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Inflammation
Erschienen in: Inflammation 5/2019

17.05.2019 | ORIGINAL ARTICLE

Co-Nanoencapsulation of Vitamin D3 and Curcumin Regulates Inflammation and Purine Metabolism in a Model of Arthritis

verfasst von: Jean Lucas G. da Silva, Daniela F. Passos, Viviane M. Bernardes, Fernanda L. Cabral, Paulo G. Schimites, Alessandra G. Manzoni, Edilene Gadelha de Oliveira, Cristiane de Bona da Silva, Ruy Carlos Ruver Beck, Matheus H. Jantsch, Roberto M. Maciel, Daniela B. R. Leal

Erschienen in: Inflammation | Ausgabe 5/2019

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Abstract

We analyzed the effects of a nanoencapsulated association of curcumin and vitamin D3 on purine metabolism enzymes in neutrophils, lymphocytes, and platelets in a model of adjuvant-induced arthritis (AIA) in rats. Following AIA induction, the animals were treated for 15 days with free and nanoencapsulated curcumin (4 mg/kg), nanocapsules of vitamin D3 (VD3) (15.84 IU/day), a nanoencapsulated combination of curcumin and VD3, vehicle, or blank nanocapsules. The animals were euthanized, and blood was collected to evaluate the activities of E-NTPDase, adenosine deaminase (ADA), and myeloperoxidase (MPO), as well as reactive oxygen species (ROS) levels and biochemical parameters. Also, the liver and kidney were collected for histological analysis. The changes in the activities of purinergic enzymes indicated that inflammation was significantly reverted by vitamin D3 and curcumin co-nanoencapsulation treatments in the arthritic rats. The reduction of inflammation was confirmed by the reduction in the signs and symptoms of AIA, as well as in MPO activity by all formulations. The treatments with nanocapsules reverted histological alterations in the kidney. Serum parameters were not altered by the induction or treatments. Our results suggest that co-nanoencapsulation of vitamin D3 and curcumin is an efficient alternative adjuvant treatment for rheumatoid arthritis as it reverts the changes in the purine metabolism and reduces arthritis-associated inflammation.
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Metadaten
Titel
Co-Nanoencapsulation of Vitamin D3 and Curcumin Regulates Inflammation and Purine Metabolism in a Model of Arthritis
verfasst von
Jean Lucas G. da Silva
Daniela F. Passos
Viviane M. Bernardes
Fernanda L. Cabral
Paulo G. Schimites
Alessandra G. Manzoni
Edilene Gadelha de Oliveira
Cristiane de Bona da Silva
Ruy Carlos Ruver Beck
Matheus H. Jantsch
Roberto M. Maciel
Daniela B. R. Leal
Publikationsdatum
17.05.2019
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 5/2019
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-019-01021-1

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