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Pediatric Nephrology

Erschienen in:

01.08.2013 | Review

Cell polarity and cystic kidney disease

verfasst von: Sorin Fedeles, Anna Rachel Gallagher

Erschienen in: Pediatric Nephrology | Ausgabe 8/2013

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Abstract

Epithelial cell polarity is essential for organ development; aberrations in this process have been implicated in various diseases, including polycystic kidney disease. Establishment and maintenance of cell polarity is governed by a number of molecular processes and how these processes operate remains an interesting question. Conserved protein complexes guide both apical–basolateral polarity and planar cell polarity. In this review we discuss the recent findings that provide insights into polarity mechanisms and the intriguing crosstalk between apical–basolateral polarity and planar cell polarity, and their relationship to cystic kidney disease.

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Titel: Cell polarity and cystic kidney disease
verfasst von: Sorin Fedeles
Anna Rachel Gallagher
Publikationsdatum: 01.08.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 8/2013
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2337-z

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