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Zeitschrift

Breast Cancer Research

Breast Cancer Research 1/2019

Ausgabe 1/2019

Inhaltsverzeichnis ( 146 Artikel )

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A method of producing genetically manipulated mouse mammary gland

Hiroaki Tagaya, Kosuke Ishikawa, Yoshito Hosokawa, Shun Kobayashi, Yukino Ueoka, Mayuna Shimada, Yasuko Ohashi, Hirofumi Mikami, Mizuki Yamamoto, Tatsuya Ihara, Kentaro Kumazawa, Kosuke Sugihara, Naoki Goshima, Shinya Watanabe, Kentaro Semba

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours

Cigdem Selli, Arran K. Turnbull, Dominic A. Pearce, Ang Li, Anu Fernando, Jimi Wills, Lorna Renshaw, Jeremy S. Thomas, J. Michael Dixon, Andrew H. Sims

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas

Joshua Hoffman, Laura Fejerman, Donglei Hu, Scott Huntsman, Min Li, Esther M. John, Gabriela Torres-Mejia, Larry Kushi, Yuan Chun Ding, Jeffrey Weitzel, Susan L. Neuhausen, Paul Lott, Magdalena Echeverry, Luis Carvajal-Carmona, Esteban Burchard, Celeste Eng, Jirong Long, Wei Zheng, Olufunmilayo Olopade, Dezheng Huo, Christopher Haiman, Elad Ziv, COLUMBUS Consortium

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain

Magdalena Kijewska, Carmen Viski, Frances Turrell, Amanda Fitzpatrick, Antoinette van Weverwijk, Qiong Gao, Marjan Iravani, Clare M. Isacke

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells

Chong Gao, Gu Xiao, Alessandra Piersigilli, Jiangtao Gou, Olorunseun Ogunwobi, Jill Bargonetti

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities

Hye Yeon Choi, Gwang-Mo Yang, Ahmed Abdal Dayem, Subbroto Kumar Saha, Kyeongseok Kim, Youngbum Yoo, Kwonho Hong, Jin-Hoi Kim, Cassian Yee, Kyung-Mi Lee, Ssang-Goo Cho

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP)

Camille Lehuédé, Xia Li, Stéphanie Dauvillier, Charlotte Vaysse, Camille Franchet, Emily Clement, David Esteve, Mélanie Longué, Léonor Chaltiel, Sophie Le Gonidec, Ikrame Lazar, Aline Geneste, Charles Dumontet, Philippe Valet, Laurence Nieto, Frédérique Fallone, Catherine Muller

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study

Fredrik Strand, Edward Azavedo, Roxanna Hellgren, Keith Humphreys, Mikael Eriksson, John Shepherd, Per Hall, Kamila Czene

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model

Ketil A. Camilio, Meng-Yu Wang, Brynjar Mauseth, Stein Waagene, Gunnar Kvalheim, Øystein Rekdal, Baldur Sveinbjørnsson, Gunhild M. Mælandsmo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer

Edward J. Jarman, Carol Ward, Arran K. Turnbull, Carlos Martinez-Perez, James Meehan, Chrysi Xintaropoulou, Andrew H. Sims, Simon P. Langdon

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer

Marie-Julie Nokin, Justine Bellier, Florence Durieux, Olivier Peulen, Gilles Rademaker, Maude Gabriel, Christine Monseur, Benoit Charloteaux, Lieven Verbeke, Steven van Laere, Patrick Roncarati, Michael Herfs, Charles Lambert, Jean Scheijen, Casper Schalkwijk, Alain Colige, Jo Caers, Philippe Delvenne, Andrei Turtoi, Vincent Castronovo, Akeila Bellahcène

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer

Abdi Ghaffari, Victoria Hoskin, Gulisa Turashvili, Sonal Varma, Jeff Mewburn, Graeme Mullins, Peter A. Greer, Friedemann Kiefer, Andrew G. Day, Yolanda Madarnas, Sandip SenGupta, Bruce E. Elliott

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling

Aurélie Chiche, Amandine Di-Cicco, Laura Sesma-Sanz, Laura Bresson, Pierre de la Grange, Marina A. Glukhova, Marisa M. Faraldo, Marie-Ange Deugnier

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier

Youdinghuan Chen, Yue Wang, Lucas A. Salas, Todd W. Miller, Kenneth Mark, Jonathan D. Marotti, Arminja N. Kettenbach, Chao Cheng, Brock C. Christensen

01.12.2019 | Letter | Ausgabe 1/2019 Open Access

Letter to the Editor: A response to Hruska’s case study on molecular breast imaging and the need for true tissue quantification

Richard M. Fleming, Matthew R. Fleming, Tapan K. Chaudhuri, William C. Dooley, Andrew McKusick

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Associations between dietary patterns and the risk of breast cancer: a systematic review and meta-analysis of observational studies

Yunjun Xiao, Junjie Xia, Liping Li, Yuebin Ke, Jinquan Cheng, Yaojie Xie, Winnie Chu, Polly Cheung, Jean Hee Kim, Graham A. Colditz, Rulla M. Tamimi, Xuefen Su

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Serum erythropoietin levels, breast cancer and breast cancer-initiating cells

Kruttika Bhat, Kiri Sandler, Sara Duhachek-Muggy, Claudia Alli, Fei Cheng, Neda A. Moatamed, Clara E. Magyar, Lin Du, Gang Li, Susan McCloskey, Erina Vlashi, Frank Pajonk

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling

Dong-Yu Wang, Deena M. A. Gendoo, Yaacov Ben-David, James R. Woodgett, Eldad Zacksenhaus

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR)

Simon Peter Gampenrieder, Andreas Peer, Christian Weismann, Matthias Meissnitzer, Gabriel Rinnerthaler, Johanna Webhofer, Theresa Westphal, Marina Riedmann, Thomas Meissnitzer, Heike Egger, Frederike Klaassen Federspiel, Roland Reitsamer, Cornelia Hauser-Kronberger, Katharina Stering, Klaus Hergan, Brigitte Mlineritsch, Richard Greil

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors

Daniela Schwarzenbacher, Christiane Klec, Barbara Pasculli, Stefanie Cerk, Beate Rinner, Michael Karbiener, Cristina Ivan, Raffaela Barbano, Hui Ling, Annika Wulf-Goldenberg, Stefanie Stanzer, Gabriel Rinnerthaler, Herbert Stoeger, Thomas Bauernhofer, Johannes Haybaeck, Gerald Hoefler, Stephan Wenzel Jahn, Paola Parrella, George Adrian Calin, Martin Pichler

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy

Alba Rodríguez-Martínez, Diego de Miguel-Pérez, Francisco Gabriel Ortega, José Luis García-Puche, Inmaculada Robles-Fernández, José Exposito, Jordi Martorell-Marugan, Pedro Carmona-Sáez, María del Carmen Garrido-Navas, Christian Rolfo, Hugh Ilyine, José Antonio Lorente, Marta Legueren, María José Serrano

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Targeted mutation detection in breast cancer using MammaSeq™

Nicholas G. Smith, Rekha Gyanchandani, Osama S. Shah, Grzegorz T. Gurda, Peter C. Lucas, Ryan J. Hartmaier, Adam M. Brufsky, Shannon Puhalla, Amir Bahreini, Karthik Kota, Abigail I. Wald, Yuri E. Nikiforov, Marina N. Nikiforova, Steffi Oesterreich, Adrian V. Lee

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB

Ya-Ling Hsu, Meng-Chi Yen, Wei-An Chang, Pei-Hsun Tsai, Yi-Chung Pan, Ssu-Hui Liao, Po-Lin Kuo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Airborne metals and polycyclic aromatic hydrocarbons in relation to mammographic breast density

Alexandra J. White, Clarice R. Weinberg, Ellen S. O’Meara, Dale P. Sandler, Brian L. Sprague

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Imprint of parity and age at first pregnancy on the genomic landscape of subsequent breast cancer

Bastien Nguyen, David Venet, Matteo Lambertini, Christine Desmedt, Roberto Salgado, Hugo Mark Horlings, Françoise Rothé, Christos Sotiriou

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Targeted therapy against Bcl-2-related proteins in breast cancer cells

Manabu Emi, Ryungsa Kim, Kazuaki Tanabe, Yoko Uchida, Tetsuya Toge

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

Yoshimi Endo Greer, Samuel F. Gilbert, Brunilde Gril, Rajesh Narwal, Danielle L. Peacock Brooks, David A. Tice, Patricia S. Steeg, Stanley Lipkowitz

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Infiltrating stromal immune cells in inflammatory breast cancer are associated with an improved outcome and increased PD-L1 expression

C. Van Berckelaer, C. Rypens, P. van Dam, L. Pouillon, M. Parizel, K. A. Schats, M. Kockx, W. A. A. Tjalma, P. Vermeulen, S. van Laere, F. Bertucci, C. Colpaert, L. Dirix

01.12.2019 | Review | Ausgabe 1/2019 Open Access

AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer

Wei Cao, Jieqing Li, Qiongyu Hao, Jaydutt V Vadgama, Yong Wu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic and predictive value of androgen receptor expression in postmenopausal women with estrogen receptor-positive breast cancer: results from the Breast International Group Trial 1–98

Kevin H. Kensler, Meredith M. Regan, Yujing J. Heng, Gabrielle M. Baker, Michael E. Pyle, Stuart J. Schnitt, Aditi Hazra, Roswitha Kammler, Beat Thürlimann, Marco Colleoni, Giuseppe Viale, Myles Brown, Rulla M. Tamimi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment

Alexus D. Kolb, Alison B. Shupp, Dimpi Mukhopadhyay, Frank C. Marini, Karen M. Bussard

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Patterns of occurrence and implications of neratinib-associated diarrhea in patients with HER2-positive breast cancer: analyses from the randomized phase III ExteNET trial

Joanne Mortimer, Jack Di Palma, Kendra Schmid, Yining Ye, Mohammad Jahanzeb

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The distribution and determinants of mammographic density measures in Western Australian aboriginal women

Kirsty McLean, Ellie Darcey, Gemma Cadby, Helen Lund, Leanne Pilkington, Andrew Redfern, Sandra Thompson, Christobel Saunders, Elizabeth Wylie, Jennifer Stone

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours

Arian Lundberg, Linda S. Lindström, Jingmei Li, J. Chuck Harrell, Eva Darai-Ramqvist, Emmanouil G. Sifakis, Theodoros Foukakis, Charles M. Perou, Kamila Czene, Jonas Bergh, Nicholas P. Tobin

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Updating the role of obesity and cholesterol in breast cancer

Laura Garcia-Estevez, Gema Moreno-Bueno

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Separation of breast cancer and organ microenvironment transcriptomes in metastases

Mohammad A. Alzubi, Tia H. Turner, Amy L. Olex, Sahib S. Sohal, Nicholas P. Tobin, Susana G. Recio, Jonas Bergh, Thomas Hatschek, Joel S. Parker, Carol A. Sartorius, Charles M. Perou, Mikhail G. Dozmorov, J. Chuck Harrell

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer

Geraldine Vidhya Vijay, Na Zhao, Petra Den Hollander, Mike J. Toneff, Robiya Joseph, Mika Pietila, Joseph H. Taube, Tapasree R. Sarkar, Esmeralda Ramirez-Pena, Steven J. Werden, Maryam Shariati, Ruli Gao, Mary Sobieski, Clifford C. Stephan, Nathalie Sphyris, Noayuki Miura, Peter Davies, Jeffrey T. Chang, Rama Soundararajan, Jeffrey M. Rosen, Sendurai A. Mani

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study

Carrie B. Hruska, Katie N. Hunt, Amy Lynn Conners, Jennifer R. Geske, Kathleen R. Brandt, Amy C. Degnim, Celine M. Vachon, Michael K. O’Connor, Deborah J. Rhodes

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

PIK3CA alterations and benefit with neratinib: analysis from the randomized, double-blind, placebo-controlled, phase III ExteNET trial

Stephen K. L. Chia, Miguel Martin, Frankie A. Holmes, Bent Ejlertsen, Suzette Delaloge, Beverly Moy, Hiroji Iwata, Gunter von Minckwitz, Janine Mansi, Carlos H. Barrios, Michael Gnant, Zorica Tomašević, Neelima Denduluri, Robert Šeparović, Sung-Bae Kim, Erik Hugger Jakobsen, Vernon Harvey, Nicholas Robert, John Smith II, Graydon Harker, Bo Zhang, Lisa D. Eli, Yining Ye, Alshad S. Lalani, Marc Buyse, Arlene Chan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Parity, breastfeeding, and breast cancer risk by hormone receptor status and molecular phenotype: results from the Nurses’ Health Studies

Renée T. Fortner, Julia Sisti, Boyang Chai, Laura C. Collins, Bernard Rosner, Susan E. Hankinson, Rulla M. Tamimi, A. Heather Eliassen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Impact of obesity on breast cancer recurrence and minimal residual disease

Brett L. Ecker, Jun Y. Lee, Christopher J. Sterner, Aaron C. Solomon, Dhruv K. Pant, Fei Shen, Javier Peraza, Lauren Vaught, Samyukta Mahendra, George K. Belka, Tien-chi Pan, Kathryn H. Schmitz, Lewis A. Chodosh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Breast cancer risk prediction in women aged 35–50 years: impact of including sex hormone concentrations in the Gail model

Tess V. Clendenen, Wenzhen Ge, Karen L. Koenig, Yelena Afanasyeva, Claudia Agnoli, Louise A. Brinton, Farbod Darvishian, Joanne F. Dorgan, A. Heather Eliassen, Roni T. Falk, Göran Hallmans, Susan E. Hankinson, Judith Hoffman-Bolton, Timothy J. Key, Vittorio Krogh, Hazel B. Nichols, Dale P. Sandler, Minouk J. Schoemaker, Patrick M. Sluss, Malin Sund, Anthony J. Swerdlow, Kala Visvanathan, Anne Zeleniuch-Jacquotte, Mengling Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer

Sean P. Kennedy, Jeremy Z. R. Han, Neil Portman, Max Nobis, Jordan F. Hastings, Kendelle J. Murphy, Sharissa L. Latham, Antonia L. Cadell, Dushan Miladinovic, Gabriella R. Marriott, Yolande E. I. O’Donnell, Robert F. Shearer, James T. Williams, Amaya Garcia Munoz, Thomas R. Cox, D. Neil Watkins, Darren N. Saunders, Paul Timpson, Elgene Lim, Walter Kolch, David R. Croucher

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Hypothyroidism and the risk of breast cancer recurrence and all-cause mortality - a Danish population-based study

Anne Mette Falstie-Jensen, Anders Kjærsgaard, Ebbe Laugaard Lorenzen, Jeanette Dupont Jensen, Kristin Valborg Reinertsen, Olaf M. Dekkers, Marianne Ewertz, Deirdre P. Cronin-Fenton

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: ECM1 regulates cell proliferation and trastuzumab resistance through activation of EGF-signaling

Kyung-min Lee, Keesoo Nam, Sunhwa Oh, Juyeon Lim, Young-Pil Kim, Jong Won Lee, Jong-Han Yu, Sei-Hyun Ahn, Sung-Bae Kim, Dong-Young Noh, Taehoon Lee, Incheol Shin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genomic signature of parity in the breast of premenopausal women

Julia Santucci-Pereira, Anne Zeleniuch-Jacquotte, Yelena Afanasyeva, Hua Zhong, Michael Slifker, Suraj Peri, Eric A. Ross, Ricardo López de Cicco, Yubo Zhai, Theresa Nguyen, Fathima Sheriff, Irma H. Russo, Yanrong Su, Alan A. Arslan, Pal Bordas, Per Lenner, Janet Åhman, Anna Stina Landström Eriksson, Robert Johansson, Göran Hallmans, Paolo Toniolo, Jose Russo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Junmei Cairns, James N. Ingle, Krishna R. Kalari, Lois E. Shepherd, Michiaki Kubo, Matthew P. Goetz, Richard M. Weinshilboum, Liewei Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype

Yiwey Shieh, Christopher G. Scott, Matthew R. Jensen, Aaron D. Norman, Kimberly A. Bertrand, V. Shane Pankratz, Kathleen R. Brandt, Daniel W. Visscher, John A. Shepherd, Rulla M. Tamimi, Celine M. Vachon, Karla Kerlikowske

01.12.2019 | Letter | Ausgabe 1/2019 Open Access

CD68, CD163, and matrix metalloproteinase 9 (MMP-9) in breast tumor microenvironment to predict breast cancer survival: are they enough?

Sara Bravaccini, Roberta Maltoni

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association between prediagnostic leukocyte telomere length and breast cancer risk: the Singapore Chinese Health Study

Hamed Samavat, Xiaoshuang Xun, Aizhen Jin, Renwei Wang, Woon-Puay Koh, Jian-Min Yuan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells

Xiaowen Zhang, Yao Wang, Huai-Chin Chiang, Yuan-Pang Hsieh, Chang Lu, Ben Ho Park, Ismail Jatoi, Victor X. Jin, Yanfen Hu, Rong Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Regular use of aspirin and other non-steroidal anti-inflammatory drugs and breast cancer risk for women at familial or genetic risk: a cohort study

Rebecca D. Kehm, John L. Hopper, Esther M. John, Kelly-Anne Phillips, Robert J. MacInnis, Gillian S. Dite, Roger L. Milne, Yuyan Liao, Nur Zeinomar, Julia A. Knight, Melissa C. Southey, Linda Vahdat, Naomi Kornhauser, Tessa Cigler, Wendy K. Chung, Graham G. Giles, Sue-Anne McLachlan, Michael L. Friedlander, Prue C. Weideman, Gord Glendon, Stephanie Nesci, Irene L. Andrulis, Saundra S. Buys, Mary B. Daly, Mary Beth Terry, kConFab Investigators

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells

Daniel Ryan, Bibbin T. Paul, Jim Koziol, Wael M. ElShamy

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The opposing effects of interferon-beta and oncostatin-M as regulators of cancer stem cell plasticity in triple-negative breast cancer

Mary R. Doherty, Jenny G. Parvani, Ilaria Tamagno, Damian J. Junk, Benjamin L. Bryson, Hyeon Joo Cheon, George R. Stark, Mark W. Jackson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer

Nana Weber-Lassalle, Julika Borde, Konstantin Weber-Lassalle, Judit Horváth, Dieter Niederacher, Norbert Arnold, Silke Kaulfuß, Corinna Ernst, Victoria G. Paul, Ellen Honisch, Kristina Klaschik, Alexander E. Volk, Christian Kubisch, Steffen Rapp, Nadine Lichey, Janine Altmüller, Louisa Lepkes, Esther Pohl-Rescigno, Holger Thiele, Peter Nürnberg, Mirjam Larsen, Lisa Richters, Kerstin Rhiem, Barbara Wappenschmidt, Christoph Engel, Alfons Meindl, Rita K. Schmutzler, Eric Hahnen, Jan Hauke

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2

Elizabeth Slocum, Amanda Craig, Augusto Villanueva, Doris Germain

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Distant metastasis dynamics following subsequent surgeries after primary breast cancer removal

Romano Demicheli, Hanna Dillekås, Oddbjørn Straume, Elia Biganzoli

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years

Christos Petridis, Iteeka Arora, Vandna Shah, Anargyros Megalios, Charlotte Moss, Anca Mera, Angela Clifford, Cheryl Gillett, Sarah E. Pinder, Ian Tomlinson, Rebecca Roylance, Michael A. Simpson, Elinor J. Sawyer

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer

Olivia K. Provance, Joan Lewis-Wambi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development of central nervous system metastases as a first site of metastatic disease in breast cancer patients treated in the neoadjuvant trials GeparQuinto and GeparSixto

Elena Laakmann, Isabell Witzel, Peter A. Fasching, Mahdi Rezai, Christian Schem, Christine Solbach, Hans Tesch, Peter Klare, Andreas Schneeweiss, Christoph Salat, Dirk-Michael Zahm, Jens-Uwe Blohmer, Barbara Ingold-Heppner, Jens Huober, Claus Hanusch, Christian Jackisch, Mattea Reinisch, Michael Untch, Gunter von Minckwitz, Valentina Nekljudova, Volkmar Müller, Sibylle Loibl

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

Maria T. Grinde, Bylgja Hilmarsdottir, Hanna Maja Tunset, Ida Marie Henriksen, Jana Kim, Mads H. Haugen, Morten Beck Rye, Gunhild M. Mælandsmo, Siver A. Moestue

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies

Clara Bodelon, Srikant Ambatipudi, Pierre-Antoine Dugué, Annelie Johansson, Joshua N. Sampson, Belynda Hicks, Eric Karlins, Amy Hutchinson, Cyrille Cuenin, Veronique Chajès, Melissa C. Southey, Isabelle Romieu, Graham G. Giles, Dallas English, Silvia Polidoro, Manuela Assumma, Laura Baglietto, Paolo Vineis, Gianluca Severi, Zdenko Herceg, James M. Flanagan, Roger L. Milne, Montserrat Garcia-Closas

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Absence of integrin α3β1 promotes the progression of HER2-driven breast cancer in vivo

Veronika Ramovs, Pablo Secades, Ji-Ying Song, Bram Thijssen, Maaike Kreft, Arnoud Sonnenberg

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

Yanzhong Wang, Jin Zeng, Weiping Wu, Shuduo Xie, Haitao Yu, Guoli Li, Tao Zhu, Fengying Li, Jie Lu, Gavin Y. Wang, Xinyou Xie, Jun Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Pascal Jézéquel, Olivier Kerdraon, Hubert Hondermarck, Catherine Guérin-Charbonnel, Hamza Lasla, Wilfried Gouraud, Jean-Luc Canon, Andrea Gombos, Florence Dalenc, Suzette Delaloge, Jérôme Lemonnier, Delphine Loussouarn, Véronique Verrièle, Mario Campone

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells

Yanling Fan, Weiyao Si, Wei Ji, Zhiyong Wang, Zicong Gao, Ran Tian, Weijie Song, He Zhang, Ruifang Niu, Fei Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models

Rachel A. Sabol, Annie C. Bowles, Alex Côté, Rachel Wise, Benjamen O’Donnell, Margarite D. Matossian, Fokhrul M. Hossain, Hope E. Burks, Luis Del Valle, Lucio Miele, Bridgette M. Collins-Burow, Matthew E. Burow, Bruce A. Bunnell

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Celine M. Vachon, Christopher G. Scott, Rulla M. Tamimi, Deborah J. Thompson, Peter A. Fasching, Jennifer Stone, Melissa C. Southey, Stacey Winham, Sara Lindström, Jenna Lilyquist, Graham G. Giles, Roger L. Milne, Robert J. MacInnis, Laura Baglietto, Jingmei Li, Kamila Czene, Manjeet K. Bolla, Qin Wang, Joe Dennis, Lothar Haeberle, Mikael Eriksson, Peter Kraft, Robert Luben, Nick Wareham, Janet E. Olson, Aaron Norman, Eric C. Polley, Gertraud Maskarinec, Loic Le Marchand, Christopher A. Haiman, John L. Hopper, Fergus J. Couch, Douglas F. Easton, Per Hall, Nilanjan Chatterjee, Montse Garcia-Closas

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Nintedanib plus letrozole in early breast cancer: a phase 0/I pharmacodynamic, pharmacokinetic, and safety clinical trial of combined FGFR1 and aromatase inhibition

Miguel Quintela-Fandino, Juan V. Apala, Diego Malon, Silvana Mouron, Javier Hornedo, Lucia Gonzalez-Cortijo, Ramon Colomer, Juan Guerra

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association between C-reactive protein and radiotherapy-related pain in a tri-racial/ethnic population of breast cancer patients: a prospective cohort study

Eunkyung Lee, Omar L. Nelson, Carolina Puyana, Cristiane Takita, Jean L. Wright, Wei Zhao, Isildinha M. Reis, Rick Y. Lin, WayWay M. Hlaing, Johnna L. Bakalar, George R. Yang, Jennifer J. Hu

01.12.2019 | Short report | Ausgabe 1/2019 Open Access

Clinical outcomes after palbociclib with or without endocrine therapy in postmenopausal women with hormone receptor positive and HER2-negative metastatic breast cancer enrolled in the TREnd trial

Lorenzo Rossi, Chiara Biagioni, Amelia McCartney, Ilenia Migliaccio, Giuseppe Curigliano, Giuseppina Sanna, Erica Moretti, Alessandro M. Minisini, Saverio Cinieri, Carlo Tondini, Grazia Arpino, Antonio Bernardo, Angelo Martignetti, Emanuela Risi, Marta Pestrin, Luca Boni, Matteo Benelli, Laura Biganzoli, Angelo Di Leo, Luca Malorni

01.12.2019 | Viewpoint | Ausgabe 1/2019 Open Access

Reanalysis of the NCCN PD-L1 companion diagnostic assay study for lung cancer in the context of PD-L1 expression findings in triple-negative breast cancer

David L. Rimm, Gang Han, Janis M. Taube, Eunhee S. Yi, Julia A. Bridge, Douglas B. Flieder, Robert Homer, Anja C. Roden, Fred R. Hirsch, Ignacio I. Wistuba, Lajos Pusztai

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

On-treatment biomarkers can improve prediction of response to neoadjuvant chemotherapy in breast cancer

Richard J. Bownes, Arran K. Turnbull, Carlos Martinez-Perez, David A. Cameron, Andrew H. Sims, Olga Oikonomidou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The p52 isoform of SHC1 is a key driver of breast cancer initiation

Kevin D. Wright, Bradley S. Miller, Sarah El-Meanawy, Shirng-Wern Tsaih, Anjishnu Banerjee, Aron M. Geurts, Yuri Sheinin, Yunguang Sun, Balaraman Kalyanaraman, Hallgeir Rui, Michael J. Flister, Andrey Sorokin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Machine learning techniques for personalized breast cancer risk prediction: comparison with the BCRAT and BOADICEA models

Chang Ming, Valeria Viassolo, Nicole Probst-Hensch, Pierre O. Chappuis, Ivo D. Dinov, Maria C. Katapodi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Gene expression signature of atypical breast hyperplasia and regulation by SFRP1

Kelly J. Gregory, Amy L. Roberts, Erin M. Conlon, Jacob A. Mayfield, Mary J. Hagen, Giovanna M. Crisi, Brooke A. Bentley, Jeffrey J. Kane, Grace Makari-Judson, Holly S. Mason, Jun Yu, Lihua Julie Zhu, Karl Simin, Jacob P. S. Johnson, Ashraf Khan, Ben R. Schneider, Sallie S. Schneider, D. Joseph Jerry

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy

Ronan P. McLaughlin, Jichao He, Vera E. van der Noord, Jevin Redel, John A. Foekens, John W. M. Martens, Marcel Smid, Yinghui Zhang, Bob van de Water

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Yan Xing, Nancy U. Lin, Matthew A. Maurer, Huiqin Chen, Armeen Mahvash, Aysegul Sahin, Argun Akcakanat, Yisheng Li, Vandana Abramson, Jennifer Litton, Mariana Chavez-MacGregor, Vicente Valero, Sarina A. Piha-Paul, David Hong, Kim-Anh Do, Emily Tarco, Dianna Riall, Agda Karina Eterovic, Gerburg M. Wulf, Lewis C. Cantley, Gordon B. Mills, L. Austin Doyle, Eric Winer, Gabriel N. Hortobagyi, Ana Maria Gonzalez-Angulo, Funda Meric-Bernstam

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer

Sònia Palomeras, Ángel Diaz-Lagares, Gemma Viñas, Fernando Setien, Humberto J. Ferreira, Glòria Oliveras, Ana B. Crujeiras, Alejandro Hernández, David H. Lum, Alana L. Welm, Manel Esteller, Teresa Puig

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer

Mustafa M. Basree, Neelam Shinde, Christopher Koivisto, Maria Cuitino, Raleigh Kladney, Jianying Zhang, Julie Stephens, Marilly Palettas, Allen Zhang, Hee Kyung Kim, Santiago Acero-Bedoya, Anthony Trimboli, Daniel G. Stover, Thomas Ludwig, Ramesh Ganju, Daniel Weng, Peter Shields, Jo Freudenheim, Gustavo W. Leone, Gina M. Sizemore, Sarmila Majumder, Bhuvaneswari Ramaswamy

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

Manila Hada, Hannah Oh, Ruth M. Pfeiffer, Roni T. Falk, Shaoqi Fan, Maeve Mullooly, Michael Pollak, Berta Geller, Pamela M. Vacek, Donald Weaver, John Shepherd, Jeff Wang, Bo Fan, Amir Pasha Mahmoudzadeh, Serghei Malkov, Sally Herschorn, Louise A. Brinton, Mark E. Sherman, Gretchen L. Gierach

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association

Eva Tonsing-Carter, Kyle M. Hernandez, Caroline R. Kim, Ryan V. Harkless, Alyce Oh, Kathleen R. Bowie, Diana C. West-Szymanski, Mayra A. Betancourt-Ponce, Bradley D. Green, Ricardo R. Lastra, Gini F. Fleming, Sarat Chandarlapaty, Suzanne D. Conzen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk

Sergey Klimov, Islam M. Miligy, Arkadiusz Gertych, Yi Jiang, Michael S. Toss, Padmashree Rida, Ian O. Ellis, Andrew Green, Uma Krishnamurti, Emad A. Rakha, Ritu Aneja

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Vitamin D receptor expression in invasive breast tumors and breast cancer survival

Linnea Huss, Salma Tunå Butt, Signe Borgquist, Karin Elebro, Malte Sandsveden, Ann Rosendahl, Jonas Manjer

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers

Christian Fougner, Helga Bergholtz, Raoul Kuiper, Jens Henrik Norum, Therese Sørlie

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The prognostic value of JUNB-positive CTCs in metastatic breast cancer: from bioinformatics to phenotypic characterization

Galatea Kallergi, Vasileia Tsintari, Stelios Sfakianakis, Ekaterini Bei, Eleni Lagoudaki, Anastasios Koutsopoulos, Nefeli Zacharopoulou, Saad Alkahtani, Saud Alarifi, Christos Stournaras, Michalis Zervakis, Vassilis Georgoulias

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers

Bradley A. Hancock, Yu-Hsiang Chen, Jeffrey P. Solzak, Mufti N. Ahmad, David C. Wedge, Dumitru Brinza, Charles Scafe, James Veitch, Rajesh Gottimukkala, Walt Short, Rutuja V. Atale, Mircea Ivan, Sunil S. Badve, Bryan P. Schneider, Xiongbin Lu, Kathy D. Miller, Milan Radovich

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Vasculogenic mimicry is associated with trastuzumab resistance of HER2-positive breast cancer

Ami Hori, Masafumi Shimoda, Yasuto Naoi, Naofumi Kagara, Tomonori Tanei, Tomohiro Miyake, Kenzo Shimazu, Seung Jin Kim, Shinzaburo Noguchi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Dynamically decreased miR-671-5p expression is associated with oncogenic transformation and radiochemoresistance in breast cancer

Xiaohui Tan, Zhongwu Li, Shuchang Ren, Katayoon Rezaei, Qing Pan, Andrew T. Goldstein, Charles J. Macri, Dengfeng Cao, Rachel F. Brem, Sidney W. Fu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes

Marcelo Sobral-Leite, Izhar Salomon, Mark Opdam, Dinja T. Kruger, Karin J. Beelen, Vincent van der Noort, Ronald L. P. van Vlierberghe, Erik J. Blok, Daniele Giardiello, Joyce Sanders, Koen Van de Vijver, Hugo M. Horlings, Peter J. K. Kuppen, Sabine C. Linn, Marjanka K. Schmidt, Marleen Kok

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Investigating the feasibility of stratified breast cancer screening using a masking risk predictor

Olivier Alonzo-Proulx, James G. Mainprize, Jennifer A. Harvey, Martin J. Yaffe

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development of a prediction model for breast cancer based on the national cancer registry in Taiwan

Ching-Chieh Huang, Soa-Yu Chan, Wen-Chung Lee, Chun-Ju Chiang, Tzu-Pin Lu, Skye Hung-Chun Cheng

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Inequities in breast cancer treatment in sub-Saharan Africa: findings from a prospective multi-country observational study

Milena Foerster, Benjamin O. Anderson, Fiona McKenzie, Moses Galukande, Angelica Anele, Charles Adisa, Annelle Zietsman, Joachim Schuz, Isabel dos Santos Silva, Valerie McCormack

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis

Aadya Nagpal, Richard P. Redvers, Xiawei Ling, Scott Ayton, Miriam Fuentes, Elnaz Tavancheh, Irmina Diala, Alshad Lalani, Sherene Loi, Steven David, Robin L. Anderson, Yvonne Smith, Delphine Merino, Delphine Denoyer, Normand Pouliot

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Disease trajectories and mortality among women diagnosed with breast cancer

Haomin Yang, Yudi Pawitan, Wei He, Louise Eriksson, Natalie Holowko, Per Hall, Kamila Czene

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research

Mary Beth Terry, Karin B. Michels, Julia Green Brody, Celia Byrne, Shiuan Chen, D. Joseph Jerry, Kristen M. C. Malecki, Mary Beth Martin, Rachel L. Miller, Susan L. Neuhausen, Kami Silk, Amy Trentham-Dietz, on behalf of Breast Cancer and the Environment Research Program (BCERP)

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Addition of zoledronic acid to neoadjuvant chemotherapy is not beneficial in patients with HER2-negative stage II/III breast cancer: 5-year survival analysis of the NEOZOTAC trial (BOOG 2010-01)

Stefanie de Groot, Hanno Pijl, Ayoub Charehbili, Saskia van de Ven, Vincent T. H. B. M. Smit, Elma Meershoek-Klein Kranenbarg, Joan B. Heijns, Laurence J. C. van Warmerdam, Lonneke W. Kessels, M. Wouter Dercksen, Manon J. A. E. Pepels, Hanneke W. M. van Laarhoven, Birgit E. P. J. Vriens, Hein Putter, Marta Fiocco, Gerrit-Jan Liefers, Jacobus J. M. van der Hoeven, Johan W. R. Nortier, Judith R. Kroep, on behalf of the Dutch Breast Cancer Research Group

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Investigating circulating tumor cells and distant metastases in patient-derived orthotopic xenograft models of triple-negative breast cancer

Vishnu C. Ramani, Clementine A. Lemaire, Melanie Triboulet, Kerriann M. Casey, Kyra Heirich, Corinne Renier, José G. Vilches-Moure, Rakhi Gupta, Aryana M. Razmara, Haiyu Zhang, George W. Sledge, Elodie Sollier, Stefanie S. Jeffrey

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis

Yutian Miao, Qiang Shen, Siheng Zhang, Hehai Huang, Xiaojing Meng, Xianchong Zheng, Zhuocheng Yao, Zhanxin He, Sitong Lu, Chunqing Cai, Fei Zou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A randomized, controlled phase II trial of neoadjuvant ado-trastuzumab emtansine, lapatinib, and nab-paclitaxel versus trastuzumab, pertuzumab, and paclitaxel in HER2-positive breast cancer (TEAL study)

Tejal A. Patel, Joe E. Ensor, Sarah L. Creamer, Toniva Boone, Angel A. Rodriguez, Poly A. Niravath, Jorge G. Darcourt, Jane L. Meisel, Xiaoxian Li, Jing Zhao, John G. Kuhn, Roberto R. Rosato, Wei Qian, Anna Belcheva, Mary R. Schwartz, Virginia G. Kaklamani, Jenny C. Chang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clonality of circulating tumor cells in breast cancer brain metastasis patients

Carlotta Riebensahm, Simon A. Joosse, Malte Mohme, Annkathrin Hanssen, Jakob Matschke, Yvonne Goy, Isabell Witzel, Katrin Lamszus, Jolanthe Kropidlowski, Cordula Petersen, Anja Kolb-Kokocinski, Sascha Sauer, Kerstin Borgmann, Markus Glatzel, Volkmar Müller, Manfred Westphal, Sabine Riethdorf, Klaus Pantel, Harriet Wikman

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Diffusion tensor imaging for characterizing tumor microstructure and improving diagnostic performance on breast MRI: a prospective observational study

Jing Luo, Daniel S. Hippe, Habib Rahbar, Sana Parsian, Mara H. Rendi, Savannah C. Partridge

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs

Momir Bosiljcic, Rachel A. Cederberg, Melisa J. Hamilton, Nancy E. LePard, Bryant T. Harbourne, Jenna L. Collier, Elizabeth C. Halvorsen, Rocky Shi, S. Elizabeth Franks, Ada Y. Kim, Judit P. Banáth, Mark Hamer, Fabio M. Rossi, Kevin L. Bennewith

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells

Chinnadurai Mani, Shirisha Jonnalagadda, Jojireddy Lingareddy, Sanjay Awasthi, William H. Gmeiner, Komaraiah Palle

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A functional role for the cancer disparity-linked genes, CRYβB2 and CRYβB2P1, in the promotion of breast cancer

Maya A. Barrow, Megan E. Martin, Alisha Coffey, Portia L. Andrews, Gieira S. Jones, Denise K. Reaves, Joel S. Parker, Melissa A. Troester, Jodie M. Fleming

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Radiomic signatures with contrast-enhanced magnetic resonance imaging for the assessment of breast cancer receptor status and molecular subtypes: initial results

Doris Leithner, Joao V. Horvat, Maria Adele Marino, Blanca Bernard-Davila, Maxine S. Jochelson, R. Elena Ochoa-Albiztegui, Danny F. Martinez, Elizabeth A. Morris, Sunitha Thakur, Katja Pinker

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Li-Fraumeni syndrome: not a straightforward diagnosis anymore—the interpretation of pathogenic variants of low allele frequency and the differences between germline PVs, mosaicism, and clonal hematopoiesis

Felipe Batalini, Ellie G. Peacock, Lindsey Stobie, Alison Robertson, Judy Garber, Jeffrey N. Weitzel, Nadine M. Tung

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Oral metronomic vinorelbine combined with endocrine therapy in hormone receptor-positive HER2-negative breast cancer: SOLTI-1501 VENTANA window of opportunity trial

Barbara Adamo, Meritxell Bellet, Laia Paré, Tomás Pascual, Maria Vidal, José A. Pérez Fidalgo, Salvador Blanch, Noelia Martinez, Laura Murillo, Patricia Gómez-Pardo, Ana López-González, Kepa Amillano, Jordi Canes, Patricia Galván, Blanca González-Farré, Xavier González, Patricia Villagrasa, Eva Ciruelos, Aleix Prat

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression

Jiang Ren, Marcel Smid, Josephine Iaria, Daniela C. F. Salvatori, Hans van Dam, Hong Jian Zhu, John W. M. Martens, Peter ten Dijke

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Adjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26–30

Seho Park, Yunan Han, Ying Liu, Adetunji T. Toriola, Lindsay L. Peterson, Graham A. Colditz, Seung Il Kim, Young Up Cho, Byeong-Woo Park, Yikyung Park

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark

My von Euler-Chelpin, Martin Lillholm, Ilse Vejborg, Mads Nielsen, Elsebeth Lynge

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tumour heterogeneity revealed by unsupervised decomposition of dynamic contrast-enhanced magnetic resonance imaging is associated with underlying gene expression patterns and poor survival in breast cancer patients

Ming Fan, Pingping Xia, Bin Liu, Lin Zhang, Yue Wang, Xin Gao, Lihua Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Metastatic behavior and overall survival according to breast cancer subtypes in stage IV inflammatory breast cancer

D. J. P. van Uden, M. C. van Maaren, L. J. A. Strobbe, P. Bult, J. J. van der Hoeven, S. Siesling, J. H. W. de Wilt, C. F. J. M. Blanken-Peeters

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Quantitative nuclear histomorphometric features are predictive of Oncotype DX risk categories in ductal carcinoma in situ: preliminary findings

Haojia Li, Jon Whitney, Kaustav Bera, Hannah Gilmore, Mangesh A. Thorat, Sunil Badve, Anant Madabhushi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cells by targeting RAD51

Jung Ok Lee, Min Ju Kang, Won Seok Byun, Shin Ae Kim, Il Hyeok Seo, Jeong Ah. Han, Ji Wook Moon, Ji Hae Kim, Su Jin Kim, Eun Jung Lee, Serk In Park, Sun Hwa Park, Hyeon Soo Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Targeting of prostate-specific membrane antigen for radio-ligand therapy of triple-negative breast cancer

Agnieszka Morgenroth, Ebru Tinkir, Andreas T. J. Vogg, Ramya Ambur Sankaranarayanan, Fatima Baazaoui, Felix M. Mottaghy

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Pre- to postdiagnosis leisure-time physical activity and prognosis in postmenopausal breast cancer survivors

Audrey Y. Jung, Sabine Behrens, Martina Schmidt, Kathrin Thoene, Nadia Obi, Anika Hüsing, Axel Benner, Karen Steindorf, Jenny Chang-Claude

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer

Kathleen R. Brandt, Christopher G. Scott, Diana L. Miglioretti, Matthew R. Jensen, Amir P. Mahmoudzadeh, Carrie Hruska, Lin Ma, Fang Fang Wu, Steven R. Cummings, Aaron D. Norman, Natalie J. Engmann, John A. Shepherd, Stacey J. Winham, Karla Kerlikowske, Celine M. Vachon

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Phase I clinical trial of the combination of eribulin and everolimus in patients with metastatic triple-negative breast cancer

Jin Sun Lee, Susan E. Yost, Suzette Blanchard, Daniel Schmolze, Hongwei Holly Yin, Raju Pillai, Kim Robinson, Aileen Tang, Norma Martinez, Jana Portnow, Wei Wen, John H. Yim, Heather Ann Brauer, Yuqi Ren, Thehang Luu, Joanne Mortimer, Yuan Yuan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Associations of race and ethnicity with risk of developing invasive breast cancer after lobular carcinoma in situ

Vanessa Dania, Ying Liu, Foluso Ademuyiwa, Jason D. Weber, Graham A. Colditz

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Actionability of HER2-amplified circulating tumor cells in HER2-negative metastatic breast cancer: the CirCe T-DM1 trial

William Jacot, Paul Cottu, Frederique Berger, Coraline Dubot, Laurence Venat-Bouvet, Alain Lortholary, Hugues Bourgeois, Marc Bollet, Veronique Servent, Elisabeth Luporsi, Marc Espié, Severine Guiu, Veronique D’Hondt, Veronique Dieras, Marie-Paule Sablin, Etienne Brain, Souhir Neffati, Jean-Yves Pierga, Francois-Clement Bidard

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Pubertal timing and breast density in young women: a prospective cohort study

Lauren C. Houghton, Seungyoun Jung, Rebecca Troisi, Erin S. LeBlanc, Linda G. Snetselaar, Nola M. Hylton, Catherine Klifa, Linda Van Horn, Kenneth Paris, John A. Shepherd, Robert N. Hoover, Joanne F. Dorgan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells

Simona Punzi, Chiara Balestrieri, Carolina D’Alesio, Daniela Bossi, Gaetano Ivan Dellino, Elena Gatti, Giancarlo Pruneri, Carmen Criscitiello, Giulia Lovati, Marine Meliksetyan, Alessandro Carugo, Giuseppe Curigliano, Gioacchino Natoli, Pier Giuseppe Pelicci, Luisa Lanfrancone

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

BRCA1 mutation influences progesterone response in human benign mammary organoids

Batzaya Davaadelger, Mi-Ran Choi, Hari Singhal, Susan E. Clare, Seema A. Khan, J. Julie Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress

Scott J. Pearson, Jessica Elswood, Rola Barhoumi, Brittini Ming-Whitfield, Monique Rijnkels, Weston W. Porter

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

High expression of NR1D1 is associated with good prognosis in triple-negative breast cancer patients treated with chemotherapy

Hyelin Na, Jinil Han, Na-Lee Ka, Min-Ho Lee, Yoon-La Choi, Young Kee Shin, Mi-Ock Lee

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC)

Nur Zeinomar, Julia A. Knight, Jeanine M. Genkinger, Kelly-Anne Phillips, Mary B. Daly, Roger L. Milne, Gillian S. Dite, Rebecca D. Kehm, Yuyan Liao, Melissa C. Southey, Wendy K. Chung, Graham G. Giles, Sue-Anne McLachlan, Michael L. Friedlander, Prue C. Weideman, Gord Glendon, Stephanie Nesci, Irene L. Andrulis, Saundra S. Buys, Esther M. John, Robert J. MacInnis, John L. Hopper, Mary Beth Terry, kConFab Investigators

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Ductal tree ablation by local delivery of ethanol prevents tumor formation in an aggressive mouse model of breast cancer

Elizabeth Kenyon, Jennifer J. Westerhuis, Maximilian Volk, Jeremy Hix, Shatadru Chakravarty, Ethan Claucherty, Erin Zaluzec, Lisa Ramsey, Zach Madaj, Galen Hostetter, Bryn Eagleson, Erik Shapiro, Anna Moore, Lorenzo F. Sempere

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer

Garhett L. Wyatt, Lyndsey S. Crump, Chloe M. Young, Veronica M. Wessells, Cole M. McQueen, Steven W. Wall, Tanya L. Gustafson, Yang-Yi Fan, Robert S. Chapkin, Weston W. Porter, Traci R. Lyons

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas

Ilianna Zoi, Michalis V. Karamouzis, Evangelia Xingi, Panagiotis Sarantis, Dimitra Thomaidou, Panayiotis Lembessis, Stamatios Theocharis, Athanasios G. Papavassiliou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

NSABP FB-7: a phase II randomized neoadjuvant trial with paclitaxel + trastuzumab and/or neratinib followed by chemotherapy and postoperative trastuzumab in HER2+ breast cancer

Samuel A. Jacobs, André Robidoux, Jame Abraham, José Manuel Pérez-Garcia, Nicla La Verde, James M. Orcutt, Marina E. Cazzaniga, Fanny Piette, Silvia Antolín, Elena Aguirre, Javier Cortes, Antonio Llombart-Cussac, Serena Di Cosimo, Rim S. Kim, Huichen Feng, Corey Lipchik, Peter C. Lucas, Ashok Srinivasan, Ying Wang, Nan Song, Patrick G. Gavin, April D. Balousek, Soonmyung Paik, Carmen J. Allegra, Norman Wolmark, Katherine L. Pogue-Geile

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer

Yu-Ju Lee, Shiuh-Rong Ho, Joshua D. Graves, Yang Xiao, Shixia Huang, Weei-Chin Lin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer

Sunil Pancholi, Mariana Ferreira Leal, Ricardo Ribas, Nikiana Simigdala, Eugene Schuster, Sophie Chateau-Joubert, Lila Zabaglo, Margaret Hills, Andrew Dodson, Qiong Gao, Stephen R. Johnston, Mitch Dowsett, Sabina C. Cosulich, Elisabetta Maragoni, Lesley-Ann Martin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Limited role of DWI with apparent diffusion coefficient mapping in breast lesions presenting as non-mass enhancement on dynamic contrast-enhanced MRI

Daly Avendano, Maria Adele Marino, Doris Leithner, Sunitha Thakur, Blanca Bernard-Davila, Danny F. Martinez, Thomas H. Helbich, Elizabeth A. Morris, Maxine S. Jochelson, Pascal A. T. Baltzer, Paola Clauser, Panagiotis Kapetas, Katja Pinker

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association of a novel circulating tumor DNA next-generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer

Andrew A. Davis, Qiang Zhang, Lorenzo Gerratana, Ami N. Shah, Youbin Zhan, Wenan Qiang, Brian S. Finkelman, Lisa Flaum, Amir Behdad, William J. Gradishar, Leonidas C. Platanias, Massimo Cristofanilli

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells

Monica M. Montano, I-Ju Yeh, Yinghua Chen, Chris Hernandez, Janna G. Kiselar, Maria de la Fuente, Adriane M. Lawes, Marvin T. Nieman, Philip D. Kiser, James Jacobberger, Agata A. Exner, Matthew C. Lawes

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Psychiatric disorders and cardiovascular diseases during the diagnostic workup of potential breast cancer: a population-based cohort study in Skåne, Sweden

Qing Shen, Anna Jöud, Maria E. C. Schelin, Arvid Sjölander, Yang Cao, Pär Sparén, Katja Fall, Kamila Czene, Unnur Valdimarsdóttir, Fang Fang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis

Bre-Anne Fifield, Ingrid Qemo, Evie Kirou, Robert D. Cardiff, Lisa Ann Porter

01.12.2019 | Short report | Ausgabe 1/2019 Open Access

Characterization of organoid cultured human breast cancer

Nadine Goldhammer, Jiyoung Kim, Vera Timmermans-Wielenga, Ole William Petersen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prediction and clinical utility of a contralateral breast cancer risk model

Daniele Giardiello, Ewout W. Steyerberg, Michael Hauptmann, Muriel A. Adank, Delal Akdeniz, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Mariël Brinkhuis, Jenny Chang-Claude, Kamila Czene, Peter Devilee, Alison M. Dunning, Douglas F. Easton, Diana M. Eccles, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Montserrat García-Closas, Lothar Haeberle, Christopher A. Haiman, Per Hall, Ute Hamann, John L. Hopper, Agnes Jager, Anna Jakubowska, Audrey Jung, Renske Keeman, Iris Kramer, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Jan Lubiński, Mehdi Manoochehri, Luigi Mariani, Heli Nevanlinna, Hester S. A. Oldenburg, Saskia Pelders, Paul D. P. Pharoah, Mitul Shah, Sabine Siesling, Vincent T. H. B. M. Smit, Melissa C. Southey, William J. Tapper, Rob A. E. M. Tollenaar, Alexandra J. van den Broek, Carolien H. M. van Deurzen, Flora E. van Leeuwen, Chantal van Ongeval, Laura J. Van’t Veer, Qin Wang, Camilla Wendt, Pieter J. Westenend, Maartje J. Hooning, Marjanka K. Schmidt

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Neutrophil extracellular traps in breast cancer and beyond: current perspectives on NET stimuli, thrombosis and metastasis, and clinical utility for diagnosis and treatment

Hunter T. Snoderly, Brian A. Boone, Margaret F. Bennewitz

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Immune gene expression profiling reveals heterogeneity in luminal breast tumors

Bin Zhu, Lap Ah Tse, Difei Wang, Hela Koka, Tongwu Zhang, Mustapha Abubakar, Priscilla Lee, Feng Wang, Cherry Wu, Koon Ho Tsang, Wing-cheong Chan, Sze Hong Law, Mengjie Li, Wentao Li, Suyang Wu, Zhiguang Liu, Bixia Huang, Han Zhang, Eric Tang, Zhengyan Kan, Soohyeon Lee, Yeon Hee Park, Seok Jin Nam, Mingyi Wang, Xuezheng Sun, Kristine Jones, Bin Zhu, Amy Hutchinson, Belynda Hicks, Ludmila Prokunina-Olsson, Jianxin Shi, Montserrat Garcia-Closas, Stephen Chanock, Xiaohong R. Yang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer

Daniel Fernandez-Garcia, Allison Hills, Karen Page, Robert K. Hastings, Bradley Toghill, Kate S. Goddard, Charlotte Ion, Olivia Ogle, Anna Rita Boydell, Kelly Gleason, Mark Rutherford, Adrian Lim, David S. Guttery, R. Charles Coombes, Jacqueline A. Shaw

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer

Iris Nederlof, Davide De Bortoli, Yacine Bareche, Bastien Nguyen, Michiel de Maaker, Gerrit K. J. Hooijer, Laurence Buisseret, Marleen Kok, Marcel Smid, Gert G. G. M. Van den Eynden, Arie B. Brinkman, Jan Hudecek, Jan Koster, Christos Sotiriou, Denis Larsimont, John W. M. Martens, Marc J. van de Vijver, Hugo M. Horlings, Roberto Salgado, Elia Biganzoli, Christine Desmedt

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Endocrine-responsive lobular carcinoma of the breast: features associated with risk of late distant recurrence

Fabio Conforti, Laura Pala, Eleonora Pagan, Giuseppe Viale, Vincenzo Bagnardi, Giulia Peruzzotti, Tommaso De Pas, Nadia Bianco, Rossella Graffeo, Elena Guerini Rocco, Andrea Vingiani, Richard D. Gelber, Alan S. Coates, Marco Colleoni, Aron Goldhirsch

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