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Medical Molecular Morphology

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17.01.2018 | Original Paper

Characteristics of pericytes in diethylstilbestrol (DES)-induced pituitary prolactinoma in rats

verfasst von: Depicha Jindatip, Ken Fujiwara, Tewarit Sarachana, Apiwat Mutirangura, Takashi Yashiro

Erschienen in: Medical Molecular Morphology | Ausgabe 3/2018

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Abstract

Prolactinomas are the most common tumor of the human pituitary. They result in excessive prolactin secretion and important changes in the vasculature. Pericytes are perivascular cells associated with capillaries and have crucial roles in physiological and pathological neovascularization. We previously reported that pericytes produce type I and III collagens in the anterior pituitary of adult rats. In addition, pituitary pericytes contained well-developed cell organelles and actively synthesized collagens during early postnatal development. However, the characteristics of pericytes in pituitary tumors are unclear. In this study, we used diethylstilbestrol (DES)-treated rats as an animal model of prolactinoma. Using five common pericyte markers, more pericytes were observed in rats treated with DES for 3 months (prolactinoma) compared to the control. Transmission electron microscopy revealed that attached and semidetached pericytes exhibited active cell organelles. Moreover, we identified pericyte migration between capillaries. Although the fine structure of pituitary pericytes was active in prolactinoma, expressions of type I and III collagen mRNAs were greatly diminished. In sum, the characteristics and functions of pericytes were altered in pituitary tumors. This study is the first to clarify fine structural changes of pericytes in rat prolactinomas and improves our understanding of the function of pericytes under pathological conditions.

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Titel: Characteristics of pericytes in diethylstilbestrol (DES)-induced pituitary prolactinoma in rats
verfasst von: Depicha Jindatip
Ken Fujiwara
Tewarit Sarachana
Apiwat Mutirangura
Takashi Yashiro
Publikationsdatum: 17.01.2018
Verlag: Springer Japan
Erschienen in: Medical Molecular Morphology / Ausgabe 3/2018
Print ISSN: 1860-1480
Elektronische ISSN: 1860-1499
DOI: https://doi.org/10.1007/s00795-018-0180-4

Springer Medizin

Characteristics of pericytes in diethylstilbestrol (DES)-induced pituitary prolactinoma in rats

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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