Ausgabe 1/2023
Inhalt (512 Artikel)
- Open Access
- COVID-19
- Research article
Individual and neighborhood risk factors of hospital admission and death during the COVID-19 pandemic: a population-based cohort study
Max Bell, Maria-Pia Hergens, Stefan Fors, Per Tynelius, Antonio Ponce de Leon, Anton Lager
- Open Access
- Research article
First-in-human phase I dose-escalation and dose-expansion trial of the selective MEK inhibitor HL-085 in patients with advanced melanoma harboring NRAS mutations
Xuan Wang, Zhiguo Luo, Jing Chen, Yu Chen, Dongmei Ji, Li Fan, Ling Chen, Qian Zhao, Pei Hu, Peng Sun, Zhongwei Jia, Jun Guo, Lu Si
- Open Access
- Research article
Survival outcomes of stage I colorectal cancer: development and validation of the ACEPLY model using two prospective cohorts
Qingbin Wu, Pengju Chen, Chi Shu, Lin Chen, Zechuan Jin, Jun Huang, Xin Wang, Xue Li, Mingtian Wei, Tinghan Yang, Xiangbing Deng, Aiwen Wu, Yazhou He, Ziqiang Wang
- Open Access
- Research Article
Lean or diabetic subtypes predict increased all-cause and disease-specific mortality in metabolic-associated fatty liver disease
Goh Eun Chung, Su Jong Yu, Jeong-Ju Yoo, Yuri Cho, Kyu-na Lee, Dong Wook Shin, Donghee Kim, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Eun Ju Cho
- Open Access
- Research article
Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study
Nikos Papadimitriou, Caroline J. Bull, Mazda Jenab, David J. Hughes, Joshua A. Bell, Eleanor Sanderson, Nicholas J. Timpson, George Davey Smith, Demetrius Albanes, Peter T. Campbell, Sébastien Küry, Loic Le Marchand, Cornelia M. Ulrich, Kala Visvanathan, Jane C. Figueiredo, Polly A. Newcomb, Rish K. Pai, Ulrike Peters, Kostas K. Tsilidis, Jolanda M. A. Boer, Emma E. Vincent, Daniela Mariosa, Marc J. Gunter, Tom G. Richardson, Neil Murphy
- Open Access
- Research article
Interstitial pneumonitis associated with combined regimen of immunotherapy and conventional therapies—pharmacovigilance database analysis with real-world data validation
Xue-Jun Guo, Xiao-Ting Cai, Zi-Xuan Rong, Yan-Pei Zhang, Yu-Xiang Wen, Xue Bai, Jian Wang, Qiang John Fu, Ze-Qin Guo, Li-Li Long, Si-Cong Ma, Xin-Ran Tang, Li Liu, Jian Guan, Zhong-Yi Dong, De-Hua Wu
- Open Access
- Research article
Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors
Feng Xu, Linlin Han, Yafeng Wang, Daling Deng, Yuanyuan Ding, Shuai Zhao, Qingtong Zhang, Lulin Ma, Xiangdong Chen
- Open Access
- Research article
Bereavement in childhood and young adulthood and the risk of atrial fibrillation: a population-based cohort study from Denmark and Sweden
Hua Chen, Imre Janszky, Mikael Rostila, Dang Wei, Fen Yang, Jiong Li, Krisztina D. László
- Open Access
- Research article
Chronic pain conditions and risk of suicidal behavior: a 10-year longitudinal co-twin control study
C. Chen, E. Pettersson, A. G. Summit, K. Boersma, Z. Chang, R. Kuja-Halkola, P. Lichtenstein, P. D. Quinn
- Open Access
- Research article
Predicting mortality in acutely hospitalised older patients: the impact of model dimensionality
Alex Tsui, Petru-Daniel Tudosiu, Mikael Brudfors, Ashwani Jha, Jorge Cardoso, Sebastien Ourselin, John Ashburner, Geraint Rees, Daniel Davis, Parashkev Nachev
- Open Access
- Research article
Results of the phase IIa study to evaluate the efficacy and safety of rezivertinib (BPI-7711) for the first-line treatment of locally advanced or metastatic/recurrent NSCLC patients with EGFR mutation from a phase I/IIa study
Yuankai Shi, Jianying Zhou, Yanqiu Zhao, Bo Zhu, Liangming Zhang, Xingya Li, Jian Fang, Jianhua Shi, Zhixiang Zhuang, Sheng Yang, Donglin Wang, Huiqing Yu, Longzhen Zhang, Rongsheng Zheng, Michael Greco, Tingting Wang
- Open Access
- Research article
Prenatal social support in low-risk pregnancy shapes placental epigenome
Markos Tesfaye, Jing Wu, Richard J. Biedrzycki, Katherine L. Grantz, Paule Joseph, Fasil Tekola-Ayele
- Open Access
- COVID-19
- Research article
Ethnic differences in COVID-19 mortality in the second and third waves of the pandemic in England during the vaccine rollout: a retrospective, population-based cohort study
Matthew L. Bosworth, Tamanna Ahmed, Tim Larsen, Luke Lorenzi, Jasper Morgan, Raghib Ali, Peter Goldblatt, Nazrul Islam, Kamlesh Khunti, Veena Raleigh, Daniel Ayoubkhani, Neil Bannister, Myer Glickman, Vahé Nafilyan
- Open Access
- Guideline
Recommendations for robust and reproducible preclinical research in personalised medicine
Vibeke Fosse, Emanuela Oldoni, Florence Bietrix, Alfredo Budillon, Evangelos P. Daskalopoulos, Maddalena Fratelli, Björn Gerlach, Peter M. A. Groenen, Sabine M. Hölter, Julia M. L. Menon, Ali Mobasheri, Nikki Osborne, Merel Ritskes-Hoitinga, Bettina Ryll, Elmar Schmitt, Anton Ussi, Antonio L. Andreu, Emmet McCormack, Rita Banzi, Jacques Demotes, Paula Garcia, Chiara Gerardi, Enrico Glaab, Josep Maria Haro, Frank Hulstaert, Lorena San Miguel, Judit Subirana Mirete, Albert Sanchez Niubo, Raphaël Porcher, Armin Rauschenberger, Montserrat Carmona Rodriguez, Cecilia Superchi, Teresa Torres
- Open Access
- Correction
Correction: Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)
Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou, Likun Chen
- Open Access
- Research article
Identification of genetic variants associated with diabetic kidney disease in multiple Korean cohorts via a genome-wide association study mega-analysis
Heejin Jin, Ye An Kim, Young Lee, Seung-hyun Kwon, Ah Ra Do, Sujin Seo, Sungho Won, Je Hyun Seo
- Open Access
- Research article
Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth
Rossella Alfano, Daniela Zugna, Henrique Barros, Mariona Bustamante, Leda Chatzi, Akram Ghantous, Zdenko Herceg, Pekka Keski-Rahkonen, Theo M. de Kok, Tim S Nawrot, Caroline L Relton, Oliver Robinson, Theano Roumeliotaki, Augustin Scalbert, Martine Vrijheid, Paolo Vineis, Lorenzo Richiardi, Michelle Plusquin
- Open Access
- Research article
Thyroid dysfunction in Chinese nasopharyngeal carcinoma after anti-PD-1 therapy and its association with treatment response
Zi-Hang Chen, Wei-Hong Zheng, Chen-Fei Wu, Jia Kou, Xing-Li Yang, Li Lin, Jia-Wei Lv, Ying Sun, Guan-Qun Zhou
- Open Access
- Research article
Real-time forecasting the trajectory of monkeypox outbreaks at the national and global levels, July–October 2022
Amanda Bleichrodt, Sushma Dahal, Kevin Maloney, Lisa Casanova, Ruiyan Luo, Gerardo Chowell
- Open Access
- Research article
Long-term variability in physiological measures in relation to mortality and epigenetic aging: prospective studies in the USA and China
Hui Chen, Tianjing Zhou, Shaowei Wu, Yaying Cao, Geng Zong, Changzheng Yuan
- Open Access
- Research article
Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019
Anuradhaa Subramanian, Amaya Azcoaga-Lorenzo, Astha Anand, Katherine Phillips, Siang Ing Lee, Neil Cockburn, Adeniyi Francis Fagbamigbe, Christine Damase-Michel, Christopher Yau, Colin McCowan, Dermot O’Reilly, Gillian Santorelli, Holly Hope, Jonathan I. Kennedy, Kathryn M. Abel, Kelly-Ann Eastwood, Louise Locock, Mairead Black, Maria Loane, Ngawai Moss, Rachel Plachcinski, Shakila Thangaratinam, Sinead Brophy, Utkarsh Agrawal, Zoe Vowles, Peter Brocklehurst, Helen Dolk, Catherine Nelson-Piercy, Krishnarajah Nirantharakumar
- Open Access
- Research Article
The impact of alcohol taxation increase on all-cause mortality inequalities in Lithuania: an interrupted time series analysis
Jakob Manthey, Domantas Jasilionis, Huan Jiang, Olga Meščeriakova, Janina Petkevičienė, Ričardas Radišauskas, Mindaugas Štelemėkas, Jürgen Rehm
- Open Access
- Research article
Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study
Ahmed Elhakeem, Justiina Ronkainen, Toby Mansell, Katherine Lange, Tuija M. Mikkola, Binisha H. Mishra, Rama J. Wahab, Tim Cadman, Tiffany Yang, David Burgner, Johan G. Eriksson, Marjo-Riitta Järvelin, Romy Gaillard, Vincent W. V. Jaddoe, Terho Lehtimäki, Olli T. Raitakari, Richard Saffery, Melissa Wake, John Wright, Sylvain Sebert, Deborah A. Lawlor
- Open Access
- Research article
Retinal nerve fiber layer thinning as a novel fingerprint for cardiovascular events: results from the prospective cohorts in UK and China
Yanping Chen, Yixiong Yuan, Shiran Zhang, Shaopeng Yang, Junyao Zhang, Xiao Guo, Wenyong Huang, Zhuoting Zhu, Mingguang He, Wei Wang
- Open Access
- Research article
Voluntary risk mitigation behaviour can reduce impact of SARS-CoV-2: a real-time modelling study of the January 2022 Omicron wave in England
Ellen Brooks-Pollock, Kate Northstone, Lorenzo Pellis, Francesca Scarabel, Amy Thomas, Emily Nixon, David A. Matthews, Vicky Bowyer, Maria Paz Garcia, Claire J. Steves, Nicholas J. Timpson, Leon Danon
- Open Access
- COVID-19
- Research article
Ethnic inequalities in the impact of COVID-19 on primary care consultations: a time series analysis of 460,084 individuals with multimorbidity in South London
Alice McGreevy, Marina Soley-Bori, Mark Ashworth, Yanzhong Wang, Emma Rezel-Potts, Stevo Durbaba, Hiten Dodhia, Julia Fox-Rushby
- Open Access
- Research article
Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality
Huiping Li, Yan Borné, Yaogang Wang, Emily Sonestedt
- Open Access
- Research article
Validation of a deep-learning-based retinal biomarker (Reti-CVD) in the prediction of cardiovascular disease: data from UK Biobank
Rachel Marjorie Wei Wen Tseng, Tyler Hyungtaek Rim, Eduard Shantsila, Joseph K. Yi, Sungha Park, Sung Soo Kim, Chan Joo Lee, Sahil Thakur, Simon Nusinovici, Qingsheng Peng, Hyeonmin Kim, Geunyoung Lee, Marco Yu, Yih-Chung Tham, Ameet Bakhai, Paul Leeson, Gregory Y.H. Lip, Tien Yin Wong, Ching-Yu Cheng
- Open Access
- Research article
Faecal haemoglobin concentrations are associated with all-cause mortality and cause of death in colorectal cancer screening
Lasse Kaalby, Ulrik Deding, Issam Al-Najami, Gabriele Berg-Beckhoff, Thomas Bjørsum-Meyer, Tinne Laurberg, Aasma Shaukat, Robert J. C. Steele, Anastasios Koulaouzidis, Morten Rasmussen, Morten Kobaek-Larsen, Gunnar Baatrup
- Open Access
- Editorial
Diabetes education for better personalized management in pediatric patients
- Open Access
- Research article
Temporal relationship between atherogenic dyslipidemia and inflammation and their joint cumulative effect on type 2 diabetes onset: a longitudinal cohort study
Yulong Lan, Guanzhi Chen, Dan Wu, Xiong Ding, Zegui Huang, Xianxuan Wang, Lois Balmer, Xingang Li, Manshu Song, Wei Wang, Shouling Wu, Youren Chen
- Open Access
- Research article
Short-term air pollution exposure associated with death from kidney diseases: a nationwide time-stratified case-crossover study in China from 2015 to 2019
Miao Cai, Jing Wei, Shiyu Zhang, Wei Liu, Lijun Wang, Zhengmin Qian, Hualiang Lin, Echu Liu, Stephen Edward McMillin, Yu Cao, Peng Yin
- Open Access
- Research article
UK government’s new placement legislation is a ‘good first step’: a rapid qualitative analysis of consumer, business, enforcement and health stakeholder perspectives
Sarah Muir, Preeti Dhuria, Emma Roe, Wendy Lawrence, Janis Baird, Christina Vogel
- Open Access
- Research article
Associations between types and sources of dietary carbohydrates and cardiovascular disease risk: a prospective cohort study of UK Biobank participants
Rebecca K. Kelly, Tammy Y. N. Tong, Cody Z. Watling, Andrew Reynolds, Carmen Piernas, Julie A. Schmidt, Keren Papier, Jennifer L. Carter, Timothy J. Key, Aurora Perez-Cornago
- Open Access
- Research article
The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study
Kurt Taylor, Robyn E. Wootton, Qian Yang, Sam Oddie, John Wright, Tiffany C. Yang, Maria Magnus, Ole A. Andreassen, Maria Carolina Borges, Massimo Caputo, Deborah A. Lawlor
- Open Access
- Research article
In silico formulation of a next-generation multiepitope vaccine for use as a prophylactic candidate against Crimean-Congo hemorrhagic fever
Rahat Alam, Abdus Samad, Foysal Ahammad, Suza Mohammad Nur, Ahad Amer Alsaiari, Raihan Rahman Imon, Md. Enamul Kabir Talukder, Zulkar Nain, Md. Mashiar Rahman, Farhan Mohammad, Tomasz M. Karpiński
- Open Access
- Research article
Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality
Jessica O’Loughlin, Francesco Casanova, Zammy Fairhurst-Hunter, Amanda Hughes, Jack Bowden, Edward R. Watkins, Rachel M. Freathy, Iona Y. Millwood, Kuang Lin, Zhengming Chen, Liming Li, Jun Lv, Robin G. Walters, Laura D. Howe, Karoline Kuchenbaecker, Jessica Tyrrell
- Open Access
- Research article
PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models
Ki Cheong Park, Jung Min Kim, Sang Yong Kim, Seok-Mo Kim, Jin Hong Lim, Min Ki Kim, Sungsoon Fang, Yonjung Kim, Gordon B. Mills, Sung Hoon Noh, Jae-Ho Cheong
- Open Access
- Research article
Associations of the circulating levels of cytokines with risk of amyotrophic lateral sclerosis: a Mendelian randomization study
Bin Liu, Linshuoshuo Lyu, Wenkai Zhou, Jie Song, Ding Ye, Yingying Mao, Guo-Bo Chen, Xiaohui Sun
- Open Access
- Research article
Glucagon-like peptide-1 receptor agonists and diabetic retinopathy: nationwide cohort and Mendelian randomization studies
Deqiang Zheng, Ning Li, Rui Hou, Xiaoyu Zhang, Lijuan Wu, Jan Sundquist, Kristina Sundquist, Jianguang Ji
- Open Access
- Research article
Association of intellectual disability with overall and type-specific cardiovascular diseases: a population-based cohort study in Denmark
Hui Wang, Priscilla Ming Yi Lee, Jun Zhang, Katrine Svendsen, Fei Li, Jiong Li
- Open Access
- Research article
Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond LDL cholesterol
Zhiyuan Wu, Jinqi Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Yue Liu, Xinlei Miao, Ze Han, Xiaoping Kang, Xia Li, Xiuhua Guo, Lixin Tao, Wei Wang
- Open Access
- Research article
Maternal prenatal cholesterol levels predict offspring weight trajectories during childhood in the Norwegian Mother, Father and Child Cohort Study
Linn K. L. Øyri, Jacob J. Christensen, Sylvain Sebert, Magne Thoresen, Trond M. Michelsen, Stine M. Ulven, Hilde K. Brekke, Kjetil Retterstøl, Anne Lise Brantsæter, Per Magnus, Martin P. Bogsrud, Kirsten B. Holven
- Open Access
- Research article
Neonatal intensive care admission for term neonates and subsequent childhood mortality: a retrospective linkage study
Shahar Talisman, Joshua Guedalia, Rivka Farkash, Tehila Avitan, Naama Srebnik, Yair Kasirer, Michael S. Schimmel, Donia Ghanem, Ron Unger, Sorina Grisaru Granovsky
- Open Access
- Research article
A modified renal risk score for Chinese patients with antineutrophil cytoplasmic antibody-associated vasculitis
Rui-Xue Wang, Jin-Wei Wang, Zhi-Ying Li, Su-Fang Chen, Xiao-Juan Yu, Su-Xia Wang, Fan Zhang, Zu-Ying Xiong, Shu-Hong Bi, Yue Wang, Ming-Hui Zhao, Min Chen
- Open Access
- Research article
Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis
Ming-Han Chen, Huai-Chia Chuang, Yi-Chen Yeh, Chung-Tei Chou, Tse-Hua Tan
- Open Access
- Research article
Association of adverse respiratory events with sodium-glucose cotransporter 2 inhibitors versus dipeptidyl peptidase 4 inhibitors among patients with type 2 diabetes in South Korea: a nationwide cohort study
Han Eol Jeong, Sohee Park, Yunha Noh, Sungho Bea, Kristian B. Filion, Oriana H. Y. Yu, Seung Hun Jang, Young Min Cho, Dong Keon Yon, Ju-Young Shin
- Open Access
- Research article
Maximizing the cost-effectiveness of cervical screening in the context of routine HPV vaccination by optimizing screening strategies with respect to vaccine uptake: a modeling analysis
Horace C. W. Choi, Kathy Leung, Karen K. L. Chan, Yuan Bai, Mark Jit, Joseph T. Wu
- Open Access
- Research article
Simultaneous attenuation of hyperglycemic memory-induced retinal, pulmonary, and glomerular dysfunctions by proinsulin C-peptide in diabetes
Hye-Yoon Jeon, Chan-Hee Moon, Eun-Bin Kim, Nilofar Danishmalik Sayyed, Ah-Jun Lee, Kwon-Soo Ha
- Open Access
- Review
Maternal obesity and programming of metabolic syndrome in the offspring: searching for mechanisms in the adipocyte progenitor pool
Taylor B. Scheidl, Amy L. Brightwell, Sarah H. Easson, Jennifer A. Thompson
- Open Access
- Research article
Postoperative Supplemental Oxygen in Liver Transplantation (PSOLT) does not reduce the rate of infections: results of a randomized controlled trial
Wojciech Figiel, Grzegorz Niewiński, Michał Grąt, Marek Krawczyk, Jan Stypułkowski, Zbigniew Lewandowski, Maciej Krasnodębski, Waldemar Patkowski, Krzysztof Zieniewicz
- Open Access
- Commentary
Oxygen “therapy” for infection in liver transplant surgery: less is more, enough is enough
Cheng-Maw Ho, Hsin-Yun Sun
- Open Access
- Research article
Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study
Li Chen, Sartaj Ahmad Mir, Anne K. Bendt, Esther W. L. Chua, Kothandaraman Narasimhan, Karen Mei-Ling Tan, See Ling Loy, Kok Hian Tan, Lynette P. Shek, Jerry Chan, Fabian Yap, Michael J. Meaney, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Neerja Karnani, Markus R. Wenk
- Open Access
- Minireview
Heart failure with preserved ejection fraction and atrial fibrillation: recent advances and open questions
Laurent Fauchier, Arnaud Bisson, Alexandre Bodin
- Open Access
- Opinion
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease
Peter C. Taylor, Ayman Askari, Ernest Choy, Michael R. Ehrenstein, Sara Else, Muhammad K. Nisar
- Open Access
- Research article
Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest
Kei Hayashida, Ryosuke Takegawa, Yusuke Endo, Tai Yin, Rishabh C. Choudhary, Tomoaki Aoki, Mitsuaki Nishikimi, Atsushi Murao, Eriko Nakamura, Muhammad Shoaib, Cyrus Kuschner, Santiago J. Miyara, Junhwan Kim, Koichiro Shinozaki, Ping Wang, Lance B. Becker
- Open Access
- Research article
Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study
Jerod M. Rasmussen, Jetro J. Tuulari, Saara Nolvi, Paul M. Thompson, Harri Merisaari, Maria Lavonius, Linnea Karlsson, Sonja Entringer, Pathik D. Wadhwa, Hasse Karlsson, Claudia Buss
- Open Access
- COVID-19
- Research article
Coding long COVID: characterizing a new disease through an ICD-10 lens
Emily R. Pfaff, Charisse Madlock-Brown, John M. Baratta, Abhishek Bhatia, Hannah Davis, Andrew Girvin, Elaine Hill, Elizabeth Kelly, Kristin Kostka, Johanna Loomba, Julie A. McMurry, Rachel Wong, Tellen D. Bennett, Richard Moffitt, Christopher G. Chute, Melissa Haendel
- Open Access
- Research article
Maternal hypertensive disorders during pregnancy and the risk of offspring diabetes mellitus in childhood, adolescence, and early adulthood: a nationwide population-based cohort study
Liu Yang, Chen Huang, Min Zhao, Priscilla M. Y. Lee, Cheng Zhang, Yongfu Yu, Bo Xi, Jiong Li
- Open Access
- COVID-19
- Correction
Correction: Prednisolone does not improve olfactory function after COVID-19: a randomized, double-blind, placebo-controlled trial
Emma J. A. Schepens, Esther E. Blijleven, Wilbert M. Boek, Sanne Boesveldt, Robert J. Stokroos, Inge Stegeman, Digna M. A. Kamalski
- Open Access
- Research article
Variety and quantity of dietary insoluble fiber intake from different sources and risk of new-onset hypertension
Ziliang Ye, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chun Zhou, Mengyi Liu, Zhuxian Zhang, Panpan He, Yuanyuan Zhang, Rui Li, Huan Li, Chengzhang Liu, Jing Nie, Fan Fan Hou, Xianhui Qin
- Open Access
- Research article
The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome
Dong Liu, Xue Gao, Xiong-Fei Pan, Tao Zhou, Cairong Zhu, Fei Li, Jian-Gao Fan, Giovanni Targher, Jian Zhao
- Open Access
- Research article
Prediction models of colorectal cancer prognosis incorporating perioperative longitudinal serum tumor markers: a retrospective longitudinal cohort study
Chunxia Li, Ke Zhao, Dafu Zhang, Xiaolin Pang, Hongjiang Pu, Ming Lei, Bingbing Fan, Jiali Lv, Dingyun You, Zhenhui Li, Tao Zhang
- Open Access
- Research article
Associations of reproductive factors with incidence of myocardial infarction and ischemic stroke in postmenopausal women: a cohort study
Su-Min Jeong, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Heesun Lee, Dong-Yun Lee, Dong Wook Shin
- Open Access
- Research article
Monocyte, neutrophil, and whole blood transcriptome dynamics following ischemic stroke
Paulina Carmona-Mora, Bodie Knepp, Glen C. Jickling, Xinhua Zhan, Marisa Hakoupian, Heather Hull, Noor Alomar, Hajar Amini, Frank R. Sharp, Boryana Stamova, Bradley P. Ander
- Open Access
- Research article
Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Yiwen Long, Lanhua Tang, Yangying Zhou, Shushan Zhao, Hong Zhu
- Open Access
- Research article
Genetic susceptibility and lifestyle modify the association of long-term air pollution exposure on major depressive disorder: a prospective study in UK Biobank
Dankang Li, Junqing Xie, Lulin Wang, Yu Sun, Yonghua Hu, Yaohua Tian
- Open Access
- Research article
Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer
Qingqing Huang, Mingcheng Liu, Duo Zhang, Bing-Biao Lin, Xing Fu, Zhiqian Zhang, Baotong Zhang, Jin-Tang Dong
- Open Access
- Research article
Assessment of redundant randomized clinical trials among patients with ST segment elevation myocardial infarction
Yuanxi Jia, Jun Liang, Wenyao Wang, Xin Wei, Shaoming Xiao, Karen A. Robinson
- Open Access
- Opinion
There is no such thing as a validated prediction model
Ben Van Calster, Ewout W. Steyerberg, Laure Wynants, Maarten van Smeden
- Open Access
- Research article
SGLT-2 inhibitors and in-stent restenosis-related events after acute myocardial infarction: an observational study in patients with type 2 diabetes
Raffaele Marfella, Celestino Sardu, Nunzia D’Onofrio, Carlo Fumagalli, Lucia Scisciola, Ferdinando Carlo Sasso, Mario Siniscalchi, Ludovica Vittoria Marfella, Davide D’Andrea, Fabio Minicucci, Giuseppe Signoriello, Arturo Cesaro, Maria Consiglia Trotta, Chiara Frigé, Francesco Prattichizzo, Maria Luisa Balestrieri, Antonio Ceriello, Paolo Calabrò, Ciro Mauro, Luca del Viscovo, Giuseppe Paolisso
- Open Access
- Research article
Efficacy and safety of iruplinalkib (WX-0593) in ALK-positive crizotinib-resistant advanced non-small cell lung cancer patients: a single-arm, multicenter phase II study (INTELLECT)
Yuankai Shi, Jianhua Chen, Helong Zhang, Zhihong Zhang, Yiping Zhang, Zhehai Wang, Shucai Zhang, Jian Zhao, Chunling Liu, Xiuwen Wang, Yanqiu Zhao, Changlu Hu, Lei Yang, Xuezhi Hao, Lin Wang, Yunpeng Liu, Yan Yu, Jun Zhao, Mengzhao Wang, Liangming Zhang, Sanyuan Sun, Yanping Hu, Kangsheng Gu, Xiaosheng Hang, Jinlu Shan, Yu Zhang, Bangxian Tan, Weihua Yang, Runxiang Yang, Meimei Si, Huaize Geng, Hui Li, Xiaoyan Kang
- Open Access
- Research article
Rare mutation-dominant compound EGFR-positive NSCLC is associated with enriched kinase domain-resided variants of uncertain significance and poor clinical outcomes
Weixin Zhao, Ailing Song, Yang Xu, Qian Wu, Cuicui Liu, Jiani C. Yin, Qiuxiang Ou, Xue Wu, Yang Shao, Xinmin Zhao
- Open Access
- Research article
Association of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study
Xingqi Cao, Zhenqing Yang, Xueqin Li, Chen Chen, Emiel O. Hoogendijk, Jingyun Zhang, Nengliang Aaron Yao, Lina Ma, Yawei Zhang, Yong Zhu, Xuehong Zhang, Yuxian Du, Xiaofeng Wang, Xifeng Wu, Thomas M. Gill, Zuyun Liu
- Open Access
- Research article
Influence of poor sleep on cardiovascular disease-free life expectancy: a multi-resource-based population cohort study
Bo-Huei Huang, Borja del Pozo Cruz, Armando Teixeira-Pinto, Peter A. Cistulli, Emmanuel Stamatakis
- Open Access
- Research article
Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals: evidence from the UK Biobank cohort
Xiaorong Yang, Shaohua Zhao, Shaohua Wang, Xuelei Cao, Yue Xu, Meichen Yan, Mingmin Pang, Fan Yi, Hao Wang
- Open Access
- Research article
Efficacy and safety of tafolecimab in Chinese patients with heterozygous familial hypercholesterolemia: a randomized, double-blind, placebo-controlled phase 3 trial (CREDIT-2)
Meng Chai, Yongming He, Wang Zhao, Xuebin Han, Guoyan Zhao, Xueping Ma, Ping Qiao, Dongmei Shi, Yuyang Liu, Wei Han, Pei An, Haoyu Li, Shuling Yan, Qingyang Ma, Huan Deng, Lei Qian, Yujie Zhou
- Open Access
- COVID-19
- Research article
Comparative effectiveness of BNT162b2 and ChAdOx1 nCoV-19 vaccines against COVID-19
Jie Wei, Weiya Zhang, Michael Doherty, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Xiaoxiao Li, Chao Zeng, Guanghua Lei, Yuqing Zhang
- Open Access
- Research article
Low serum anti-Müllerian hormone is associated with semen quality in infertile men and not influenced by vitamin D supplementation
Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Christine Hjorth Andreassen, Anna-Maria Andersson, Anders Juul, Niels Jørgensen, Martin Blomberg Jensen
- Open Access
- Research article
Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
Joseph A. Rothwell, Jelena Bešević, Niki Dimou, Marie Breeur, Neil Murphy, Mazda Jenab, Roland Wedekind, Vivian Viallon, Pietro Ferrari, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Augustin Scalbert, Inge Huybrechts, Cornelia Prehn, Jerzy Adamski, Amanda J. Cross, Hector Keun, Marc Chadeau-Hyam, Marie-Christine Boutron-Ruault, Kim Overvad, Christina C. Dahm, Therese Haugdahl Nøst, Torkjel M. Sandanger, Guri Skeie, Raul Zamora-Ros, Kostas K. Tsilidis, Fabian Eichelmann, Matthias B. Schulze, Bethany van Guelpen, Linda Vidman, Maria-José Sánchez, Pilar Amiano, Eva Ardanaz, Karl Smith-Byrne, Ruth Travis, Verena Katzke, Rudolf Kaaks, Jeroen W. G. Derksen, Sandra Colorado-Yohar, Rosario Tumino, Bas Bueno-de-Mesquita, Paolo Vineis, Domenico Palli, Fabrizio Pasanisi, Anne Kirstine Eriksen, Anne Tjønneland, Gianluca Severi, Marc J. Gunter
- Open Access
- Research article
Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study
Oliver M. Shannon, Janice M. Ranson, Sarah Gregory, Helen Macpherson, Catherine Milte, Marleen Lentjes, Angela Mulligan, Claire McEvoy, Alex Griffiths, Jamie Matu, Tom R. Hill, Ashley Adamson, Mario Siervo, Anne Marie Minihane, Graciela Muniz-Tererra, Craig Ritchie, John C. Mathers, David J. Llewellyn, Emma Stevenson
- Open Access
- Research article
Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study
Stephanie K. Nishi, Nancy Babio, Indira Paz-Graniel, Lluís Serra-Majem, Jesús Vioque, Montserrat Fitó, Dolores Corella, Xavier Pintó, Aurora Bueno-Cavanillas, Josep A. Tur, Laura Diez-Ricote, J. Alfredo Martinez, Carlos Gómez-Martínez, Andrés González-Botella, Olga Castañer, Andrea Alvarez-Sala, Cristina Montesdeoca-Mendoza, Marta Fanlo-Maresma, Naomi Cano-Ibáñez, Cristina Bouzas, Lidia Daimiel, María Ángeles Zulet, John L. Sievenpiper, Kelly L. Rodriguez, Zenaida Vázquez-Ruiz, Jordi Salas-Salvadó
- Open Access
- Research article
The long-term and short-term effects of ambient air pollutants on sleep characteristics in the Chinese population: big data analysis from real world by sleep records of consumer wearable devices
Peining Zhou, Jing Ma, Xueying Li, Yixue Zhao, Kunyao Yu, Rui Su, Rui Zhou, Hui Wang, Guangfa Wang
- Open Access
- Research article
Circulating levels of micronutrients and risk of infections: a Mendelian randomization study
Helene M. Flatby, Anuradha Ravi, Jan K. Damås, Erik Solligård, Tormod Rogne
- Open Access
- Research article
Assessing the impacts of COVID-19 vaccination programme’s timing and speed on health benefits, cost-effectiveness, and relative affordability in 27 African countries
Yang Liu, Simon R. Procter, Carl A. B. Pearson, Andrés Madriz Montero, Sergio Torres-Rueda, Elias Asfaw, Benjamin Uzochukwu, Tom Drake, Eleanor Bergren, Rosalind M. Eggo, Francis Ruiz, Nicaise Ndembi, Justice Nonvignon, Mark Jit, Anna Vassall
- Open Access
- Research article
Comparing a PD-L1 inhibitor plus chemotherapy to chemotherapy alone in neoadjuvant therapy for locally advanced ESCC: a randomized Phase II clinical trial
Yong Li, Aiping Zhou, Shuoyan Liu, Ming He, Keneng Chen, Ziqiang Tian, Yin Li, Jianjun Qin, Zhen Wang, Haiquan Chen, Hui Tian, Yue Yu, Wang Qu, Liyan Xue, Shun He, Shuhang Wang, Fenglong Bie, Guangyu Bai, Bolun Zhou, Zhaoyang Yang, Huiyao Huang, Yan Fang, Benjamin Li, Xiangrong Dai, Shugeng Gao, Jie He
- Open Access
- Research article
Association between progression-free survival and overall survival in women receiving first-line treatment for metastatic breast cancer: evidence from the ESME real-world database
Coralie Courtinard, Sophie Gourgou, William Jacot, Matthieu Carton, Olivier Guérin, Laure Vacher, Aurélie Bertaut, Marie-Cécile Le Deley, David Pérol, Patricia Marino, Christelle Levy, Lionel Uwer, Geneviève Perrocheau, Renaud Schiappa, Florence Bachelot, Damien Parent, Mathias Breton, Thierry Petit, Thomas Filleron, Agnès Loeb, Simone Mathoulin-Pélissier, Mathieu Robain, Suzette Delaloge, Carine Bellera
- Open Access
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Associations of risk factor burden and genetic predisposition with the 10-year risk of atrial fibrillation: observations from a large prospective study of 348,904 participants
Junguo Zhang, Ge Chen, ChongJian Wang, Xiaojie Wang, Zhengmin (Min) Qian, Miao Cai, Michael G. Vaughn, Elizabeth Bingheim, Haitao Li, Yanhui Gao, Gregory Y. H. Lip, Hualiang Lin
- Open Access
- Commentary
‘Willpower’ is not enough: time for a new approach to public health policy to prevent obesity
Susan A. Jebb, Paul Aveyard
- Open Access
- Research article
Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis
Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li, Xuesong Yang
- Open Access
- Research article
Unravelling the potential of social prescribing in individual-level type 2 diabetes prevention: a mixed-methods realist evaluation
Sara Calderón-Larrañaga, Trish Greenhalgh, Megan Clinch, John Robson, Isabel Dostal, Fabiola Eto, Sarah Finer
- Open Access
- Research article
Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
Luiz Gustavo dos Anjos Borges, Jana Pastuschek, Yvonne Heimann, Kristin Dawczynski, Michael Bergner, Roland Haase, Johannes Stubert, Dirk Olbertz, Iris Plumeier, Silke Kahl, Ann Kathrin Heroven, Ekkehard Schleußner, Dietmar H. Pieper, Janine Zöllkau
- Open Access
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Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants
Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke, Charlotte A. M. Cecil, Janine F. Felix, Hans J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton, Brenda W. J. H. Penninx
- Open Access
- Research article
The efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial
Lin-Quan Tang, Xiao-Yun Li, Zhi-Ming Li, Zhi-Gang Liu, Miao-Zhen Lin, Huan Zhou, Qi-Wen Yu, Jian Zhou, Chong Zhao, Ze-Bin Chen, Xi-Cheng Wang, Jia-Yu Peng, Qiu-Yan Chen, Wen-Feng Fang, Yun-Peng Yang, Bei Zhang, Liang-Ping Xia, Pi-Li Hu, Wei-Han Hu, Yi-Jie Li, Hai-Qiang Mai, Xiu-Yu Cai
- Open Access
- Research article
Light at night and cause-specific mortality risk in Mainland China: a nationwide observational study
Yao Lu, Peng Yin, Jie Wang, Yiping Yang, Fei Li, Hong Yuan, Shenxin Li, Zheng Long, Maigeng Zhou
- Open Access
- Research article
Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway
Yu Ning, Peisen Huang, Guihao Chen, Yuyan Xiong, Zhaoting Gong, Chunxiao Wu, Junyan Xu, Wenyang Jiang, Xiaosong Li, Ruijie Tang, Lili Zhang, Mengjin Hu, Jing Xu, Jun Xu, Haiyan Qian, Chen Jin, Yuejin Yang
- Open Access
- Research article
Relative role of border restrictions, case finding and contact tracing in controlling SARS-CoV-2 in the presence of undetected transmission: a mathematical modelling study
Rachael Pung, Hannah E. Clapham, Timothy W. Russell, Vernon J. Lee, Adam J. Kucharski
- Open Access
- Research article
Safety, tolerability, pharmacokinetics, and antiviral activity of the novel core protein allosteric modulator ZM-H1505R (Canocapavir) in chronic hepatitis B patients: a randomized multiple-dose escalation trial
Haiyan Jia, Jiajia Mai, Min Wu, Hong Chen, Xiaojiao Li, Cuiyun Li, Jingrui Liu, Chengjiao Liu, Yue Hu, Xiaoxue Zhu, Xiuhong Jiang, Bo Hua, Tian Xia, Gang Liu, Aiyun Deng, Bo Liang, Ruoling Guo, Hui Lu, Zhe Wang, Huanming Chen, Zhijun Zhang, Hong Zhang, Junqi Niu, Yanhua Ding
- Open Access
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Exploring preconception signatures of metabolites in mothers with gestational diabetes mellitus using a non-targeted approach
Ling-Jun Li, Ximeng Wang, Yap Seng Chong, Jerry Kok Yen Chan, Kok Hian Tan, Johan G. Eriksson, Zhongwei Huang, Mohammad L. Rahman, Liang Cui, Cuilin Zhang
- Open Access
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Strategies to inTerrupt RAbies Transmission for the Elimination Goal by 2030 In China (STRATEGIC): a modelling study
Qiulan Chen, Qiuping Liu, Chao Gong, Wenwu Yin, Di Mu, Yu Li, Shujun Ding, Yifang Liu, Hao Yang, Shuwu Zhou, Sa Chen, Zhongfa Tao, Yanping Zhang, Xun Tang
- Open Access
- Research article
Life expectancy among older adults with or without frailty in China: multistate modelling of a national longitudinal cohort study
Junling Gao, Yujie Wang, Jixiang Xu, Junjia Jiang, Shitong Yang, Qianyi Xiao
- Open Access
- Research article
The association of gestational age and birthweight with blood pressure, cardiac structure, and function in 4 years old: a prospective birth cohort study
Bowen Du, Hualin Wang, Yujian Wu, Zhuoyan Li, Yiwei Niu, Qianchuo Wang, Lin Zhang, Sun Chen, Yurong Wu, Jihong Huang, Kun Sun, Jian Wang
- Open Access
- Research article
The association between menstrual cycle characteristics and cardiometabolic outcomes in later life: a retrospective matched cohort study of 704,743 women from the UK
Kelvin Okoth, William Parry Smith, G. Neil Thomas, Krishnarajah Nirantharakumar, Nicola J. Adderley
- Open Access
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Bayesian network modelling to identify on-ramps to childhood obesity
Wanchuang Zhu, Roman Marchant, Richard W. Morris, Louise A. Baur, Stephen J. Simpson, Sally Cripps
- Open Access
- Research article
Potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya: a modelling study
Naomi R. Waterlow, Sreejith Radhakrishnan, Jeanette Dawa, Edwin van Leeuwen, Simon R. Procter, Philipp Lambach, Joseph Bresee, Marie Mazur, Rosalind M. Eggo, Mark Jit
- Open Access
- Editorial
Shining a light on endometriosis: time to listen and take action
- Open Access
- Research article
Rates of maternal weight gain over the course of pregnancy and offspring risk of neurodevelopmental disorders
Shuyun Chen, Mengyu Fan, Brian K. Lee, Christina Dalman, Håkan Karlsson, Renee M. Gardner
- Open Access
- Opinion
Navigating the complexities of mobile medical app development from idea to launch, a guide for clinicians and biomedical researchers
Robert G. Mannino, Santiago J. Arconada Alvarez, Morgan Greenleaf, Maren Parsell, Comfort Mwalija, Wilbur A. Lam
- Open Access
- Review
Rapid antigen-based and rapid molecular tests for the detection of SARS-CoV-2: a rapid review with network meta-analysis of diagnostic test accuracy studies
Areti Angeliki Veroniki, Andrea C. Tricco, Jennifer Watt, Sofia Tsokani, Paul A. Khan, Charlene Soobiah, Ahmed Negm, Amanda Doherty-Kirby, Paul Taylor, Carole Lunny, Jessie McGowan, Julian Little, Patrick Mallon, David Moher, Sabrina Wong, Jacqueline Dinnes, Yemisi Takwoingi, Lynora Saxinger, Adrienne Chan, Wanrudee Isaranuwatchai, Bryn Lander, Adrienne Meyers, Guillaume Poliquin, Sharon E. Straus
- Open Access
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Ethnic minority representation in UK COVID-19 trials: systematic review and meta-analysis
Mayur Murali, Leher Gumber, Hannah Jethwa, Divolka Ganesh, Jamie Hartmann-Boyce, Harpreet Sood, Francesco Zaccardi, Kamlesh Khunti
- Open Access
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The normality assumption on between-study random effects was questionable in a considerable number of Cochrane meta-analyses
Ziyu Liu, Fahad M. Al Amer, Mengli Xiao, Chang Xu, Luis Furuya-Kanamori, Hwanhee Hong, Lianne Siegel, Lifeng Lin
- Open Access
- Correction
Correction: Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder
Shile Qi, Vince D. Calhoun, Daoqiang Zhang, Jeremy Miller, Zhi-De Deng, Katherine L. Narr, Yvette Sheline, Shawn M. McClintock, Rongtao Jiang, Xiao Yang, Joel Upston, Tom Jones, Jing Sui, Christopher C. Abbott
- Open Access
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Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study
Jiazhen Zheng, Can Ni, Yingchai Zhang, Jinghan Huang, Daniel Nyarko Hukportie, Buwen Liang, Shaojun Tang
- Open Access
- Research article
NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer
Shunyi Wang, Yihe Kuai, Simin Lin, Li Li, Quliang Gu, Xiaohan Zhang, Xiaoming Li, Yajun He, Sishuo Chen, Xiaoru Xia, Zhang Ruan, Caixia Lin, Yi Ding, Qianqian Zhang, Cuiling Qi, Jiangchao Li, Xiaodong He, Janak L. Pathak, Weijie Zhou, Side Liu, Lijing Wang, Lingyun Zheng
- Open Access
- Research article
Association of the American Heart Association’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality: prospective cohort study
Jiahong Sun, Yanzhi Li, Min Zhao, Xiao Yu, Cheng Zhang, Costan G. Magnussen, Bo Xi
- Open Access
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Association between epicardial adipose tissue and incident heart failure mediating by alteration of natriuretic peptide and myocardial strain
Manting Choy, Yuwen Huang, Yang Peng, Weihao Liang, Xin He, Chen Chen, Jiayong Li, Wengen Zhu, Fang-fei Wei, Yugang Dong, Chen Liu, Yuzhong Wu
- Open Access
- Correspondence
The CARAMAL study could not assess the effectiveness of rectal artesunate in treating suspected severe malaria
James A. Watson, Thomas J. Peto, Nicholas J. White
- Open Access
- Correspondence
Pre-referral rectal artesunate is no “magic bullet” in weak health systems
Manuel W. Hetzel, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Phyllis Awor, Aita Signorell, Marek Kwiatkowski, Mark J. Lambiris, Theodoor Visser, Justin M. Cohen, Valentina Buj, Christian Burri, Christian Lengeler
- Open Access
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Estimating the cost-effectiveness of maternal vaccination and monoclonal antibodies for respiratory syncytial virus in Kenya and South Africa
Mihaly Koltai, Jocelyn Moyes, Bryan Nyawanda, Joyce Nyiro, Patrick K. Munywoki, Stefano Tempia, Xiao Li, Marina Antillon, Joke Bilcke, Stefan Flasche, Philippe Beutels, D. James Nokes, Cheryl Cohen, Mark Jit
- Open Access
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Cost of childhood RSV management and cost-effectiveness of RSV interventions: a systematic review from a low- and middle-income country perspective
Rachel Wittenauer, Clint Pecenka, Ranju Baral
- Open Access
- Research article
Estimates of the national burden of respiratory syncytial virus in Kenyan children aged under 5 years, 2010–2018
Bryan O. Nyawanda, Nickson Murunga, Nancy A. Otieno, Godfrey Bigogo, Joyce U. Nyiro, Elisabeth Vodicka, Marc Bulterys, D. James Nokes, Patrick K. Munywoki, Gideon O. Emukule
- Open Access
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Associations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK Biobank participants
Fanny Petermann-Rocha, Michael D. Wirth, Jirapitcha Boonpor, Solange Parra-Soto, Ziyi Zhou, John C. Mathers, Katherine Livingstone, Ewan Forrest, Jill P. Pell, Frederick K. Ho, James R. Hébert, Carlos Celis-Morales
- Open Access
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Maternal metabolic syndrome in pregnancy and child development at age 5: exploring mediating mechanisms using cord blood markers
Janell Kwok, Lydia Gabriela Speyer, Georgia Soursou, Aja Louise Murray, Kostas A. Fanti, Bonnie Auyeung
- Open Access
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Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)
Robyn E. Wootton, Rebecca B. Lawn, Maria C. Magnus, Jorien L. Treur, Elizabeth C. Corfield, Pål R. Njølstad, Ole A. Andreassen, Deborah A. Lawlor, Marcus R. Munafò, Siri E. Håberg, George Davey Smith, Ted Reichborn-Kjennerud, Per Magnus, Alexandra Havdahl
- Open Access
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Rheumatoid arthritis and the risk of postpartum psychiatric disorders: a Nordic population-based cohort study
Min Luan, Fen Yang, Maohua Miao, Wei Yuan, Mika Gissler, Elizabeth V. Arkema, Donghao Lu, Jiong Li, Krisztina D. László
- Open Access
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Identifying the causal effects of long-term exposure to PM2.5 and ground surface ozone on individual medical costs in China—evidence from a representative longitudinal nationwide cohort
Ke Ju, Liyong Lu, Jingguo Yang, Ting Chen, Tianjiao Lan, Zhongxin Duan, Zongyou Xu, En Zhang, Wen Wang, Jay Pan
- Open Access
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Identifying the potential causal role of insomnia symptoms on 11,409 health-related outcomes: a phenome-wide Mendelian randomisation analysis in UK Biobank
Mark J. Gibson, Deborah A. Lawlor, Louise A. C. Millard
- Open Access
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Safety, pharmacokinetics, and pharmacodynamics of SHR7280, an oral gonadotropin-releasing hormone receptor antagonist, in healthy men: a randomized, double-blind, placebo-controlled phase 1 study
Xin Li, Feifei Sun, Xiaolei Zhang, Pingping Lin, Kai Shen, Yu Shen, Lingyu Ma, Yu Cao, Chenjing Wang
- Open Access
- Editorial
Food insecurity: a neglected public health issue requiring multisectoral action
- Open Access
- Review
Interventions to improve well-being among children and youth aged 6–17 years during the COVID-19 pandemic: a systematic review
Stephana J. Moss, Sara J. Mizen, Maia Stelfox, Rebecca Brundin Mather, Emily A. FitzGerald, Perri Tutelman, Nicole Racine, Kathryn A. Birnie, Kirsten M. Fiest, Henry T. Stelfox, Jeanna Parsons Leigh
- Open Access
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Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis
Zhijian Zheng, Ming Wu, Hongyan Li, Wenxia Xu, Mengxiang Yang, Kailing Pan, Yuqi Ni, Ting Jiang, Hongjuan Zheng, Xiayun Jin, Yanfei Zhang, Linchao Ding, Jianfei Fu
- Open Access
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Comprehensive proteomics and platform validation of urinary biomarkers for bladder cancer diagnosis and staging
Kamala Vanarsa, Jessica Castillo, Long Wang, Kyung Hyun Lee, Claudia Pedroza, Yair Lotan, Chandra Mohan
- Open Access
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Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo–YAP1 pathway
Duanrui Liu, Yunyun Liu, Wenshuai Zhu, Yi Lu, Jingyu Zhu, Xiaoli Ma, Yuanxin Xing, Mingjie Yuan, Bin Ning, Yunshan Wang, Yanfei Jia
- Open Access
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Preserved vegetable consumption and its association with mortality among 440,415 people in the China Kadoorie Biobank
Pan Zhuang, Fei Wu, Xiaohui Liu, Fanghuan Zhu, Yin Li, Jingjing Jiao, Yu Zhang
- Open Access
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Increased iron deposition in nucleus accumbens associated with disease progression and chronicity in migraine
Xiaopei Xu, Mengting Zhou, Xiao Wu, Fangling Zhao, Xiao Luo, Kaicheng Li, Qingze Zeng, Jiahui He, Hongrong Cheng, Xiaojun Guan, Peiyu Huang, Minming Zhang, Kaiming Liu
- Open Access
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Whole sporozoite immunization with Plasmodium falciparum strain NF135 in a randomized trial
Saskia C. van der Boor, Manon Alkema, Geert-Jan van Gemert, Karina Teelen, Marga van de Vegte-Bolmer, Jona Walk, Reinout van Crevel, Quirijn de Mast, Christian F. Ockenhouse, Robert W. Sauerwein, Matthew B. B. McCall
- Open Access
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Cost-effectiveness of pharmaceutical strategies to prevent respiratory syncytial virus disease in young children: a decision-support model for use in low-income and middle-income countries
Sarwat Mahmud, Ranju Baral, Colin Sanderson, Clint Pecenka, Mark Jit, You Li, Andrew Clark
- Open Access
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The burden of RSV-associated illness in children aged < 5 years, South Africa, 2011 to 2016
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
- Open Access
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Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study
Line Riis Jølving, Jan Nielsen, Mette Louise Andersen, Sonia Friedman, Bente Mertz Nørgård
- Open Access
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Associations of bullying perpetration and peer victimization subtypes with preadolescent’s suicidality, non-suicidal self-injury, neurocognition, and brain development
Xue Wen, Yinuo Shu, Diyang Qu, Yinzhe Wang, Zaixu Cui, Xiaoqian Zhang, Runsen Chen
- Open Access
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Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment
Alejandro Cáceres, Natàlia Carreras-Gallo, Sandra Andrusaityte, Mariona Bustamante, Ángel Carracedo, Leda Chatzi, Varun B. Dwaraka, Regina Grazuleviciene, Kristine Bjerve Gutzkow, Johanna Lepeule, Léa Maitre, Tavis L. Mendez, Mark Nieuwenhuijsen, Remy Slama, Ryan Smith, Nikos Stratakis, Cathrine Thomsen, Jose Urquiza, Hannah Went, John Wright, Tiffany Yang, Maribel Casas, Martine Vrijheid, Juan R. González
- Open Access
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Exploring the causal role of the immune response to varicella-zoster virus on multiple traits: a phenome-wide Mendelian randomization study
Xinzhu Yu, Artitaya Lophatananon, Krisztina Mekli, Kenneth R. Muir, Hui Guo
- Open Access
- Commentary
Sudan Ebola virus (SUDV) outbreak in Uganda, 2022: lessons learnt and future priorities for sub-Saharan Africa
Godfrey Bwire, Benn Sartorius, Philippe Guerin, Merawi Aragaw Tegegne, Sam I. Okware, Ambrose O. Talisuna
- Open Access
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Previous BCG vaccination is associated with less severe clinical progression of COVID-19
Susan Martins Pereira, Florisneide Rodrigues Barreto, Ramon Andrade de Souza, Carlos Antonio de Souza Teles Santos, Marcos Pereira, Enny Santos da Paixão, Carla Cristina Oliveira de Jesus Lima, Marcio Santos da Natividade, Ana Angélica Bulcão Portela Lindoso, Eder Gatti Fernandes, Evonio Barros Campelo Junior, Julia Moreira Pescarini, Kaio Vinicius Freitas de Andrade, Fernanda Mattos de Souza, Elisangela Alves de Britto, Ceuci Nunes, Maria Yuri Ichihara, Margareth Dalcolmo, Anete Trajman, Manoel Barral-Netto, Ibrahim Abubakar, Mauricio Lima Barreto, Ricardo Arraes de Alencar Ximenes, Laura Cunha Rodrigues
- Open Access
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The economic burden of RSV-associated illness in children aged < 5 years, South Africa 2011–2016
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
- Open Access
- Research article
Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes
Huan Wang, Yiming Wang, Jiongyuan Li, Ziyi He, Sarah A. Boswell, Mirra Chung, Fuping You, Sen Han
- Open Access
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Validation of patient- and GP-reported core sets of quality indicators for older adults with multimorbidity in primary care: results of the cross-sectional observational MULTIqual validation study
Ingmar Schäfer, Josefine Schulze, Katharina Glassen, Amanda Breckner, Heike Hansen, Anja Rakebrandt, Jessica Berg, Eva Blozik, Joachim Szecsenyi, Dagmar Lühmann, Martin Scherer
- Open Access
- Research article
Cost-effectiveness of the screen-and-treat strategies using HPV test linked to thermal ablation for cervical cancer prevention in China: a modeling study
Xue-Lian Zhao, Shuang Zhao, Chang-Fa Xia, Shang-Ying Hu, Xian-Zhi Duan, Zhi-Hua Liu, Yue-Yun Wang, Ting-Ting You, Meng Gao, You-Lin Qiao, Partha Basu, Fang-Hui Zhao
- Open Access
- Research article
Liver biomarkers, lipid metabolites, and risk of gestational diabetes mellitus in a prospective study among Chinese pregnant women
Ping Wu, Yi Wang, Yi Ye, Xue Yang, Yichao Huang, Yixiang Ye, Yuwei Lai, Jing Ouyang, Linjing Wu, Jianguo Xu, Jiaying Yuan, Yayi Hu, Yi-Xin Wang, Gang Liu, Da Chen, An Pan, Xiong-Fei Pan
- Open Access
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Clinical prediction models for serious infections in children: external validation in ambulatory care
David A. G. Bos, Tine De Burghgraeve, An De Sutter, Frank Buntinx, Jan Y. Verbakel
- Open Access
- Research article
Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature
Anita Semertzidou, Harriet Grout-Smith, Ilkka Kalliala, Akanksha Garg, Vasso Terzidou, Julian Marchesi, David MacIntyre, Phillip Bennett, Konstantinos Tsilidis, Maria Kyrgiou
- Open Access
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Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population
Zhu Zhang, Haobo Li, Haoyi Weng, Geyu Zhou, Hong Chen, Guoru Yang, Ping Zhang, Xiangyan Zhang, Yingqun Ji, Kejing Ying, Bo Liu, Qixia Xu, Yongjun Tang, Guangfa Zhu, Zhihong Liu, Shuyue Xia, Xiaohong Yang, Lixia Dong, Ling Zhu, Mian Zeng, Yadong Yuan, Yuanhua Yang, Nuofu Zhang, Xiaomao Xu, Wenyi Pang, Meng Zhang, Yu Zhang, Kaiyuan Zhen, Dingyi Wang, Jieping Lei, Sinan Wu, Shi Shu, Yunxia Zhang, Shuai Zhang, Qian Gao, Qiang Huang, Chao Deng, Xi Fu, Gang Chen, Wenxin Duan, Jun Wan, Wanmu Xie, Peng Zhang, Shengfeng Wang, Peiran Yang, Xianbo Zuo, Zhenguo Zhai, Chen Wang
- Open Access
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The impact of metabolic endotoxaemia on the browning process in human adipocytes
Farah Omran, Alice M. Murphy, Awais Z. Younis, Ioannis Kyrou, Jana Vrbikova, Vojtech Hainer, Petra Sramkova, Martin Fried, Graham Ball, Gyanendra Tripathi, Sudhesh Kumar, Philip G. McTernan, Mark Christian
- Open Access
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MECP2 germline mosaicism plays an important part in the inheritance of Rett syndrome: a study of MECP2 germline mosaicism in males
Yongxin Wen, Jiaping Wang, Qingping Zhang, Xiaoxu Yang, Liping Wei, Xinhua Bao
- Open Access
- Research article
NREM sleep as a novel protective cognitive reserve factor in the face of Alzheimer's disease pathology
Zsófia Zavecz, Vyoma D. Shah, Olivia G. Murillo, Raphael Vallat, Bryce A. Mander, Joseph R. Winer, William J. Jagust, Matthew P. Walker
- Open Access
- Research article
Third dose mRNA vaccination against SARS-CoV-2 reduces medical complaints seen in primary care: a matched cohort study
Fredrik Methi, Jon Michael Gran, Morten Valberg, Jonas Minet Kinge, Kjetil Telle, Karin Magnusson
- Open Access
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Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study
Héléne T. Cronjé, Ville Karhunen, G. Kees Hovingh, Ken Coppieters, Jens O. Lagerstedt, Michael Nyberg, Dipender Gill
- Open Access
- Research article
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Xia Zhu, Jun Lv, Meng Zhu, Caiwang Yan, Bin Deng, Canqing Yu, Yu Guo, Jing Ni, Qiang She, Tianpei Wang, Jiayu Wang, Yue Jiang, Jiaping Chen, Dong Hang, Ci Song, Xuefeng Gao, Jian Wu, Juncheng Dai, Hongxia Ma, Ling Yang, Yiping Chen, Mingyang Song, Qingyi Wei, Zhengming Chen, Zhibin Hu, Hongbing Shen, Yanbing Ding, Liming Li, Guangfu Jin
- Open Access
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Shiyao Xu, Jincheng Li, Hongyuan Wang, Fuzhen Wang, Zundong Yin, Zhifeng Wang
- Open Access
- Research article
Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability
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- Open Access
- Research article
Impact of oral intervention on the oral and overall health of children living with HIV in Cambodia: a randomized controlled trial
Kimiyo Kikuchi, Sovannary Tuot, Junko Yasuoka, Makoto Murayama, Sumiyo Okawa, Akira Shibanuma, Keiko Nanishi, Sothearith Eng, Chantheany Huot, Siyan Yi
- Open Access
- Research article
Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study
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- Open Access
- Research article
Central nervous system efficacy of furmonertinib (AST2818) in patients with EGFR T790M mutated non-small cell lung cancer: a pooled analysis from two phase 2 studies
Xingsheng Hu, Shucai Zhang, Zhiyong Ma, Jifeng Feng, Lin Wu, Dongqing Lv, Jianying Zhou, Xiaodong Zhang, Li Liu, Qitao Yu, Wangjun Liao, Yiping Zhang, Xiang Wang, Ying Cheng, Hongrui Niu, Ziping Wang, Dong Wang, Cheng Huang, Chunling Liu, Hui Zhao, Jian Feng, Jingzhang Li, Kejing Ying, Nong Yang, Shukui Qin, Jie Hu, Fei Liu, Yong Jiang, Nan Ge, Yuankai Shi
- Open Access
- Research article
Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Woo-Jeong Shon, Jae Won Song, Seung Hoon Oh, Keon-Hee Lee, Hobin Seong, Hyun Ju You, Je Kyung Seong, Dong-Mi Shin
- Open Access
- Retraction Note
Retraction Note: Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis
Amir Abbas Momtazi-Borojeni, Mahmoud Reza Jaafari, Ali Badiee, Maciej Banach, Amirhossein Sahebkar
- Open Access
- Research article
Differentiation between fetal and postnatal iron deficiency in altering brain substrates of cognitive control in pre-adolescence
Mengdi Hua, Donglin Shi, Wenwen Xu, Liuyan Zhu, Xiaoxin Hao, Bingquan Zhu, Qiang Shu, Betsy Lozoff, Fengji Geng, Jie Shao
- Open Access
- Research article
Housing modification for malaria control: impact of a “lethal house lure” intervention on malaria infection prevalence in a cluster randomised control trial in Côte d’Ivoire
Jackie Cook, Eleanore Sternberg, Carine J. Aoura, Raphael N’Guessan, Immo Kleinschmidt, Alphonsine A. Koffi, Matthew B. Thomas, Serge-Brice Assi
- Open Access
- Research article
Association between chronic pain and risk of incident dementia: findings from a prospective cohort
Jing Tian, Graeme Jones, Xin Lin, Yuan Zhou, Anna King, James Vickers, Feng Pan
- Open Access
- Research article
Investigating the relationship between depression and breast cancer: observational and genetic analyses
Xueyao Wu, Wenqiang Zhang, Xunying Zhao, Li Zhang, Minghan Xu, Yu Hao, Jinyu Xiao, Ben Zhang, Jiayuan Li, Peter Kraft, Jordan W. Smoller, Xia Jiang
- Open Access
- Opinion
Combination therapies for cancer: challenges and opportunities
Zhijun Zhou, Barish H. Edil, Min Li
- Open Access
- Correspondence
Saving time and money in biomedical publishing: the case for free-format submissions with minimal requirements
Amy Clotworthy, Megan Davies, Timothy J. Cadman, Jessica Bengtsson, Thea O. Andersen, Manik Kadawathagedara, Johan L. Vinther, Tri-Long Nguyen, Tibor V. Varga
- Open Access
- Research article
Safety and efficacy of apatinib in patients with advanced gastric or gastroesophageal junction adenocarcinoma after the failure of two or more lines of chemotherapy (AHEAD): a prospective, single-arm, multicenter, phase IV study
Jin Li, Shukui Qin, Lu Wen, Junsheng Wang, Wenying Deng, Weijian Guo, Tongfu Jia, Da Jiang, Guifang Zhang, Yifu He, Yi Ba, Haijun Zhong, Lin Wang, Xiaoyan Lin, Jianwei Yang, Jun Zhao, Yuxian Bai, Xiangyuan Wu, Feng Gao, Guogui Sun, Yongjuan Wu, Feng Ye, Qiong Wang, Zhong Xie, Tienan Yi, Yong Huang, Guohua Yu, Lin Lu, Ying Yuan, Wei Li, Likun Liu, Yuping Sun, Ying Sun, Lifeng Yin, Zhiguo Hou
- Open Access
- Research article
Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites
Yuntao Zhang, Lin Liu, Chunbo Wei, Xuanyang Wang, Ran Li, Xiaoqing Xu, Yingfeng Zhang, Guannan Geng, Keke Dang, Zhu Ming, Xinmiao Tao, Huan Xu, Xuemin Yan, Jia Zhang, Jinxia Hu, Ying Li
- Open Access
- Correction
Correction: Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study
Jiazhen Zheng, Can Ni, Yingchai Zhang, Jinghan Huang, Daniel Nyarko Hukportie, Buwen Liang, Shaojun Tang
- Open Access
- Research article
Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis
Sandi M Azab, Meera Shanmuganathan, Russell J de Souza, Zachary Kroezen, Dipika Desai, Natalie C Williams, Katherine M Morrison, Stephanie A Atkinson, Koon K Teo, Meghan B Azad, Elinor Simons, Theo J Moraes, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Philip Britz-McKibbin, Sonia S Anand
- Open Access
- Editorial
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Padmini Srikantiah, Keith P. Klugman
- Open Access
- Research article
Chemotherapy-induced weight gain in early-stage breast cancer: a prospective matched cohort study reveals associations with inflammation and gut dysbiosis
John Walker, Anil Abraham Joy, Larissa J. Vos, Trevor H. Stenson, John R. Mackey, Juan Jovel, Dina Kao, Karen L. Madsen, Gane Ka-Shu Wong
- Open Access
- Research article
Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study
Shu Xu, Xiaozhi Li, Shenghong Zhang, Cancan Qi, Zhenhua Zhang, Ruiqi Ma, Liyuan Xiang, Lianmin Chen, Yijun Zhu, Ce Tang, Arno R. Bourgonje, Miaoxin Li, Yao He, Zhirong Zeng, Shixian Hu, Rui Feng, Minhu Chen
- Open Access
- Research article
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Ran Zhong, Rui Gao, Wenhai Fu, Caichen Li, Zhenyu Huo, Yuewen Gao, Yi Lu, Feng Li, Fan Ge, Hengjia Tu, Zhixuan You, Jianxing He, Wenhua Liang
- Open Access
- Research article
Change in habitual intakes of flavonoid-rich foods and mortality in US males and females
Nicola P. Bondonno, Yan Lydia Liu, Yan Zheng, Kerry Ivey, Walter C. Willett, Meir J. Stampfer, Eric B. Rimm, Aedín Cassidy
- Open Access
- Guideline
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Jörg Rahnenführer, Riccardo De Bin, Axel Benner, Federico Ambrogi, Lara Lusa, Anne-Laure Boulesteix, Eugenia Migliavacca, Harald Binder, Stefan Michiels, Willi Sauerbrei, Lisa McShane
- Open Access
- Research article
Unexpectedly higher levels of anti-orthopoxvirus neutralizing antibodies are observed among gay men than general adult population
Yanmeng Feng, Yifan Zhang, Shengya Liu, Meng Guo, Haojie Huang, Cuiyuan Guo, Wanhai Wang, Wenhong Zhang, Heng Tang, Yanmin Wan
- Open Access
- Research article
Increasing emergency number utilisation is not driven by low-acuity calls: an observational study of 1.5 million emergency calls (2018–2021) from Berlin
David Herr, Sangeeta Bhatia, Florian Breuer, Stefan Poloczek, Christopher Pommerenke, Janosch Dahmen
- Open Access
- Research article
The impact of non-alcoholic fatty liver disease and liver fibrosis on adverse clinical outcomes and mortality in patients with chronic kidney disease: a prospective cohort study using the UK Biobank
Theresa J. Hydes, Oliver J. Kennedy, Ryan Buchanan, Daniel J. Cuthbertson, Julie Parkes, Simon D. S. Fraser, Paul Roderick
- Open Access
- Research article
Autophagy-related genes analysis reveals potential biomarkers for prediction of the impaired walking capacity of peripheral arterial disease
Mengjun Dai, Kangbo Li, Mesud Sacirovic, Claudia Zemmrich, Eva Buschmann, Oliver Ritter, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann, Philipp Hillmeister
- Open Access
- Commentary
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Shiu Lun Au Yeung, Dipender Gill
- Open Access
- Editorial
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- Open Access
- Research article
Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review
Rebekah Maksoud, Chandi Magawa, Natalie Eaton-Fitch, Kiran Thapaliya, Sonya Marshall-Gradisnik
- Open Access
- Research article
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Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Mohammad Alhadj Ali, Colin Dayan, Bart Keymeulen, Katharine R. Owen, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Roxana R. Ahangarani, Evelien Gebruers, Nicolas Bovy, Luc Vanderelst, Marcelle Van Mechelen, Pierre Vandepapelière, Christian Boitard
- Open Access
- Research article
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- Open Access
- Research article
The effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial
Jia Sun, Yuting Ruan, Ningning Xu, Peili Wu, Nie Lin, Kun Yuan, Shengli An, Pei Kang, Shu Li, Qiya Huang, Yingzhang, Yuzhong Li, Jialin Su, Wenjun Ma, Bo Chen, Xiuwei Zhang, Xiaoming Chen, Yongqian Liang, Zeyuan Lu, Guobao Deng, Zhen Zhang, Yuqin Wang, Weiheng Wen, Huijie Zhang, Hong Chen
- Open Access
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A combination of genetically engineered oncolytic virus and melittin-CpG for cancer viro-chemo-immunotherapy
Amirhossein Bahreyni, Huitao Liu, Yasir Mohamud, Yuan Chao Xue, Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Honglin Luo
- Open Access
- Research article
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Jinfeng Liang, Yi Huang, Li Yin, Fatemeh Sadeghi, Yanping Yang, Xue Xiao, Hans-Olov Adami, Weimin Ye, Zhe Zhang, Fang Fang
- Open Access
- Research article
The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study
Yan Li, Hongyan Liu, Shuting Ye, Bumei Zhang, Xiaopei Li, Jiapei Yuan, Yongrui Du, Jianmei Wang, Yang Yang
- Open Access
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Effects of ketogenic diet on health outcomes: an umbrella review of meta-analyses of randomized clinical trials
Chanthawat Patikorn, Pantakarn Saidoung, Tuan Pham, Pochamana Phisalprapa, Yeong Yeh Lee, Krista A. Varady, Sajesh K. Veettil, Nathorn Chaiyakunapruk
- Open Access
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Adipsin alleviates cardiac microvascular injury in diabetic cardiomyopathy through Csk-dependent signaling mechanism
Xuebin Zhang, Yu Duan, Xiao Zhang, Mengyuan Jiang, Wanrong Man, Yan Zhang, Dexi Wu, Jiye Zhang, Xinglong Song, Congye Li, Jie Lin, Dongdong Sun
- Open Access
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Chao Ma, Liyang Wang, Dengpan Song, Chuntian Gao, Linkai Jing, Yang Lu, Dongkang Liu, Weitao Man, Kaiyuan Yang, Zhe Meng, Huifang Zhang, Ping Xue, Yupeng Zhang, Fuyou Guo, Guihuai Wang
- Open Access
- Research article
MPC-n (IgG) improves long-term cognitive impairment in the mouse model of repetitive mild traumatic brain injury
Chaonan Zhang, Cheng Wei, Xingqi Huang, Changxin Hou, Chuan Liu, Shu Zhang, Zilong Zhao, Yafan Liu, Ruiguang Zhang, Lei Zhou, Ying Li, Xubo Yuan, Jianning Zhang
- Open Access
- Correction
Correction: Childhood diabetes mellitus and early-onset kidney diseases later in life: a nationwide population-based matched cohort study
Jiahong Sun, Ce Wang, Min Zhao, Priscilla M. Y. Lee, Bo Xi, Yongfu Yu, Jiong Li
- Open Access
- Research article
Disease-specific health spending by age, sex, and type of care in Norway: a national health registry study
Jonas Minet Kinge, Joseph L. Dieleman, Øystein Karlstad, Ann Kristin Knudsen, Søren Toksvig Klitkou, Simon I. Hay, Theo Vos, Christopher J. L. Murray, Stein Emil Vollset
- Open Access
- Research article
What effect have commissioners’ policies for body mass index had on hip replacement surgery?: an interrupted time series analysis from the National Joint Registry for England
Joanna McLaughlin, Ruth Kipping, Amanda Owen-Smith, Hugh McLeod, Samuel Hawley, J. Mark Wilkinson, Andrew Judge
- Open Access
- Commentary
Shared genetic correlation and causal association between major depressive disorder and breast cancer
Kazutaka Ohi
- Open Access
- Research article
Trends in cognitive function before and after stroke in China
Jianian Hua, Jianye Dong, Guo-Chong Chen, Yueping Shen
- Open Access
- Research article
Neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementia
Lin Sun, Jie Zhang, Wei Li, Jianhua Sheng, Shifu Xiao
- Open Access
- Research article
miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis
Genpeng Li, Linye He, Jing Huang, Jiaye Liu, Wenjie Chen, Jinjing Zhong, Tao Wei, Zhihui Li, Jingqiang Zhu, Jianyong Lei
- Open Access
- Correction
Correction: Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients
Flávio de Azevedo Figueiredo, Lucas Emanuel Ferreira Ramos, Rafael Tavares Silva, Daniela Ponce, Rafael Lima Rodrigues de Carvalho, Alexandre Vargas Schwarzbold, Amanda de Oliveira Maurílio, Ana Luiza Bahia Alves Scotton, Andresa Fontoura Garbini, Bárbara Lopes Farace, Bárbara Machado Garcia, Carla Thais Cândida Alves da Silva, Christiane Corrêa Rodrigues Cimini, Cíntia Alcantara de Carvalho, Cristiane dos Santos Dias, Daniel Vitório Silveira, Euler Roberto Fernandes Manenti, Evelin Paola de Almeida Cenci, Fernando Anschau, Fernando Graça Aranha, Filipe Carrilho de Aguiar, Frederico Bartolazzi, Giovanna Grunewald Vietta, Guilherme Fagundes Nascimento, Helena Carolina Noal, Helena Duani, Heloisa Reniers Vianna, Henrique Cerqueira Guimarães, Joice Coutinho de Alvarenga, José Miguel Chatkin, Júlia Drumond Parreiras de Morais, Juliana Machado-Rugolo, Karen Brasil Ruschel, Karina Paula Medeiros Prado Martins, Luanna Silva Monteiro Menezes, Luciana Siuves Ferreira Couto, Luís César de Castro, Luiz Antônio Nasi, Máderson Alvares de Souza Cabral, Maiara Anschau Floriani, Maíra Dias Souza, Maira Viana Rego Souza-Silva, Marcelo Carneiro, Mariana Frizzo de Godoy, Maria Aparecida Camargos Bicalho, Maria Clara Pontello Barbosa Lima, Márlon Juliano Romero Aliberti, Matheus Carvalho Alves Nogueira, Matheus Fernandes Lopes Martins, Milton Henriques Guimarães-Júnior, Natália da Cunha Severino Sampaio, Neimy Ramos de Oliveira, Patricia Klarmann Ziegelmann, Pedro Guido Soares Andrade, Pedro Ledic Assaf, Petrônio José de Lima Martelli, Polianna Delfino-Pereira, Raphael Castro Martins, Rochele Mosmann Menezes, Saionara Cristina Francisco, Silvia Ferreira Araújo, Talita Fischer Oliveira, Thainara Conceição de Oliveira, Thaís Lorenna Souza Sales, Thiago Junqueira Avelino-Silva, Yuri Carlotto Ramires, Magda Carvalho Pires, Milena Soriano Marcolino
- Open Access
- Research article
Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study
Yalan Tian, Jiahui Liu, Yue Zhao, Nana Jiang, Xiao Liu, Gang Zhao, Xia Wang
- Open Access
- Research article
Antidepressant drug prescription and incidence of COVID-19 in mental health outpatients: a retrospective cohort study
Oleg O. Glebov, Christoph Mueller, Robert Stewart, Dag Aarsland, Gayan Perera
- Open Access
- Research article
Efficacy of COVID-19 mRNA vaccination in patients with autoimmune disorders: humoral and cellular immune response
Federica Filippini, Mauro Giacomelli, Chiara Bazzani, Micaela Fredi, Paolo Semeraro, Cesare Tomasi, Franco Franceschini, Arnaldo Caruso, Ilaria Cavazzana, Cinzia Giagulli
- Open Access
- Research article
Associations between smoking and vaping prevalence, product use characteristics, and mental health diagnoses in Great Britain: a population survey
Eve Taylor, Leonie S Brose, Ann McNeill, Jamie Brown, Loren Kock, Debbie Robson
- Open Access
- Research article
A multicentre, prospective, non-interventional study evaluating the safety of dapagliflozin in patients with type 2 diabetes in routine clinical practice in China (DONATE)
Lixin Guo, Jing Wang, Li Li, Lin Yuan, Sheng Chen, Hui Wang, Tonghuan Li, Lin Qi, Hong Yang
- Open Access
- Opinion
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Michael Bunce, Jemma L. Geoghegan, David Winter, Joep de Ligt, Siouxsie Wiles
- Open Access
- Research article
Workplace-based primary prevention intervention reduces incidence of hypertension: a post hoc analysis of cluster randomized controlled study
Zhen Hu, Xin Wang, Conglin Hong, Congyi Zheng, Linfeng Zhang, Zuo Chen, Haoqi Zhou, Yixin Tian, Xue Cao, Jiayin Cai, Runqing Gu, Ye Tian, Lan Shao, Zengwu Wang
- Open Access
- Research article
Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis
Mengqiang Fan, Peijian Tong, Li Yan, Ting Li, Jiadan Ren, Jiefeng Huang, Wenxi Du, Li Zhou, Letian Shan
- Open Access
- Research article
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Dorien M. Kimenai, Atul Anand, Marie de Bakker, Martin Shipley, Takeshi Fujisawa, Magnus N. Lyngbakken, Kristian Hveem, Torbjørn Omland, Carlos A. Valencia-Hernández, Joni V. Lindbohm, Mika Kivimaki, Archana Singh-Manoux, Fiona E. Strachan, Anoop S. V. Shah, Isabella Kardys, Eric Boersma, Eric J. Brunner, Nicholas L. Mills
- Open Access
- Editorial
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- Open Access
- Research article
Reactogenicity and safety of COVID-19 primary immunisation and booster vaccination regimens: a comparative observational cohort study
Lisette Warkentin, Felix Werner, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla, Isabelle Kaiser, Maria Sebastião, Susann Hueber
- Open Access
- Research article
Expression of the endocannabinoid system and response to cannabinoid components by the human fetal testis
J. Dochez-Arnault, C. Desdoits-Lethimonier, I. Matias, B. Evrard, M. Lagarrigue, M. Toupin, A. Lardenois, F. Chalmel, S. Mazaud-Guittot, N. Dejucq-Rainsford, A. Gely-Pernot
- Open Access
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Varenicline and counseling for vaping cessation: a double-blind, randomized, parallel-group, placebo-controlled trial
Pasquale Caponnetto, Davide Campagna, Jasjit S. Ahluwalia, Christopher Russell, Marilena Maglia, Paolo Marco Riela, Carmelo Fabio Longo, Barbara Busa, Riccardo Polosa
- Open Access
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Effectiveness of mHealth consultation services for preventing postpartum depressive symptoms: a randomized clinical trial
Yuki Arakawa, Maho Haseda, Kosuke Inoue, Daisuke Nishioka, Shiho Kino, Daisuke Nishi, Hideki Hashimoto, Naoki Kondo
- Open Access
- Research article
Global, regional, and national burden of cardiovascular diseases in youths and young adults aged 15–39 years in 204 countries/territories, 1990–2019: a systematic analysis of Global Burden of Disease Study 2019
Jiahong Sun, Yanan Qiao, Min Zhao, Costan G. Magnussen, Bo Xi
- Open Access
- Research article
Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease
Wenwen Li, Yana Pang, Yan Wang, Fan Mei, Mengmeng Guo, Yiping Wei, Xinyue Li, Wei Qin, Wei Wang, Longfei Jia, Jianping Jia
- Open Access
- Research article
Understanding the age spectrum of respiratory syncytial virus associated hospitalisation and mortality burden based on statistical modelling methods: a systematic analysis
Bingbing Cong, Izzie Dighero, Tiantian Zhang, Alexandria Chung, Harish Nair, You Li
- Open Access
- Research article
Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries: results from the EPIC cohort study
Carlota Castro-Espin, Catalina Bonet, Marta Crous-Bou, Núria Nadal-Zaragoza, Anne Tjønneland, Lene Mellemkjær, Mariem Hajji-Louati, Thérèse Truong, Verena Katzke, Charlotte Le Cornet, Matthias B. Schulze, Franziska Jannasch, Giovanna Masala, Sabina Sieri, Salvatore Panico, Chiara Di Girolamo, Guri Skeie, Kristin Benjaminsen Borch, Karina Standahl Olsen, Maria-Jose Sánchez, Pilar Amiano, María-Dolores Chirlaque, Marcela Guevara, Malin Sund, Stina Bodén, Marc J. Gunter, Esther M. Gonzalez-Gil, Elisabete Weiderpass, Inmaculada Aguilera-Buenosvinos, Kostas K. Tsilidis, Alicia K. Heath, Dagfinn Aune, Laure Dossus, Antonio Agudo
- Open Access
- Research article
Pyrotinib in combination with letrozole for hormone receptor-positive, human epidermal growth factor receptor 2-positive metastatic breast cancer (PLEHERM): a multicenter, single-arm, phase II trial
Zhe-Yu Hu, Min Yan, Huihua Xiong, Li Ran, Jincai Zhong, Ting Luo, Tao Sun, Ning Xie, Liping Liu, Xiaohong Yang, Huawu Xiao, Jing Li, Binliang Liu, Quchang Ouyang
- Open Access
- Research article
Prevalence, risk factors, impact and management of pneumonia among preschool children in Chinese seven cities: a cross-sectional study with interrupted time series analysis
Haonan Shi, Tingting Wang, Zhuohui Zhao, Dan Norback, Xiaowei Wang, Yongsheng Li, Qihong Deng, Chan Lu, Xin Zhang, Xiaohong Zheng, Hua Qian, Ling Zhang, Wei Yu, Yuqing Shi, Tianyi Chen, Huaijiang Yu, Huizhen Qi, Ye Yang, Lan Jiang, Yuting Lin, Jian Yao, Junwen Lu, Qi Yan
- Open Access
- Research article
The relationship between alcohol consumption and health: J-shaped or less is more?
Min-Kuang Tsai, Wayne Gao, Chi-Pang Wen
- Open Access
- Correspondence
The Full Value of Vaccine Assessments (FVVA): a framework for assessing and communicating the value of vaccines for investment and introduction decision-making
Raymond Hutubessy, Jeremy A. Lauer, Birgitte Giersing, So Yoon Sim, Mark Jit, David Kaslow, Siobhan Botwright
- Open Access
- Research article
Phase 1 dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and anti-tumor activity of FCN-159 in adults with neurofibromatosis type 1-related unresectable plexiform neurofibromas
Xiaojie Hu, Wenbin Li, Kang Zeng, Zhongyuan Xu, Changxing Li, Zhuang Kang, Shenglan Li, Xin Huang, Pu Han, Hongmei Lin, Ai-Min Hui, Yan Tan, Lei Diao, Ben Li, Xingli Wang, Zhuli Wu, Xiaoxi Lin
- Open Access
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Plasma protein N-glycome composition associates with postprandial lipaemic response
Panayiotis Louca, Tamara Štambuk, Azra Frkatović-Hodžić, Ana Nogal, Massimo Mangino, Sarah E. Berry, Helena Deriš, George Hadjigeorgiou, Jonathan Wolf, Martina Vinicki, Paul W. Franks, Ana M. Valdes, Tim D. Spector, Gordan Lauc, Cristina Menni
- Open Access
- Research article
Evaluation of post-acute care and one-year outcomes among Medicare beneficiaries with hip fractures: a retrospective cohort study
Melissa R. Riester, Francesca L. Beaudoin, Richa Joshi, Kaleen N. Hayes, Meghan A. Cupp, Sarah D. Berry, Andrew R. Zullo
- Open Access
- Research article
Neutralizing antibody levels associated with injectable and aerosolized Ad5-nCoV boosters and BA.2 infection
Fuzhen Wang, Baoying Huang, Yao Deng, Shaobai Zhang, Xiaoqiang Liu, Lei Wang, Qianqian Liu, Li Zhao, Lin Tang, Wenling Wang, Xiaoqi Wang, Fei Ye, Weijun Hu, Haitao Yang, Siquan Wang, Jiao Ren, Xiaoyu Liu, Cangning Wang, Xuhua Guan, Ruize Wang, Yan Zheng, Xianfeng Zhang, Hui Zheng, Dan Wu, Zhijie An, Wenbo Xu, Lawrence E. Rodewald, George F. Gao, Zundong Yin, Wenjie Tan
- Open Access
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Analysis of phase III clinical trials in metastatic NSCLC to assess the correlation between QoL results and survival outcomes
Alberto Servetto, Massimo Di Maio, Fabio Salomone, Fabiana Napolitano, Chiara Paratore, Fabrizio Di Costanzo, Giuseppe Viscardi, Antonio Santaniello, Luigi Formisano, Roberto Bianco
- Open Access
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Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study
Guoyi Yang, C. Mary Schooling
- Open Access
- Research article
The usage of data in NHS primary care commissioning: a realist review
Alexandra Jager, Geoff Wong, Chrysanthi Papoutsi, Nia Roberts
- Open Access
- Research article
Progressive trajectories of schizophrenia across symptoms, genes, and the brain
Sisi Jiang, Huan Huang, Jingyu Zhou, Hechun Li, Mingjun Duan, Dezhong Yao, Cheng Luo
- Open Access
- Research article
Dobutamine-induced alternations in cerebral blood flow of healthy adults: a 3D pseudocontinuous arterial spin labeling study
Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
- Open Access
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Family history and breast cancer risk for Asian women: a systematic review and meta-analysis
Heran Wang, Robert J. MacInnis, Shuai Li
- Open Access
- Research article
Eligibility criteria in clinical trials in breast cancer: a cohort study
Katarzyna Szlezinger, Katarzyna Pogoda, Agnieszka Jagiełło-Gruszfeld, Danuta Kłosowska, Andrzej Górski, Jan Borysowski
- Open Access
- Research article
Sampling inequalities affect generalization of neuroimaging-based diagnostic classifiers in psychiatry
Zhiyi Chen, Bowen Hu, Xuerong Liu, Benjamin Becker, Simon B. Eickhoff, Kuan Miao, Xingmei Gu, Yancheng Tang, Xin Dai, Chao Li, Artemiy Leonov, Zhibing Xiao, Zhengzhi Feng, Ji Chen, Hu Chuan-Peng
- Open Access
- Research article
Adherence to healthy diet and risk of cardiovascular disease in adult survivors of childhood cancer in the St. Jude Lifetime Cohort: a cross-sectional study
Tuo Lan, Mei Wang, Matthew J. Ehrhardt, Shu Jiang, Jennifer Q. Lanctot, Gregory T. Armstrong, Melissa M. Hudson, Graham A. Colditz, Leslie L. Robison, Yikyung Park
- Open Access
- Research article
Informing a target product profile for rapid tests to identify HBV-infected pregnant women with high viral loads: a discrete choice experiment with African healthcare workers
Yasir Shitu Isa, Jonathan Sicsic, Henry Njuguna, John Ward, Mohamed Chakroun, Mohamed El-Kassas, Rado Ramanampamonjy, Salim Chalal, Jeanne Perpétue Vincent, Monique Andersson, Hailemichael Desalegn, Fatou Fall, Asgeir Johannessen, Philippa C. Matthews, Gibril Ndow, Edith Okeke, Nicholas Riches, Moussa Seydi, Edford Sinkala, C. Wendy Spearman, Alexander Stockdale, Michael J. Vinikoor, Gilles Wandeler, Roger Sombié, Maud Lemoine, Judith E. Mueller, Yusuke Shimakawa
- Open Access
- Research article
Providing multimedia information to children and young people increases recruitment to trials: pre-planned meta-analysis of SWATs
Peter Knapp, Thirimon Moe-Byrne, Jacqueline Martin-Kerry, Rebecca Sheridan, Jenny Roche, Elizabeth Coleman, Peter Bower, Steven Higgins, Catherine Stones, Jonathan Graffy, Jenny Preston, Carrol Gamble, Bridget Young, Daniel Perry, Annegret Dahlmann-Noor, Mohamed Abbas, Payal Khandelwal, Siobhan Ludden, Augusto Azuara-Blanco, Emma McConnell, Nicky Mandall, Anna Lawson, Chris A. Rogers, Helena J. M. Smartt, Rachael Heys, Simon R. Stones, Danielle Horton Taylor, Sophie Ainsworth, Jenny Ainsworth
- Open Access
- Research article
Proteomic profiling of longitudinal changes in kidney function among middle-aged and older men and women: the KORA S4/F4/FF4 study
Jie-sheng Lin, Jana Nano, Agnese Petrera, Stefanie M. Hauck, Tanja Zeller, Wolfgang Koenig, Christian L. Müller, Annette Peters, Barbara Thorand
- Open Access
- Research article
Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study
Olga Solovyeva, Munyaradzi Dimairo, Christopher J. Weir, Siew Wan Hee, Aude Espinasse, Moreno Ursino, Dhrusti Patel, Andrew Kightley, Sarah Hughes, Thomas Jaki, Adrian Mander, Thomas R. Jeffry Evans, Shing Lee, Sally Hopewell, Khadija Rerhou Rantell, An-Wen Chan, Alun Bedding, Richard Stephens, Dawn Richards, Lesley Roberts, John Kirkpatrick, Johann de Bono, Christina Yap
- Open Access
- Research article
Caregiver burden in Parkinson’s disease: a mixed-methods study
Angelika D. Geerlings, Willanka M. Kapelle, Charlotte J. Sederel, Emma Tenison, Hilde Wijngaards-Berenbroek, Marjan J. Meinders, Marten Munneke, Yoav Ben-Shlomo, Bastiaan R. Bloem, Sirwan K. L. Darweesh
- Open Access
- Research article
Estimating the delivery costs of COVID-19 vaccination using the COVID-19 Vaccine Introduction and deployment Costing (CVIC) tool: the Lao People’s Democratic Republic experience
Karene Hoi Ting Yeung, Eunkyoung Kim, Wei Aun Yap, Chansay Pathammavong, Lauren Franzel, Yu Lee Park, Peter Cowley, Ulla Kou Griffiths, Raymond Christiaan W. Hutubessy
- Open Access
- Research article
Investigating the risk of metabolic and cardiovascular comorbidities among patients with parathyroid cancer: a nationwide representative cohort study in Taiwan
Ming-Chieh Tsai, Min-Shu Hsu, Hsin-Yin Hsu, Tzu-Lin Yeh, Chun-Ju Chiang, Wen-Chung Lee, Jing-Rong Jhuang, Shih-Ping Cheng, Po-Jung Tseng, Kuo-Liong Chien
- Open Access
- Research article
Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia
Long-Biao Cui, Xian-Yang Wang, Yu-Fei Fu, Xiao-Fan Liu, Yongbin Wei, Shu-Wan Zhao, Yue-Wen Gu, Jing-Wen Fan, Wen-Jun Wu, Hengfen Gong, Bochao Danae Lin, Hong Yin, Fanglin Guan, Xiao Chang
- Open Access
- Research article
Associations between an obesity-related dietary pattern and incidence of overall and site-specific cancers: a prospective cohort study
Maiwulamujiang Maimaitiyiming, Hongxi Yang, Lihui Zhou, Xinyu Zhang, Qiliang Cai, Yaogang Wang
- Open Access
- Research article
Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice
Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu, Qingchun Zeng
- Open Access
- Research article
PARP inhibitor exerts an anti-tumor effect via LMO2 and synergizes with cisplatin in natural killer/T cell lymphoma
Jiazhuo Wu, Cunzhen Shi, Hongwen Li, Wenting Song, Shuo Huang, Jianxiang Zhang, Wencai Li, Zhaoming Li, Mingzhi Zhang
- Open Access
- Research article
Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function
Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang, Xiao Xiao
- Open Access
- Research article
Individualized dynamic methylation-based analysis of cell-free DNA in postoperative monitoring of lung cancer
Kezhong Chen, Guannan Kang, Zhihong Zhang, Analyn Lizaso, Stephan Beck, Iben Lyskjær, Olga Chervova, Bingsi Li, Haifeng Shen, Chenyang Wang, Bing Li, Heng Zhao, Xi Li, Fan Yang, Nnennaya Kanu, Jun Wang
- Open Access
- Research article
Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice
Mei-Yu Yin, Lei Guo, Li-Juan Zhao, Chen Zhang, Wei-Peng Liu, Chu-Yi Zhang, Jin-Hua Huo, Lu Wang, Shi-Wu Li, Chang-Bo Zheng, Xiao Xiao, Ming Li, Chuang Wang, Hong Chang
- Open Access
- Research article
Assessment of cardio-renal-hepatic function in patients with valvular heart disease: a multi-biomarker approach—the cardio-renal-hepatic score
Junxing Lv, Bin Zhang, Yunqing Ye, Zhe Li, Weiwei Wang, Qinghao Zhao, Qingrong Liu, Zhenyan Zhao, Haitong Zhang, Bincheng Wang, Zikai Yu, Zhenya Duan, Shuai Guo, Yanyan Zhao, Runlin Gao, Haiyan Xu, Yongjian Wu
- Open Access
- Research article
A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth
Li Wang, Robert M. Rossi, Xiaoting Chen, Jing Chen, Jilian Runyon, Mehak Chawla, Daniel Miller, Carmy Forney, Arthur Lynch, Xuzhe Zhang, Fansheng Kong, Bo Jacobsson, Leah C. Kottyan, Matthew T. Weirauch, Ge Zhang, Louis J. Muglia
- Open Access
- Research article
Healthcare use attributable to COVID-19: a propensity-matched national electronic health records cohort study of 249,390 people in Wales, UK
J Kennedy , M Parker, M Seaborne, M Mhereeg , A Walker , V Walker, S Denaxas, N Kennedy, S. V Katikireddi, S Brophy
- Open Access
- Research article
Random capillary glucose levels throughout pregnancy, obstetric and neonatal outcomes, and long-term neurodevelopmental conditions in children: a group-based trajectory analysis
Shuyun Chen, Margareta Persson, Rui Wang, Christina Dalman, Brian K. Lee, Håkan Karlsson, Renee M. Gardner
- Open Access
- Research article
Causal effects of COVID-19 on structural changes in specific brain regions: a Mendelian randomization study
Shaojiong Zhou, Tao Wei, Xiaoduo Liu, Yufei Liu, Weiyi Song, Xinwei Que, Yi Xing, Zhibin Wang, Yi Tang
- Open Access
- Research article
Probiotic supplementation during antibiotic treatment is unjustified in maintaining the gut microbiome diversity: a systematic review and meta-analysis
Anna Júlia Éliás, Viktória Barna, Cristina Patoni, Dóra Demeter, Dániel Sándor Veres, Stefania Bunduc, Bálint Erőss, Péter Hegyi, László Földvári-Nagy, Katalin Lenti
- Open Access
- Research article
Early non-response as a predictor of later non-response to antipsychotics in schizophrenia: a randomized trial
Yujun Long, Qiongqiong Wu, Ye Yang, Jingda Cai, Jingmei Xiao, Zhaoqian Liu, Yifeng Xu, Ying Chen, Manli Huang, Ruiguo Zhang, Xijia Xu, Jian Hu, Zhifen Liu, Fang Liu, Yingjun Zheng, Huaqing Meng, Zhimin Wang, Yanqing Tang, Xueqin Song, Yunchun Chen, Xueyi Wang, Tiebang Liu, Xiaoli Wu, Maosheng Fang, Chunling Wan, Jingping Zhao, Renrong Wu
- Open Access
- Research article
Gastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites
Deyu Zhang, Siyuan Weng, Chuanchao Xia, Yuqing Ren, Zaoqu Liu, Yudi Xu, Xiaoli Yang, Ruhao Wu, Lisi Peng, Liqi Sun, Jiaqi Zhu, Xuesong Liang, Yin Jia, Huaizhou Wang, Qian Chen, Dongtian Liu, Yi Chen, Honglei Guo, Xinwei Han, Zhendong Jin, Cui Chen, Xia Yang, Zhaoshen Li, Haojie Huang
- Open Access
- Research article
Cost-effectiveness of prehabilitation prior to elective surgery: a systematic review of economic evaluations
Tanja Rombey, Helene Eckhardt, Jörn Kiselev, Julia Silzle, Tim Mathes, Wilm Quentin
- Open Access
- Research article
Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants
Yisen Shi, Fabin Lin, Yueping Li, Yingqing Wang, Xiaochun Chen, Fangang Meng, Qinyong Ye, Guoen Cai
- Open Access
- Research article
A network medicine approach to study comorbidities in heart failure with preserved ejection fraction
Jan D. Lanzer, Alberto Valdeolivas, Mark Pepin, Hauke Hund, Johannes Backs, Norbert Frey, Hans-Christoph Friederich, Jobst-Hendrik Schultz, Julio Saez-Rodriguez, Rebecca T. Levinson
- Open Access
- Research article
The expression profiles of signature genes from CD103+LAG3+ tumour-infiltrating lymphocyte subsets predict breast cancer survival
Zi-An Xia, Can Lu, Can Pan, Jia Li, Jun Li, Yitao Mao, Lunquan Sun, Jiang He
- Open Access
- Research article
Efficacy of sustained knowledge translation (KT) interventions in chronic disease management in older adults: systematic review and meta-analysis of complex interventions
Areti Angeliki Veroniki, Charlene Soobiah, Vera Nincic, Yonda Lai, Patricia Rios, Heather MacDonald, Paul A. Khan, Marco Ghassemi, Fatemeh Yazdi, Ross C. Brownson, David A. Chambers, Lisa R. Dolovich, Annemarie Edwards, Paul P. Glasziou, Ian D. Graham, Brenda R. Hemmelgarn, Bev J. Holmes, Wanrudee Isaranuwatchai, France Legare, Jessie McGowan, Justin Presseau, Janet E. Squires, Henry T. Stelfox, Lisa Strifler, Trudy Van der Weijden, Christine Fahim, Andrea C. Tricco, Sharon E. Straus
- Open Access
- Research article
Artificial intelligence for the diagnosis of clinically significant prostate cancer based on multimodal data: a multicenter study
Huiyong Zhang, Jin Ji, Zhe Liu, Huiru Lu, Chong Qian, Chunmeng Wei, Shaohua Chen, Wenhao Lu, Chengbang Wang, Huan Xu, Yalong Xu, Xi Chen, Xing He, Zuheng Wang, Xiaodong Zhao, Wen Cheng, Xingfa Chen, Guijian Pang, Guopeng Yu, Yue Gu, Kangxian Jiang, Bin Xu, Junyi Chen, Bin Xu, Xuedong Wei, Ming Chen, Rui Chen, Jiwen Cheng, Fubo Wang
- Open Access
- Research article
Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study
Ke Yu, Xiao-Feng Chen, Jing Guo, Sen Wang, Xiao-Ting Huang, Yan Guo, Shan-Shan Dong, Tie-Lin Yang
- Open Access
- Research article
Current coffee consumption is associated with decreased striatal dopamine transporter availability in Parkinson’s disease patients and healthy controls
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang
- Open Access
- Correspondence
Estimating the full health and economic benefits of current and future influenza vaccines
K. E. Lafond, R. Gharpure, V. G. Dugan, E. Azziz-Baumgartner
- Open Access
- Research article
Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
- Open Access
- Research article
Metabolic systems approaches update molecular insights of clinical phenotypes and cardiovascular risk in patients with homozygous familial hypercholesterolemia
Zhiyong Du, Fan Li, Long Jiang, Linyi Li, Yunhui Du, Huahui Yu, Yan Luo, Yu Wang, Haili Sun, Chaowei Hu, Jianping Li, Ya Yang, Xiaolu Jiao, Luya Wang, Yanwen Qin
- Open Access
- Opinion
Why estimands are needed to define treatment effects in clinical trials
Oliver N. Keene, Helle Lynggaard, Stefan Englert, Vivian Lanius, David Wright
- Open Access
- Research article
Estimated projection of incidence and mortality of alcohol-related liver disease in China from 2022 to 2040: a modeling study
Meiyu Wu, Shuxia Qin, Chongqing Tan, Sini Li, Ouyang Xie, Xiaomin Wan
- Open Access
- Research article
Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: a prospective cohort study of 413,914 UK Biobank participants
James Webster, Darren C. Greenwood, Janet E. Cade
- Open Access
- Research article
Expanding hepatitis C virus test uptake using self-testing among men who have sex with men in China: two parallel randomized controlled trials
Cheng Wang, Peizhen Zhao, Ann Marie Weideman, Wenqian Xu, Jason J. Ong, Muhammad S. Jamil, Bin Yang, Joseph D. Tucker
- Open Access
- Research article
The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort
Shunming Zhang, Anna Stubbendorff, Ulrika Ericson, Per Wändell, Kaijun Niu, Lu Qi, Yan Borné, Emily Sonestedt
- Open Access
- Editorial
Diabetes and climate change: breaking the vicious cycle
- Open Access
- Research article
A culturally adapted manual-assisted problem-solving intervention (CMAP) for adults with a history of self-harm: a multi-centre randomised controlled trial
Nusrat Husain, Tayyeba Kiran, Imran Bashir Chaudhry, Christopher Williams, Richard Emsley, Usman Arshad, Moin Ahmed Ansari, Paul Bassett, Penny Bee, Moti Ram Bhatia, Carolyn Chew-Graham, Muhammad Omair Husain, Muhammad Irfan, Ayesha Khaliq, Fareed A. Minhas, Farooq Naeem, Haider Naqvi, Asad Tamizuddin Nizami, Amna Noureen, Maria Panagioti, Ghulam Rasool, Sofiya Saeed, Sumira Qambar Bukhari, Sehrish Tofique, Zainab F. Zadeh, Shehla Naeem Zafar, Nasim Chaudhry
- Open Access
- Research article
Ageing as risk factor for tinnitus and its complex interplay with hearing loss—evidence from online and NHANES data
Lisa Reisinger, Fabian Schmidt, Kaja Benz, Lorenzo Vignali, Sebastian Roesch, Martin Kronbichler, Nathan Weisz
- Open Access
- Editorial
Safeguarding mothers and newborns: the urgent need to address hepatitis during pregnancy
- Open Access
- Research article
Common mental health disorders in adults with inflammatory skin conditions: nationwide population-based matched cohort studies in the UK
Alasdair D. Henderson, Elizabeth Adesanya, Amy Mulick, Julian Matthewman, Nhung Vu, Firoza Davies, Catherine H. Smith, Joseph Hayes, Kathryn E. Mansfield, Sinéad M. Langan
- Open Access
- Research article
CSF1R regulates schizophrenia-related stress response and vascular association of microglia/macrophages
Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L. Elliot Hong, Yunlong Tan, Li Tian
- Open Access
- Research article
Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn’s disease
Longyuan Zhou, Liguo Zhu, Xiaomin Wu, Shixian Hu, Shenghong Zhang, Min Ning, Jun Yu, Minhu Chen
- Open Access
- Research article
New tuberculosis vaccines in India: modelling the potential health and economic impacts of adolescent/adult vaccination with M72/AS01E and BCG-revaccination
Rebecca A. Clark, Chathika K. Weerasuriya, Allison Portnoy, Christinah Mukandavire, Matthew Quaife, Roel Bakker, Danny Scarponi, Rebecca C. Harris, Kirankumar Rade, Sanjay Kumar Mattoo, Dheeraj Tumu, Nicolas A. Menzies, Richard G. White
- Open Access
- Research article
Racial differences in long-term social, physical, and psychological health among adolescent and young adult cancer survivors
Sooyeon Kim, Juhee Cho, Dong Wook Shin, Su-Min Jeong, Danbee Kang
- Open Access
- Opinion
Early neuro-rehabilitation in traumatic brain injury: the need for an African perspective
Franklin Chu Buh, Peter J. A. Hutchinson, Fahim Anwar
- Open Access
- Research article
Neurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study
Nanyu Kuang, Zhaowen Liu, Gechang Yu, Xinran Wu, Benjamin Becker, Huaxin Fan, Songjun Peng, Kai Zhang, Jiajia Zhao, Jujiao Kang, Guiying Dong, Xingming Zhao, Barbara J. Sahakian, Trevor W. Robbins, Wei Cheng, Jianfeng Feng, Gunter Schumann, Lena Palaniyappan, Jie Zhang
- Open Access
- Research article
Initiation and duration of folic acid supplementation in preventing congenital malformations
Jing Dong, Lin-Liang Yin, Xue-Dong Deng, Chun-Ya Ji, Qi Pan, Zhong Yang, Ting Peng, Jiang-Nan Wu, Gui-Hua Wu, Liu-Ying Zhou, Mei Li, Yue-Qin Chen, Jia-Xiang Yang, Bai-Song Liang, Tong Ru, Chun-Li Jing, Weng-Rong Zhou, Li Cao, Qin Li, Gui-Ping Li, Tai-Zhu Yang, Xin-Ru Gao, Li-Ling Shi, Yu-Qing Zhou, Xue-Qin Ji, Bo Liang, Qing Han, Ling Ren, Wen-Rong Wang, Guo-Wei Tao
- Open Access
- Research article
Effect of home-based online training and activity feedback on oxygen uptake in patients after surgical cancer therapy: a randomized controlled trial
Roberto Falz, Christian Bischoff, René Thieme, Uwe Tegtbur, Peter Hillemanns, Jens-Uwe Stolzenburg, Bahriye Aktas, Ulrich Bork, Jürgen Weitz, Johannes Lässing, Christian Leps, Johannes Voß, Florian Lordick, Antina Schulze, Ines Gockel, Martin Busse
- Open Access
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Identification of a novel bile marker clusterin and a public online prediction platform based on deep learning for cholangiocarcinoma
Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung, Shun He, Jinqiu Yuan, Wenbo Meng, Xun Li
- Open Access
- Commentary
NICE and NHS England leads the way to improve diabetes care with access to continuous glucose monitoring for people with type 1 diabetes
Sze May Ng
- Open Access
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Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization
Benjamin Woolf, Héléne T. Cronjé, Loukas Zagkos, Stephen Burgess, Dipender Gill, Susanna C. Larsson
- Open Access
- Research article
Adverse childhood and adulthood experiences and risk of new-onset cardiovascular disease with consideration of social support: a prospective cohort study
Wanxin Wang, Yifeng Liu, Yuwei Yang, Weiqing Jiang, Yanyan Ni, Xue Han, Ciyong Lu, Lan Guo
- Open Access
- Research article
Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM
Annelieke R. Müller, Michiel A. J. Luijten, Lotte Haverman, Wendela L. de Ranitz-Greven, Peter Janssens, André B. Rietman, Leontine W. ten Hoopen, Laura C. G. de Graaff, Marie-Claire de Wit, Anna C. Jansen, Tanjala Gipson, Jamie K. Capal, Petrus J. de Vries, Agnies M. van Eeghen
- Open Access
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Estimating disparities in breast cancer screening programs towards mortality, case fatality, and DALYs across BRICS-plus
Sumaira Mubarik, Saima Shakil Malik, Zhang Yanran, Eelko Hak, Nawsherwan, Fang Wang, Chuanhua Yu
- Open Access
- Research article
Pyrotinib plus capecitabine for trastuzumab-resistant, HER2-positive advanced breast cancer (PICTURE): a single-arm, multicenter phase 2 trial
Jun Cao, Yuee Teng, Huiping Li, Lili Zhang, Quchang Ouyang, Weimin Xie, Yueyin Pan, Zhenchuan Song, Xiaoling Ling, Xiaohong Wu, Jingwei Xu, Li Li, Liping Ren, Hong Wang, Dongxian Zhou, Jing Luo, Xichun Hu
- Open Access
- Correspondence
Correspondence to: Estimating the full health and economic benefits of current and future influenza vaccines
Naomi R. Waterlow, Simon R. Procter, Rosalind M. Eggo, Mark Jit
- Open Access
- Research article
Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis
Pan Li, Ping Shuai, Sj Shen, Huimin Zheng, Ping Sun, Renfang Zhang, Shanwei Lan, Zixin Lan, Thisun Jayawardana, Yumei Yang, Jianhui Zhao, Yuping Liu, Xia Chen, Emad M. El-Omar, Zhengwei Wan
- Open Access
- Guideline
Intensive community care services for children and young people in psychiatric crisis: an expert opinion
Eleanor Keiller, Saba Masood, Ben Hoi-ching Wong, Cerian Avent, Kofi Bediako, Rebecca Margaret Bird, Isabel Boege, Marta Casanovas, Veronika Beatrice Dobler, Maya James, Jane Kiernan, Maria Martinez-Herves, Thinh Vinh Thanh Ngo, Ana Pascual-Sanchez, Izabela Pilecka, Paul L Plener, Karin Prillinger, Isabelle Sabbah Lim, Tania Saour, Nidhita Singh, Eirini Skouta, Mariana Steffen, Jovanka Tolmac, Hemma Velani, Ruth Woolhouse, Toby Zundel, Dennis Ougrin
- Open Access
- Research article
Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population
Aravind Lathika Rajendrakumar, Simona M. Hapca, Anand Thakarakkattil Narayanan Nair, Yu Huang, Mehul Kumar Chourasia, Ryan Shun-Yuen Kwan, Charvi Nangia, Moneeza K. Siddiqui, Prathiba Vijayaraghavan, Shona Z. Matthew, Graham P. Leese, Viswanathan Mohan, Ewan R. Pearson, Alexander S. F. Doney, Colin N. A. Palmer
- Open Access
- Research article
Healthcare fragmentation, multimorbidity, potentially inappropriate medication, and mortality: a Danish nationwide cohort study
Anders Prior, Claus Høstrup Vestergaard, Peter Vedsted, Susan M. Smith, Line Flytkjær Virgilsen, Linda Aagaard Rasmussen, Morten Fenger-Grøn
- Open Access
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Potential value of ctDNA monitoring in metastatic HR + /HER2 − breast cancer: longitudinal ctDNA analysis in the phase Ib MONALEESASIA trial
Joanne Chiu, Fei Su, Mukta Joshi, Norikazu Masuda, Takashi Ishikawa, Tomoyuki Aruga, Juan Pablo Zarate, Naveen Babbar, O. Alejandro Balbin, Yoon-Sim Yap
- Open Access
- Research article
The associations of dietary patterns with depressive and anxiety symptoms: a prospective study
Han Chen, Zhi Cao, Yabing Hou, Hongxi Yang, Xiaohe Wang, Chenjie Xu
- Open Access
- Commentary
Underrepresentation of ethnic minorities in UK COVID-19 trials: comment on a recent systematic review and meta-analysis
Zeynep Ersoy Guller, Frederick Green, Anna L. Goodman
- Open Access
- Research article
Impact of data source choice on multimorbidity measurement: a comparison study of 2.3 million individuals in the Welsh National Health Service
Clare MacRae, Daniel Morales, Stewart W. Mercer, Nazir Lone, Andrew Lawson, Emily Jefferson, David McAllister, Marjan van den Akker, Alan Marshall, Sohan Seth, Anna Rawlings, Jane Lyons, Ronan A. Lyons, Amy Mizen, Eleojo Abubakar, Chris Dibben, Bruce Guthrie
- Open Access
- Research article
Association between plant-based dietary pattern and biological aging trajectory in a large prospective cohort
Sicong Wang, Wenyuan Li, Shu Li, Huakang Tu, Junlin Jia, Wenting Zhao, Andi Xu, Wenxin Xu, Min Kuang Tsai, David Ta-Wei Chu, Chi Pang Wen, Xifeng Wu
- Open Access
- Correction
Correction: Socioeconomic position and prognosis in premenopausal breast cancer: a population-based cohort study in Denmark
Cathrine Fonnesbech Hjorth, Per Damkier, Bent Ejlertsen, Timothy Lash, Henrik Toft Sørensen, Deirdre Cronin-Fenton
- Open Access
- Research article
Inappropriate hospital admission as a risk factor for the subsequent development of adverse events: a cross-sectional study
Diego San Jose-Saras, Jorge Vicente-Guijarro, Paulo Sousa, Paloma Moreno-Nunez, Jesús María Aranaz-Andres, Cristina Díaz-Agero Pérez, Miguel Ignacio Cuchi Alfaro, Juan Manuel Ramos López, Mercedes García Haro, Abelardo Claudio Fernández Chávez, Cornelia Bischofberger Valdés, Amaranta Mcgee Laso, Carmen Garrote Liarte, Gerardo Gómez Montero, Juan Daniel Miranda Cortes, Gema Nieto Gomez, Jessica Alia Herrero, Sara de la Hoz San Clemente, Marta Gonzalez Touya, Moisés David Espejo Mambié, Diana Carretero Gomez, Manuela Serrano Pareja, Marco Antonio Espinel Ruiz, Raquel Gutierrez Gallardo, Eva Elisa Álvarez León, Paloma Navas Gutiérrez, Nerea Armenteros Arzá, Francisco Bolumar Montrull, Ana García de la Santa Viñuela, Raquel Arguedas Sanz, Miriam Roncal Redín
- Open Access
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Global impact and cost-effectiveness of one-dose versus two-dose human papillomavirus vaccination schedules: a comparative modelling analysis
Kiesha Prem, Yoon Hong Choi, Élodie Bénard, Emily A. Burger, Liza Hadley, Jean-François Laprise, Mary Caroline Regan, Mélanie Drolet, Stephen Sy, Kaja Abbas, Allison Portnoy, Jane J. Kim, Marc Brisson, Mark Jit
- Open Access
- Research article
The development of a core outcome set for studies of pregnant women with multimorbidity
Siang Ing Lee, Stephanie Hanley, Zoe Vowles, Rachel Plachcinski, Ngawai Moss, Megha Singh, Chris Gale, Adeniyi Francis Fagbamigbe, Amaya Azcoaga-Lorenzo, Anuradhaa Subramanian, Beck Taylor, Catherine Nelson-Piercy, Christine Damase-Michel, Christopher Yau, Colin McCowan, Dermot O’Reilly, Gillian Santorelli, Helen Dolk, Holly Hope, Katherine Phillips, Kathryn M. Abel, Kelly-Ann Eastwood, Lisa Kent, Louise Locock, Maria Loane, Mohamed Mhereeg, Peter Brocklehurst, Sharon McCann, Sinead Brophy, Steven Wambua, Sudasing Pathirannehelage Buddhika Hemali Sudasinghe, Shakila Thangaratinam, Krishnarajah Nirantharakumar, Mairead Black
- Open Access
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Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8+ T cells to demote the antitumor immunity
Ruochan Zhang, Kun Chen, Caifeng Gong, Zhiyuan Wu, Chungui Xu, Xing-Ning Li, Fei Zhao, Dongmei Wang, Jianqiang Cai, Aiping Zhou, Chunfeng Qu
- Open Access
- Research article
An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses
Jong Yeob Kim, Minku Song, Min Seo Kim, Pradeep Natarajan, Ron Do, Woojae Myung, Hong-Hee Won
- Open Access
- Research article
Maternal pre-pregnancy BMI, offspring epigenome-wide DNA methylation, and childhood obesity: findings from the Boston Birth Cohort
Jiahui Si, Anat Yaskolka Meir, Xiumei Hong, Guoying Wang, Wanyu Huang, Colleen Pearson, William G. Adams, Xiaobin Wang, Liming Liang
- Open Access
- Research article
Alcohol exposure before and during pregnancy is associated with reduced fetal growth: the Safe Passage Study
Marin Pielage, Hanan El Marroun, Hein J. Odendaal, Sten P. Willemsen, Manon H. J. Hillegers, Eric A. P. Steegers, Melek Rousian
- Open Access
- Research article
Understanding primary care transformation and implications for ageing populations and health inequalities: a systematic scoping review of new models of primary health care in OECD countries and China
D. A. G Henderson, E Donaghy, M Dozier, B Guthrie, H Huang, M Pickersgill, E Stewart, A Thompson, H. H. X Wang, S. W Mercer
- Open Access
- Research article
Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study
Makoto Saito, Aung Pyae Phyo, Cindy Chu, Stephane Proux, Marcus J. Rijken, Candy Beau, Htun Htun Win, Laypaw Archasuksan, Jacher Wiladphaingern, Nguyen H. Phu, Tran T. Hien, Nick P. Day, Arjen M. Dondorp, Nicholas J. White, François Nosten, Rose McGready
- Open Access
- Research article
Benefits of near-universal vaccination and treatment access to manage COVID-19 burden in the United States
Fuhan Yang, Thu Nguyen-Anh Tran, Emily Howerton, Maciej F. Boni, Joseph L. Servadio
- Open Access
- Research article
Vestibular rehabilitation therapy on balance and gait in patients after stroke: a systematic review and meta-analysis
Lijiao Meng, Qiu Liang, Jianrong Yuan, Siyi Li, Yanlei Ge, Jingyi Yang, Raymond C C Tsang, Quan Wei
- Open Access
- Research article
Metabolic characteristics and pathogenesis of precocious puberty in girls: the role of perfluorinated compounds
Jinxia Wu, Jing Chen, Rong Huang, Hongwei Zhu, Lin Che, Yanyan Lin, Yajie Chang, Guiping Shen, Jianghua Feng
- Open Access
- Research article
Chronic remote ischemic conditioning treatment in patients with chronic stable angina (EARLY-MYO-CSA): a randomized, controlled proof-of-concept trial
Quan Guo, Zhenzhou Zhao, Fan Yang, Zhiwen Zhang, Xiaoyu Rao, Jing Cui, Qingbo Shi, Kaiyuan Liu, Kang Zhao, Haiyu Tang, Liang Peng, Cao Ma, Jun Pu, Muwei Li
- Open Access
- Commentary
Sustainability of knowledge translation interventions: the evidence lacks evidence
Alexis Descatha, Marc Fadel
- Open Access
- Research article
Identification and prediction model of placenta-brain axis genes associated with neurodevelopmental delay in moderate and late preterm children
Yumin Zhu, Yimin Zhang, Yunfan Jin, Heyue Jin, Kun Huang, Juan Tong, Hong Gan, Chen Rui, Jia Lv, Xianyan Wang, Qu’nan Wang, Fangbiao Tao
- Open Access
- Research article
Targeted delivery of a PD-1-blocking scFv by CD133-specific CAR-T cells using nonviral Sleeping Beauty transposition shows enhanced antitumour efficacy for advanced hepatocellular carcinoma
Chaopin Yang, Jinqi You, Qiuzhong Pan, Yan Tang, Liming Cai, Yue Huang, Jiamei Gu, Yizhi Wang, Xinyi Yang, Yufei Du, Dijun Ouyang, Hao Chen, Haoran Zhong, Yongqiang Li, Jieying Yang, Yulong Han, Fengze Sun, Yuanyuan Chen, Qijing Wang, Desheng Weng, Zhongqiu Liu, Tong Xiang, Jianchuan Xia
- Open Access
- Research article
Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China
Tianqi Tan, Tingting Chen, Wenwen Zhu, Lin Gong, Yizhong Yan, Qian Li, Li Chen, Yiling Li, Jialin Liu, Yanan Li, Xuefeng Yang, Liping Hao, Huaiji Wang, Nianhong Yang, Sheng Wei
- Open Access
- Research article
Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases
Qi Zhou, Xufeng Tao, Fangyue Guo, Yu Wu, Dawei Deng, Linlin Lv, Deshi Dong, Dong Shang, Hong Xiang
- Open Access
- Research article
CAR-T cells targeting CD38 and LMP1 exhibit robust antitumour activity against NK/T cell lymphoma
Hongwen Li, Wenting Song, Jiazhuo Wu, Zhuangzhuang Shi, Yuyang Gao, Jiwei Li, Lijuan Han, Jianxiang Zhang, Zhaoming Li, Yong Li, Mingzhi Zhang
- Open Access
- Software
Tabby2: a user-friendly web tool for forecasting state-level TB outcomes in the United States
Nicole A. Swartwood, Christian Testa, Ted Cohen, Suzanne M. Marks, Andrew N. Hill, Garrett Beeler Asay, Jennifer Cochran, Kevin Cranston, Liisa M. Randall, Andrew Tibbs, C. Robert Horsburgh Jr, Joshua A. Salomon, Nicolas A. Menzies
- Open Access
- Review
Telehealth in antenatal care: recent insights and advances
Jessica Atkinson, Roxanne Hastie, Susan Walker, Anthea Lindquist, Stephen Tong
- Open Access
- Editorial
Psychobiotics and the need for better interventional data
- Open Access
- Editorial
The write algorithm: promoting responsible artificial intelligence usage and accountability in academic writing
Steven Bell
- Open Access
- Research article
Fluorescence-tagged salivary small extracellular vesicles as a nanotool in early diagnosis of Parkinson’s disease
Simran Rastogi, Komal Rani, Sanskriti Rai, Rishabh Singh, Prahalad Singh Bharti, Vaibhav Sharma, Jyoti Sahu, Vrinda Kapoor, Poorvi Vishwakarma, Sumit Garg, Shivajirao Lahu Gholap, Krishna Kishore Inampudi, Gyan Prakash Modi, Neerja Rani, Madhavi Tripathi, Achal Srivastava, Roopa Rajan, Fredrik Nikolajeff, Saroj Kumar
- Open Access
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Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening
Zhongguang Luo, Bangting Wang, Feifei Luo, Yumeng Guo, Ning Jiang, Jinsong Wei, Xin Wang, Yujen Tseng, Jian Chen, Bing Zhao, Jie Liu
- Open Access
- Research article
Exogenous female sex steroid hormones and new-onset asthma in women: a matched case–control study
Guoqiang Zhang, Rani Basna, Maya B. Mathur, Cecilia Lässer, Roxana Mincheva, Linda Ekerljung, Göran Wennergren, Madeleine Rådinger, Bo Lundbäck, Hannu Kankaanranta, Bright I. Nwaru
- Open Access
- Research article
Effect of chimeric antigen receptor T cells against protease-activated receptor 1 for treating pancreatic cancer
Hao-Chien Hung, Ming-Huei Fan, Daniel Wang, Carol H. Miao, Pong Su, Chao-Lien Liu
- Open Access
- Research article
Evidence of questionable research practices in clinical prediction models
Nicole White, Rex Parsons, Gary Collins, Adrian Barnett
- Open Access
- Research article
Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance
Wichanon Sae-jie, Suangsuda Supasai, Mika Kivimaki, Jackie F. Price, Andrew Wong, Meena Kumari, Jorgen Engmann, Tina Shah, Amand F. Schmidt, Tom R. Gaunt, Aroon Hingorani, Pimphen Charoen
- Open Access
- Research article
Prenatal ambient air pollution exposure and child weight trajectories from the 3rd trimester of pregnancy to 2 years of age: a cohort study
Nan Ji, Mark Johnson, Sandrah P. Eckel, William J. Gauderman, Thomas A. Chavez, Kiros Berhane, Dema Faham, Fred Lurmann, Nathan R. Pavlovic, Brendan H. Grubbs, Deborah Lerner, Rima Habre, Shohreh F. Farzan, Theresa M. Bastain, Carrie V. Breton
- Open Access
- Research article
Detection of diabetic patients in people with normal fasting glucose using machine learning
Kun Lv, Chunmei Cui, Rui Fan, Xiaojuan Zha, Pengyu Wang, Jun Zhang, Lina Zhang, Jing Ke, Dong Zhao, Qinghua Cui, Liming Yang
- Open Access
- Correspondence
Re: Molecular testing to deliver personalised chemotherapy recommendations
Peter Gibbs, Wei Hong, Jeanne Tie
- Open Access
- Correspondence
Additional considerations before using a ctDNA-guided approach for informing adjuvant chemotherapy in colorectal cancer
Timothée Olivier, Alyson Haslam, Vinay Prasad
- Open Access
- Correspondence
Substantially more children receiving antidepressants see a specialist than reported by Jack et al.
Vicky P. Taxiarchi, Carolyn A. Chew-Graham, Matthias Pierce
- Open Access
- Correspondence
Importance of accurate and accessible recording of healthcare contacts in mental health
Ruth H. Jack, Carol A. C. Coupland, Rebecca M. Joseph, Chris Hollis, Richard Morriss, Roger David Knaggs, Andrea Cipriani, Samuele Cortese, Julia Hippisley-Cox
- Open Access
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Integrated epigenome, whole genome sequence and metabolome analyses identify novel multi-omics pathways in type 2 diabetes: a Middle Eastern study
Noha A. Yousri, Omar M. E. Albagha, Steven C. Hunt
- Open Access
- Research article
Association of caesarean delivery with offspring health outcomes in full-cohort versus sibling-comparison studies: a comparative meta-analysis and simulation study
Hong-zhao Yu, Xiao-wei Wang, Zhen-yu Guo, Zhi Lin, Yu-bo Zhou, Hong-tian Li, Jian-meng Liu
- Open Access
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Integrated unbiased multiomics defines disease-independent placental clusters in common obstetrical syndromes
Oren Barak, Tyler Lovelace, Samantha Piekos, Tianjiao Chu, Zhishen Cao, Elena Sadovsky, Jean-Francois Mouillet, Yingshi Ouyang, W. Tony Parks, Leroy Hood, Nathan D. Price, Panayiotis V. Benos, Yoel Sadovsky
- Open Access
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Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysis
Claire Prince, Laura D. Howe, Gemma C. Sharp, Abigail Fraser, Rebecca C. Richmond
- Open Access
- Research article
Plant-based diets, genetic predisposition and risk of non-alcoholic fatty liver disease
Yanling Lv, Shuang Rong, Yan Deng, Wei Bao, Yang Xia, Liangkai Chen
- Open Access
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Maternal multimorbidity and preterm birth in Scotland: an observational record-linkage study
Amaya Azcoaga-Lorenzo, Adeniyi Francis Fagbamigbe, Utkarsh Agrawal , Mairead Black, Muhammad Usman, Siang Ing Lee, Kelly-Ann Eastwood, Ngawai Moss, Rachel Plachcinski, Catherine Nelson-Piercy, Sinead Brophy, Dermot O’Reilly, Krishnarajah Nirantharakumar, Colin McCowan
- Open Access
- Research article
Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses
Li Zhang, Wenqiang Zhang, Lin He, Huijie Cui, Yutong Wang, Xueyao Wu, Xunying Zhao, Peijing Yan, Chao Yang, Changfeng Xiao, Mingshuang Tang, Lin Chen, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Yanfang Yang, Ling Zhang, Yuqin Yao, Jiayuan Li, Zhenmi Liu, Chunxia Yang, Xia Jiang, Ben Zhang
- Open Access
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A roadmap for sex- and gender-disaggregated health research
Sanne A. E. Peters, Mark Woodward
- Open Access
- Research article
Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study
Vasilios Karageorgiou, Francesco Casanova, Jessica O’Loughlin, Harry Green, Trevelyan J. McKinley, Jack Bowden, Jessica Tyrrell
- Open Access
- Research article
Financial hardship associated with catastrophic out-of-pocket spending tied to primary care services in low- and lower-middle-income countries: findings from a modeling study
Sarah Bolongaita, Yeeun Lee, Kjell Arne Johansson, Øystein A. Haaland, Mieraf Taddesse Tolla, Jongwook Lee, Stéphane Verguet
- Open Access
- Research article
A urinary assay for mutation and methylation biomarkers in the diagnosis and recurrence prediction of non-muscle invasive bladder cancer patients
Hai Huang, Ao Liu, Yiming Liang, Yaqun Xin, Jiacheng Liu, Yining Hao, Da Huang, Lu Chen, Wei Li, Guangliang Jiang, Yuhua Huang, Yaoting Xu, Jie Zhang, Tonghui Ma, Danfeng Xu, Yi Gao
- Open Access
- Research article
Patient-reported reactogenicity and safety of COVID-19 vaccinations vs. comparator vaccinations: a comparative observational cohort study
Felix Werner, Nikoletta Zeschick, Thomas Kühlein, Philipp Steininger, Klaus Überla, Isabelle Kaiser, Maria Sebastião, Susann Hueber, Lisette Warkentin
- Open Access
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The influence of explainable vs non-explainable clinical decision support systems on rapid triage decisions: a mixed methods study
Daniel Laxar, Magdalena Eitenberger, Mathias Maleczek, Alexandra Kaider, Fabian Peter Hammerle, Oliver Kimberger
- Open Access
- Research article
Small volume bone marrow aspirates with high progenitor cell concentrations maximize cell therapy dose manufacture and substantially reduce donor hemoglobin loss
Jeremy Epah, Gabriele Spohn, Kathrin Preiß, Markus M. Müller, Johanna Dörr, Rainer Bauer, Shabnam Daqiq-Mirdad, Joachim Schwäble, Stefanie N. Bernas, Alexander H. Schmidt, Erhard Seifried, Richard Schäfer
- Open Access
- Research article
Larval therapy vs conventional silver dressings for full-thickness burns: a randomized controlled trial
Jasem Gaffari, Kamran Akbarzadeh, Mozhgan Baniardalani, Reza Hosseini, Safdar Masoumi, Zahra Sadat Amiri, Razieh Shabani Kordshouli, Javad Rafinejad, Mostafa Dahmardehei
- Open Access
- Research article
Evidencing general acceptability of open-label placebo use for tackling overtreatment in primary care: a mixed methods study
E. M. Krockow, T. Emerson, E. Youssef, S. Scott, S. Tromans
- Open Access
- Research article
Incidence of immune-mediated inflammatory diseases following COVID-19: a matched cohort study in UK primary care
Umer Syed, Anuradhaa Subramanian, David C. Wraith, Janet M. Lord, Kirsty McGee, Krishna Ghokale, Krishnarajah Nirantharakumar, Shamil Haroon
- Open Access
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The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial
Anat Yaskolka Meir, Maria Keller, Anne Hoffmann, Ehud Rinott, Gal Tsaban, Alon Kaplan, Hila Zelicha, Tobias Hagemann, Uta Ceglarek, Berend Isermann, Ilan Shelef, Matthias Blüher, Michael Stumvoll, Jun Li, Sven-Bastian Haange, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Martin von Bergen, Frank B. Hu, Meir J. Stampfer, Peter Kovacs, Liming Liang, Iris Shai
- Open Access
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Diagnostic and societal impact of implementing the syncope guidelines of the European Society of Cardiology (SYNERGY study)
M. Ghariq, W. B. van den Hout, O. M. Dekkers, M. Bootsma, B. de Groot, J. G. J. Groothuis, M. P. M. Harms, M. E. W. Hemels, E. C. A. Kaal, E. M. Koomen, F. J. de Lange, S. Y. G. Peeters, I. A. van Rossum, J. H. W. Rutten, E. W. van Zwet, J. G. van Dijk, R. D. Thijs, R. M. Tuinema, W. Voet, D. B. Boerman, M. Firouzi, C. Fokke
- Open Access
- Research article
ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization
Xiaolin Lu, Ruiqi Liu, Yuanyu Liao, Luying Cui, Haoxiu Sun, Dongzhi Zhang, Bojun Wang, Lin Fang, Xin Guan, Yuanfei Yao, Chao Liu, Yanqiao Zhang
- Open Access
- Research article
What is the impact of one’s chronic illness on his or her spouse’s future chronic illness: a community-based prospective cohort study
Hoyoung An, Hee Won Yang, Dae Jong Oh, Eunji Lim, Jin Shin, Dong Gyu Moon, Seung Wan Suh, Seonjeong Byun, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Jong Bin Bae, Ji Won Han, Ki Woong Kim
- Open Access
- Correction
Correction: Identification of a novel bile marker clusterin and a public online prediction platform based on deep learning for cholangiocarcinoma
Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung, Shun He, Jinqiu Yuan, Wenbo Meng, Xun Li
- Open Access
- Correction
Correction: Multiplex immunohistochemistry defines the tumor immune microenvironment and immunotherapeutic outcome in CLDN18.2-positive gastric cancer
Keren Jia, Yang Chen, Yu Sun, Yajie Hu, Lei Jiao, Jie Ma, Jiajia Yuan, Changsong Qi, Yanyan Li, Jifang Gong, Jing Gao, Xiaotian Zhang, Jian Li, Cheng Zhang, Lin Shen
- Open Access
- Research article
Healthcare professionals’ views on the accessibility and acceptability of perinatal mental health services for South Asian and Black women: a qualitative study
Kiren Bains, Sarah Bicknell, Nikolina Jovanović, Maev Conneely, Rosemarie McCabe, Alex Copello, Jessica Fletcher-Rogers, Stefan Priebe, Jelena Janković
- Open Access
- Commentary
Perinatal mental health services for women from minority ethnic groups: why patient-centred approach matter
Shanquan Chen, Huyang Zhang, Hannah Kuper
- Open Access
- Review
Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress
Yu Shi, Wen Wu
- Open Access
- Research article
Five-year results of a treatment program for chronic hepatitis B in Ethiopia
Hailemichael Desalegn, Stian Magnus Staurung Orlien, Hanna Aberra, Eyerusalem Mamo, Sine Grude, Kristina Hommersand, Nega Berhe, Svein Gunnar Gundersen, Asgeir Johannessen
- Open Access
- Research article
Assessing changes in incubation period, serial interval, and generation time of SARS-CoV-2 variants of concern: a systematic review and meta-analysis
Xiangyanyu Xu, Yanpeng Wu, Allisandra G. Kummer, Yuchen Zhao, Zexin Hu, Yan Wang, Hengcong Liu, Marco Ajelli, Hongjie Yu
- Open Access
- Research article
Real-world data emulating randomized controlled trials of non-vitamin K antagonist oral anticoagulants in patients with venous thromboembolism
Dongwon Yoon, Han Eol Jeong, Sohee Park, Seng Chan You, Soo-Mee Bang, Ju-Young Shin
- Open Access
- Research article
A phase 1 trial of fuzuloparib in combination with apatinib for advanced ovarian and triple-negative breast cancer: efficacy, safety, pharmacokinetics and germline BRCA mutation analysis
Yaxin Liu, Wei Wang, Rutie Yin, Youzhong Zhang, Yu Zhang, Keqiang Zhang, Hongming Pan, Ke Wang, Ge Lou, Guiling Li, Ruyan Zhang, Kun Li, Jing Rao, Ben Zhang, Yuting Wang, Quanren Wang, Yunong Gao, Huiping Li
- Open Access
- Research article
Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma
Qiangsheng Wang, Qiqin Shi, Zhenqian Wang, Jiawen Lu, Jian Hou
- Open Access
- Research article
Non-pharmacological interventions for smoking cessation: analysis of systematic reviews and meta-analyses
Tao Nian, Kangle Guo, Wendi Liu, Xinxin Deng, Xiaoye Hu, Meng Xu, Fenfen E, Ziyi Wang, Guihang Song, Kehu Yang, Xiuxia Li, Wenru Shang
- Open Access
- Research article
Effect of provision of non-alcoholic beverages on alcohol consumption: a randomized controlled study
Hisashi Yoshimoto, Kyoko Kawaida, Shohei Dobashi, Go Saito, Yukiko Owaki
- Open Access
- Research article
Return to work and health-related quality of life up to 1 year in patients hospitalized for COVID-19: the CO-FLOW study
L. M. Bek, J. C. Berentschot, M. E. Hellemons, S. C. Remerie, J. van Bommel, J. G. J. V. Aerts, G. M. Ribbers, H. J. G. van den Berg-Emons, M. H. Heijenbrok-Kal, Michel E. van Genderen, Diederik A. M. P. J. Gommers, Erwin Ista, Robert van der Stoep, Rutger Osterthun, Markus P. J. M. Wijffels, Marieke M. Visser, Janette J. Tazmi-Staal, Eva G. Willems, Roxane Heller, Shai A. Gajadin, Wouter J. B. Blox, Laurien Oswald, Sieshem Bindraban, Herbert J. van de Sande, Ronald N. van Rossem, Stephanie van Loon-Kooij
- Open Access
- Research article
Impacts of performance-based financing on health system performance: evidence from the Democratic Republic of Congo
Gil Shapira, Emma Clarke-Deelder, Baudouin Makuma Booto, Hadia Samaha, György Bèla Fritsche, Michel Muvudi, Dominique Baabo, Delphin Antwisi, Didier Ramanana, Saloua Benami, Günther Fink
- Open Access
- Research article
Effects of a text messaging smoking cessation intervention amongst online help-seekers and primary health care visitors: findings from a randomised controlled trial
Jenny Blomqvist, Katarina Ulfsdotter Gunnarsson, Preben Bendtsen, Marcus Bendtsen
- Open Access
- Research article
The Biomarker Toolkit — an evidence-based guideline to predict cancer biomarker success and guide development
Katerina-Vanessa Savva, Michal Kawka, Bhamini Vadhwana, Rahul Penumaka, Imogen Patton, Komal Khan, Claire Perrott, Saranya Das, Maxime Giot, Stella Mavroveli, George B. Hanna, Melody Zhifang Ni, Christopher J. Peters
- Open Access
- Research article
Social connection and mortality in UK Biobank: a prospective cohort analysis
Hamish M. E. Foster, Jason M. R. Gill, Frances S. Mair, Carlos A. Celis-Morales, Bhautesh D. Jani, Barbara I. Nicholl, Duncan Lee, Catherine A. O’Donnell
- Open Access
- Research article
Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study
Nikhil Arora, Laxmi Bhatta, Eivind Schjelderup Skarpsno, Håvard Dalen, Bjørn Olav Åsvold, Ben Michael Brumpton, Rebecca Claire Richmond, Linn Beate Strand
- Open Access
- Research article
Phase III clinical trial of autologous CD34 + cell transplantation to accelerate fracture nonunion repair
Ryosuke Kuroda, Takahiro Niikura, Tomoyuki Matsumoto, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Hironobu Minami, Hiroshi Matsuoka, Kimikazu Yakushijin, Yoshiharu Miyata, Shinichiro Kawamoto, Tatsuo Kagimura, Yasuyuki Fujita, Atsuhiko Kawamoto
- Open Access
- Commentary
The one-dose schedule opens the door to rapid scale-up of HPV vaccination
Zhuoru Zou, Lei Zhang
- Open Access
- Research article
Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial
Mingtong Xu, Kan Sun, Wenjie Xu, Chuan Wang, Dewen Yan, Shu Li, Li Cong, Yinzhen Pi, Weihong Song, Qingyuan Sun, Rijun Xiao, Weixia Peng, Jianping Wang, Hui Peng, Yawei Zhang, Peng Duan, Meiying Zhang, Jianying Liu, Qingmei Huang, Xuefeng Li, Yan Bao, Tianshu Zeng, Kun Wang, Li Qin, Chaoming Wu, Chunying Deng, Chenghu Huang, Shuang Yan, Wei Zhang, Meizi Li, Li Sun, Yanjun Wang, HongMei Li, Guang Wang, Shuguang Pang, Xianling Zheng, Haifang Wang, Fujun Wang, Xiuhai Su, Yujin Ma, Wei Zhang, Ziling Li, Zuoling Xie, Ning Xu, Lin Ni, Li Zhang, Xiangqun Deng, Tianrong Pan, Qijuan Dong, Xiaohong Wu, Xingping Shen, Xin Zhang, Qijing Zou, Chengxia Jiang, Jue Xi, Jianhua Ma, Jingchao Sun, Li Yan
- Open Access
- Research article
Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study
Hui Gao, Shuhao Zheng, Xin Yuan, Jiarong Xie, Lei Xu
- Open Access
- Research article
Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
Sangeetha Shyam, Jesús Francisco García-Gavilán, Indira Paz-Graniel, José J. Gaforio, Miguel Ángel Martínez-González, Dolores Corella, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, J. Luís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martín Sánchez, Xavier Pintó, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia-Regata, Estefania Toledo, Eva M. Asensio, Olga Castañer, Antonio Garcia-Rios, Laura Torres-Collado, Enrique Gómez-Gracia, M. Angeles Zulet, Nuria Goñi Ruiz, Rosa Casas, Naomi Cano-Ibáñez, Lucas Tojal-Sierra, A. M. Gómez-Perez, Jose V. Sorlí, Sergio Cinza-Sanjurjo, Sandra Martín-Peláez, Patricia J. Peña-Orihuela, Alejandro Oncina-Canovas, Rafael Perez-Araluce, María Dolores Zomeño, Alice Chaplin, Miguel Delgado-Rodríguez, Nancy Babio, Montserrat Fitó, Jordi Salas-Salvadó
- Open Access
- Research article
Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer
Katharina Nimptsch, Krasimira Aleksandrova, Thu Thi Pham, Nikos Papadimitriou, Jürgen Janke, Sofia Christakoudi, Alicia Heath, Anja Olsen, Anne Tjønneland, Matthias B. Schulze, Verena Katzke, Rudolf Kaaks, Bethany van Guelpen, Justin Harbs, Domenico Palli, Alessandra Macciotta, Fabrizio Pasanisi, Sandra Milena Colorado Yohar, Marcela Guevara, Pilar Amiano, Sara Grioni, Paula Gabriela Jakszyn, Jane C. Figueiredo, N. Jewel Samadder, Christopher I. Li, Victor Moreno, John D. Potter, Robert E. Schoen, Caroline Y. Um, Elisabete Weiderpass, Mazda Jenab, Marc J. Gunter, Tobias Pischon
- Open Access
- Research article
Beneficial effects of recombinant CER-001 high-density lipoprotein infusion in sepsis: results from a bench to bedside translational research project
Alessandra Stasi, Marco Fiorentino, Rossana Franzin, Francesco Staffieri, Sabrina Carparelli, Rosa Losapio, Alberto Crovace, Luca Lacitignola, Maria Teresa Cimmarusti, Francesco Murgolo, Monica Stufano, Cesira Cafiero, Giuseppe Castellano, Fabio Sallustio, Chiara Ferrari, Mario Ribezzi, Nicola Brienza, Annalisa Schirinzi, Francesca Di Serio, Salvatore Grasso, Paola Pontrelli, Cyrille Tupin, Ronald Barbaras, Constance Keyserling-Peyrottes, Antonio Crovace, Loreto Gesualdo
- Open Access
- Research article
Association of breastfeeding with mental disorders in mother and child: a systematic review and meta-analysis
Polina Bugaeva, Inna Arkusha, Rinat Bikaev, Igor Kamenskiy, Aleksandra Pokrovskaya, Yasmin El-Taravi, Valeria Caso, Alla Avedisova, Derek K. Chu, Jon Genuneit, Gabriel Torbahn, Timothy R. Nicholson, Dina Baimukhambetova, Aigun Mursalova, Anastasia Kolotilina, Svetlana Gadetskaya, Elena Kondrikova, Mikhail Zinchuk, Renat Akzhigitov, Robert J. Boyle, Alla Guekht, Daniel Munblit
- Open Access
- Research article
Cardiovascular outcomes between COVID-19 and non-COVID-19 pneumonia: a nationwide cohort study
Min-Taek Lee, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung, Won-Young Kim
- Open Access
- Research article
Combination of GT90001 and nivolumab in patients with advanced hepatocellular carcinoma: a multicenter, single-arm, phase 1b/2 study
Chiun Hsu, Yi-Fang Chang, Chia-Jui Yen, Yu-Wei Xu, Min Dong, You-Zhi Tong
- Open Access
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Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection
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Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo
Marie A. Onyamboko, Peter Olupot-Olupot, Winifred Were, Cate Namayanja, Peter Onyas, Harriet Titin, Joy Baseke, Rita Muhindo, Daddy K. Kayembe, Pauline O. Ndjowo, Benjamin B. Basara, Charles B. Okalebo, Thomas N. Williams, Sophie Uyoga, Chiraporn Taya, Adeola Bamisaiye, Caterina Fanello, Kathryn Maitland, Nicholas P. J. Day, Walter R. J. Taylor, Mavuto Mukaka
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Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank
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Racial differences in healthcare expenditures for prevalent multimorbidity combinations in the USA: a cross-sectional study
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- Open Access
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A 10-year update to the principles for clinical trial data sharing by pharmaceutical companies: perspectives based on a decade of literature and policies
Natansh D. Modi, Ganessan Kichenadasse, Tammy C. Hoffmann, Mark Haseloff, Jessica M. Logan, Areti A. Veroniki, Rebecca L. Venchiarutti, Amelia K. Smit, Haitham Tuffaha, Harindra Jayasekara, Arkady Manning-Bennet, Erin Morton, Ross A. McKinnon, Andrew Rowland, Michael J. Sorich, Ashley M. Hopkins
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- Correction
Correction: Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM
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A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy
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Interventions to address unprofessional behaviours between staff in acute care: what works for whom and why? A realist review
Jill Maben, Justin Avery Aunger, Ruth Abrams, Judy M. Wright, Mark Pearson, Johanna I. Westbrook, Aled Jones, Russell Mannion
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Substitution of animal-based with plant-based foods on cardiometabolic health and all-cause mortality: a systematic review and meta-analysis of prospective studies
Manuela Neuenschwander, Julia Stadelmaier, Julian Eble, Kathrin Grummich, Edyta Szczerba, Eva Kiesswetter, Sabrina Schlesinger, Lukas Schwingshackl
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Deep learning models of ultrasonography significantly improved the differential diagnosis performance for superficial soft-tissue masses: a retrospective multicenter study
Bin Long, Haoyan Zhang, Han Zhang, Wen Chen, Yang Sun, Rui Tang, Yuxuan Lin, Qiang Fu, Xin Yang, Ligang Cui, Kun Wang
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Shoulder replacement surgery’s rising demand, inequality of provision, and variation in outcomes: cohort study using Hospital Episode Statistics for England
Epaminondas Markos Valsamis, Rafael Pinedo-Villanueva, Adrian Sayers, Gary S. Collins, Jonathan L. Rees
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Adherence to the 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations and risk of 14 lifestyle-related cancers in the UK Biobank prospective cohort study
Fiona C. Malcomson, Solange Parra-Soto, Frederick K. Ho, Liya Lu, Carlos Celis-Morales, Linda Sharp, John C. Mathers
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Plasma metabolomics profiles in Black and White participants of the Adventist Health Study-2 cohort
Fayth M. Butler, Jason Utt, Roy O. Mathew, Carlos A. Casiano, Suzanne Montgomery, Seth A. Wiafe, Johanna W. Lampe, Gary E. Fraser
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Gut mycobiome as a potential non-invasive tool in early detection of lung adenocarcinoma: a cross-sectional study
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Shan Luo, Hugh Simon Lam, Yap Hang Chan, Clara Sze Man Tang, Baoting He, Man Ki Kwok, Gabriel M. Leung, C Mary Schooling, Shiu Lun Au Yeung
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Joint association of sedentary behavior and vitamin D status with mortality among cancer survivors
Yu Yu, Sijing Cheng, Hao Huang, Yu Deng, Chi Cai, Min Gu, Xuhua Chen, Hongxia Niu, Wei Hua
- Open Access
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Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis
Milena Paw, Agnieszka A. Kusiak, Kinga Nit, Jacek J. Litewka, Marcin Piejko, Dawid Wnuk, Michał Sarna, Kinga Fic, Kinga B. Stopa, Ruba Hammad, Olga Barczyk-Woznicka, Toni Cathomen, Ewa Zuba-Surma, Zbigniew Madeja, Paweł E. Ferdek, Sylwia Bobis-Wozowicz
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Association between antenatal corticosteroid treatment and severe adverse events in pregnant women
Hui-Ju Tsai, Beth I. Wallace, Akbar K. Waljee, Xiumei Hong, Sheng-Mao Chang, Yi-Fen Tsai, Mei-Leng Cheong, Ann Chen Wu, Tsung-Chieh Yao
- Open Access
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Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies
Wanglong Gou, Huijun Wang, Xin-yi Tang, Yan He, Chang Su, Jiguo Zhang, Ting-yu Sun, Zengliang Jiang, Zelei Miao, Yuanqing Fu, Hui Zhao, Yu-ming Chen, Bing Zhang, Hongwei Zhou, Ju-Sheng Zheng
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Associations of ultra-processed food consumption, circulating protein biomarkers, and risk of cardiovascular disease
Huiping Li, Yaogang Wang, Emily Sonestedt, Yan Borné
- Open Access
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Experience with 2 years’ intervention to progressively reduce salt supply to kitchens in elderly care facilities—challenges and further research: post hoc analysis of the DECIDE-Salt randomized clinical trial
Yifang Yuan, Aoming Jin, Peifen Duan, La’e Cao, Hongxia Wang, Senke Hu, Jiayu Li, Xiangxian Feng, Qianku Qiao, Hui Zhang, Ruijuan Zhang, Huijuan Li, Pei Gao, Gaoqiang Xie, Jianhui Yuan, Lili Cheng, Sujuan Wang, Wenyi Niu, Paul Elliott, Runlin Gao, Darwin Labarthe, Yangfeng Wu
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Six-hour time-restricted feeding inhibits lung cancer progression and reshapes circadian metabolism
Dan Shi, Gaofeng Fang, Qianyao Chen, Jianling Li, Xiongzhong Ruan, Xuemei Lian
- Open Access
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Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies
Emma Fontvieille, Vivian Viallon, Martina Recalde, Reynalda Cordova, Anna Jansana, Laia Peruchet-Noray, Hannah Lennon, Alicia K. Heath, Dagfinn Aune, Sofia Christakoudi, Verena Katzke, Rudolf Kaaks, Elif Inan-Eroglu, Matthias B. Schulze, Lene Mellemkjær, Anne Tjønneland, Kim Overvad, Marta Farràs, Dafina Petrova, Pilar Amiano, María-Dolores Chirlaque, Conchi Moreno-Iribas, Sandar Tin Tin, Giovanna Masala, Sabina Sieri, Fulvio Ricceri, Salvatore Panico, Anne M. May, Evelyn M. Monninkhof, Elisabete Weiderpass, Marc J. Gunter, Pietro Ferrari, Heinz Freisling
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Plasma glial fibrillary acidic protein as a biomarker of disease progression in Parkinson’s disease: a prospective cohort study
Junyu Lin, Ruwei Ou, Chunyu Li, Yanbing Hou, Lingyu Zhang, Qianqian Wei, Dejiang Pang, Kuncheng Liu, Qirui Jiang, Tianmi Yang, Yi Xiao, Bi Zhao, Xueping Chen, Wei Song, Jing Yang, Ying Wu, Huifang Shang
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Malnutrition-related mortality trends in older adults in the United States from 1999 to 2020
Naydeen Mostafa, Ahmed Sayed, Omar Rashad, Omar Baqal
- Open Access
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Associations between maternal metabolic conditions and neurodevelopmental conditions in offspring: the mediating effects of obstetric and neonatal complications
Shuyun Chen, Xi Wang, Brian K. Lee, Renee M. Gardner
- Open Access
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Anlotinib as a third-line or further treatment for recurrent or metastatic nasopharyngeal carcinoma: a single-arm, phase 2 clinical trial
Yu Fang, Ning Su, Qihua Zou, Yi Cao, Yi Xia, Linquan Tang, Xiaopeng Tian, Panpan Liu, Qingqing Cai
- Open Access
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Real-world outcomes of concomitant antidepressant and statin use in primary care patients with depression: a population-based cohort study
Riccardo De Giorgi, Franco De Crescenzo, Philip J. Cowen, Catherine J. Harmer, Andrea Cipriani
- Open Access
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Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of ‘studies within a trial’ (SWATs)
Vichithranie W. Madurasinghe, Peter Knapp, Sandra Eldridge, David Collier, Shaun Treweek, Jo Rick, Jonathan Graffy, Adwoa Parker, Chris Salisbury, David Torgerson, Kate Jolly, Manbinder S. Sidhu, Christopher Fife-Schaw, Mark A. Hull, Kirsty Sprange, Elizabeth Brettell, Sunil Bhandari, Alan Montgomery, Peter Bower
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Impact of vaccination against severe COVID-19 in the French population aged 50 years and above: a retrospective population-based study
Laetitia Tan-Lhernould, Cynthia Tamandjou, Guilhem Deschamps, Johnny Platon, Cécile Sommen, Fanny Chereau, Isabelle Parent du Châtelet, Simon Cauchemez, Sophie Vaux, Juliette Paireau
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The association between telomere length and non-alcoholic fatty liver disease: a prospective study
Linxi Tang, Dankang Li, Yudiyang Ma, Feipeng Cui, Jianing Wang, Yaohua Tian
- Open Access
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The case for better governance to mitigate against childhood obesity: the UK experience
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A quantitative evaluation of the impact of vaccine roll-out rate and coverage on reducing deaths: insights from the first 2 years of COVID-19 epidemic in Iran
Mahan Ghafari, Sepanta Hosseinpour, Mohammad Saeid Rezaee-Zavareh, Stefan Dascalu, Somayeh Rostamian, Kiarash Aramesh, Kaveh Madani, Shahram Kordasti
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Periodontitis and systemic inflammation as independent and interacting risk factors for mortality: evidence from a prospective cohort study
Christiane Pink, Birte Holtfreter, Henry Völzke, Matthias Nauck, Marcus Dörr, Thomas Kocher
- Open Access
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Cardiovascular events and venous thromboembolism after primary malignant or non-malignant brain tumour diagnosis: a population matched cohort study in Wales (United Kingdom)
Michael T. C. Poon, Paul M. Brennan, Kai Jin, Cathie L. M. Sudlow, Jonine D. Figueroa
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Advancing the communication of genetic risk for cardiometabolic diseases: a critical interpretive synthesis
Jing Hui Law, Najia Sultan, Sarah Finer, Nina Fudge
- Open Access
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Association between ethnicity and migration status with the prevalence of single and multiple long-term conditions in UK healthcare workers
Winifred Ekezie, Christopher A. Martin, Rebecca F. Baggaley, Lucy Teece, Joshua Nazareth, Daniel Pan, Shirley Sze, Luke Bryant, Katherine Woolf, Laura J. Gray, Kamlesh Khunti, Manish Pareek, Laura Nellums, Anna L. Guyatt, Catherine John, I Chris McManus, Ibrahim Abubakar, Amit Gupta, Keith R. Abrams, Martin D. Tobin, Louise Wain, Sue Carr, Edward Dove, David Ford, Robert Free
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Trends in the ability of socioeconomic position to predict individual body mass index: an analysis of repeated cross-sectional data, 1991–2019
Liam Wright, Charis Bridger Staatz, Richard J. Silverwood, David Bann
- Open Access
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Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits
Kevin M. Cook, Josepheen De Asis-Cruz, Jung-Hoon Kim, Sudeepta K. Basu, Nickie Andescavage, Jonathan Murnick, Emma Spoehr, Melissa Liggett, Adré J. du Plessis, Catherine Limperopoulos
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Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study
Marcos D. Machado-Fragua, Séverine Sabia, Aurore Fayosse, Céline Ben Hassen, Frank van der Heide, Mika Kivimaki, Archana Singh-Manoux
- Open Access
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Nonselective beta-adrenoceptor blocker use and risk of Parkinson’s disease: from multiple real-world evidence
Zeying Feng, Qiuping Zhao, Jingjing Wu, Yiping Yang, Xinru Jia, Junlong Ma, Haibo Tang, Hong Yuan, Guoping Yang, Yao Lu
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Circulating oxysterols and prognosis among women with a breast cancer diagnosis: results from the MARIE patient cohort
Nina Sophia Decker, Theron Johnson, Johannes A. Vey, Charlotte Le Cornet, Sabine Behrens, Nadia Obi, Rudolf Kaaks, Jenny Chang-Claude, Renée Turzanski Fortner
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A mathematical model of Marburg virus disease outbreaks and the potential role of vaccination in control
George Y. Qian, W. John Edmunds, Daniel G. Bausch, Thibaut Jombart
- Open Access
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Transient increased risk of influenza infection following RSV infection in South Africa: findings from the PHIRST study, South Africa, 2016–2018
Naomi R. Waterlow, Jackie Kleynhans, Nicole Wolter, Stefano Tempia, Rosalind M. Eggo, Orienka Hellferscee, Limakatso Lebina, Neil Martinson, Ryan G. Wagner, Jocelyn Moyes, Anne von Gottberg, Cheryl Cohen, Stefan Flasche
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The effects of creatine supplementation on cognitive performance—a randomised controlled study
Julia Fabienne Sandkühler, Xenia Kersting, Annika Faust, Eva Kathrin Königs, George Altman, Ulrich Ettinger, Silke Lux, Alexandra Philipsen, Helge Müller, Jan Brauner
- Open Access
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Establishing international optimal cut-offs of waist-to-height ratio for predicting cardiometabolic risk in children and adolescents aged 6–18 years
Xin’nan Zong, Roya Kelishadi, Young Mi Hong, Peter Schwandt, Tandi E. Matsha, Jose G. Mill, Peter H. Whincup, Lucia Pacifico, Abel López-Bermejo, Carmelo Antonio Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Mostafa Qorbani, Fariborz Sharifian Jazi, Gerda-Maria Haas, Rafael de Oliveira Alvim, Divanei Zaniqueli, Claudio Chiesa, Judit Bassols, Elisabetta Lucia Romeo, Danielle Franklin de Carvalho, Mônica Oliveira da Silva Simões, George S. Stergiou, Evangelos Grammatikos, Min Zhao, Costan G. Magnussen, Bo Xi
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Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease
Yi Li, Mengyao Wang, Xue Liu, Jian Rong, Patricia Emogene Miller, Roby Joehanes, Tianxiao Huan, Xiuqing Guo, Jerome I. Rotter, Jennifer A. Smith, Bing Yu, Matthew Nayor, Daniel Levy, Chunyu Liu, Jiantao Ma
- Open Access
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Associations between types and sources of dietary carbohydrates and liver fat: a UK Biobank study
Josefina Orliacq, Aurora Pérez-Cornago, Siôn A Parry, Rebecca K Kelly, Dimitrios A Koutoukidis, Jennifer L Carter
- Open Access
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Mood, Activity Participation, and Leisure Engagement Satisfaction (MAPLES): results from a randomised controlled pilot feasibility trial for low mood in acquired brain injury
Andrea Kusec, Fionnuala C. Murphy, Polly V. Peers, Ron Bennett, Estela Carmona, Aleksandra Korbacz, Cara Lawrence, Emma Cameron, Andrew Bateman, Peter Watson, Judith Allanson, Pieter duToit, Tom Manly
- Open Access
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The association between cognitive ability and opioid prescribing in vulnerable older adults with chronic pain in ambulatory care: a secondary data analysis using the Medical Expenditure Panel Survey
Ulrike Muench, Kyung Mi Kim, Zachary Zimmer, Todd B. Monroe
- Open Access
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Comparative effectiveness of multiple different treatment regimens for nonalcoholic fatty liver disease with type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis of randomised controlled trials
Manjun Deng, Yonghao Wen, JingXin Yan, Yichen Fan, Zhixin Wang, Ruixia Zhang, Li Ren, Yinggui Ba, Haijiu Wang, Qian Lu, Haining Fan
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The psychological legacy of past obesity and early mortality: evidence from two longitudinal studies
I Gusti Ngurah Edi Putra, Michael Daly, Angelina Sutin, Andrew Steptoe, Eric Robinson
- Open Access
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Placental inflammatory cytokines mRNA expression and preschool children’s cognitive performance: a birth cohort study in China
Jixing Zhou, Juan Tong, Xue Ru, Yuzhu Teng, Menglong Geng, Shuangqin Yan, Fangbiao Tao, Kun Huang
- Open Access
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Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study
Unnur Jakobsdottir Smari, Unnur Anna Valdimarsdottir, Thor Aspelund, Arna Hauksdottir, Edda Bjork Thordardottir, Catharina A. Hartman, Pontus Andell, Henrik Larsson, Helga Zoega
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Comparing associations of handgrip strength and chair stand performance with all-cause mortality—implications for defining probable sarcopenia: the Tromsø Study 2015–2020
Jonas Johansson, Sameline Grimsgaard, Bjørn Heine Strand, Avan A. Sayer, Rachel Cooper
- Open Access
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Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction
Zhuoyao Ma, Jinyu Li, Li Fu, Rong Fu, Ningyuan Tang, Yanmei Quan, Zhixiang Xin, Zhide Ding, Yue Liu
- Open Access
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Attention-deficit/hyperactivity disorder symptoms and subsequent cardiometabolic disorders in adults: investigating underlying mechanisms using a longitudinal twin study
Maja Dobrosavljevic, Ralf Kuja-Halkola, Lin Li, Zheng Chang, Henrik Larsson, Ebba Du Rietz
- Open Access
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Longitudinal evolution of sleep disturbances in early multiple system atrophy: a 2‐year prospective cohort study
Lingyu Zhang, Yanbing Hou, Chunyu Li, Qianqian Wei, Ruwei Ou, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Qirui Jiang, Bi Zhao, Huifang Shang
- Open Access
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Metabolic dynamics and prediction of sFGR and adverse fetal outcomes: a prospective longitudinal cohort study
Nana Huang, Wei Chen, Hai Jiang, Jing Yang, Youzhen Zhang, Huifeng Shi, Ying Wang, Pengbo Yuan, Jie Qiao, Yuan Wei, Yangyu Zhao
- Open Access
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The impact of the new acute respiratory distress syndrome (ARDS) criteria on Berlin criteria ARDS patients: a multicenter cohort study
Lina Zhao, Fuhong Su, Nannan Zhang, Hening Wu, Yuehao Shen, Haiying Liu, Xuguang Li, Yun Li, Keliang Xie
- Open Access
- Review
Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis
Shuang-Ling Han, De-Chun Liu, Chen-Chen Tan, Lan Tan, Wei Xu
- Open Access
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Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia—an exploratory study
Tove Lekva, Arvind Y.FM. Sundaram, Marie Cecilie Paasche Roland, June Åsheim, Annika E. Michelsen, Errol R. Norwitz, Pål Aukrust, Gregor D. Gilfillan, Thor Ueland
- Open Access
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Safety, tolerability, pharmacokinetics and effects of diet on AD16, a novel neuroinflammatory inhibitor for Alzheimer’s disease: a randomized phase 1 study
Daizhuang Peng, Sumei Xu, Ting Zou, Yahui Wang, Wenjuan Ouyang, Yalan Zhang, Chengmei Dong, Dai Li, Jie Guo, Qiuying Shen, Xiaolei Hu, Wenzhi Zhou, Xiaomin Li, Qun Qin
- Open Access
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Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression
Sushma Marla, Sally Mortlock, Taija Heinosalo, Matti Poutanen, Grant W. Montgomery, Brett David McKinnon
- Open Access
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Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study
Wei-Jie Chen, Chun-Xia Gan, Yang-Wei Cai, Yang-Yang Liu, Pei-Lin Xiao, Li-Li Zou, Qing-Song Xiong, Fang Qin, Xie-Xin Tao, Ran Li, Hua-An Du, Zeng-Zhang Liu, Yue-Hui Yin, Zhi-Yu Ling
- Open Access
- Commentary
Why diversity among participants in clinical studies is not always preferable: the case for small, exploratory studies
Anne-Marie Ellegaard, Filip Krag Knop
- Open Access
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Are breast cancer patients with suboptimal adherence to cardiovascular treatment more likely to discontinue adjuvant endocrine therapy? Competing risk survival analysis in a nationwide cohort of postmenopausal women
Juliette Artignan, Perrine Capmas, Henri Panjo, Panayotis Constantinou, Nathalie Pelletier-Fleury
- Open Access
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Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study
Ting Liu, Di Dong, Xun Zhao, Xiao-Min Ou, Jun-Lin Yi, Jian Guan, Ye Zhang, Lv Xiao-Fei, Chuan-Miao Xie, Dong-Hua Luo, Rui Sun, Qiu-Yan Chen, Lv Xing, Shan-Shan Guo, Li-Ting Liu, Da-Feng Lin, Yan-Zhou Chen, Jie-Yi Lin, Mei-Juan Luo, Wen-Bin Yan, Mei-Lin He, Meng-Yuan Mao, Man-Yi Zhu, Wen-Hui Chen, Bo-Wen Shen, Shi-Qian Wang, Hai-Lin Li, Lian-Zhen Zhong, Chao-Su Hu, De-Hua Wu, Hai-Qiang Mai, Jie Tian, Lin-Quan Tang
- Open Access
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Radiomics in precision oncology: hype or ludum mutante
Shi Hui Tay, Xin Zhang, Melvin L. K. Chua
- Open Access
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A novel approach to risk exposure and epigenetics—the use of multidimensional context to gain insights into the early origins of cardiometabolic and neurocognitive health
Jane W. Y. Ng, Janine F. Felix, David M. Olson
- Open Access
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Prognostic value of circulating tumor DNA in operable non-small cell lung cancer: a systematic review and reconstructed individual patient-data based meta-analysis
Dali Chen, Jinbao Guo, Hao Huang, Lei Tian, Yunbo Xie, Qingchen Wu
- Open Access
- Review
Identifying patterns of reported findings on long-term cardiac complications of COVID-19: a systematic review and meta-analysis
Boya Guo, Chenya Zhao, Mike Z. He, Camilla Senter, Zhenwei Zhou, Jin Peng, Song Li, Annette L. Fitzpatrick, Sara Lindström, Rebecca C. Stebbins, Grace A. Noppert, Chihua Li
- Open Access
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Genetically predicted plasma levels of amino acids and metabolic dysfunction-associated fatty liver disease risk: a Mendelian randomization study
Jian Zhao, Jing Zeng, Cairong Zhu, Xuechao Li, Dong Liu, Jun Zhang, Fei Li, Giovanni Targher, Jian-Gao Fan
- Open Access
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A pilot study of multi-antigen stimulated cell therapy-I plus camrelizumab and apatinib in patients with advanced bone and soft-tissue sarcomas
Yan Zhou, Mei Li, Bing Zhang, Cheng Yang, Yaling Wang, Shuier Zheng, Lina Tang, Chenliang Zhou, Guowei Qian, Yujing Huang, Wenxi Yu, Hongtao Li, Yonggang Wang, Aina He, Zan Shen, Jianjun Zhang, Xiaoshuang Li, Qingcheng Yang, Haiyan Hu, Yang Yao
- Open Access
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Representativeness in health research studies: an audit of Greater Manchester Clinical Research Network studies between 2016 and 2021
Kathryn M. Abel, Maja R. Radojčić, Archie Rayner, Rabia Butt, Pauline Whelan, Isaac Parr, Lauren F. Gledhill, Ashley Minchin, Peter Bower, Holly Hope
- Open Access
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Maternal glycemic status during pregnancy and mid-childhood plasma amino acid profiles: findings from a multi-ethnic Asian birth cohort
Mengjiao Liu, Shiao-Yng Chan, Johan G. Eriksson, Yap Seng Chong, Yung Seng Lee, Fabian Yap, Mary Foong-Fong Chong, Mya Thway Tint, Jiaxi Yang, David Burgner, Cuilin Zhang, Ling-Jun Li
- Open Access
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Clinical efficacy of sodium bicarbonate in treating pediatric metabolic acidosis with varying level of acid–base balance parameters: a real-world study
Huaqing Liu, Yanmei Cao, Xiaoyan Xue, Zhenjiang Bai, Shuiyan Wu
- Open Access
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Have there been sustained impacts of the COVID-19 pandemic on trends in smoking prevalence, uptake, quitting, use of treatment, and relapse? A monthly population study in England, 2017–2022
Sarah E. Jackson, Harry Tattan-Birch, Lion Shahab, Emma Beard, Jamie Brown
- Open Access
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Dissemination of Registered COVID-19 Clinical Trials (DIRECCT): a cross-sectional study
Maia Salholz-Hillel, Molly Pugh-Jones, Nicole Hildebrand, Tjada A. Schult, Johannes Schwietering, Peter Grabitz, Benjamin Gregory Carlisle, Ben Goldacre, Daniel Strech, Nicholas J. DeVito
- Open Access
- Software
Predicting drug response from single-cell expression profiles of tumours
Simona Pellecchia, Gaetano Viscido, Melania Franchini, Gennaro Gambardella
- Open Access
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Coronary microvascular function in male physicians with burnout and job stress: an observational study
Roland von Känel, Mary Princip, Sarah A. Holzgang, Chrysoula Garefa, Alexia Rossi, Dominik C. Benz, Andreas A. Giannopoulos, Philipp A. Kaufmann, Ronny R. Buechel, Claudia Zuccarella-Hackl, Aju P. Pazhenkottil
- Open Access
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Change of the vaginal microbiome with oral contraceptive therapy in women with polycystic ovary syndrome: a 6-month longitudinal cohort study
Xiang Hong, Pengfei Qin, Liting Gao, Lingling Huang, Yong Shi, Danhong Peng, Bei Wang
- Open Access
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Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns
Guanqun Yao, Ting Zou, Jing Luo, Shuang Hu, Langxiong Yang, Jing Li, Xinrong Li, Yuqi Zhang, Kun Feng, Yong Xu, Pozi Liu
- Open Access
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Comparison of post-acute sequelae following hospitalization for COVID-19 and influenza
Ting-Hui Liu, Po-Yu Huang, Jheng-Yan Wu, Min-Hsiang Chuang, Wan-Hsuan Hsu, Ya-Wen Tsai, Chih-Cheng Lai
- Open Access
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Noninvasive urinary protein signatures combined clinical information associated with microvascular invasion risk in HCC patients
Yaru Wang, Bo Meng, Xijun Wang, Anke Wu, Xiaoyu Li, Xiaohong Qian, Jianxiong Wu, Wantao Ying, Ting Xiao, Weiqi Rong
- Open Access
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Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone
Isabelle M. McGrath, Grant W. Montgomery, Sally Mortlock
- Open Access
- Research article
A low-inflammatory diet is associated with a lower incidence of diabetes: role of diabetes-related genetic risk
Rongrong Yang, Jing Lin, Hongxi Yang, Michelle M. Dunk, Jiao Wang, Weili Xu, Yaogang Wang
- Open Access
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Performance of a safe and dignified burial intervention during an Ebola epidemic in the eastern Democratic Republic of the Congo, 2018–2019
Abdihamid Warsame, Gwendolen Eamer, Alaria Kai, Lucia Robles Dios, Hana Rohan, Patrick Keating, Jacques Katshishi, Francesco Checchi
- Open Access
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