Ausgabe 12/2023
Inhalt (42 Artikel)
PD-1 and PD-L1 inhibitors in cold colorectal cancer: challenges and strategies
Ke Xin Lin, Alexandra C. Istl, Douglas Quan, Anton Skaro, Ephraim Tang, Xiufen Zheng
Tumor-associated macrophages as a potential therapeutic target in thyroid cancers
Liya Zhu, Xiu Juan Li, Prakash Gangadaran, Xiuli Jing, Byeong-Cheol Ahn
Human anaerobic microbiome: a promising and innovative tool in cancer prevention and treatment by targeting pyruvate metabolism
Hari Om, Umesh Chand, Pramod Kumar Kushawaha
Beyond BCMA, why GPRC5D could be the right way: treatment strategies with immunotherapy at relapse after anti-BCMA agents
Maria Livia Del Giudice, Sara Galimberti, Gabriele Buda
Current state of the art: immunotherapy in esophageal cancer and gastroesophageal junction cancer
Ningjing Li, Davendra Sohal
The progress of research on immune checkpoint inhibitor resistance and reversal strategies for hepatocellular carcinoma
Liqiu Kou, Xiaolu Xie, Xiu Chen, Bo Li, Jun Li, Yaling Li
Organ-on-a-chip models for development of cancer immunotherapies
M. Chernyavska, M. Masoudnia, T. Valerius, W. P. R. Verdurmen
Bis-indole-derived NR4A1 antagonists inhibit colon tumor and splenic growth and T-cell exhaustion
Kumaravel Mohankumar, Gus Wright, Subhashree Kumaravel, Rupesh Shrestha, Lei Zhang, Maen Abdelrahim, Robert S. Chapkin, Stephen Safe
Targeting alternative splicing as a new cancer immunotherapy-phosphorylation of serine arginine-rich splicing factor (SRSF1) by SR protein kinase 1 (SRPK1) regulates alternative splicing of PD1 to generate a soluble antagonistic isoform that prevents T cell exhaustion
Mussarat Wahid, Benjamart Pratoomthai, Isioma U. Egbuniwe, Hannah R. Evans, Roya Babaei-Jadidi, Jason O. Amartey, Viola Erdelyi, Kiren Yacqub-Usman, Andrew M. Jackson, Jonathan C. Morris, Poulam M. Patel, David O. Bates
XFab-α4-1BB/CD40L fusion protein activates dendritic cells, improves expansion of antigen-specific T cells, and exhibits antitumour efficacy in multiple solid tumour models
Bochun Wang, Yujie Liu, Ruofei Yuan, Xiaoqian Dou, Niliang Qian, Xiujie Pan, Guili Xu, Qinzhi Xu, Bo Dong, Cuima Yang, Hongjie Li, Jingjing Wang, Guijun Bai, Liangfa Liu, Xin Gao
Translational development of a novel BAFF-R CAR-T therapy targeting B-cell lymphoid malignancies
Yan Luo, Yaqing Qie, Martha E. Gadd, Alak Manna, Rocio Rivera-Valentin, Tommy To, Shuhua Li, Farah Yassine, Hemant S. Murthy, Roxana Dronca, Mohamed A. Kharfan-Dabaja, Hong Qin
Toxicity-specific peripheral blood T and B cell dynamics in anti-PD-1 and combined immune checkpoint inhibition
Mick J. M. van Eijs, Rik J. Verheijden, Stefanie A. van der Wees, Stefan Nierkens, Anne S. R. van Lindert, Karijn P. M. Suijkerbuijk, Femke van Wijk, Linde Meyaard, Jürgen H. E. Kuball, Bas Oldenburg, Jeanette H. W. Leusen
An alternatively spliced PD-L1 isoform PD-L1∆3, and PD-L2 expression in breast cancers: implications for eligibility scoring and immunotherapy response
Didem Naz Dioken, Ibrahim Ozgul, Irem Yilmazbilek, Mustafa Cengiz Yakicier, Ezgi Karaca, Ayse Elif Erson-Bensan
Carbon ion radiotherapy combined with immunotherapy: synergistic anti-tumor efficacy and preliminary investigation of ferroptosis
Qingting Huang, Jiyi Hu, Li Chen, Wanzun Lin, Jing Yang, Weixu Hu, Jing Gao, Haojiong Zhang, Jiade Jay Lu, Lin Kong
Intensified NK cell therapy in combination with low-dose chemoradiotherapy against human colorectal cancer
Huy Phuoc Quang Nguyen, Woo Kyun Bae, Myong Suk Park, Ik-Joo Chung, Taek-Keun Nam, Jae-Uk Jeong, Tung Nguyen Thanh Uong, Duck Cho, Sang-Ki Kim, Meesun Yoon
A modified immune cell infiltration score achieves ideal stratification for CD8+ T cell efficacy and immunotherapy benefit in hepatocellular carcinoma
Banglun Pan, Yue Luo, Dongjie Ye, Jiacheng Qiu, Xiaoxia Zhang, Xiaoxuan Wu, Yuxin Yao, Xiaoqian Wang, Nanhong Tang
Correction to: A modified immune cell infiltration score achieves ideal stratification for CD8+ T cell efficacy and immunotherapy benefit in hepatocellular carcinoma
Banglun Pan, Yue Luo, Dongjie Ye, Jiacheng Qiu, Xiaoxia Zhang, Xiaoxuan Wu, Yuxin Yao, Xiaoqian Wang, Nanhong Tang
Apolipoprotein C-III itself stimulates the Syk/cPLA2-induced inflammasome activation of macrophage to boost anti-tumor activity of CD8+ T cell
Xiangyu Hu, Shizhen Ding, Guotao Lu, Zhijie Lin, Liting Liao, Weiming Xiao, Yanbing Ding, Yu Zhang, Zhengbing Wang, Weijuan Gong, Xiaoqin Jia
ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1
Karin Enell Smith, Sara Fritzell, Anneli Nilsson, Karin Barchan, Anna Rosén, Lena Schultz, Laura Varas, Anna Säll, Nadia Rose, Maria Håkansson, Laura von Schantz, Peter Ellmark
PD-1 Inhibitors combined with paclitaxel (Albumin-bound) and cisplatin for larynx preservation in locally advanced laryngeal and hypopharyngeal squamous cell carcinoma: a retrospective study
Qi Fang, Pengfei Xu, Fei Cao, Di Wu, Xuekui Liu
The influence of plasma sPD-L1 concentration on the effectiveness of immunotherapy in advanced NSCLC patients
Izabela Chmielewska, Anna Grenda, Paweł Krawczyk, Małgorzata Frąk, Barbara Kuźnar Kamińska, Weronika Mitura, Janusz Milanowski
A novel CD47-blocking peptide fused to pro-apoptotic KLA repeat inhibits lung cancer growth in mice
Linyue Pan, Lu Hu, Mengjie Chen, Yuanlin Song, Zhihong Chen, Yutong Gu, Chun Li, Zhilong Jiang
Functional enhancement of mesothelin-targeted TRuC-T cells by a PD1-CD28 chimeric switch receptor
Derrick McCarthy, Michael Lofgren, Amy Watt, Holly Horton, Philippe Kieffer-Kwon, Jian Ding, Sebastian Kobold, Patrick A. Baeuerle, Robert Hofmeister, Dario A. Gutierrez, Robert Tighe
Evaluation of neoadjuvant chemotherapy combined with PD-1 inhibitors in patients with oropharyngeal and hypopharyngeal squamous cell carcinoma: a comparative study of antitumor activity
Pengfei Xu, Qi Fang, Zheng Zhao, Fei Cao, Di Wu, Xuekui Liu
The dysfunctional immune response in renal cell carcinoma correlates with changes in the metabolic landscape of ccRCC during disease progression
Nicola E. Annels, M. Denyer, D. Nicol, S. Hazell, A. Silvanto, M. Crockett, M. Hussain, Carla Moller-Levet, Hardev Pandha
The impact of oncogenic driver mutations on neoadjuvant immunotherapy outcomes in patients with resectable non-small cell lung cancer
Ziyun Shen, Meixin Teng, Lu Han, Dongliang Bian, Jing Zhang, Xinsheng Zhu, Yang Qing, Shiqi Hu, Yan Chen, Wangchao Yao, Huansha Yu, Lele Zhang, Peng Zhang
Esophageal cancer cell-derived small extracellular vesicles decrease circulating Tfh/Tfr via sEV-PDL1 to promote immunosuppression
Zijie Li, Yuehua Zhang, He Hao, Lu Chen, Tingting Lv, Xiaokuan Zhang, Yuying Qi, Zhiyu Wang
Statins abrogate gemcitabine-induced PD-L1 expression in pancreatic cancer-associated fibroblasts and cancer cells with improved therapeutic outcome
Aliva Prity Minz, Debasish Mohapatra, Madhuri Dutta, Manisha Sethi, Deepti Parida, Amlan Priyadarshee Mohapatra, Swayambara Mishra, Salona Kar, Prakash K. Sasmal, Shantibhusan Senapati
BCLAF1-induced HIF-1α accumulation under normoxia enhances PD-L1 treatment resistances via BCLAF1-CUL3 complex
Bowen Yao, Ye Lu, Yazhao Li, Yixue Bai, Xinyu Wei, Yuanyuan Yang, Demao Yao
Tumor-associated neutrophils upregulate PANoptosis to foster an immunosuppressive microenvironment of non-small cell lung cancer
Qin Hu, Runtian Wang, Jiaxin Zhang, Qun Xue, Bo Ding
Chronological interplay, clinical features, and treatments among patients with cancer and primary Sjögren’s syndrome
Philine Witkowski Durand Viel, Kim Henry, Jacques Morel, William Jacot, Christian Jorgensen, Sophie Riviere, Alexandre Thibault Jacques Maria, Valérie Rigau, Alain Le Quellec, Radjiv Goulabchand, Philippe Guilpain
Comprehensive analysis of scRNA-Seq and bulk RNA-Seq data reveals dynamic changes in tumor-associated neutrophils in the tumor microenvironment of hepatocellular carcinoma and leads to the establishment of a neutrophil-related prognostic model
Dashuai Yang, Yu Zhou, Yanbing Zhang, Yang Su, Jie Shen, Bin Yu, Kailiang Zhao, Youming Ding
GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma
Lijuan Qin, Jiuru Wang, Fang Cheng, Jiamin Cheng, Han Zhang, Huaguo Zheng, Yongai Liu, Zhentao Liang, Baifeng Wang, Changfei Li, Haoyu Wang, Ying Ju, Huaqin Tian, Songdong Meng
A retrospective real-world study: the efficacy of immune-related combination therapies in advanced non-small cell lung cancer after resistance to EGFR-TKIs
Ruoxue Cai, Ying Liu, Mingyan Yu, Huanhuan Sha, Mengya Guo, Yue Chen, Jinjun Ye, Guoren Zhou, Ying Fang, Bo Shen
HPV-associated head and neck cancer is characterized by distinct profiles of CD8+ T cells and myeloid-derived suppressor cells
Benjamin A. Kansy, Tim P. Wehrs, Kirsten Bruderek, Yu Si, Sonja Ludwig, Freya Droege, Pia Hasskamp, Uta Henkel, Nina Dominas, Thomas K. Hoffmann, Peter A. Horn, Martin Schuler, Thomas C. Gauler, Monika Lindemann, Stephan Lang, Agnes Bankfalvi, Sven Brandau
Spatial immune composition of tumor microenvironment in patients with pancreatic cancer
Eline S. Zwart, Thomas van Ee, Alsya J. Affandi, Lenka N. C. Boyd, Ernesto Rodriguez, Joke M. M. den Haan, Arantza Farina, Nicole C. T. van Grieken, Laura L. Meijer, Yvette van Kooyk, Reina E. Mebius, Geert Kazemier
Immune characteristics and prognostic implications of mucosal-associated invariant T cells in acute myeloid leukemia
Qian Peng, Renhua Huang, Huiping Wang, Hao Xiao, Yiping Wang, Zhimin Zhai, Zhitao Wang
Unraveling intratumoral complexity in metastatic dermatofibrosarcoma protuberans through single-cell RNA sequencing analysis
Ling-Ling Ge, Zhi-Chao Wang, Cheng-Jiang Wei, Jing-Xuan Huang, Jun Liu, Yi-Hui Gu, Wei Wang, Qing-Feng Li
Tumor immunology meets oncology (TIMO) XVII, April 20–22 2023 in Halle/Saale, Germany
Barbara Seliger
Cholesterol induction in CD8+ T cell exhaustion in colorectal cancer via the regulation of endoplasmic reticulum-mitochondria contact sites
Han Shuwen, Wu Yinhang, Zhuang Jing, Yan Qiang, Jiang Yizhen, Qi Quan, Jin Yin, Liu Jiang, Yang Xi
An optimized protocol for the generation and monitoring of conditional orthotopic lung cancer in the KP mouse model using an adeno-associated virus vector compatible with biosafety level 1
Haibin Deng, Huixiang Ge, Christelle Dubey, Tereza Losmanova, Michaela Medová, Georgia Konstantinidou, Seyran Mathilde Mutlu, Fabienne Esther Birrer, Tess Melinda Brodie, Deborah Stroka, Wenxiang Wang, Ren-Wang Peng, Patrick Dorn, Thomas Michael Marti
Correction to: Extended duration of treatment using reduced‑frequency dosing of anti‑PD‑1 therapy in patients with advanced melanoma and Merkel cell carcinoma
Lisa May Ling Tachiki, Daniel S. Hippe, Karly Williams Silva, Evan Thomas Hall, William McCamy, Dane Fritzsche, Andrea Perdue, Julia Majovski, Thomas Pulliam, Daniel A. Goldstein, Joshua Veatch, Joel Ho, Paul T. Nghiem, John A. Thompson, Shailender Bhatia