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15.02.2024 | Original Article

Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials

verfasst von: Parisa Hajihashemi, Fahimeh Haghighatdoost, Nazila Kassaian, Laleh Hoveida, Babak Tamizifar, Hassan Nili, Marzieh Rahim Khorasani, Peyman Adibi

Erschienen in: Digestive Diseases and Sciences | Ausgabe 4/2024

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Abstract

Background

Increasing intestinal permeability causes chronic inflammation, which is one of the etiological factors of many diseases that presently constitute global challenges.

Aims

Considering the importance of developing therapies to eliminate the increased intestinal permeability, in this systematic review and meta-analysis, we analyze the impact of bovine colostrum (BC) on the gut barrier and its permeability.

Methods

Online databases, including PubMed, ISI Web of Science, and Scopus, were searched to find pertinent articles up to March 2022. Weighted mean difference (WMD) and 95% confidence intervals (CI) were considered as effect sizes. The random-effects model was used to pool the study results.

Results

A total of ten articles were included in the meta-analysis. The pooled effect revealed a significant reduction in the 5-h urinary lactulose/rhamnose ratio after BC consumption [mean difference (MD): −0.24; 95% CI −0.43 to −0.04; I² = 99%] and urinary lactulose/mannitol ratio (MD: −0.01; 95% CI −0.02 to −0.001; I² = 29.8%). No differences were observed in the plasma intestinal fatty acid-binding protein (I-FABP) between BC and control groups (MD: 2.30; 95% CI −293.9 to 298.5; I² = 92%).

Conclusions

BC supplementation significantly reduced intestinal permeability; however, to confirm the results, more randomized clinical trials considering different quality, dose, and duration are needed.

Graphical Abstract

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Titel: Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials
verfasst von: Parisa Hajihashemi
Fahimeh Haghighatdoost
Nazila Kassaian
Laleh Hoveida
Babak Tamizifar
Hassan Nili
Marzieh Rahim Khorasani
Peyman Adibi
Publikationsdatum: 15.02.2024
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 4/2024
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-023-08219-2

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Abstract

Background

Aims

Methods

Results

Conclusions

Graphical Abstract

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