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12.04.2019 | Magnetic Resonance | Ausgabe 11/2019

Cortical morphology of chronic users of codeine-containing cough syrups: association with sulcal depth, gyrification, and cortical thickness

Zeitschrift:: European Radiology > Ausgabe 11/2019

Autoren:: Meng Li, Kelei Hua, Shumei Li, Changhong Li, Wenfeng Zhan, Hua Wen, Xiaofen Ma, Junzhang Tian, Guihua Jiang

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Wichtige Hinweise

Meng Li and Kelei Hua contributed equally to this work.

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Objectives

The study aimed to explore the effects of codeine-containing cough syrup (CCS) exposure on cortical morphology and the relationship between cortical characteristics and CCS dependence.

Methods

Cortical morphometry based on Computational Anatomy Toolbox (CAT12) was used to compare changes in sulcal depth, gyrification, and cortical thickness of the cerebral cortex from 40 CCS users and 40 healthy controls (HCs) with two-sample t tests (p < 0.05, multiple comparison corrected). Relationships between abnormal cortical morphological changes and the duration of CCS use, impulsivity traits, and age of first use were investigated with correlation analysis (p < 0.05, uncorrected).

Results

CCS users exhibited significantly increased sulcal depth in the bilateral insula, bilateral lingual, bilateral superior frontal, right precuneus, and right middle frontal regions; increased gyrification in the right precentral cortex; and increased cortical thickness in the bilateral precentral, bilateral precuneus, and right superior temporal cortices compared to HCs. In addition, we found significant correlations between the bilateral insula, right superior frontal cortex, and right precentral gyrus and Barratt Impulsiveness Scale (BIS) total scores.

Conclusions

Chronic CCS abuse may be associated with aberrant sulcal depth, gyrification, and cortical thickness. These morphological changes might serve as an underlying neurobiological mechanism of impulsive behavior in the CCS users.

Key Points

• Cortical morphological changes were detected in CCS users.

• Increased sulcal depth, gyrification, and cortical thickness of some regions were found in the CCS users.

• Positive correlations between cortical morphological changes and BIS total scores were identified.

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Titel: Cortical morphology of chronic users of codeine-containing cough syrups: association with sulcal depth, gyrification, and cortical thickness
Autoren:: Meng Li
Kelei Hua
Shumei Li
Changhong Li
Wenfeng Zhan
Hua Wen
Xiaofen Ma
Junzhang Tian
Guihua Jiang
Publikationsdatum: 12.04.2019
DOI: https://doi.org/10.1007/s00330-019-06165-0
Verlag: Springer Berlin Heidelberg
Zeitschrift: European Radiology
Ausgabe 11/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084

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Cortical morphology of chronic users of codeine-containing cough syrups: association with sulcal depth, gyrification, and cortical thickness

Publisher’s note

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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