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Acta Diabetologica

Erschienen in:

12.04.2019 | Original Article

CETP activity is not associated with carotid intima-media thickness in patients with poorly controlled type 2 diabetes

verfasst von: Benjamin Bouillet, T. Gautier, B. Terriat, L. Lagrost, B. Verges, J. M. Petit

Erschienen in: Acta Diabetologica | Ausgabe 7/2019

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Abstract

Aim

The impact of cholesteryl ester transfer protein (CETP) on atherosclerotic development in humans remains unclear. Plasma cholesteryl ester transfer was shown to be associated with carotid intima-media thickness in type 2 diabetic (T2D) patients with adequate metabolic control. Since glycation of CETP may influence cholesteryl ester transfer processes, it is important to determine if plasma cholesteryl ester transfer is still a determinant of carotid intima-media thickness (IMT) in patients with poorly controlled diabetes. The aim of the present study was to determine whether CETP activity influences carotid IMT in T2D patients with poor metabolic control.

Methods

In 110 individuals with T2D, we measured CETP mass concentration with ELISA, CETP activity with a radioactivity method and carotid intima-media thickness with high-resolution real-time B-mode ultrasonography.

Results

The mean HbA1C was 8.8 ± 1.7%. Carotid IMT did not correlate with CETP activity in the total population. In T2D patients with HbA1C < 8% (n = 33), mean HbA1C was 6.9% and the correlation between carotid IMT and CETP activity was not significant (p = 0.09). In a multivariable analysis that included the total population, carotid intima-media thickness was positively associated with diabetes duration (p = 0.02) but not with CETP activity or HbA1C.

Conclusions

We observed no correlation between carotid intima-media thickness, a marker of early atherosclerosis, and CETP activity in T2D patients with poor metabolic control. Disease duration, which reflects accumulated metabolic abnormalities, may have blunted the potential effect of CETP on atherosclerosis. Metabolic control appears essential to determine the pro- or anti-atherogenic influence of CETP in patients with T2D.

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Titel: CETP activity is not associated with carotid intima-media thickness in patients with poorly controlled type 2 diabetes
verfasst von: Benjamin Bouillet
T. Gautier
B. Terriat
L. Lagrost
B. Verges
J. M. Petit
Publikationsdatum: 12.04.2019
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 7/2019
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-019-01340-7

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