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Zeitschrift

Breast Cancer Research

Breast Cancer Research 1/2019

Ausgabe 1/2019

Inhaltsverzeichnis ( 80 Artikel )

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A method of producing genetically manipulated mouse mammary gland

Hiroaki Tagaya, Kosuke Ishikawa, Yoshito Hosokawa, Shun Kobayashi, Yukino Ueoka, Mayuna Shimada, Yasuko Ohashi, Hirofumi Mikami, Mizuki Yamamoto, Tatsuya Ihara, Kentaro Kumazawa, Kosuke Sugihara, Naoki Goshima, Shinya Watanabe, Kentaro Semba

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours

Cigdem Selli, Arran K. Turnbull, Dominic A. Pearce, Ang Li, Anu Fernando, Jimi Wills, Lorna Renshaw, Jeremy S. Thomas, J. Michael Dixon, Andrew H. Sims

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas

Joshua Hoffman, Laura Fejerman, Donglei Hu, Scott Huntsman, Min Li, Esther M. John, Gabriela Torres-Mejia, Larry Kushi, Yuan Chun Ding, Jeffrey Weitzel, Susan L. Neuhausen, Paul Lott, Magdalena Echeverry, Luis Carvajal-Carmona, Esteban Burchard, Celeste Eng, Jirong Long, Wei Zheng, Olufunmilayo Olopade, Dezheng Huo, Christopher Haiman, Elad Ziv, COLUMBUS Consortium

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain

Magdalena Kijewska, Carmen Viski, Frances Turrell, Amanda Fitzpatrick, Antoinette van Weverwijk, Qiong Gao, Marjan Iravani, Clare M. Isacke

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells

Chong Gao, Gu Xiao, Alessandra Piersigilli, Jiangtao Gou, Olorunseun Ogunwobi, Jill Bargonetti

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities

Hye Yeon Choi, Gwang-Mo Yang, Ahmed Abdal Dayem, Subbroto Kumar Saha, Kyeongseok Kim, Youngbum Yoo, Kwonho Hong, Jin-Hoi Kim, Cassian Yee, Kyung-Mi Lee, Ssang-Goo Cho

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP)

Camille Lehuédé, Xia Li, Stéphanie Dauvillier, Charlotte Vaysse, Camille Franchet, Emily Clement, David Esteve, Mélanie Longué, Léonor Chaltiel, Sophie Le Gonidec, Ikrame Lazar, Aline Geneste, Charles Dumontet, Philippe Valet, Laurence Nieto, Frédérique Fallone, Catherine Muller

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study

Fredrik Strand, Edward Azavedo, Roxanna Hellgren, Keith Humphreys, Mikael Eriksson, John Shepherd, Per Hall, Kamila Czene

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model

Ketil A. Camilio, Meng-Yu Wang, Brynjar Mauseth, Stein Waagene, Gunnar Kvalheim, Øystein Rekdal, Baldur Sveinbjørnsson, Gunhild M. Mælandsmo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer

Edward J. Jarman, Carol Ward, Arran K. Turnbull, Carlos Martinez-Perez, James Meehan, Chrysi Xintaropoulou, Andrew H. Sims, Simon P. Langdon

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer

Marie-Julie Nokin, Justine Bellier, Florence Durieux, Olivier Peulen, Gilles Rademaker, Maude Gabriel, Christine Monseur, Benoit Charloteaux, Lieven Verbeke, Steven van Laere, Patrick Roncarati, Michael Herfs, Charles Lambert, Jean Scheijen, Casper Schalkwijk, Alain Colige, Jo Caers, Philippe Delvenne, Andrei Turtoi, Vincent Castronovo, Akeila Bellahcène

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer

Abdi Ghaffari, Victoria Hoskin, Gulisa Turashvili, Sonal Varma, Jeff Mewburn, Graeme Mullins, Peter A. Greer, Friedemann Kiefer, Andrew G. Day, Yolanda Madarnas, Sandip SenGupta, Bruce E. Elliott

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling

Aurélie Chiche, Amandine Di-Cicco, Laura Sesma-Sanz, Laura Bresson, Pierre de la Grange, Marina A. Glukhova, Marisa M. Faraldo, Marie-Ange Deugnier

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier

Youdinghuan Chen, Yue Wang, Lucas A. Salas, Todd W. Miller, Kenneth Mark, Jonathan D. Marotti, Arminja N. Kettenbach, Chao Cheng, Brock C. Christensen

01.12.2019 | Letter | Ausgabe 1/2019 Open Access

Letter to the Editor: A response to Hruska’s case study on molecular breast imaging and the need for true tissue quantification

Richard M. Fleming, Matthew R. Fleming, Tapan K. Chaudhuri, William C. Dooley, Andrew McKusick

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Associations between dietary patterns and the risk of breast cancer: a systematic review and meta-analysis of observational studies

Yunjun Xiao, Junjie Xia, Liping Li, Yuebin Ke, Jinquan Cheng, Yaojie Xie, Winnie Chu, Polly Cheung, Jean Hee Kim, Graham A. Colditz, Rulla M. Tamimi, Xuefen Su

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Serum erythropoietin levels, breast cancer and breast cancer-initiating cells

Kruttika Bhat, Kiri Sandler, Sara Duhachek-Muggy, Claudia Alli, Fei Cheng, Neda A. Moatamed, Clara E. Magyar, Lin Du, Gang Li, Susan McCloskey, Erina Vlashi, Frank Pajonk

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling

Dong-Yu Wang, Deena M. A. Gendoo, Yaacov Ben-David, James R. Woodgett, Eldad Zacksenhaus

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR)

Simon Peter Gampenrieder, Andreas Peer, Christian Weismann, Matthias Meissnitzer, Gabriel Rinnerthaler, Johanna Webhofer, Theresa Westphal, Marina Riedmann, Thomas Meissnitzer, Heike Egger, Frederike Klaassen Federspiel, Roland Reitsamer, Cornelia Hauser-Kronberger, Katharina Stering, Klaus Hergan, Brigitte Mlineritsch, Richard Greil

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors

Daniela Schwarzenbacher, Christiane Klec, Barbara Pasculli, Stefanie Cerk, Beate Rinner, Michael Karbiener, Cristina Ivan, Raffaela Barbano, Hui Ling, Annika Wulf-Goldenberg, Stefanie Stanzer, Gabriel Rinnerthaler, Herbert Stoeger, Thomas Bauernhofer, Johannes Haybaeck, Gerald Hoefler, Stephan Wenzel Jahn, Paola Parrella, George Adrian Calin, Martin Pichler

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy

Alba Rodríguez-Martínez, Diego de Miguel-Pérez, Francisco Gabriel Ortega, José Luis García-Puche, Inmaculada Robles-Fernández, José Exposito, Jordi Martorell-Marugan, Pedro Carmona-Sáez, María del Carmen Garrido-Navas, Christian Rolfo, Hugh Ilyine, José Antonio Lorente, Marta Legueren, María José Serrano

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Targeted mutation detection in breast cancer using MammaSeq™

Nicholas G. Smith, Rekha Gyanchandani, Osama S. Shah, Grzegorz T. Gurda, Peter C. Lucas, Ryan J. Hartmaier, Adam M. Brufsky, Shannon Puhalla, Amir Bahreini, Karthik Kota, Abigail I. Wald, Yuri E. Nikiforov, Marina N. Nikiforova, Steffi Oesterreich, Adrian V. Lee

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB

Ya-Ling Hsu, Meng-Chi Yen, Wei-An Chang, Pei-Hsun Tsai, Yi-Chung Pan, Ssu-Hui Liao, Po-Lin Kuo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Airborne metals and polycyclic aromatic hydrocarbons in relation to mammographic breast density

Alexandra J. White, Clarice R. Weinberg, Ellen S. O’Meara, Dale P. Sandler, Brian L. Sprague

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Imprint of parity and age at first pregnancy on the genomic landscape of subsequent breast cancer

Bastien Nguyen, David Venet, Matteo Lambertini, Christine Desmedt, Roberto Salgado, Hugo Mark Horlings, Françoise Rothé, Christos Sotiriou

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Targeted therapy against Bcl-2-related proteins in breast cancer cells

Manabu Emi, Ryungsa Kim, Kazuaki Tanabe, Yoko Uchida, Tetsuya Toge

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Endo Greer, Samuel F. Gilbert, Brunilde Gril, Rajesh Narwal, Danielle L. Peacock Brooks, David A. Tice, Patricia S. Steeg, Stanley Lipkowitz

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Infiltrating stromal immune cells in inflammatory breast cancer are associated with an improved outcome and increased PD-L1 expression

C. Van Berckelaer, C. Rypens, P. van Dam, L. Pouillon, M. Parizel, K. A. Schats, M. Kockx, W. A. A. Tjalma, P. Vermeulen, S. van Laere, F. Bertucci, C. Colpaert, L. Dirix

01.12.2019 | Review | Ausgabe 1/2019 Open Access

AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer

Wei Cao, Jieqing Li, Qiongyu Hao, Jaydutt V Vadgama, Yong Wu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic and predictive value of androgen receptor expression in postmenopausal women with estrogen receptor-positive breast cancer: results from the Breast International Group Trial 1–98

Kevin H. Kensler, Meredith M. Regan, Yujing J. Heng, Gabrielle M. Baker, Michael E. Pyle, Stuart J. Schnitt, Aditi Hazra, Roswitha Kammler, Beat Thürlimann, Marco Colleoni, Giuseppe Viale, Myles Brown, Rulla M. Tamimi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment

Alexus D. Kolb, Alison B. Shupp, Dimpi Mukhopadhyay, Frank C. Marini, Karen M. Bussard

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Patterns of occurrence and implications of neratinib-associated diarrhea in patients with HER2-positive breast cancer: analyses from the randomized phase III ExteNET trial

Joanne Mortimer, Jack Di Palma, Kendra Schmid, Yining Ye, Mohammad Jahanzeb

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The distribution and determinants of mammographic density measures in Western Australian aboriginal women

Kirsty McLean, Ellie Darcey, Gemma Cadby, Helen Lund, Leanne Pilkington, Andrew Redfern, Sandra Thompson, Christobel Saunders, Elizabeth Wylie, Jennifer Stone

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours

Arian Lundberg, Linda S. Lindström, Jingmei Li, J. Chuck Harrell, Eva Darai-Ramqvist, Emmanouil G. Sifakis, Theodoros Foukakis, Charles M. Perou, Kamila Czene, Jonas Bergh, Nicholas P. Tobin

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Updating the role of obesity and cholesterol in breast cancer

Laura Garcia-Estevez, Gema Moreno-Bueno

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Separation of breast cancer and organ microenvironment transcriptomes in metastases

Mohammad A. Alzubi, Tia H. Turner, Amy L. Olex, Sahib S. Sohal, Nicholas P. Tobin, Susana G. Recio, Jonas Bergh, Thomas Hatschek, Joel S. Parker, Carol A. Sartorius, Charles M. Perou, Mikhail G. Dozmorov, J. Chuck Harrell

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Geraldine Vidhya Vijay, Na Zhao, Petra Den Hollander, Mike J. Toneff, Robiya Joseph, Mika Pietila, Joseph H. Taube, Tapasree R. Sarkar, Esmeralda Ramirez-Pena, Steven J. Werden, Maryam Shariati, Ruli Gao, Mary Sobieski, Clifford C. Stephan, Nathalie Sphyris, Noayuki Miura, Peter Davies, Jeffrey T. Chang, Rama Soundararajan, Jeffrey M. Rosen, Sendurai A. Mani

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study

Carrie B. Hruska, Katie N. Hunt, Amy Lynn Conners, Jennifer R. Geske, Kathleen R. Brandt, Amy C. Degnim, Celine M. Vachon, Michael K. O’Connor, Deborah J. Rhodes

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

PIK3CA alterations and benefit with neratinib: analysis from the randomized, double-blind, placebo-controlled, phase III ExteNET trial

Stephen K. L. Chia, Miguel Martin, Frankie A. Holmes, Bent Ejlertsen, Suzette Delaloge, Beverly Moy, Hiroji Iwata, Gunter von Minckwitz, Janine Mansi, Carlos H. Barrios, Michael Gnant, Zorica Tomašević, Neelima Denduluri, Robert Šeparović, Sung-Bae Kim, Erik Hugger Jakobsen, Vernon Harvey, Nicholas Robert, John Smith II, Graydon Harker, Bo Zhang, Lisa D. Eli, Yining Ye, Alshad S. Lalani, Marc Buyse, Arlene Chan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Parity, breastfeeding, and breast cancer risk by hormone receptor status and molecular phenotype: results from the Nurses’ Health Studies

Renée T. Fortner, Julia Sisti, Boyang Chai, Laura C. Collins, Bernard Rosner, Susan E. Hankinson, Rulla M. Tamimi, A. Heather Eliassen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Impact of obesity on breast cancer recurrence and minimal residual disease

Brett L. Ecker, Jun Y. Lee, Christopher J. Sterner, Aaron C. Solomon, Dhruv K. Pant, Fei Shen, Javier Peraza, Lauren Vaught, Samyukta Mahendra, George K. Belka, Tien-chi Pan, Kathryn H. Schmitz, Lewis A. Chodosh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Breast cancer risk prediction in women aged 35–50 years: impact of including sex hormone concentrations in the Gail model

Tess V. Clendenen, Wenzhen Ge, Karen L. Koenig, Yelena Afanasyeva, Claudia Agnoli, Louise A. Brinton, Farbod Darvishian, Joanne F. Dorgan, A. Heather Eliassen, Roni T. Falk, Göran Hallmans, Susan E. Hankinson, Judith Hoffman-Bolton, Timothy J. Key, Vittorio Krogh, Hazel B. Nichols, Dale P. Sandler, Minouk J. Schoemaker, Patrick M. Sluss, Malin Sund, Anthony J. Swerdlow, Kala Visvanathan, Anne Zeleniuch-Jacquotte, Mengling Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer

Sean P. Kennedy, Jeremy Z. R. Han, Neil Portman, Max Nobis, Jordan F. Hastings, Kendelle J. Murphy, Sharissa L. Latham, Antonia L. Cadell, Dushan Miladinovic, Gabriella R. Marriott, Yolande E. I. O’Donnell, Robert F. Shearer, James T. Williams, Amaya Garcia Munoz, Thomas R. Cox, D. Neil Watkins, Darren N. Saunders, Paul Timpson, Elgene Lim, Walter Kolch, David R. Croucher

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Hypothyroidism and the risk of breast cancer recurrence and all-cause mortality - a Danish population-based study

Anne Mette Falstie-Jensen, Anders Kjærsgaard, Ebbe Laugaard Lorenzen, Jeanette Dupont Jensen, Kristin Valborg Reinertsen, Olaf M. Dekkers, Marianne Ewertz, Deirdre P. Cronin-Fenton

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: ECM1 regulates cell proliferation and trastuzumab resistance through activation of EGF-signaling

Kyung-min Lee, Keesoo Nam, Sunhwa Oh, Juyeon Lim, Young-Pil Kim, Jong Won Lee, Jong-Han Yu, Sei-Hyun Ahn, Sung-Bae Kim, Dong-Young Noh, Taehoon Lee, Incheol Shin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genomic signature of parity in the breast of premenopausal women

Julia Santucci-Pereira, Anne Zeleniuch-Jacquotte, Yelena Afanasyeva, Hua Zhong, Michael Slifker, Suraj Peri, Eric A. Ross, Ricardo López de Cicco, Yubo Zhai, Theresa Nguyen, Fathima Sheriff, Irma H. Russo, Yanrong Su, Alan A. Arslan, Pal Bordas, Per Lenner, Janet Åhman, Anna Stina Landström Eriksson, Robert Johansson, Göran Hallmans, Paolo Toniolo, Jose Russo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Junmei Cairns, James N. Ingle, Krishna R. Kalari, Lois E. Shepherd, Michiaki Kubo, Matthew P. Goetz, Richard M. Weinshilboum, Liewei Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype

Yiwey Shieh, Christopher G. Scott, Matthew R. Jensen, Aaron D. Norman, Kimberly A. Bertrand, V. Shane Pankratz, Kathleen R. Brandt, Daniel W. Visscher, John A. Shepherd, Rulla M. Tamimi, Celine M. Vachon, Karla Kerlikowske

01.12.2019 | Letter | Ausgabe 1/2019 Open Access

CD68, CD163, and matrix metalloproteinase 9 (MMP-9) in breast tumor microenvironment to predict breast cancer survival: are they enough?

Sara Bravaccini, Roberta Maltoni

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association between prediagnostic leukocyte telomere length and breast cancer risk: the Singapore Chinese Health Study

Hamed Samavat, Xiaoshuang Xun, Aizhen Jin, Renwei Wang, Woon-Puay Koh, Jian-Min Yuan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells

Xiaowen Zhang, Yao Wang, Huai-Chin Chiang, Yuan-Pang Hsieh, Chang Lu, Ben Ho Park, Ismail Jatoi, Victor X. Jin, Yanfen Hu, Rong Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Regular use of aspirin and other non-steroidal anti-inflammatory drugs and breast cancer risk for women at familial or genetic risk: a cohort study

Rebecca D. Kehm, John L. Hopper, Esther M. John, Kelly-Anne Phillips, Robert J. MacInnis, Gillian S. Dite, Roger L. Milne, Yuyan Liao, Nur Zeinomar, Julia A. Knight, Melissa C. Southey, Linda Vahdat, Naomi Kornhauser, Tessa Cigler, Wendy K. Chung, Graham G. Giles, Sue-Anne McLachlan, Michael L. Friedlander, Prue C. Weideman, Gord Glendon, Stephanie Nesci, Irene L. Andrulis, Saundra S. Buys, Mary B. Daly, Mary Beth Terry, kConFab Investigators

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells

Daniel Ryan, Bibbin T. Paul, Jim Koziol, Wael M. ElShamy

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The opposing effects of interferon-beta and oncostatin-M as regulators of cancer stem cell plasticity in triple-negative breast cancer

Mary R. Doherty, Jenny G. Parvani, Ilaria Tamagno, Damian J. Junk, Benjamin L. Bryson, Hyeon Joo Cheon, George R. Stark, Mark W. Jackson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer

Nana Weber-Lassalle, Julika Borde, Konstantin Weber-Lassalle, Judit Horváth, Dieter Niederacher, Norbert Arnold, Silke Kaulfuß, Corinna Ernst, Victoria G. Paul, Ellen Honisch, Kristina Klaschik, Alexander E. Volk, Christian Kubisch, Steffen Rapp, Nadine Lichey, Janine Altmüller, Louisa Lepkes, Esther Pohl-Rescigno, Holger Thiele, Peter Nürnberg, Mirjam Larsen, Lisa Richters, Kerstin Rhiem, Barbara Wappenschmidt, Christoph Engel, Alfons Meindl, Rita K. Schmutzler, Eric Hahnen, Jan Hauke

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2

Elizabeth Slocum, Amanda Craig, Augusto Villanueva, Doris Germain

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Distant metastasis dynamics following subsequent surgeries after primary breast cancer removal

Romano Demicheli, Hanna Dillekås, Oddbjørn Straume, Elia Biganzoli

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years

Christos Petridis, Iteeka Arora, Vandna Shah, Anargyros Megalios, Charlotte Moss, Anca Mera, Angela Clifford, Cheryl Gillett, Sarah E. Pinder, Ian Tomlinson, Rebecca Roylance, Michael A. Simpson, Elinor J. Sawyer

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer

Olivia K. Provance, Joan Lewis-Wambi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development of central nervous system metastases as a first site of metastatic disease in breast cancer patients treated in the neoadjuvant trials GeparQuinto and GeparSixto

Elena Laakmann, Isabell Witzel, Peter A. Fasching, Mahdi Rezai, Christian Schem, Christine Solbach, Hans Tesch, Peter Klare, Andreas Schneeweiss, Christoph Salat, Dirk-Michael Zahm, Jens-Uwe Blohmer, Barbara Ingold-Heppner, Jens Huober, Claus Hanusch, Christian Jackisch, Mattea Reinisch, Michael Untch, Gunter von Minckwitz, Valentina Nekljudova, Volkmar Müller, Sibylle Loibl

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

Maria T. Grinde, Bylgja Hilmarsdottir, Hanna Maja Tunset, Ida Marie Henriksen, Jana Kim, Mads H. Haugen, Morten Beck Rye, Gunhild M. Mælandsmo, Siver A. Moestue

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies

Clara Bodelon, Srikant Ambatipudi, Pierre-Antoine Dugué, Annelie Johansson, Joshua N. Sampson, Belynda Hicks, Eric Karlins, Amy Hutchinson, Cyrille Cuenin, Veronique Chajès, Melissa C. Southey, Isabelle Romieu, Graham G. Giles, Dallas English, Silvia Polidoro, Manuela Assumma, Laura Baglietto, Paolo Vineis, Gianluca Severi, Zdenko Herceg, James M. Flanagan, Roger L. Milne, Montserrat Garcia-Closas

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Absence of integrin α3β1 promotes the progression of HER2-driven breast cancer in vivo

Veronika Ramovs, Pablo Secades, Ji-Ying Song, Bram Thijssen, Maaike Kreft, Arnoud Sonnenberg

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

Yanzhong Wang, Jin Zeng, Weiping Wu, Shuduo Xie, Haitao Yu, Guoli Li, Tao Zhu, Fengying Li, Jie Lu, Gavin Y. Wang, Xinyou Xie, Jun Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Pascal Jézéquel, Olivier Kerdraon, Hubert Hondermarck, Catherine Guérin-Charbonnel, Hamza Lasla, Wilfried Gouraud, Jean-Luc Canon, Andrea Gombos, Florence Dalenc, Suzette Delaloge, Jérôme Lemonnier, Delphine Loussouarn, Véronique Verrièle, Mario Campone

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells

Yanling Fan, Weiyao Si, Wei Ji, Zhiyong Wang, Zicong Gao, Ran Tian, Weijie Song, He Zhang, Ruifang Niu, Fei Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models

Rachel A. Sabol, Annie C. Bowles, Alex Côté, Rachel Wise, Benjamen O’Donnell, Margarite D. Matossian, Fokhrul M. Hossain, Hope E. Burks, Luis Del Valle, Lucio Miele, Bridgette M. Collins-Burow, Matthew E. Burow, Bruce A. Bunnell

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Celine M. Vachon, Christopher G. Scott, Rulla M. Tamimi, Deborah J. Thompson, Peter A. Fasching, Jennifer Stone, Melissa C. Southey, Stacey Winham, Sara Lindström, Jenna Lilyquist, Graham G. Giles, Roger L. Milne, Robert J. MacInnis, Laura Baglietto, Jingmei Li, Kamila Czene, Manjeet K. Bolla, Qin Wang, Joe Dennis, Lothar Haeberle, Mikael Eriksson, Peter Kraft, Robert Luben, Nick Wareham, Janet E. Olson, Aaron Norman, Eric C. Polley, Gertraud Maskarinec, Loic Le Marchand, Christopher A. Haiman, John L. Hopper, Fergus J. Couch, Douglas F. Easton, Per Hall, Nilanjan Chatterjee, Montse Garcia-Closas

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Nintedanib plus letrozole in early breast cancer: a phase 0/I pharmacodynamic, pharmacokinetic, and safety clinical trial of combined FGFR1 and aromatase inhibition

Miguel Quintela-Fandino, Juan V. Apala, Diego Malon, Silvana Mouron, Javier Hornedo, Lucia Gonzalez-Cortijo, Ramon Colomer, Juan Guerra

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association between C-reactive protein and radiotherapy-related pain in a tri-racial/ethnic population of breast cancer patients: a prospective cohort study

Eunkyung Lee, Omar L. Nelson, Carolina Puyana, Cristiane Takita, Jean L. Wright, Wei Zhao, Isildinha M. Reis, Rick Y. Lin, WayWay M. Hlaing, Johnna L. Bakalar, George R. Yang, Jennifer J. Hu

01.12.2019 | Short report | Ausgabe 1/2019 Open Access

Clinical outcomes after palbociclib with or without endocrine therapy in postmenopausal women with hormone receptor positive and HER2-negative metastatic breast cancer enrolled in the TREnd trial

Lorenzo Rossi, Chiara Biagioni, Amelia McCartney, Ilenia Migliaccio, Giuseppe Curigliano, Giuseppina Sanna, Erica Moretti, Alessandro M. Minisini, Saverio Cinieri, Carlo Tondini, Grazia Arpino, Antonio Bernardo, Angelo Martignetti, Emanuela Risi, Marta Pestrin, Luca Boni, Matteo Benelli, Laura Biganzoli, Angelo Di Leo, Luca Malorni

01.12.2019 | Viewpoint | Ausgabe 1/2019 Open Access

Reanalysis of the NCCN PD-L1 companion diagnostic assay study for lung cancer in the context of PD-L1 expression findings in triple-negative breast cancer

David L. Rimm, Gang Han, Janis M. Taube, Eunhee S. Yi, Julia A. Bridge, Douglas B. Flieder, Robert Homer, Anja C. Roden, Fred R. Hirsch, Ignacio I. Wistuba, Lajos Pusztai

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

On-treatment biomarkers can improve prediction of response to neoadjuvant chemotherapy in breast cancer

Richard J. Bownes, Arran K. Turnbull, Carlos Martinez-Perez, David A. Cameron, Andrew H. Sims, Olga Oikonomidou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The p52 isoform of SHC1 is a key driver of breast cancer initiation

Kevin D. Wright, Bradley S. Miller, Sarah El-Meanawy, Shirng-Wern Tsaih, Anjishnu Banerjee, Aron M. Geurts, Yuri Sheinin, Yunguang Sun, Balaraman Kalyanaraman, Hallgeir Rui, Michael J. Flister, Andrey Sorokin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Machine learning techniques for personalized breast cancer risk prediction: comparison with the BCRAT and BOADICEA models

Chang Ming, Valeria Viassolo, Nicole Probst-Hensch, Pierre O. Chappuis, Ivo D. Dinov, Maria C. Katapodi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Gene expression signature of atypical breast hyperplasia and regulation by SFRP1

Kelly J. Gregory, Amy L. Roberts, Erin M. Conlon, Jacob A. Mayfield, Mary J. Hagen, Giovanna M. Crisi, Brooke A. Bentley, Jeffrey J. Kane, Grace Makari-Judson, Holly S. Mason, Jun Yu, Lihua Julie Zhu, Karl Simin, Jacob P. S. Johnson, Ashraf Khan, Ben R. Schneider, Sallie S. Schneider, D. Joseph Jerry

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy

Ronan P. McLaughlin, Jichao He, Vera E. van der Noord, Jevin Redel, John A. Foekens, John W. M. Martens, Marcel Smid, Yinghui Zhang, Bob van de Water

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Yan Xing, Nancy U. Lin, Matthew A. Maurer, Huiqin Chen, Armeen Mahvash, Aysegul Sahin, Argun Akcakanat, Yisheng Li, Vandana Abramson, Jennifer Litton, Mariana Chavez-MacGregor, Vicente Valero, Sarina A. Piha-Paul, David Hong, Kim-Anh Do, Emily Tarco, Dianna Riall, Agda Karina Eterovic, Gerburg M. Wulf, Lewis C. Cantley, Gordon B. Mills, L. Austin Doyle, Eric Winer, Gabriel N. Hortobagyi, Ana Maria Gonzalez-Angulo, Funda Meric-Bernstam

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer

Sònia Palomeras, Ángel Diaz-Lagares, Gemma Viñas, Fernando Setien, Humberto J. Ferreira, Glòria Oliveras, Ana B. Crujeiras, Alejandro Hernández, David H. Lum, Alana L. Welm, Manel Esteller, Teresa Puig

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer

Mustafa M. Basree, Neelam Shinde, Christopher Koivisto, Maria Cuitino, Raleigh Kladney, Jianying Zhang, Julie Stephens, Marilly Palettas, Allen Zhang, Hee Kyung Kim, Santiago Acero-Bedoya, Anthony Trimboli, Daniel G. Stover, Thomas Ludwig, Ramesh Ganju, Daniel Weng, Peter Shields, Jo Freudenheim, Gustavo W. Leone, Gina M. Sizemore, Sarmila Majumder, Bhuvaneswari Ramaswamy

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