Skip to main content
Erschienen in: Indian Journal of Pediatrics 3/2012

01.03.2012 | Original Article

Bordetella Pertussis IgG and IgA Antibodies Seroprevalence Among 1–35 y-old Population: The Role of Subclinical Pertussis Infection

verfasst von: Mohammed-Jafar Saffar, Ali-Reza Khalilian, Ali-Reza Rafee, Mohammed Reza Parsaei, Shadi Imanikhani, Jalil Shojaei, Hana Saffar

Erschienen in: Indian Journal of Pediatrics | Ausgabe 3/2012

Einloggen, um Zugang zu erhalten

Abstract

Objective

To determine age-dependent pertussis specific IgG and IgA antibodies seroprevalence in apparently healthy subjects.

Methods

A total of 595 healthy 1-35-y-old individuals divided into 5 different age groups were selected from Sari district. Antipertussis IgG and IgA antibodies levels were measured quantitatively by ELISA method. Positive sera for IgA and also IgG titer ≥150 were considered for recent pertussis infection.

Results

High seroprevelence levels (72% and 71%) were observed among preschool (<7 y) children. After decreasing the seroprevelence rates significally to lowest level (54.4%) among school aged (7–11 y), the rates increased again to the highest levels of 60% and 73% at adulthood (P = 0.03 and P = 0.003). In total, 1.55% of study subjects were IgA positive, and 5.7% showed high IgG titers.

Conclusions

The present study reveals, vaccine induced immunity has decreased among school-aged children and natural pertussis infection is common among adolescent and young adults. Also, asymptomatic/sub-clinical recent pertussis infection was prevalent among studied population. These findings necessitate developing new strategies to reduce and control pertussis infection in Iran.
Literatur
1.
Zurück zum Zitat Cherry JD, Grimprel E, Guiso N, Heininger U, Mertsola J. Defining pertussis epidemiology: clinical, microbiologic and serologic perspectives. Pediatr Infect Dis J. 2005;24:S25–34.PubMedCrossRef Cherry JD, Grimprel E, Guiso N, Heininger U, Mertsola J. Defining pertussis epidemiology: clinical, microbiologic and serologic perspectives. Pediatr Infect Dis J. 2005;24:S25–34.PubMedCrossRef
2.
Zurück zum Zitat Edwards KM. Overview of pertussis: focus on epidemiology, sources of infection, and long term protection after infant vaccination. Pediatr Infect Dis J. 2005;24:S104–8.PubMedCrossRef Edwards KM. Overview of pertussis: focus on epidemiology, sources of infection, and long term protection after infant vaccination. Pediatr Infect Dis J. 2005;24:S104–8.PubMedCrossRef
3.
Zurück zum Zitat Edwards KM, Decker MD, Mortimer EA. Pertussis vaccine. In: Plotkin SA, Orenstein WA, eds. Textbook of vaccine. Philadelphia: Saunders; 1999. pp. 293–344. Edwards KM, Decker MD, Mortimer EA. Pertussis vaccine. In: Plotkin SA, Orenstein WA, eds. Textbook of vaccine. Philadelphia: Saunders; 1999. pp. 293–344.
4.
Zurück zum Zitat Cherry JD, Heininger U. Pertussis and other Bordetella infections. In: Feigin C, Demmeler K, eds. Textbook of pediatric infectious diseases. 5th ed. Philadelphia: Saunders; 1588. pp. 1608–2004. Cherry JD, Heininger U. Pertussis and other Bordetella infections. In: Feigin C, Demmeler K, eds. Textbook of pediatric infectious diseases. 5th ed. Philadelphia: Saunders; 1588. pp. 1608–2004.
5.
Zurück zum Zitat Broutin H, Rohani P, Guégan JF, Grenfell BT, Simondon F. Loss of immunity to pertussis in a rural community in Senegal. Vaccine. 2004;22:594–6.PubMed Broutin H, Rohani P, Guégan JF, Grenfell BT, Simondon F. Loss of immunity to pertussis in a rural community in Senegal. Vaccine. 2004;22:594–6.PubMed
6.
Zurück zum Zitat Olin P, Gustafsson L, Barreto L, et al. Declining pertussis incidence in Sweden following the introduction of acellular pertussis vaccine. Vaccine. 2003;21:2015–21.PubMedCrossRef Olin P, Gustafsson L, Barreto L, et al. Declining pertussis incidence in Sweden following the introduction of acellular pertussis vaccine. Vaccine. 2003;21:2015–21.PubMedCrossRef
7.
Zurück zum Zitat Greenberg DP. Pertussis in adolescents: increasing incidence brings attention to the need for booster immunization of adolescents. Pediatr Infect Dis J. 2005;24:721–8.PubMedCrossRef Greenberg DP. Pertussis in adolescents: increasing incidence brings attention to the need for booster immunization of adolescents. Pediatr Infect Dis J. 2005;24:721–8.PubMedCrossRef
8.
Zurück zum Zitat American Academy of Pediatrics. Pertussis. In: Pickering LK, Baker CJ, Long SS, McMillan JA, eds. Red book: 2006 report of the committee on infectious diseases. 27th ed. Elk Grove Village: American Academy of Pediatrics; 2006. pp. 498–520. American Academy of Pediatrics. Pertussis. In: Pickering LK, Baker CJ, Long SS, McMillan JA, eds. Red book: 2006 report of the committee on infectious diseases. 27th ed. Elk Grove Village: American Academy of Pediatrics; 2006. pp. 498–520.
9.
Zurück zum Zitat Expanded programme on immunization, Global Advisory Group. Weekly Epidemiology Record. 1981;56:9–16 Expanded programme on immunization, Global Advisory Group. Weekly Epidemiology Record. 1981;56:9–16
10.
Zurück zum Zitat Esteghamati MR, Mansour-ghanei R. Guidelines for surveillance of Pertussis (pamphelet). Tehran: Centers for Diseases Control and Prevention. Deputy of Health: Ministry of health and Medical Education; 2009. Esteghamati MR, Mansour-ghanei R. Guidelines for surveillance of Pertussis (pamphelet). Tehran: Centers for Diseases Control and Prevention. Deputy of Health: Ministry of health and Medical Education; 2009.
11.
Zurück zum Zitat Goya MM. pertussis reemergence Notification, Tehran: Centers for Diseases Control and Prevention. Deputy of Health: Ministry of health and Medical Education; No:24740;20 February 2007. Goya MM. pertussis reemergence Notification, Tehran: Centers for Diseases Control and Prevention. Deputy of Health: Ministry of health and Medical Education; No:24740;20 February 2007.
12.
Zurück zum Zitat Saffar MJ, Ajami A, Khalilian AR, Qaheri A, Saffar H. Pertussis seroimmunity among mother-infant pairs and infant immune response to pertussis vaccination. Indian Pediatr. 2007;44:916–8.PubMed Saffar MJ, Ajami A, Khalilian AR, Qaheri A, Saffar H. Pertussis seroimmunity among mother-infant pairs and infant immune response to pertussis vaccination. Indian Pediatr. 2007;44:916–8.PubMed
13.
Zurück zum Zitat Cattaneo LA, Reed GW, Haase DH, Wills MJ, Edwards KM. The seroepidemiology of Bordetella pertussis infections: a study of persons ages 1–65 y. J Infect Dis. 1996;173:1256–9.PubMedCrossRef Cattaneo LA, Reed GW, Haase DH, Wills MJ, Edwards KM. The seroepidemiology of Bordetella pertussis infections: a study of persons ages 1–65 y. J Infect Dis. 1996;173:1256–9.PubMedCrossRef
14.
Zurück zum Zitat Konda T, Kamachi K, Iwaki M, et al. Distribution of pertussis antibodies among different age groups in Japan. Vaccine. 2002;20:1711–7.PubMedCrossRef Konda T, Kamachi K, Iwaki M, et al. Distribution of pertussis antibodies among different age groups in Japan. Vaccine. 2002;20:1711–7.PubMedCrossRef
15.
Zurück zum Zitat García-Corbeira P, Dal-Ré R, Aguilar L, García-de-Lomas J. Seroepidemiology of Bordetella pertussis infections in the Spanish population: a cross-sectional study. Vaccine. 2000;18:2173–6.PubMedCrossRef García-Corbeira P, Dal-Ré R, Aguilar L, García-de-Lomas J. Seroepidemiology of Bordetella pertussis infections in the Spanish population: a cross-sectional study. Vaccine. 2000;18:2173–6.PubMedCrossRef
16.
Zurück zum Zitat Baker JD, Halperin SA, Edwards KM, Miller B, Decker M, Stephens D. Antibody response to Bordetella pertussis antigens after immunization with American and Canadian whole-cell vaccines. J Pediatr. 1992;121:523–7.PubMedCrossRef Baker JD, Halperin SA, Edwards KM, Miller B, Decker M, Stephens D. Antibody response to Bordetella pertussis antigens after immunization with American and Canadian whole-cell vaccines. J Pediatr. 1992;121:523–7.PubMedCrossRef
17.
Zurück zum Zitat Wendelboe AM, Van Rie A, Salmaso S, Englund JA. Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis J. 2005;24:S58–61.PubMedCrossRef Wendelboe AM, Van Rie A, Salmaso S, Englund JA. Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis J. 2005;24:S58–61.PubMedCrossRef
18.
Zurück zum Zitat Thomas MG, Ashworth LA, Miller E, Lambert HP. Serum IgG, IgA, and IgM responses to pertussis toxin, filamentous hemagglutinin, and agglutinogens 2 and 3 after infection with Bordetella pertussis and immunization with whole-cell pertussis vaccine. J Infect Dis. 1989;160:838–45.PubMedCrossRef Thomas MG, Ashworth LA, Miller E, Lambert HP. Serum IgG, IgA, and IgM responses to pertussis toxin, filamentous hemagglutinin, and agglutinogens 2 and 3 after infection with Bordetella pertussis and immunization with whole-cell pertussis vaccine. J Infect Dis. 1989;160:838–45.PubMedCrossRef
19.
Zurück zum Zitat de Melker HE, Versteegh FG, Conyn-Van Spaendonck MA. Specificity and sensitivity of high levels of immunoglobulin G antibodies against pertussis toxin in a single serum sample for diagnosis of infection with Bordetella pertussis. J Clin Microbiol. 2000;38:800–6.PubMed de Melker HE, Versteegh FG, Conyn-Van Spaendonck MA. Specificity and sensitivity of high levels of immunoglobulin G antibodies against pertussis toxin in a single serum sample for diagnosis of infection with Bordetella pertussis. J Clin Microbiol. 2000;38:800–6.PubMed
20.
Zurück zum Zitat Eidlitz-Markus T, Mimouni M, Zeharia A. Pertussis symptoms in adolescents and children versus infants: the influence of vaccination and age. Clin Pediatr (Phila). 2007;46:718–23.CrossRef Eidlitz-Markus T, Mimouni M, Zeharia A. Pertussis symptoms in adolescents and children versus infants: the influence of vaccination and age. Clin Pediatr (Phila). 2007;46:718–23.CrossRef
21.
Zurück zum Zitat Yaari E, Yafe-Zimerman Y, Schwartz SB, et al. Clinical manifestations of Bordetella pertussis infection in immunized children and young adults. Chest. 1999;115:1254–8.PubMedCrossRef Yaari E, Yafe-Zimerman Y, Schwartz SB, et al. Clinical manifestations of Bordetella pertussis infection in immunized children and young adults. Chest. 1999;115:1254–8.PubMedCrossRef
22.
Zurück zum Zitat Cherry JD. Epidemiological, clinical, and laboratory aspects of pertussis in adults. Clin Infect Dis. 1999;28:S112–7.PubMedCrossRef Cherry JD. Epidemiological, clinical, and laboratory aspects of pertussis in adults. Clin Infect Dis. 1999;28:S112–7.PubMedCrossRef
Metadaten
Titel
Bordetella Pertussis IgG and IgA Antibodies Seroprevalence Among 1–35 y-old Population: The Role of Subclinical Pertussis Infection
verfasst von
Mohammed-Jafar Saffar
Ali-Reza Khalilian
Ali-Reza Rafee
Mohammed Reza Parsaei
Shadi Imanikhani
Jalil Shojaei
Hana Saffar
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
Indian Journal of Pediatrics / Ausgabe 3/2012
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-011-0593-8

Weitere Artikel der Ausgabe 3/2012

Indian Journal of Pediatrics 3/2012 Zur Ausgabe

Symposium on PGIMER Protocols in Neurological Emergencies

Approach to Headache in Emergency Department

Mit dem Seitenschneider gegen das Reißverschluss-Malheur

03.06.2024 Urologische Notfallmedizin Nachrichten

Wer ihn je erlebt hat, wird ihn nicht vergessen: den Schmerz, den die beim Öffnen oder Schließen des Reißverschlusses am Hosenschlitz eingeklemmte Haut am Penis oder Skrotum verursacht. Eine neue Methode für rasche Abhilfe hat ein US-Team getestet.

Reanimation bei Kindern – besser vor Ort oder während Transport?

29.05.2024 Reanimation im Kindesalter Nachrichten

Zwar scheint es laut einer Studie aus den USA und Kanada bei der Reanimation von Kindern außerhalb einer Klinik keinen Unterschied für das Überleben zu machen, ob die Wiederbelebungsmaßnahmen während des Transports in die Klinik stattfinden oder vor Ort ausgeführt werden. Jedoch gibt es dabei einige Einschränkungen und eine wichtige Ausnahme.

Alter der Mutter beeinflusst Risiko für kongenitale Anomalie

28.05.2024 Kinder- und Jugendgynäkologie Nachrichten

Welchen Einfluss das Alter ihrer Mutter auf das Risiko hat, dass Kinder mit nicht chromosomal bedingter Malformation zur Welt kommen, hat eine ungarische Studie untersucht. Sie zeigt: Nicht nur fortgeschrittenes Alter ist riskant.

Begünstigt Bettruhe der Mutter doch das fetale Wachstum?

Ob ungeborene Kinder, die kleiner als die meisten Gleichaltrigen sind, schneller wachsen, wenn die Mutter sich mehr ausruht, wird diskutiert. Die Ergebnisse einer US-Studie sprechen dafür.

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.