Skip to main content
Erschienen in: European Radiology 7/2005

01.07.2005 | Contrast Media

Contrast media: interactions with other drugs and clinical tests

verfasst von: Sameh K. Morcos, Henrik S. Thomsen, C. M. Exley, Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)

Erschienen in: European Radiology | Ausgabe 7/2005

Einloggen, um Zugang zu erhalten

Abstract

Many patients with multiple medical problems who are receiving a variety of drugs are investigated with imaging techniques which require intravascular contrast media. The Contrast Media Safety Committee of the European Society of Urogenital Radiology therefore decided to review the literature and to draw up simple guidelines on interactions between contrast media and other drugs. An extensive literature search was carried out and summarized in a report. Based on the available information, simple guidelines have been drawn up. The report and guidelines were discussed at the 11th European Symposium on Urogenital Radiology in Santiago de Compostela. Contrast media may interact with other drugs, and may interfere with isotope studies and biochemical measurements. Awareness of the patient drug history is important to avoid potential hazards. Simple guidelines are presented.
Literatur
1.
Zurück zum Zitat Jakobsen JÅ, Oyen R, Thomsen HS, Morcos SK, members of contrast media safety committee of the European Society of Urogenital Radiology (ESUR) (2005) Safety of ultrasound contrast agents. Eur Radiol DOI 10.1007/s00330-004-2601-0 Jakobsen JÅ, Oyen R, Thomsen HS, Morcos SK, members of contrast media safety committee of the European Society of Urogenital Radiology (ESUR) (2005) Safety of ultrasound contrast agents. Eur Radiol DOI 10.​1007/​s00330-004-2601-0
2.
Zurück zum Zitat Frohlich JM (2001) Systematic survey of interactions between contrast media and other drugs. Special edition by Guerbet Switzerland Frohlich JM (2001) Systematic survey of interactions between contrast media and other drugs. Special edition by Guerbet Switzerland
3.
Zurück zum Zitat Thomsen HS, Morcos SK, ESUR Contrast Media Safety Committee (1999) Contrast media and metformin. Guidelines to distinguish the risk of lactic acidosis in non-insulin dependent diabetics after administration of contrast media. Eur Radiol 9:738–740 Thomsen HS, Morcos SK, ESUR Contrast Media Safety Committee (1999) Contrast media and metformin. Guidelines to distinguish the risk of lactic acidosis in non-insulin dependent diabetics after administration of contrast media. Eur Radiol 9:738–740
4.
Zurück zum Zitat Morcos SK (1998) Contrast media-induced nephrotoxicity—questions and answers. Br J Radiol 71:357–365 Morcos SK (1998) Contrast media-induced nephrotoxicity—questions and answers. Br J Radiol 71:357–365
5.
Zurück zum Zitat Morcos SK, Thomsen HS, Webb JAW and ESUR Contrast Media Safety Committee (1999) Contrast media-induced nephrotoxicity: a consensus report. Eur Radiol 9:1602–1613CrossRef Morcos SK, Thomsen HS, Webb JAW and ESUR Contrast Media Safety Committee (1999) Contrast media-induced nephrotoxicity: a consensus report. Eur Radiol 9:1602–1613CrossRef
6.
Zurück zum Zitat Thomsen HS, Morcos SK (2003) Contrast media and the kidney: European Society of Urogenital Radiology (ESUR) guidelines. Br J Radiol 76:513–518 Thomsen HS, Morcos SK (2003) Contrast media and the kidney: European Society of Urogenital Radiology (ESUR) guidelines. Br J Radiol 76:513–518
7.
Zurück zum Zitat Swanson DP, Chilton HM, Thrall JH (eds) (1990) Pharmaceuticals in medical imaging: radiopaque contrast media, radiopharmaceuticals, enhancement agents for magnetic resonance imaging and ultrasound. Macmillan Publishers, New York, p 42 Swanson DP, Chilton HM, Thrall JH (eds) (1990) Pharmaceuticals in medical imaging: radiopaque contrast media, radiopharmaceuticals, enhancement agents for magnetic resonance imaging and ultrasound. Macmillan Publishers, New York, p 42
8.
Zurück zum Zitat Choyke PL, Miller DL, Lotze MT, Whireis JM, Ebbitt B, Rosenberg SA (1992) Delayed reactions to contrast media after interleukin-2 immunotherapy. Radiology 183:111–114 Choyke PL, Miller DL, Lotze MT, Whireis JM, Ebbitt B, Rosenberg SA (1992) Delayed reactions to contrast media after interleukin-2 immunotherapy. Radiology 183:111–114
9.
Zurück zum Zitat Reynolds N, Wallington TB, Burton JL (1993) Hydralazine predisposes to acute cutaneous vasculitis following urography with iopamidol. Br J Dermatol 129:82–85 Reynolds N, Wallington TB, Burton JL (1993) Hydralazine predisposes to acute cutaneous vasculitis following urography with iopamidol. Br J Dermatol 129:82–85
10.
Zurück zum Zitat Laurence DR, Bennett PN (1992) Clinical pharmacology, 7th edn. Churchill Livingstone, Edinburgh, pp 416–423 Laurence DR, Bennett PN (1992) Clinical pharmacology, 7th edn. Churchill Livingstone, Edinburgh, pp 416–423
11.
Zurück zum Zitat Lang DM, Alpern MB, Visintainer PF, Smith ST (1991) Increased risk for anaphylactoid reaction from contrast media in patients on beta-adrenergic blockers or with asthma. Ann Intern Med 115:270–276 Lang DM, Alpern MB, Visintainer PF, Smith ST (1991) Increased risk for anaphylactoid reaction from contrast media in patients on beta-adrenergic blockers or with asthma. Ann Intern Med 115:270–276
12.
Zurück zum Zitat Lang DM, Alpern MB, Visintainer PF, Smith ST (1993) Elevated risk of anaphylactoid reaction from radiographic contrast media is associated with both beta-blocker exposure and cardiovascular disorders. Arch Intern Med 153:2033–2040. Erratum in: Arch Intern Med 1993; 153:2412 Lang DM, Alpern MB, Visintainer PF, Smith ST (1993) Elevated risk of anaphylactoid reaction from radiographic contrast media is associated with both beta-blocker exposure and cardiovascular disorders. Arch Intern Med 153:2033–2040. Erratum in: Arch Intern Med 1993; 153:2412
13.
Zurück zum Zitat Abi-Aad AS, Figlin RA, Belldegrun A, de Kernion JB (1991) Metastatic renal cell cancer: interleukin-2 toxicity induced by contrast agent injection. J Immunother 10:292–295 Abi-Aad AS, Figlin RA, Belldegrun A, de Kernion JB (1991) Metastatic renal cell cancer: interleukin-2 toxicity induced by contrast agent injection. J Immunother 10:292–295
14.
Zurück zum Zitat Massee DR, Smith DC, Westengard JC, Bull BS (1991) Heparin supplementation of nonionic contrast agents. J Vasc Interv Radiol 2:209–213 Massee DR, Smith DC, Westengard JC, Bull BS (1991) Heparin supplementation of nonionic contrast agents. J Vasc Interv Radiol 2:209–213
15.
Zurück zum Zitat Parvez Z, Moncada R, Messmore HL, Fareed J (1982) Ionic and nonionic contrast media interaction with anticoagulant drugs. Acta Radiol Diagn (Stockh) 23:401–404 Parvez Z, Moncada R, Messmore HL, Fareed J (1982) Ionic and nonionic contrast media interaction with anticoagulant drugs. Acta Radiol Diagn (Stockh) 23:401–404
16.
Zurück zum Zitat Dehmer GJ, Gresalfi N, Daly D, Oberhardt B, Tate DA (1995) Impairment of fibrinolysis by streptokinase, urokinase and recombinant tissue-type plasminogen activator in the presence of radiographic contrast agents. J Am Coll Cardiol 25:1069–1075 Dehmer GJ, Gresalfi N, Daly D, Oberhardt B, Tate DA (1995) Impairment of fibrinolysis by streptokinase, urokinase and recombinant tissue-type plasminogen activator in the presence of radiographic contrast agents. J Am Coll Cardiol 25:1069–1075
17.
Zurück zum Zitat Pislaru S, Pislaru C, Szilard M, Arnout J, van de Werf F (1998) In vivo effects of contrast media on coronary thrombolysis. J Am Coll Cardiol 32:1102–1108 Pislaru S, Pislaru C, Szilard M, Arnout J, van de Werf F (1998) In vivo effects of contrast media on coronary thrombolysis. J Am Coll Cardiol 32:1102–1108
18.
Zurück zum Zitat Higgins CB, Kruber M, Slutsky RA (1983) Interaction between verapamil and contrast media in coronary arteriography: comparison of standard ionic and new nonionic media. Circulation 68:628–635 Higgins CB, Kruber M, Slutsky RA (1983) Interaction between verapamil and contrast media in coronary arteriography: comparison of standard ionic and new nonionic media. Circulation 68:628–635
19.
Zurück zum Zitat Morris DL, Wisneski JA, Gertz EW, Wexman M, Axelrod R, Langberg JJ (1985) Potentiation by nifedipine and diltiazem of the hypotensive response after contrast angiography. J Am Coll Cardiol 6:785–791 Morris DL, Wisneski JA, Gertz EW, Wexman M, Axelrod R, Langberg JJ (1985) Potentiation by nifedipine and diltiazem of the hypotensive response after contrast angiography. J Am Coll Cardiol 6:785–791
20.
Zurück zum Zitat Morcos SK, Dawson P, Pearson JD et al (1998) The hemodynamic effects of iodinated water soluble radiographic contrast media: a review. Eur J Radiol 29:31–46 Morcos SK, Dawson P, Pearson JD et al (1998) The hemodynamic effects of iodinated water soluble radiographic contrast media: a review. Eur J Radiol 29:31–46
21.
Zurück zum Zitat Fischer HW, Morris TW (1980) Possible factors in intravascular contrast media toxicity. Invest Radiol 15(Suppl 6):S232–S238 Fischer HW, Morris TW (1980) Possible factors in intravascular contrast media toxicity. Invest Radiol 15(Suppl 6):S232–S238
22.
Zurück zum Zitat Van der Molen AJ, Thomsen HS, Morcos SK, ESUR Contrast Media Safety Committee (2004) Effect of iodinated contrast media on thyroid function in adults. Eur Radiol 14:902–907PubMed Van der Molen AJ, Thomsen HS, Morcos SK, ESUR Contrast Media Safety Committee (2004) Effect of iodinated contrast media on thyroid function in adults. Eur Radiol 14:902–907PubMed
23.
Zurück zum Zitat Crawford JA, Gumerman LW (1978) Alteration of body distribution of Tc99m-pyrophosphate by radiographic contrast material. Clin Nucl Med 3:305–307 Crawford JA, Gumerman LW (1978) Alteration of body distribution of Tc99m-pyrophosphate by radiographic contrast material. Clin Nucl Med 3:305–307
24.
Zurück zum Zitat Tatum JL, Burke TS, Hirsch JI, Miller WW, Fratkin MJ (1983) Pitfall to modified in vivo method of technetium-99m red blood cell labeling. Iodinated contrast media. Clin Nucl Med 8:585–587 Tatum JL, Burke TS, Hirsch JI, Miller WW, Fratkin MJ (1983) Pitfall to modified in vivo method of technetium-99m red blood cell labeling. Iodinated contrast media. Clin Nucl Med 8:585–587
25.
Zurück zum Zitat Kim SH, Lee HK, Han MC (1992) Incompatibility of water-soluble contrast media and intravascular pharmacologic agents. An in vitro study. Invest Radiol 27:45–49 Kim SH, Lee HK, Han MC (1992) Incompatibility of water-soluble contrast media and intravascular pharmacologic agents. An in vitro study. Invest Radiol 27:45–49
26.
Zurück zum Zitat Morcos SK, El Nahas AM, Brown P, Haylor J (1992). Effect of iodinated water soluble contrast media on urinary protein assays. BMJ 305:29 Morcos SK, El Nahas AM, Brown P, Haylor J (1992). Effect of iodinated water soluble contrast media on urinary protein assays. BMJ 305:29
27.
Zurück zum Zitat Prince MR, Erel HE, Lent RW et al (2003) Gadodiamide administration causes spurious hypocalcemia. Radiology 227:639–646 Prince MR, Erel HE, Lent RW et al (2003) Gadodiamide administration causes spurious hypocalcemia. Radiology 227:639–646
28.
Zurück zum Zitat Choyke PL, Knopp MV (2003). Pseudohypocalcemia with MR imaging contrast agents: a cautionary tale. Radiology 227:627–628 Choyke PL, Knopp MV (2003). Pseudohypocalcemia with MR imaging contrast agents: a cautionary tale. Radiology 227:627–628
29.
Zurück zum Zitat Proctor KAS, Rao LV, Roberts WL (2004) Gadolinium magnetic resonance contrast agents produce analytic interference in multiple serum assays. Am J Clin Pathol 121:282–292 Proctor KAS, Rao LV, Roberts WL (2004) Gadolinium magnetic resonance contrast agents produce analytic interference in multiple serum assays. Am J Clin Pathol 121:282–292
30.
Zurück zum Zitat Normann PT, Frøysa A, Svaland M (1995) Interference of gadodiamide injection (OMNISCAN®) on the colorimetric determination of serum calcium. Scand J Clin Lab Invest 55:421–426 Normann PT, Frøysa A, Svaland M (1995) Interference of gadodiamide injection (OMNISCAN®) on the colorimetric determination of serum calcium. Scand J Clin Lab Invest 55:421–426
31.
Zurück zum Zitat Junge W, Troge B (1991) Kontrastmittel als Störfaktoren in der laborchemischen Analytik. In: Peters PE, Zetler E (eds) Röntgen Kontrastmittel. Springer Verlag, Berlin Heidelberg New York, pp 76–82 Junge W, Troge B (1991) Kontrastmittel als Störfaktoren in der laborchemischen Analytik. In: Peters PE, Zetler E (eds) Röntgen Kontrastmittel. Springer Verlag, Berlin Heidelberg New York, pp 76–82
32.
Zurück zum Zitat Barrs TJ (2002) Establishing safeguards for the use of imaging related drugs. Am J Health-Syst Pharm 59:1449–1553 Barrs TJ (2002) Establishing safeguards for the use of imaging related drugs. Am J Health-Syst Pharm 59:1449–1553
Metadaten
Titel
Contrast media: interactions with other drugs and clinical tests
verfasst von
Sameh K. Morcos
Henrik S. Thomsen
C. M. Exley
Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)
Publikationsdatum
01.07.2005
Erschienen in
European Radiology / Ausgabe 7/2005
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-004-2600-1

Weitere Artikel der Ausgabe 7/2005

European Radiology 7/2005 Zur Ausgabe

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

S3-Leitlinie zu Pankreaskrebs aktualisiert

23.04.2024 Pankreaskarzinom Nachrichten

Die Empfehlungen zur Therapie des Pankreaskarzinoms wurden um zwei Off-Label-Anwendungen erweitert. Und auch im Bereich der Früherkennung gibt es Aktualisierungen.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.