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01.07.2020 | Head and Neck

Characterization of parotid gland tumors: added value of permeability MR imaging to DWI and DCE-MRI

verfasst von: Hidetake Yabuuchi, Takeshi Kamitani, Koji Sagiyama, Yuzo Yamasaki, Tomoyuki Hida, Yuko Matsuura, Takuya Hino, Yuriko Murayama, Ryuji Yasumatsu, Hidetaka Yamamoto

Erschienen in: European Radiology | Ausgabe 12/2020

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Abstract

Objectives

To determine added value of permeability MRI in parotid tumor characterization to T2-weighted imaging (T2WI), semi-quantitative analysis of time-intensity curve (TIC), and intra-voxel incoherent motion diffusion-weighted imaging (IVIM-DWI).

Methods

This retrospective study was approved by the institutional review board, and the informed consent was waived. Sixty-one parotid tumors in 61 patients were examined using T2WI, IVIM-DWI, and permeability MRI. TIC patterns were categorized as persistent, washout, or plateau. Signal intensity ratio of lesion-to-muscle on T2WI, apparent diffusion coefficients (ADCs), D and f values from IVIM-DWI, and K_trans, k_ep, V_e, and V_p values from permeability MRI were measured. Multiple comparisons were applied to determine whether any differences among 4 histopathologic types (pleomorphic adenomas, Warthin’s tumors, other benign tumors, and malignant tumors) existed. Diagnostic accuracy was compared before and after modification diagnosis referring to permeability MRI. In a validation study, 60 parotid tumors in 60 patients were examined.

Results

ADC and D values of malignant tumors were significantly lower than those of benign tumors other than Warthin’s tumors, but higher than those of Warthin’s tumors. k_ep and V_p values of Warthin’s tumors were significantly higher than those of malignant tumors. Multivariate analyses showed that TIC pattern, D, and k_ep values were suitable parameters. McNemar’s test showed a significant increase of sensitivity (11/12, 92%) and specificity (46/49, 94%) with adding k_ep. The validation study yielded high sensitivity (14/16, 88%) and specificity (41/44, 93%).

Conclusion

Permeability MRI offers added value to IVIM-MRI and semi-quantitative TIC analysis of DCE-MRI in characterization of parotid tumors

Key Points

• Permeability MR imaging offers added value in the characterization of parotid gland tumors in combination with semi-quantitative TIC analysis and IVIM analyses with D parameter.

• The combination of TIC pattern, D, and k _ep might facilitate accurate characterization of parotid gland tumor, thereby avoiding unnecessary surgery for benign tumors or delayed treatment for malignant tumors.

• A combination of permeability and diffusion MR imaging can be used to guide the selection of an appropriate biopsy site.

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Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L (2010) Major and minor salivary gland tumors. Crit Rev Oncol Hematol 74:134–148CrossRefPubMedCentral

Spiro RH (1986) Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 8:177–184CrossRefPubMedCentral

Larian B (2016) Parotidectomy for benign parotid tumors. Otolaryngol Clin North Am 49:395–413CrossRef

Dell'Aversana Orabona G, Bonavolontà P, Iaconetta G, Forte R, Califano L (2013) Surgical management of benign tumors of the parotid gland: extracapsular dissection versus superficial parotidectomy-our experience in 232 cases. J Oral Maxillofac Surg 71:410–413CrossRef

Lim YC, Lee SY, Kim K et al (2005) Conservative parotidectomy for the treatment of parotid cancers. Oral Oncol 41:1021–1027CrossRef

Zhang YF, Li H, Wang XM, Cai YF (2019) Sonoelastography for differential diagnosis between malignant and benign parotid lesions: a meta-analysis. Eur Radiol 29:725–735CrossRefPubMedCentral

Zengel P, Notter F, Clevert DA (2018) Does acoustic radiation force elastography improve the diagnostic capability of ultrasound in the preoperative characterization of masses of the parotid gland? Dentomaxillofac Radiol 47:20180068CrossRefPubMedCentral

Christensen RK, Bjørndal K, Godballe C, Krogdahl A (2010) Value of fine-needle aspiration biopsy of salivary gland lesions. Head Neck 32:104–108

Howlett DC, Menezes LJ, Lewis K, Moody AB, Violaris N, Williams MD (2007) Sonographically guided core biopsy of a parotid mass. AJR Am J Roentgenol 188:223–227CrossRef

10.

Liu CC, Jethwa AR, Khariwala SS, Johnson J, Shin JJ (2016) Sensitivity, specificity, and posttest probability of parotid fine-needle aspiration: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 154:9–23CrossRef

11.

Ishibashi M, Fujii S, Kawamoto K et al (2010) Capsule of parotid gland tumor: evaluation by 3.0 T magnetic resonance imaging using surface coils. Acta Radiol 51:1103–1110CrossRefPubMedCentral

12.

Okahara M, Kiyosue H, Hori Y, Matsumoto A, Mori H, Yokoyama S (2003) Parotid tumors: MR imaging with pathological correlation. Eur Radiol 13:25–33CrossRef

13.

Yabuuchi H, Fukuya T, Tajima T, Hachitanda Y, Tomita K, Koga M (2003) Salivary gland tumors: diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation. Radiology 226:345–354CrossRefPubMedCentral

14.

Yabuuchi H, Matsuo Y, Kamitani T et al (2008) Parotid gland tumors: can addition of diffusion-weighted MR imaging to dynamic contrast-enhanced MR imaging improve diagnostic accuracy in characterization? Radiology 249:909–916CrossRef

15.

Sumi M, Van Cauteren M, Sumi T, Obara M, Ichikawa Y, Nakamura T (2012) Salivary gland tumors: use of intravoxel incoherent motion MR imaging for assessment of diffusion and perfusion for the differentiation of benign from malignant tumors. Radiology 263:770–777CrossRef

16.

Wu Q, Zhu LN, Jiang JS, Bu SS, Xu XQ, Wu FY (2020) Characterization of parotid gland tumors using T2 mapping imaging: initial findings. Acta Radiol:629–635

17.

Leiva-Salinas C, Provenzale JM, Kudo K, Sasaki M, Wintermark M (2012) The alphabet soup of perfusion CT and MR imaging: terminology revisited and clarified in five questions. Neuroradiology 54:907–918CrossRef

18.

Calamante F (2013) Arterial input function in perfusion MRI: a comprehensive review. Prog Nucl Magn Reson Spectrosc 74:1–32CrossRef

19.

Lee FK, King AD, Ma BB, Yeung DK (2012) Dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) for differential diagnosis in head and neck cancers. Eur J Radiol 81:784–788CrossRef

20.

Cha S, Yang L, Johnson G et al (2006) Comparison of microvascular permeability measurements, K(trans), determined with conventional steady-state T1-weighted and first-pass T2*-weighted MR imaging methods in gliomas and meningiomas. AJNR Am J Neuroradiol 27:409–417

21.

Falk A, Fahlström M, Rostrup E et al (2014) Discrimination between glioma grades II and III in suspected low-grade gliomas using dynamic contrast-enhanced and dynamic susceptibility contrast perfusion MR imaging: a histogram analysis approach. Neuroradiology 56:1031–1038CrossRef

22.

Li X, Arlinghaus LR, Ayers GD et al (2014) DCE-MRI analysis methods for predicting the response of breast cancer to neoadjuvant chemotherapy: pilot study findings. Magn Reson Med 71:1592–1602CrossRef

23.

Kato H, Kanematsu M, Watanabe H et al (2015) Perfusion imaging of parotid gland tumours: usefulness of arterial spin labeling for differentiating Warthin’s tumours. Eur Radiol 25:3247–3254CrossRef

24.

Razek AAKA (2019) Multi-parametric MR imaging using pseudo-continuous arterial-spin labeling and diffusion-weighted MR imaging in differentiating subtypes of parotid tumors. Magn Reson Imaging 63:55–59CrossRef

25.

Xu Z, Zheng S, Pan A, Cheng X, Gao M (2019) A multiparametric analysis based on DCE-MRI to improve the accuracy of parotid tumor discrimination. Eur J Nucl Med Mol Imaging 46:2228–2234CrossRef

26.

Tofts PS, Brix G, Buckley DL et al (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10:223–232CrossRef

27.

Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307–310CrossRef

Titel: Characterization of parotid gland tumors: added value of permeability MR imaging to DWI and DCE-MRI
verfasst von: Hidetake Yabuuchi
Takeshi Kamitani
Koji Sagiyama
Yuzo Yamasaki
Tomoyuki Hida
Yuko Matsuura
Takuya Hino
Yuriko Murayama
Ryuji Yasumatsu
Hidetaka Yamamoto
Publikationsdatum: 01.07.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 12/2020
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-020-07004-3

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Characterization of parotid gland tumors: added value of permeability MR imaging to DWI and DCE-MRI