Introduction
Methods and materials
Patients and tissue samples
Immunohistochemistry staining and evaluation
Statistical analysis
Results
Patient and tumor characteristics of CB patients
Variable | Categories | All (n) | Axial (n) | Extra-axial (n) | P-value |
---|---|---|---|---|---|
Age (years) | Continuous | 132 (29.2 ± 13.4) | 61 (34.1 ± 14.6) | 71 (24.9 ± 10.8) | < 0.001 |
Gender | Female | 46 | 19 | 27 | 0.408 |
Male | 86 | 42 | 44 | ||
Duration of symptoms (months) | Continuous | 132 (8.3 ± 7.4) | 61 (8.3 ± 6.7) | 71 (8.3 ± 8.1) | 0.955 |
Tumor size (in diameter, cm) | Continuous | 132 (3.9 ± 1.8) | 61 (5.3 ± 1.5) | 71 (2.6 ± 0.9) | < 0.001 |
Type of resection | Wide | 65 | 27 | 38 | 0.289 |
Not wide | 67 | 34 | 33 | ||
Surrounding tissue invasion | No | 59 | 12 | 47 | < 0.001 |
Yes | 73 | 49 | 24 | ||
Adjuvant radiotherapy | No | 98 | 44 | 54 | 0.607 |
Yes | 34 | 17 | 17 | ||
Preoperative sensory or motor dysfunction | No | 97 | 39 | 58 | 0.021 |
Yes | 35 | 22 | 13 | ||
Postoperative sensory or motor dysfunction | No | 53 | 20 | 33 | 0.110 |
Yes | 79 | 41 | 38 | ||
Secondary ABC | No | 74 | 33 | 41 | 0.674 |
Yes | 58 | 28 | 30 | ||
Chicken-wire calcification | No | 63 | 24 | 39 | 0.074 |
Yes | 69 | 37 | 23 | ||
Recurrence during follow-up | No | 95 | 39 | 56 | 0.057 |
Yes | 37 | 22 | 15 | ||
S100 | Low | 27 | 13 | 14 | 0.821 |
High | 105 | 48 | 57 | ||
Vim | Low | 37 | 9 | 28 | 0.002 |
High | 95 | 52 | 43 | ||
CK | Low | 91 | 42 | 49 | 0.984 |
High | 41 | 19 | 22 |
Comparison of clinicopathological characteristics between ACB and EACB patients
Univariate Kaplan–Meier analysis and multivariate Cox analyses of prognostic factors in patients with ACB
Factors | Categories | Numbers | Local recurrence-free survival | Overall survival | ||
---|---|---|---|---|---|---|
P-value | HR (95% CI) | P-value | HR (95% CI) | |||
Type of resection | Wide | 27 | 0.002 | 0.137 (0.039–0.479) | 0.027 | 0.097 (0.012–0.768) |
Not wide | 34 | |||||
Surrounding tissue invasion | No | 18 | / | / | 0.192 | 0.242 (0.029–2.039) |
Yes | 43 | |||||
Chicken-wire calcification | No | 24 | 0.003 | 3.913 (1.583–9.672) | 0.063 | 3.167 (0.938–10.695) |
Yes | 37 |
Univariate Kaplan–Meier analysis and multivariate Cox analyses of prognostic factors in patients with EACB
Factors | Categories | Numbers | Local recurrence-free survival | Overall survival | ||
---|---|---|---|---|---|---|
P-value | HR (95% CI) | P-value | HR (95% CI) | |||
Type of resection | Wide | 27 | 0.019 | 4.774 (1.295–17.593) | 0.039 | 5.405 (1.086–26.901) |
Not wide | 34 | |||||
Surrounding tissue invasion | No | 18 | 0.041 | 3.052 (1.048–8.889) | 0.102 | 2.626 (0.826–8.344) |
Yes | 43 | |||||
Adjuvant radiotherapy | No | 54 | 0.313 | 1.739 (0.593–5.096) | 0.365 | 1.728 (0.529–5.639) |
Yes | 17 | |||||
Postoperative sensory or motor dysfunction | No | 33 | / | / | 0.032 | 0.242 (0.066–0.887) |
Yes | 38 |