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01.10.2008

Genetic engineering of T cells for adoptive immunotherapy

verfasst von: Angel Varela-Rohena, Carmine Carpenito, Elena E. Perez, Max Richardson, Richard V. Parry, Michael Milone, John Scholler, Xueli Hao, Angela Mexas, Richard G. Carroll, Carl H. June, James L. Riley

Erschienen in: Immunologic Research | Ausgabe 1-3/2008

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Abstract

To be effective for the treatment of cancer and infectious diseases, T cell adoptive immunotherapy requires large numbers of cells with abundant proliferative reserves and intact effector functions. We are achieving these goals using a gene therapy strategy wherein the desired characteristics are introduced into a starting cell population, primarily by high efficiency lentiviral vector-mediated transduction. Modified cells are then expanded using ex vivo expansion protocols designed to minimally alter the desired cellular phenotype. In this article, we focus on strategies to (1) dissect the signals controlling T cell proliferation; (2) render CD4 T cells resistant to HIV-1 infection; and (3) redirect CD8 T cell antigen specificity.

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Titel: Genetic engineering of T cells for adoptive immunotherapy
verfasst von: Angel Varela-Rohena
Carmine Carpenito
Elena E. Perez
Max Richardson
Richard V. Parry
Michael Milone
John Scholler
Xueli Hao
Angela Mexas
Richard G. Carroll
Carl H. June
James L. Riley
Publikationsdatum: 01.10.2008
Verlag: Humana Press Inc
Erschienen in: Immunologic Research / Ausgabe 1-3/2008
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-008-8057-6

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Genetic engineering of T cells for adoptive immunotherapy

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