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22.05.2019 | Original Contribution

Correlations between urinary concentrations and dietary intakes of flavonols in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

verfasst von: Yaiza Garro-Aguilar, Valerie Cayssials, David Achaintre, Heiner Boeing, Francesca Romana Mancini, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Tilman Kühn, Verena Katzke, Antonia Trichopoulou, Anna Karakatsani, Paschalis Thriskos, Giovanna Masala, Sara Grioni, Maria Santucci de Magistris, Rosario Tumino, Fulvio Ricceri, Inge Huybrechts, Antonio Agudo, Augustin Scalbert, Raul Zamora-Ros

Erschienen in: European Journal of Nutrition | Ausgabe 4/2020

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Abstract

Purpose

In this study, we aimed to study the correlation between acute and habitual intakes of flavonols, their main food sources and their 24-h urinary concentrations in an European population.

Methods

A 24-h dietary recall (24-HDR) and 24-h urine samples were collected on the same day from a convenience subsample of 475 men and women from four countries (France, Italy, Greece and Germany) of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A standardized 24-HDR software and a country/centre-specific validated dietary questionnaire (DQ) were used to collect acute and habitual dietary data, respectively. The intake of dietary flavonols was estimated using the Phenol-Explorer database. Urinary flavonols (quercetin, isorhamnetin, and kaempferol) were analysed using tandem mass spectrometry with a previous enzymatic hydrolysis.

Results

Weak partial Spearman correlations between both dietary acute and habitual intake and urinary concentrations of quercetin (both R_partial ~ 0.3) and total flavonols (both R_partial ~ 0.2) were observed. No significant correlations were found for kaempferol and isorhamentin. Regarding flavonol-rich foods, weak correlations were found between urinary concentrations of quercetin and total flavonols and the acute intake of onions and garlics, fruits, tea, and herbal tea (all R_partial ~ 0.2). For habitual intake, statistically significant correlations were only found between urinary quercetin concentration and herbal tea (R_partial = 0.345) and between urinary total flavonol concentration and tea, and herbal tea consumption (R_partial ~ 0.2).

Conclusions

Our results suggest that urinary quercetin level can be used as potential concentration biomarkers of both acute and habitual quercetin intake, while urinary concentrations of flavonols are unlikely to be useful biomarkers of individual flavonol-rich foods.

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Titel: Correlations between urinary concentrations and dietary intakes of flavonols in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
verfasst von: Yaiza Garro-Aguilar
Valerie Cayssials
David Achaintre
Heiner Boeing
Francesca Romana Mancini
Yahya Mahamat-Saleh
Marie-Christine Boutron-Ruault
Tilman Kühn
Verena Katzke
Antonia Trichopoulou
Anna Karakatsani
Paschalis Thriskos
Giovanna Masala
Sara Grioni
Maria Santucci de Magistris
Rosario Tumino
Fulvio Ricceri
Inge Huybrechts
Antonio Agudo
Augustin Scalbert
Raul Zamora-Ros
Publikationsdatum: 22.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 4/2020
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-02005-5

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