Critical Care

Equipment review: Cooling catheters to induce therapeutic hypothermia?

Kees H Polderman, Jeannie Callaghan

Therapeutic hypothermia after cardiac arrest – the implementation of the ILCOR guidelines in clinical routine is possible!

Christian Storm, Joerg C Schefold, Lutz Nibbe, Frank Martens, Anne Krueger, Michael Oppert, Achim Joerres, Dietrich Hasper

Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure – a newly appreciated syndrome in the critically ill

Trung C Nguyen, Joseph A Carcillo

Bench-to-bedside review: The role of glycosaminoglycans in respiratory disease

Alba B Souza-Fernandes, Paolo Pelosi, Patricia RM Rocco

Drotrecogin alfa (activated) should not be used in patients with severe sepsis and low risk for death

Sanjay Gupta, Eric B Milbrandt, Lakshmipathi Chelluri

A disheartening story: Aprotinin in cardiac surgery

Marcus Lien, Eric B Milbrandt

Clinical review: Patient-ventilator interaction in chronic obstructive pulmonary disease

Philippe Jolliet, Didier Tassaux

Vital organ blood flow during high-frequency ventilation

Patrick Meybohm, Jens Scholz, Berthold Bein

Live and let die: asymmetric dimethylarginine and septic shock

Rainer H Böger

Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics

Eric B Milbrandt, Derek C Angus

Can you justify not using ultrasound guidance for central venous access?

Andrew R Bodenham

Can passive leg raising be used to guide fluid administration?

Daniel De Backer

Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials

Mette M Berger, Philippe Eggimann, Daren K Heyland, René L Chioléro, Jean-Pierre Revelly, Andrew Day, Wassim Raffoul, Alan Shenkin

Optimizing neurologic prognosis after cardiac arrest

David Tirschwell

Causes of death and determinants of outcome in critically ill patients

Viktoria D Mayr, Martin W Dünser, Veronika Greil, Stefan Jochberger, Günter Luckner, Hanno Ulmer, Barbara E Friesenecker, Jukka Takala, Walter R Hasibeder

Iatrogenesis, inflammation and organ injury: insights from a murine model

John C Marshall

Intrathecal colistin for treatment of Pseudomonas aeruginosa ventriculitis: report of a case with successful outcome

Rezzan Yagmur, Figen Esen

Vasopressin in vasodilatory shock: ensure organ blood flow, but take care of the heart!

Martin W Dünser, Walter R Hasibeder

Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome

Léa Fialkow, Luciano Fochesatto Filho, Mary C Bozzetti, Adriana R Milani, Edison M Rodrigues Filho, Roberta M Ladniuk, Paula Pierozan, Rafaela M de Moura, João C Prolla, Eric Vachon, Gregory P Downey

Heterotopic ossification – a long-term consequence of prolonged immobility

Sonia J Hudson, Stephen J Brett

How emergency departments might alert for prehospital heat-related excess mortality?

Yann-Erick Claessens, Pierre Taupin, Gérald Kierzek, Jean-Louis Pourriat, Michel Baud, Christine Ginsburg, Jean-Philippe Jais, Eric Jougla, Bruno Riou, Jean-François Dhainaut, Paul Landais

Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat

Christian Lehmann, Konrad Meissner, Andreas Knöck, Stephan Diedrich, Dragan Pavlovic, Matthias Gründling, Taras Usichenko, Michael Wendt, Jürgen Birnbaum

Multicentre study on peri- and postoperative central venous oxygen saturation in high-risk surgical patients

Ethics review: Position papers and policies – are they really helpful to front-line ICU teams?

Laura Hawryluck

Bench-to-bedside review: High-frequency oscillatory ventilation in adults with acute respiratory distress syndrome

James Downar, Sangeeta Mehta

Severe brain injury ICU outcomes are associated with Cranial-Arterial Pressure Index and noninvasive Bispectral Index and transcranial oxygen saturation: a prospective, preliminary study

Michael Dunham, Kenneth J Ransom, Clyde E McAuley, Brian S Gruber, Dev Mangalat, Laurie L Flowers

Four-day antithrombin therapy does not seem to attenuate hypercoagulability in patients suffering from sepsis

Christopher Gonano, Christian Sitzwohl, Eva Meitner, Christian Weinstabl, Stephan C Kettner

Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury

Mark R Looney, Michael A Matthay

Outcome of postoperative critically ill patients with heparin-induced thrombocytopenia: an observational retrospective case-control study

Elise M Gettings, Kathryn A Brush, Elizabeth M Van Cott, William E Hurford

Real-time ultrasound-guided catheterisation of the internal jugular vein: a prospective comparison with the landmark technique in critical care patients

Dimitrios Karakitsos, Nicolaos Labropoulos, Eric De Groot, Alexandros P Patrianakos, Gregorios Kouraklis, John Poularas, George Samonis, Dimosthenis A Tsoutsos, Manousos M Konstadoulakis, Andreas Karabinis

Luminal concentrations of L- and D-lactate in the rectum may relate to severity of disease and outcome in septic patients

Vibeke L Jørgensen, Nanna Reiter, Anders Perner

Comparison of uncalibrated arterial waveform analysis in cardiac surgery patients with thermodilution cardiac output measurements

Michael Sander, Claudia D Spies, Herko Grubitzsch, Achim Foer, Marcus Müller, Christian von Heymann

Clinical review: Use of helium-oxygen in critically ill patients

Marc Gainnier, Jean-Marie Forel

The diagnosis of adrenal insufficiency in the critically ill patient: does it really matter?

Paul E Marik

Recently published papers: putting fluids in and taking fluids out

Catriona JM Shaw, Lui G Forni

Obituary: William J Sibbald, MD, FRCP(C)

Michael R Pinsky

Children undergoing cardiac surgery for complex cardiac defects show imbalance between pro- and anti-thrombotic activity

Ruth Heying, Wim van Oeveren, Stefanie Wilhelm, Katharina Schumacher, Ralph G Grabitz, Bruno J Messmer, Marie-Christine Seghaye

Seleno-enzymes and seleno-compounds: the two faces of selenium

Xavier Forceville

Blood glucose measurements in the critically ill: more than just a blood draw

Frank M Brunkhorst, Hans G Wahl

Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis

Evangelos J Giamarellos-Bourboulis, Thomas Tsaganos, Ekaterini Spyridaki, Maria Mouktaroudi, Diamantis Plachouras, Ilia Vaki, Vassiliki Karagianni, Anastasia Antonopoulou, Vassiliki Veloni, Helen Giamarellou

Clinical review: Management of difficult airways

Olivier Langeron, Julien Amour, Benoît Vivien, Frédéric Aubrun

Hyperlactatemia during cardiopulmonary bypass: determinants and impact on postoperative outcome

Marco Ranucci, Barbara De Toffol, Giuseppe Isgrò, Federica Romitti, Daniela Conti, Maira Vicentini

Bench-to-bedside review: Human subjects research – are more standards needed?

David T Huang, Mehrnaz Hadian

Evaluation of furosemide regimens in neonates treated with extracorporeal membrane oxygenation

Maria MJ van der Vorst, Enno Wildschut, Robbert J Houmes, Saskia J Gischler, Joana E Kist-van Holthe, Jacobus Burggraaf, Albert J van der Heijden, Dick Tibboel

Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death

Jan O Friedrich, Neill KJ Adhikari, Maureen O Meade

Effect of extracorporeal liver support by MARS and Prometheus on serum cytokines in acute-on-chronic liver failure

Vanessa Stadlbauer, Peter Krisper, Reingard Aigner, Bernd Haditsch, Aleksandra Jung, Carolin Lackner, Rudolf E Stauber

Informed consent for research obtained during the intensive care unit stay

Catherine Chenaud, Paolo Merlani, Samuel Luyasu, Bara Ricou

Should we use central venous saturation to guide management in high-risk surgical patients?

Rupert M Pearse, Charles J Hinds

Prediction of fluid responsiveness using respiratory variations in left ventricular stroke area by transoesophageal echocardiographic automated border detection in mechanically ventilated patients

Maxime Cannesson, Juliette Slieker, Olivier Desebbe, Fadi Farhat, Olivier Bastien, Jean-Jacques Lehot

Microdialysis shows metabolic effects in skin during fluid resuscitation in burn-injured patients

Anders Samuelsson, Ingrid Steinvall, Folke Sjöberg

Pulmonary artery catheter versus pulse contour analysis: a prospective epidemiological study

Shigehiko Uchino, Rinaldo Bellomo, Hiroshi Morimatsu, Makoto Sugihara, Craig French, Dianne Stephens, Julia Wendon, Patrick Honore, John Mulder, Andrew Turner

Fasting and nutrient-stimulated plasma peptide-YY levels are elevated in critical illness and associated with feed intolerance: an observational, controlled study

Nam Q Nguyen, Robert JL Fraser, Marianne Chapman, Laura K Bryant, Judith Wishart, Richard H Holloway, Michael Horowitz

Microcirculatory alterations induced by sedation in intensive care patients. Effects of midazolam alone and in association with sufentanil

Veronique Lamblin, Raphael Favory, Marie Boulo, Daniel Mathieu

Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage

Lars Heslet, Jorn Dalsgaard Nielsen, Marcel Levi, Henrik Sengeløv, Pär I Johansson

Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials

Sandro B Rizoli, Kenneth D Boffard, Bruno Riou, Brian Warren, Philip Iau, Yoram Kluger, Rolf Rossaint, Michael Tillinger

A modified McCabe score for stratification of patients after intensive care unit discharge: the Sabadell score

Rafael Fernandez, Francisco Baigorri, Gema Navarro, Antonio Artigas