Erschienen in:
01.03.2012 | Original Article
Bordetella Pertussis IgG and IgA Antibodies Seroprevalence Among 1–35 y-old Population: The Role of Subclinical Pertussis Infection
verfasst von:
Mohammed-Jafar Saffar, Ali-Reza Khalilian, Ali-Reza Rafee, Mohammed Reza Parsaei, Shadi Imanikhani, Jalil Shojaei, Hana Saffar
Erschienen in:
Indian Journal of Pediatrics
|
Ausgabe 3/2012
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Abstract
Objective
To determine age-dependent pertussis specific IgG and IgA antibodies seroprevalence in apparently healthy subjects.
Methods
A total of 595 healthy 1-35-y-old individuals divided into 5 different age groups were selected from Sari district. Antipertussis IgG and IgA antibodies levels were measured quantitatively by ELISA method. Positive sera for IgA and also IgG titer ≥150 were considered for recent pertussis infection.
Results
High seroprevelence levels (72% and 71%) were observed among preschool (<7 y) children. After decreasing the seroprevelence rates significally to lowest level (54.4%) among school aged (7–11 y), the rates increased again to the highest levels of 60% and 73% at adulthood (P = 0.03 and P = 0.003). In total, 1.55% of study subjects were IgA positive, and 5.7% showed high IgG titers.
Conclusions
The present study reveals, vaccine induced immunity has decreased among school-aged children and natural pertussis infection is common among adolescent and young adults. Also, asymptomatic/sub-clinical recent pertussis infection was prevalent among studied population. These findings necessitate developing new strategies to reduce and control pertussis infection in Iran.