nach oben

Erschienen in:

01.04.2015 | Magnetic Resonance

Characterizing the contrast of white matter and grey matter in high-resolution phase difference enhanced imaging of human brain at 3.0 T

verfasst von: Li Yang, Shanshan Wang, Bin Yao, Lili Li, Xiaofei Xu, Lingfei Guo, Lianxin Zhao, Xinjuan Zhang, Weibo Chen, Queenie Chan, Guangbin Wang

Erschienen in: European Radiology | Ausgabe 4/2015

Einloggen, um Zugang zu erhalten

Abstract

Objectives

The purpose of this study was to address the feasibility of characterizing the contrast both between and within grey matter and white matter using the phase difference enhanced (PADRE) technique.

Methods

PADRE imaging was performed in 33 healthy volunteers. Vessel enhancement (VE), tissue enhancement (TE), and PADRE images were reconstructed from source images and were evaluated with regard to differentiation of grey-to-white matter interface, the stria of Gennari, and the two layers, internal sagittal stratum (ISS) and external sagittal stratum (ESS), of optic radiation.

Results

White matter regions showed decreased signal intensity compared to grey matter regions. Discrimination was sharper between white matter and cortical grey matter in TE images than in PADRE images, but was poorly displayed in VE images. The stria of Gennari was observed on all three image sets. Low-signal-intensity bands displayed in VE images representing the optic radiation were delineated as two layers of different signal intensities in TE and PADRE images. Statistically significant differences in phase shifts were found between frontal grey and white matter, as well as between ISS and ESS (p < 0.01).

Conclusions

The PADRE technique is capable of identifying grey-to-white matter interface, the stria of Gennari, and ISS and ESS, with improved contrast in PADRE and TE images compared to VE images.

Key Points

• Phase difference enhanced (PADRE) imaging can yield diverse contrasts between tissues

• The PADRE technique utilizes the inherent variety of magnetic susceptibilities

• PADRE MR imaging provides better visualization of certain cerebral anatomy in vivo

• PADRE imaging is able to delineate the stria of Gennari in the primary visual cortex

• PADRE imaging is able to identify the two optic radiation layers

Rauscher A, Sedlacik J, Barth M, Mentzel HJ, Reichenbach JR (2005) Magnetic susceptibility-weighted MR phase imaging of the human brain. AJNR Am J Neuroradiol 26:736–742PubMed

Abduljalil AM, Schmalbrock P, Novak V, Chakeres DW (2003) Enhanced gray and white matter contrast of phase susceptibility-weighted images in ultra-high-field magnetic resonance imaging. J Magn Reson Imaging 18:284–290CrossRefPubMed

Duyn JH, van Gelderen P, Li TQ, de Zwart JA, Koretsky AP, Fukunaga M (2007) High-field MRI of brain cortical substructure based on signal phase. Proc Natl Acad Sci U S A 104:11796–11801CrossRefPubMedCentralPubMed

Haacke EM, Xu Y, Cheng YC, Reichenbach JR (2004) Susceptibility weighted imaging (SWI). Magn Reson Med 52:612–618CrossRefPubMed

Hammond KE, Lupo JM, Xu D et al (2008) Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases. Neuroimage 39:1682–1692CrossRefPubMedCentralPubMed

Manova ES, Habib CA, Boikov AS et al (2009) Characterizing the mesencephalon using susceptibility-weighted imaging. AJNR Am J Neuroradiol 30:569–574CrossRefPubMedCentralPubMed

Reichenbach JR, Haacke EM (2001) High-resolution BOLD venographic imaging: a window into brain function. NMR Biomed 14:453–467CrossRefPubMed

Yoneda T, Hirai T, Hiai Y, et al (2009) Triple-layer appearance of human cerebral cortices on phase-difference enhanced imaging using 3D principle of echo shifting with a train of observations (PRESTO) sequence. Proc Int Soc Magn Reson Med pp 27

Hagberg GE, Welch EB, Greiser A (2010) The sign convention for phase values on different vendor systems: definition and implications for susceptibility-weighted imaging. Magn Reson Imaging 28:297–300CrossRefPubMed

10.

Yamada N, Imakita S, Sakuma T, Takamiya M (1996) Intracranial calcification on gradient-echo phase image: depiction of diamagnetic susceptibility. Radiology 198:171–178CrossRefPubMed

11.

Robinson RJ, Bhuta S (2011) Susceptibility-weighted imaging of the brain: current utility and potential applications. J Neuroimaging 21:e189–e204CrossRefPubMed

12.

Kakeda S, Korogi Y, Yoneda T et al (2011) A novel tract imaging technique of the brainstem using phase difference enhanced imaging: normal anatomy and initial experience in multiple system atrophy. Eur Radiol 21:2202–2210CrossRefPubMed

13.

Kakeda S, Korogi Y, Yoneda T et al (2013) Parkinson’s disease: diagnostic potential of high-resolution phase difference enhanced MR imaging at 3 T. Eur Radiol 23:1102–1111CrossRefPubMed

14.

Haacke EM, Ayaz M, Khan A et al (2007) Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging 26:256–264CrossRefPubMed

15.

Series SC (2003) Measurement of observer agreement. Radiology 228:303–308CrossRef

16.

Shrout PE, Fleiss JL (1979) Intraclass correlations: uses in assessing rater reliability. Psychol Bull 86:420–428CrossRefPubMed

17.

Mori N, Miki Y, Kasahara S et al (2009) Susceptibility-weighted imaging at 3 Tesla delineates the optic radiation. Invest Radiol 44:140–145CrossRefPubMed

18.

Trampel R, Ott DV, Turner R (2011) Do the congenitally blind have a stria of Gennari? First intracortical insights in vivo. Cereb Cortex 21:2075–2081CrossRefPubMed

19.

Clark VP, Courchesne E, Grafe M (1992) In vivo myeloarchitectonic analysis of human striate and extrastriate cortex using magnetic resonance imaging. Cereb Cortex 2:417–424CrossRefPubMed

20.

Fukunaga M, Li TQ, van Gelderen P et al (2010) Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci U S A 107:3834–3839CrossRefPubMedCentralPubMed

21.

Ide S, Kakeda S, Korogi Y et al (2012) Delineation of optic radiation and stria of Gennari on high-resolution phase difference enhanced imaging. Acad Radiol 19:1283–1289CrossRefPubMed

22.

Li TQ, van Gelderen P, Merkle H, Talagala L, Koretsky AP, Duyn J (2006) Extensive heterogeneity in white matter intensity in high-resolution T2*-weighted MRI of the human brain at 7.0 T. Neuroimage 32:1032–1040CrossRefPubMed

23.

Kitajima M, Korogi Y, Takahashi M, Eto K (1996) MR signal intensity of the optic radiation. Am J Neuroradiol 17:1379–1383PubMed

24.

Petridou N, Wharton SJ, Lotfipour A, Gowland P, Bowtell R (2010) Investigating the effect of blood susceptibility on phase contrast in the human brain. Neuroimage 50:491–498CrossRefPubMed

25.

Lee J, Hirano Y, Fukunaga M, Silva AC, Duyn JH (2010) On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field. Neuroimage 49:193–198CrossRefPubMedCentralPubMed

26.

Yao B, Li TQ, Gelderen P, Shmueli K, de Zwart JA, Duyn JH (2009) Susceptibility contrast in high field MRI of human brain as a function of tissue iron content. Neuroimage 44:1259–1266CrossRefPubMedCentralPubMed

27.

Lee J, Shmueli K, Kang BT et al (2012) The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain. Neuroimage 59:3967–3975CrossRefPubMedCentralPubMed

28.

Langkammer C, Krebs N, Goessler W et al (2012) Susceptibility induced gray-white matter MRI contrast in the human brain. Neuroimage 59:1413–1419CrossRefPubMedCentralPubMed

29.

Cavaglia M, Dombrowski SM, Drazba J, Vasanji A, Bokesch PM, Janigro D (2001) Regional variation in brain capillary density and vascular response to ischemia. Brain Res 910:81–93CrossRefPubMed

30.

Bell MA, Ball MJ (1985) Laminar variation in the microvascular architecture of normal human visual cortex (area 17). Brain Res 335:139–143CrossRefPubMed

31.

Haacke EM, Cheng NY, House MJ et al (2005) Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 23:1–25CrossRefPubMed

32.

Curnes JT, Burger PC, Djang WT, Boyko OB (1988) MR imaging of compact white matter pathways. Am J Neuroradiol 9:1061–1068PubMed

33.

Brady S, Siegel G, Albers RW, Price D (2005) Basic Neurochemistry: Molecular, cellular and medical aspects. Academic Press

34.

Liu C, Li W, Johnson GA, Wu B (2011) High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. Neuroimage 56:930–938CrossRefPubMedCentralPubMed

35.

Mackay A, Whittall K, Adler J, Li D, Paty D, Graeb D (1994) In vivo visualization of myelin water in brain by magnetic resonance. Magn Reson Med 31:673–677CrossRefPubMed

36.

Zhong K, Leupold J, von Elverfeldt D, Speck O (2008) The molecular basis for gray and white matter contrast in phase imaging. Neuroimage 40:1561–1566CrossRefPubMed

37.

Shmueli K, Dodd SJ, Li TQ, Duyn JH (2011) The contribution of chemical exchange to MRI frequency shifts in brain tissue. Magn Reson Med 65:35–43CrossRefPubMedCentralPubMed

38.

Saini J, Kesavadas C, Thomas B et al (2009) Susceptibility weighted imaging in the diagnostic evaluation of patients with intractable epilepsy. Epilepsia 50:1462–1473CrossRefPubMed

39.

Madan N, Grant PE (2009) New directions in clinical imaging of cortical dysplasias. Epilepsia 50(Suppl 9):9–18CrossRefPubMed

40.

van Rooden S, Versluis MJ, Liem MK et al (2014) Cortical phase changes in Alzheimer's disease at 7 T MRI: A novel imaging marker. Alzheimers Dement 10:e19–e26CrossRefPubMed

41.

Bridge H, Clare S (2006) High-resolution MRI: in vivo histology? Philos Trans R Soc B Biol Sci 361:137–146CrossRef

Titel: Characterizing the contrast of white matter and grey matter in high-resolution phase difference enhanced imaging of human brain at 3.0 T
verfasst von: Li Yang
Shanshan Wang
Bin Yao
Lili Li
Xiaofei Xu
Lingfei Guo
Lianxin Zhao
Xinjuan Zhang
Weibo Chen
Queenie Chan
Guangbin Wang
Publikationsdatum: 01.04.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 4/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3480-7

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Characterizing the contrast of white matter and grey matter in high-resolution phase difference enhanced imaging of human brain at 3.0 T