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Immunologic Research
Erschienen in: Immunologic Research 1-3/2010

01.07.2010

Controlling somatic hypermutation in immunoglobulin variable and switch regions

verfasst von: Robert W. Maul, Patricia J. Gearhart

Erschienen in: Immunologic Research | Ausgabe 1-3/2010

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Abstract

Activation-induced deaminase (AID) is a B-cell-specific enzyme required for initiating the mechanisms of affinity maturation and isotype switching of antibodies. AID functions by deaminating cytosine to uracil in DNA, which initiates a cascade of events resulting in mutations and strand breaks in the immunoglobulin loci. There is an intricate interplay between faithful DNA repair and mutagenic DNA repair during somatic hypermutation, in that some proteins from accurate repair pathways are also involved in mutagenesis. One factor that shifts the balance from faithful to mutagenic repair is the genomic sequence of the switch regions. Indeed, the sequence of the switch μ region is designed to maximize AID access to increase the abundance of clustered dU bases. The frequency and proximity of these dU nucleotides then in turn inhibit faithful repair and promote strand breaks.
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Metadaten
Titel
Controlling somatic hypermutation in immunoglobulin variable and switch regions
verfasst von
Robert W. Maul
Patricia J. Gearhart
Publikationsdatum
01.07.2010
Verlag
Humana Press Inc
Erschienen in
Immunologic Research / Ausgabe 1-3/2010
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-009-8142-5

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