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Immunologic Research
Erschienen in: Immunologic Research 1-3/2008

01.10.2008

Cbl- and Nedd4-family ubiquitin ligases: balancing tolerance and immunity

verfasst von: Denise L. Gay, Hilda Ramón, Paula M. Oliver

Erschienen in: Immunologic Research | Ausgabe 1-3/2008

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Abstract

Engagement of the T cell receptor (TCR) with its cognate peptide/MHC initiates a cascade of signaling events that results in T cell activation. Limiting the extent and duration of TCR signaling ensures a tightly constrained response, protecting cells from the deleterious impact of chronic activation. In order to limit the duration of activation, T cells must adjust levels of key signaling proteins. This can be accomplished by altering protein synthesis or by changing the rate of protein degradation. Ubiquitination is a process of ‘tagging’ a protein with ubiquitin and is one means of initiating protein degradation. This process is activated when an E3 ubiquitin ligase mediates the transfer of ubiquitin to a target protein. Accordingly, E3 ubiquitin ligases have recently emerged as key regulators of immune cell function. This review will explore how a small group of E3 ubiquitin ligases regulate T cell responses and thus direct adaptive immunity.
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Metadaten
Titel
Cbl- and Nedd4-family ubiquitin ligases: balancing tolerance and immunity
verfasst von
Denise L. Gay
Hilda Ramón
Paula M. Oliver
Publikationsdatum
01.10.2008
Verlag
Humana Press Inc
Erschienen in
Immunologic Research / Ausgabe 1-3/2008
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-008-8034-0

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