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European Radiology
Erschienen in: European Radiology 4/2015

01.04.2015 | Cardiac

Extent of late gadolinium enhancement at right ventricular insertion points in patients with hypertrophic cardiomyopathy: relation with diastolic dysfunction

verfasst von: Yinsu Zhu, Eun-Ah Park, Whal Lee, Hyung-Kwan Kim, Ajung Chu, Jin Wook Chung, Jae Hyung Park

Erschienen in: European Radiology | Ausgabe 4/2015

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Abstract

Objectives

Our aim was to examine the association between the extent of late gadolinium enhancement (LGE) at right ventricular insertion points (RVIP) and left ventricular (LV) functional parameters in patients with hypertrophic cardiomyopathy (HCM).

Methods

Sixty-one HCM patients underwent echocardiography and cardiovascular magnetic resonance (CMR) within one week. Mitral annular velocities (E/E’) were obtained from echocardiography; LV ejection fraction (EF), LV mass index, LV wall maximal thickness, and left atrial volume index (LAVI) were obtained from MR. LGE extent was quantified (proportion of total LV myocardial mass) according to location: % RVIP-LGE and % non-RVIP-LGE.

Results

Although LGE was commonly present in both apical (74 %) and non-apical HCMs (88 %) (p = 0.163), RVIP-LGE was more frequent (86 % vs. 47 %, p = 0.002) in non-apical HCMs in which E/E' was significantly higher (19.23 ± 8.40 vs. 13.13 ± 5.06, p = 0.009). In addition, RVIP-LGE extent was associated with LV diastolic dysfunction (r = 0.45, p < 0.001 for E/E'; r = 0.53, p < 0.001 for LAVI) and lower LVEF (r = -0.42, p = 0.001). There was no correlation between non-RVIP-LGE extent and other parameters. Multiple linear regression analysis revealed RVIP-LGE extent as an independent predictor of E/E’ (β = 0.45, p < 0.001) and LAVI in HCM patients (β = 0.53, p < 0.001).

Conclusions

The extent of LGE at RVIPs in HCM patients is associated with increased estimated LV filling pressure and chronic diastolic burden.

Key Points

• Late gadolinium enhancement at RV insertion points is frequently seen in HCM.
• RVIP-LGE extent is correlated with increased estimated LV filling pressure in HCM.
• Non-RVIP-LGE extent did not show any association with LV diastolic dysfunction.
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Metadaten
Titel
Extent of late gadolinium enhancement at right ventricular insertion points in patients with hypertrophic cardiomyopathy: relation with diastolic dysfunction
verfasst von
Yinsu Zhu
Eun-Ah Park
Whal Lee
Hyung-Kwan Kim
Ajung Chu
Jin Wook Chung
Jae Hyung Park
Publikationsdatum
01.04.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 4/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3390-8

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