richard D. Riley, Alexander Pate, Paula Dhiman, Lucinda Archer, Glen P. Martin, Gary S. Collins

Prediction of acute kidney injury incidence following acute type A aortic dissection surgery with novel biomarkers: a prospective observational study

Zhigang Wang, Jingfang Xu, Yu Zhang, Cheng Chen, Chuiyu Kong, Lu Tang, Yi Jiang, Ronghuang Yu, Qiuyan Zong, Lifang Zhang, Dongjin Wang

The citrate transporter SLC13A5 as a therapeutic target for kidney disease: evidence from Mendelian randomization to inform drug development

Dipender Gill, Loukas Zagkos, Rubinder Gill, Thomas Benzing, Jens Jordan, Andreas L. Birkenfeld, Stephen Burgess, Grit Zahn

Post-COVID-19 condition risk in patients with intellectual and developmental disabilities: a retrospective cohort study involving 36,308 patients

Ting-Hui Liu, Po-Yu Huang, Jheng-Yan Wu, Min-Hsiang Chuang, Wan-Hsuan Hsu, Ya-Wen Tsai, Pei-Hsin Kao, Chih-Cheng Lai

Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data

Farid H. Mahmud, Antoine B. M. Clarke, Yesmino Elia, Jacqueline Curtis, Paul Benitez-Aguirre, Fergus J. Cameron, Scott T. Chiesa, Cheril Clarson, Jennifer J. Couper, Maria E. Craig, R. Neil Dalton, Denis Daneman, Elizabeth A. Davis, John E. Deanfield, Kim C. Donaghue, Timothy W. Jones, Sally M. Marshall, Andrew Neil, M. Loredana Marcovecchio

Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still’s disease

Jinchao Jia, Mengyan Wang, Yuning Ma, Jianfen Meng, Dehao Zhu, Xia Chen, Hui Shi, Yue Sun, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Tingting Liu, Zhuochao Zhou, Fan Wang, Longfang Chen, Da Yi, Yu Xiao, Chengde Yang, Jialin Teng, Qiongyi Hu

Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

Gabin Drouard, Fiona A. Hagenbeek, Alyce M. Whipp, René Pool, Jouke Jan Hottenga, Rick Jansen, Nikki Hubers, Aleksei Afonin, Gonneke Willemsen, Eco J. C. de Geus, Samuli Ripatti, Matti Pirinen, Katja M. Kanninen, Dorret I. Boomsma, Jenny van Dongen, Jaakko Kaprio

Risk of newly developed atrial fibrillation by alcohol consumption differs according to genetic predisposition to alcohol metabolism: a large-scale cohort study with UK Biobank

Chan Soon Park, Jaewon Choi, JungMin Choi, Kyung-Yeon Lee, Hyo-Jeong Ahn, Soonil Kwon, So-Ryoung Lee, Eue-Keun Choi, Soo Heon Kwak, Seil Oh

Maternal sevoflurane exposure increases the epilepsy susceptibility of adolescent offspring by interrupting interneuron development

Xinyue Liang, Ming Jiang, Hao Xu, Tianxiang Tang, Xiangpeng Shi, Yi Dong, Lei Xiao, Yunli Xie, Fang Fang, Jing Cang

A systematic review and meta-analysis of short-stay programmes for total hip and knee replacement, focusing on safety and optimal patient selection

Danielle Berkovic, Patrick Vallance, Ian A. Harris, Justine M. Naylor, Peter L. Lewis, Richard de Steiger, Rachelle Buchbinder, Zanfina Ademi, Sze-Ee Soh, Ilana N. Ackerman

Cholesterol-modified prognostic nutritional index (CPNI) as an effective tool for assessing the nutrition status and predicting survival in patients with breast cancer

Jinyu Shi, Tong Liu, Yizhong Ge, Chenan Liu, Qi Zhang, Hailun Xie, Guotian Ruan, Shiqi Lin, Xin Zheng, Yue Chen, Heyang Zhang, Mengmeng Song, Xiaowei Zhang, Chunlei Hu, Xiangrui Li, Ming Yang, Xiaoyue Liu, Li Deng, Hanping Shi