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01.06.2012 | Original Article

Carotid artery intima-media thickness and elasticity in relation to glucose tolerance

verfasst von: Kalle Sipilä, Mika Kähönen, Veikko Salomaa, Markku Päivänsalo, Hannu Karanko, Marjut Varpula, Antti Jula, Risto Kaaja, Y. Antero Kesäniemi, Antti Reunanen, Leena Moilanen

Erschienen in: Acta Diabetologica | Ausgabe 3/2012

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Abstract

The association between diabetes and subclinical atherosclerosis is well established. The effect of non-diabetic glucose intolerance on early atherosclerosis is not as straightforward, and the data regarding sex-related differences in this matter are limited. Therefore, our aim was to investigate these associations in men and women separately. We studied 1,304 Finnish men and women over 45 years of age who participated in the Finnish Health 2000 Survey. Ultrasonically determined carotid artery intima-media thickness and elasticity were used as markers of early atherosclerosis. Glucose tolerance was categorized according to the American Diabetes Association criteria for diabetes mellitus. Age-adjusted means for carotid artery intima-media thickness and elasticity indices were significantly (P < 0.05) associated with glucose tolerance status in both sexes. There was a trend of increasing early atherosclerosis with the worsening of glucose tolerance in men and women. These associations were weakened in both sexes after further adjustments for other cardiovascular risk factors. In women, but not in men, significant (P < 0.05) associations between glucose tolerance status and carotid artery elasticity were seen even after these further adjustments. Diabetes and non-diabetic glucose intolerance are associated with increased early carotid atherosclerosis compared with normal glucose tolerance in both sexes. Our results suggest that women with glucose intolerance may be in greater risk than men.

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Titel: Carotid artery intima-media thickness and elasticity in relation to glucose tolerance
verfasst von: Kalle Sipilä
Mika Kähönen
Veikko Salomaa
Markku Päivänsalo
Hannu Karanko
Marjut Varpula
Antti Jula
Risto Kaaja
Y. Antero Kesäniemi
Antti Reunanen
Leena Moilanen
Publikationsdatum: 01.06.2012
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 3/2012
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-011-0291-z

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