Danfeng Peng and Jie Wang contributed equally to this work.
The authors declare that they have no competing interests.
DP and JW carried out the majority of the analyses and drafted the manuscript. RZ, ST and FJ participated in the design of the study. MC, JY, XS, TW and SW participated in the data analysis. YB provided helpful comments on study design and data analysis. CH and WJ conceived the study, and participated in its design and helped to draft the manuscript. All authors read and approved the final manuscript.
Diabetic retinopathy (DR) is an important microvascular complication of diabetes with a high concordance rate in patients with diabetes. Inflammation is supposed to participate in the development of DR. This study aimed to investigate whether genetic variants of CRP are associated with DR.
A total of 1,018 patients with type 2 diabetes were recruited in this study. Of these patients, 618 were diagnosed with DR, 400 were patients with diabetes for over 10 years but without DR, considered as cases and controls for DR, respectively. Four tagging SNPs (rs2808629, rs3093077, rs1130864 and rs2808634) within CRP region were genotyped for all the participants. Fundus photography was performed for diagnosis and classification for DR.
rs2808629 was significantly associated with increased susceptibility to DR (odds ratio 1.296, 95% CI 1.076-1.561, P = 0.006, empirical P = 0.029, for G allele). This association remained significant after adjustment for confounding factors (odds ratio 1.261, 95% CI 1.022-1.555, P = 0.030).
In this study, we found CRP rs2808629 was associated with DR in the Chinese patients with type 2 diabetes.
The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. The New England journal of medicine. 2000;342(6):381–9. CrossRefPubMedCentral
Koenig W, Sund M, Frohlich M, Fischer HG, Lowel H, Doring A, et al. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation. 1999;99(2):237–42. CrossRefPubMed
Jia WP, Pang C, Chen L, Bao YQ, Lu JX, Lu HJ, et al. Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities. Diabetologia. 2007;50(2):286–92. CrossRefPubMed
- C-reactive protein genetic variant is associated with diabetic retinopathy in Chinese patients with type 2 diabetes
- BioMed Central
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