Critical Care

Video versus direct laryngoscopy in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

Beatriz Araújo, André Rivera, Suzany Martins, Renatha Abreu, Paula Cassa, Maicon Silva, Alice Gallo de Moraes

Analysis and applications of respiratory surface EMG: report of a round table meeting

A. H. Jonkman, R. S. P. Warnaar, W. Baccinelli, N. M. Carbon, R. F. D’Cruz, J. Doorduin, J. L. M. van Doorn, J. Elshof, L. Estrada-Petrocelli, J. Graßhoff, L. M. A. Heunks, A. A. Koopman, D. Langer, C. M. Moore, J. M. Nunez Silveira, E. Petersen, D. Poddighe, M. Ramsay, A. Rodrigues, L. H. Roesthuis, A. Rossel, A. Torres, M. L. Duiverman, E. Oppersma

Expanding the scope of prehabilitation: reducing critical illness weakness across elective surgical patients scheduled for postoperative ICU care

Wen Gao, Jingfen Jin

Invasive group A streptococcal infections requiring admission to ICU: a nationwide, multicenter, retrospective study (ISTRE study)

Arthur Orieux, Renaud Prevel, Margot Dumery, Jean-Baptiste Lascarrou, Noémie Zucman, Florian Reizine, Pierre Fillatre, Charles Detollenaere, Cédric Darreau, Nadiejda Antier, Mélanie Saint-Léger, Guillaume Schnell, Béatrice La Combe, Charlotte Guesdon, Franklin Bruna, Antoine Guillon, Caroline Varillon, Olivier Lesieur, Hubert Grand, Benjamin Bertrand, Shidasp Siami, Pierre Oudeville, Céline Besnard, Romain Persichini, Pierrick Bauduin, Martial Thyrault, Mathieu Evrard, David Schnell, Johann Auchabie, Adrien Auvet, Jean-Philippe Rigaud, Pascal Beuret, Maxime Leclerc, Asaël Berger, Omar Ben Hadj Salem, Julien Lorber, Annabelle Stoclin, Olivier Guisset, Léa Bientz, Pierre Khan, Vivien Guillotin, Jean-Claude Lacherade, Alexandre Boyer, Arthur Orieux, Renaud Prevel, Margot Dumery, Jean-Baptiste Lascarrou, Noémie Zucman, Florian Reizine, Pierre Fillatre, Charles Detollenaere, Cédric Darreau, Nadiejda Antier, Mélanie Saint-Léger, Guillaume Schnell, Béatrice La Combe, Charlotte Guesdon, Franklin Bruna, Antoine Guillon, Caroline Varillon, Olivier Lesieur, Hubert Grand, Benjamin Bertrand, Shidasp Siami, Pierre Oudeville, Céline Besnard, Romain Persichini, Pierrick Bauduin, Martial Thyrault, Mathieu Evrard, David Schnell, Johann Auchabie, Adrien Auvet, Jean-Philippe Rigaud, Pascal Beuret, Maxime Leclerc, Asaël Berger, Omar Ben Hadj Salem, Julien Lorber, Annabelle Stoclin, Olivier Guisset, Léa Bientz, Pierre Khan, Vivien Guillotin, Jean-Claude Lacherade, Alexandre Boyer

Remote ischemic conditioning reduces adverse events in patients with acute ischemic stroke complicating acute myocardial infarction: a randomized controlled trial

Sijie Li, Xiurong Xing, Lanjing Wang, Jiali Xu, Changhong Ren, Yalin Li, Jing Wang, Zhi Liu, Heng Zhao, Wenbo Zhao, Xunming Ji

Immature neutrophils and myeloid-derived suppressor cells in sepsis: differences in occurrence kinetics

Rémy Coudereau, Muzhda Haem Rahimi, Anne-Claire Lukaszewicz, Martin Cour, Frank Bidar, Laurent Argaud, Fabienne Venet, Guillaume Monneret

Lost in a number: concealed heterogeneity within the sequential organ failure assessment (SOFA) score

Neville Dusaj, Eleni Papoutsi, Katherine L. Hoffman, Ilias I. Siempos, Edward James Schenck

Does inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients? Unleashing the potential of individualized functional electrical stimulation-cycling in critical illness

Murillo Frazão, Gerson Cipriano Jr., Paulo Eugênio Silva

Reply to “Potential confounders in linking elevated S100A8/A9 to left ventricular dysfunction in septic shock patients”

Gabriel Jakobsson, Henrik Andersson, Michelle Chew, Alexandru Schiopu

Single-drug versus combination antimicrobial therapy in critically ill patients with hospital-acquired pneumonia and ventilator-associated pneumonia due to Gram-negative pathogens: a multicenter retrospective cohort study

François Barbier, Claire Dupuis, Niccolò Buetti, Carole Schwebel, Élie Azoulay, Laurent Argaud, Yves Cohen, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Jean-Marie Forel, Christophe Adrie, Étienne de Montmollin, Jean Reignier, Stéphane Ruckly, Jean-Ralph Zahar, Jean-François Timsit

Correction to: Bayesian methods: a potential path forward for sepsis trials

George Tomlinson, Ali Al-Khafaji, Steven A. Conrad, Faith N. F. Factora, Debra M. Foster, Claude Galphin, Kyle J. Gunnerson, Sobia Khan, Roopa Kohli-Seth, Paul McCarthy, Nikhil K. Meena, Ronald G. Pearl, Jean-Sebastien Rachoin, Ronald Rains, Michael Seneff, Mark Tidswell, Paul M. Walker, John A. Kellum

Influence of therapeutic plasma exchange treatment on short-term mortality of critically ill adult patients with sepsis-induced organ dysfunction: a systematic review and meta-analysis

Vladimir Kuklin, Michael Sovershaev, Johan Bjerner, Philip Keith, L. Keith Scott, Owen Matthew Truscott Thomas, Wladimir Szpirt, Gail Rock, Bernd Stegmayr

Fever or hypothermia following ECMO decannulation: the association of body temperature with survival

Markus Busch, Benjamin Seeliger, Jan Fuge, Marius M. Hoeper, Klaus Stahl, Christian Kühn, Julius Schmidt, Nina Rittgerodt, Christine Fegbeutel, Olaf Wiesner, Heiner Wedemeyer

Life-threatening complications and intensive care unit management in patients treated with blinatumomab for B-cell acute lymphoblastic leukemia

Irene Urbino, Etienne Lengliné, Sandrine Valade, Marco Cerrano, Marie Sebert, Emmanuel Raffoux, Florence Rabian, Elie Azoulay, Nicolas Boissel

The effects of higher versus lower protein delivery in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

Zheng-Yii Lee, Ellen Dresen, Charles Chin Han Lew, Julia Bels, Aileen Hill, M. Shahnaz Hasan, Lu Ke, Arthur van Zanten, Marcel C. G. van de Poll, Daren K. Heyland, Christian Stoppe

To identify Harlequin syndrome in patients with venoarterial extracorporeal membrane oxygenation using radial near-infrared spectroscopy

Yongwei Yu, Xing Fang, Zhipeng Xu, Tong Li, Jueyue Yan

Triggering receptor expressed on myeloid cells-1 in sepsis, and current insights into clinical studies

Vivienne Theobald, Felix Carl Fabian Schmitt, Chiara Simone Middel, Lena Gaissmaier, Thorsten Brenner, Markus Alexander Weigand

Gut mycobiome dysbiosis after sepsis and trauma

Gwoncheol Park, Jennifer A. Munley, Lauren S. Kelly, Kolenkode B. Kannan, Robert T. Mankowski, Ashish Sharma, Gilbert Upchurch, Gemma Casadesus, Paramita Chakrabarty, Shannon M. Wallet, Robert Maile, Letitia E. Bible, Bo Wang, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron, Ravinder Nagpal

Driving pressure of respiratory system and lung stress in mechanically ventilated patients with active breathing

Vaia Stamatopoulou, Evangelia Akoumianaki, Katerina Vaporidi, Efstathios Stamatopoulos, Eumorfia Kondili, Dimitrios Georgopoulos

Combined effects of targeted blood pressure, oxygenation, and duration of device-based fever prevention after out-of-hospital cardiac arrest on 1-year survival: post hoc analysis of a randomized controlled trial

Martin A. S. Meyer, Christian Hassager, Simon Mølstrøm, Britt Borregaard, Johannes Grand, Benjamin Nyholm, Laust E. R. Obling, Rasmus P. Beske, Anna Sina P. Meyer, Ditte Bekker‑Jensen, Matilde Winther-Jensen, Vibeke L. Jørgensen, Henrik Schmidt, Jacob E. Møller, Jesper Kjaergaard

The importance of assessing left ventricular longitudinal function in presence of increased afterload

Cristina Santonocito, Ryota Sato, Siddharth Dugar, Filippo Sanfilippo

Rotten and gold apples: inside and outside the gray zone of a ROC curve

Antonio Messina, Michelle Chew, Maurizio Cecconi

The effect of passive leg raising test on intracranial pressure and cerebral autoregulation in brain injured patients: a physiological observational study

Antonio Messina, Agnieszka Uryga, Alberto Giardina, Pietro Ciliberti, Denise Battaglini, Nicolo’ Patroniti, Marek Czosnyka, Xavier Monnet, Maurizio Cecconi, Chiara Robba

Association between urea trajectory and protein dose in critically ill adults: a secondary exploratory analysis of the effort protein trial (RE-EFFORT)

Ryan W. Haines, John R. Prowle, Andrew Day, Danielle E. Bear, Daren K. Heyland, Zudin Puthucheary

Potential correlation between hemodynamic improvement and an immune-modulation effect in pediatric patients with septic shock treated with renal replacement therapy and CytoSorb®: an insight from the PedCyto study

Gabriella Bottari, Corrado Cecchetti, Carmela Serpe, David Grimaldi, Fabio S. Taccone

Enhanced exclusive enteral nutrition delivery during the first 7 days is associated with decreased 28-day mortality in critically ill patients with normal lactate level: a post hoc analysis of a multicenter randomized trial

Yizhe Chen, Zirui Liu, Qiuhui Wang, Fei Gao, Hongyang Xu, Lu Ke, Zheng-Yii Lee, Christian Stoppe, Daren K. Heyland, Fengming Liang, Jiajia Lin

A comparison of video laryngoscopy and direct laryngoscopy in critically ill patients

Yang Zhao, Qian Wang, Bin Zang

Effect of prehospital high-dose glucocorticoid on hemodynamics in patients resuscitated from out-of-hospital cardiac arrest: a sub-study of the STEROHCA trial

Laust E. R. Obling, Rasmus P. Beske, Martin A. S. Meyer, Johannes Grand, Sebastian Wiberg, Thomas Mohr, Anders Damm-Hejmdal, Julie L. Forman, Ruth Frikke-Schmidt, Fredrik Folke, Jacob E. Møller, Jesper Kjaergaard, Christian Hassager

Societal costs of sepsis in the Netherlands

Erik C. N. Luijks, Elisabeth C. van der Slikke, Arthur R. H. van Zanten, Jan C. ter Maaten, Maarten J. Postma, Henk B. M. Hilderink, Robert H. Henning, Hjalmar R. Bouma

Prognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings

Andrew Li, Lowell Ling, Hanyu Qin, Yaseen M. Arabi, Sheila Nainan Myatra, Moritoki Egi, Je Hyeong Kim, Mohd Basri Mat Nor, Do Ngoc Son, Wen-Feng Fang, Bambang Wahyuprajitno, Madiha Hashmi, Mohammad Omar Faruq, Boonsong Patjanasoontorn, Maher Jaffer Al Bahrani, Babu Raja Shrestha, Ujma Shrestha, Khalid Mahmood Khan Nafees, Kyi Kyi Sann, Jose Emmanuel M. Palo, Naranpurev Mendsaikhan, Aidos Konkayev, Khamsay Detleuxay, Yiong Huak Chan, Bin Du, Jigeeshu Vasishtha Divatia, Younsuck Koh, Jason Phua, Uzzal Kumar Mallick, Motiul Islam, Tarequl Hamid, A. K. M. Shirazul Islam, Rabiul Halim, Md Arifur Rahman Khan, Mohammad Asaduzzaman, Md Rezaul Karim, Nahim Sarwar, Shamsul Hoque Milon, Rashed Mahmud, A. K. M. Sirajul Islam Hirok, Ashraful Haque, Amina Sultana, Mir Atiqur Rahman Shajal, Farha Andalib, Rashedul Hasan, Khalid Mahmood Khan Nafees, Shah Sudhirchandra Dhansukhlal, Ning Li, Xiaowei Liu, Haiwei Yang, Ming Hou, Ying Li, Jian Zhang, Lifeng Huang, Wenxiong Li, Meili Duan, Taotao Liu, Wei He, Fangyu Ning, Xiaozhi Wang, Xiaoyan Zhou, Sun Yu, Xiang Xiang, Liang Pan, Feihu Zhou, Yaoli Wang, Jian Zhou, Tao Wang, Xuefei Yang, Yu Ma, Xuan Song, Haiying Wu, Chuanyun Qian, Lixin Zhou, Zuohang Xu, Kun Zhang, Zhenjie Hu, Xingsheng Lin, Songjing Shi, Xiaoguang Zhang, Rongguo Yu, Liqin Zhang, Yuan Yuan, Huiru Zhou, Xiandong Wang, Zhonghua Wang, Tiehe Qin, Xianqing Shi, Rui Li, Zhenyang He, Xiangrong Zuo, Quan Cao, Tao He, Yuanda Sui, Tiejun Wu, Ying Xu, Qin Gu, Weizheng Shuai, Hanyu Qin, Bin Du, Hong Qiao, Shuangling Li, Guiying Dong, Xiujuan Zhao, Fengxue Zhu, Junshi Wang, Lei Huang, Tianchang Wang, Hao Wang, Siqing Ma, Zhengping Yang, Yuan Gao, Ruoming Tan, Yun Xie, Ruilan Wang, Jia Jia, Bin Zang, Jun Wang, Ling Lin, Yuwen Wu, Yunfu Wu, Penglin Ma, Yanfang Li, Li Yu, Rui Guo, Jiuzhi Zhang, Xianyao Wan, Feng Shen, Qindong Shi, Jun Xu, Qiang Fang, Shaohua Liu, Tongwen Sun, Mian Zeng, Weiyun Pan, Zhongmin Liu, Qingling Lin, Nan Wang, Jing Pang, Bin Xiong, Deliang Wen, Fuxin Kang, Liuhui Chang, Yun Sun, Jingxiao Zhang, Yongjie Yin, Liu Qing, Jiajun Sun, Nahui Li, Yongqiang Wang, Songtao Shou, Yanfen Chai, Lei Xu, Xiaobo Yang, Xuelian Liao, Xian Kang, Shuangping Zhao, Liquan Huang, Run Zhang, Renhua Sun, Chao Shen, Yan He, Fu Loi Chow, Michele Tang, Philip Lam, Esther Cham, Kin Bong Tang, Lowell Ling, Manimala Dharmangadan, Pauline Yeung Ng, Kin Ho Ling, Vincent Lau, Samir Sahu, Sharmila Chatterjee, Sushmita Basu, Zubair Umer Mohamed, Sudeep Sirga, Siddhartha Reddy Kasireddy, M. A. Aleem, Swarna Deepak Kuragayala, Sai Praveen Haranath, Nagarajan Ramakrishnan, Pravin Amin, Joanne Mascarenhas, Radhika Dash, Venkat Raman Kola, R. Vaidyanathan, Siddharth Agarwal, Pradip K. Bhattacharya, Deepak Jeswani, Parshotum Lal Gautam, Abdul Samad Ansari, Vivek Nangia, Mrinal Sircar, V. M. Balasubramani, S. Maneendra, Sanghamitra Mishra, Anjeev Kumar, Rajesh Chawla, Trevor Francis Sequeira, Om Prakash Shrivastava, T. V. Sreevalsan, Rajesh Mohan Shetty, Manjunath Thimmappa, M. M. Harish, Yatin Mehta, Divya Saxena, Vipul Mishra, Rishi Kumar, Simnt Kumar Jha, Prashant Sakhavalkar, Dnyaneshwar Diwane, Subhal Dixit, Kalaiselvan, Manoranjan Pattnaik, Lalit Singh, Fareed Khan, Mehul Shah, Prasanna, Ziokov Joshi, Sheila Ninan Myatra, Manoj Gorade, Bharat G. Jagiasi, Amol Hartalkar, B. Saroj Kumar Prusty, Yogesh, Ade Winata, Maulydia, Surya Oto Wijaya, Hermin Prihartini, Shinta V. R. Hutajulu, Rudy Manalu, Christrijogo Sumartono, Chrisma Adryana Albandjar, Ira Pitaloka, Dewi Kusumawati, Arifin, Akhmad Yun Jufan, Bambang Pujo Semedi, Vanessy Theodora Silalahi, Yudianto, Erwin Pradian, Achsanuddin Hanafie, Mariza Fitriati, Tinni Trihartini Maskoen, Satriawan Abadi, Calcarina Fitriani Retno Wisudarti, Johan Arifin, Reza Widyanto Sudjud, Prananda Surya Airlangga, Rupi’i, I. Made Wiryana, Anang Achmadi, Patra Rijalul Harly, Edward Kusuma, Primartanto Wibowo, Ade Veronica HY, Jeni Sarah Mandang, Meriwijanti, I. Wayan Aryabiantara, Faisal Muchtar, Fachrul Jamal Isa, Dita Aditianingsiih, Nicolaas Parningotan Simamora, Moch. Hasyim, I. Gusti Putu Manuaba, Novita Anggraeni, Rudy Ariyanto Sanoesi, Arief Munandar, Duma Saurma Siahaan, Sri Rachmawati, Oky Susianto, Liliriawati Ananta Kahar, Zulkifli, Mordekhai Leopold Laihad, Nakada Takaaki, Yoshitaka Hara, Osamu Nishida, Kenji Uehara, Makoto Takatori, Shinichiro Ohshimo, Kazuya Kikutani, Nobuaki Shime, Shin Nunomiya, Shinshu Katayama, Bengo Atari, Takashi Ito, Yasuyuki Kakihana, Kohei Takimoto, Machi Yanai, Moritoki Egi, Tomoaki Yatabe, Yuki Kishiara, Ushio Higashijima, Motohiro Sekino, Kazuaki Atagi, Hiroshi Ogura, Tsunehiro Matsubara, Tadashi Kamio, Shigeki Fujitani, Toru Yoshida, Yukari Aoyagi, Shigehiko Uchino, Masatsugu Hasegawa, Jun Oto, Naoki Yamaguchi, Yuki Enomoto, Masaki Nakane, G. S. Amirova, Murat Daribaev, Markov Viktor Evgenievich, A. A. Vorobiev, A. V. Andrushenko, Aliya Torpakbaeva, M. E. Konkayeva, A. V. Galkin, P. A. Ostanin, Khamsay Detleuxay, Noryani Mohd Samat, Ismail Tan, Nahla Irtiza Ismail, Chew Har Lim, Wan Nasrudin Wan Ismail, Siti Rohayah Sulaiman, Anita Alias, Joanne Tiong Jia Wen, Azmin Huda Abdul Rahim, Asmah Zainudin, Nik Azman Nik Adib, Zihni Abdullah, Hafizah, Mohd Zulfakar Mazlan, Mohd Basri Mat Nor, Munkhasiakhan, Naranpurev, Cho Myint Tun, Thinzar Maw, Cho Cho, Han Sein, Myo Malar Win, Lwin Lwin Hnin, Cho Cho Lwin, Aye Su Mon, Yi Sandar Thein, Khin Le Le Yi, Myo Min Naing, Nu Nu May, Lun Naing, Khin Saw Yu Aung, Moe Thu Lin, Aung Kyi, Kyaw Min Min Tun, Suu New Khin, Khin Pyone Yi, Khin May Waan, Moe Thidar, Kyi Kyi Sann, Mu Mu Naing, Win Win Mar, Naing Naing Lin, Lalit Rajbanshi, Trishant Limbu, Baburaja Shrestha, Ujma Shrestha, Ashish Shrestha, Rosi Pradhan, Ravi Ram Shrestha, Sulav Acharya, Pramesh Sunder Shrestha, Puja Thapa Karki, Moosa Awladthani, Jacob Paul, Nadia Al Badi, Adil Al Kharusi, Khalil Al Kharousi, Sandeep Kantor, Yohannan John, Said Al Mandhari, Geetha Jacob, Amr Muhammad Esmat, B. M. J. Shetty, Ahmed Mostafa, Naveed Haroon Rashid, Muhammad Sohaib, Sonia Joseph, Safia Zafar, Ahmed Farooq, Muhammad Sheharyar Ashraf, Tanveer Hussain, Muhammad Hayat, Ataur Rehman, Syed Muneeb Ali, Saad ur Rehman, Ashok Kumar, Aaron Hernandez, Crystal Aperocho, Raymundo Resurreccion, Debbie Noblezada-Uy, Jose Emmanuel Palo, Julie Visperas, Amer Asiri, Ali Beshabshi, Fahad Al-Hameed, Ohoud Al Orabi, Yaseen Arabi, Eman Al Qasim, Masood Iqbal, Tharwat Aisa, Mohammed Saeed Al Shahrani, Laila Asonto, Ayman Kharaba, Abdullah al Mutairi, Khaild Al Ghamdi, Lama Hefni, Ahmad Al Qurashi, Galeb Al Makhlafi, Roshni Sadashiv Gokhale, Noelle Lim, Manjit Pawar, Venkatesan Kumaresh, Naville Chia Chi Hock, Tan Chee Keat, Tan Rou An, Jared De Souza, Andrew Li, Yip Hwee Seng, Jason Phua, Addy Tan YH, Melvin Tay Chee Kiang, Ng Shin Yi, Ho Vui Kian, Kiran Sharma, Sennen Lew, Lee Rui Min, Do Wan Kim, Yoon Mi Shin, Song-I. Lee, Kyung Chan Kim, Yun-Seong Kang, Soo Hwan Lee, Ho Cheol Kim, Yun Su Sim, Sunghoon Park, Tai Sun Park, Hongyeul Lee, Youjin Chang, Heung Bum Lee, Je Hyeong Kim, Young Seok Lee, Won Gun Kwack, In Byung Kim, Tae Yun Park, Young Jae Cho, Sang-Min Lee, Kyeongman Jeon, Jongmin Lee, Shin Young Kim, Jin-Won Huh, Jong Joon Ahn, Jae Hwa Cho, Won-Yeon Lee, Chin-Kuo Lin, Chang-Ke Chu, Jiun-Ting Wu, Chiung-Yu Lin, Yu-Mu Chen, Kuo-Tung Huang, Han-Chung Hu, Cong-tat Cia, Jung-Yien Chien, Chun-Te Huang, Pin-Kuei Fu, Nattachai Srisawas, Manasnun Kongwibulwut, Kaweesak Chittawatanarat, Worapot Daewtrakulchai, Anakapong Phunmanee, Anupol Panitchote, Boonsong Patjanasoontorn, Chaiwut Sawawiboon, Lê Minh Trung, Đỗ Ngọc Sơn, B. S. Bùi Nhật Hà, Dương Thiện Phước, Huỳnh Quang Đại, Nguyễn Tấn Hùng, Lê Thị Phương Thúy, Hoàng Bùi Hải, Hoàng Trọng Ái Quốc, Trần Hoài Linh, Vũ Hải Yến, Phạm Trà Giang, Nguyễn Thị Ngà, Nguyễn Đăng Tuân

Association between CA-125 and post-extubation respiratory failure: a cohort study

Fataki Lombuli, Tiago Hermes Maeso Montes, Márcio Manozzo Boniatti

Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study)

Annika Reintam Blaser, Merli Mändul, Martin Björck, Stefan Acosta, Miklosh Bala, Zsolt Bodnar, Dumitru Casian, Zaza Demetrashvili, Mario D’Oria, Virginia Durán Muñoz-Cruzado, Alastair Forbes, Hanne Fuglseth, Moran Hellerman Itzhaki, Benjamin Hess, Karri Kase, Mikhail Kirov, Kristoffer Lein, Matthias Lindner, Cecilia Inés Loudet, Damian J. Mole, Marko Murruste, Alexandre Nuzzo, Sten Saar, Maximilian Scheiterle, Joel Starkopf, Peep Talving, Anna-Liisa Voomets, Kenneth K. T. Voon, Mohammad Alif Yunus, Kadri Tamme, Olivier Corcos, Yves Castier, Maxime Ronot, Alan Biloslavo, Lucia Paiano, Gunnar Elke, Denise Nagel, David I. Radke, Jacqueline Vilca Becerra, María Elina Abeleyra, Martin Cahenzli, Tatjana Semenkova, Anton Nikonov, Alexey Smetkin, Geir Ivar Nedredal, Øivind Irtun, Oded Cohen-Arazi, Asaf Keda, Gheorghe Rojnoveanu, Alexandr Ursu, Felipe Pareja Ciuró, Anabel García-Leon, Carlos Javier García-Sánchez, Lim Jia Hui, Loy Yuan Ling, Ilya Kagan, Pierre Singer, Edgar Lipping, Ana Tvaladze, Dimitrios Damaskos, Darja Clinch, Too Xiao Qing, Morten Vetrhus, Jacopo Martellucci, Giulia Cerino, Donghuang Hong, Jinsheng Liu, Ernest Ong, Kursat Kundogan, Tutkun Talih, Lovenish Bains, Diego Visconti, Lorenzo Gibello, Ruhi Fadzlyana Jailani, Muhammad Amirul Ashra, Andee Dzulkarnaen Zakaria, Ahmad Faiz Najmuddin Mohd Ghazi, Nur Suriyana Abd Ghani, Mohd Fadliyazid Ab Rahim, Goran Augustin, Damir Halužan, Mohan Gurjar, Rahul Rahul, Firdaus Hayati, Jin-Jiun Mah

Cerebral autoregulation in traumatic brain injury: ultra-low-frequency pressure reactivity index and intracranial pressure across age groups

Paolo Gritti, Marco Bonfanti, Rosalia Zangari, Ezio Bonanomi, Alessia Farina, Giulio Pezzetti, Isabella Pelliccioli, Luca Longhi, Maria Di Matteo, Andrea Viscone, Gabriele Lando, Gaia Cavalleri, Simonetta Gerevini, Francesco Biroli, Ferdinando Luca Lorini

Time in ICU and post-intensive care syndrome: how long is long enough?

Dylan Flaws, John F. Fraser, Kevin Laupland, Jayshree Lavana, Sue Patterson, Alexis Tabah, Oystein Tronstad, Mahesh Ramanan

Trajectories of post-traumatic stress in sepsis survivors two years after ICU discharge: a secondary analysis of a randomized controlled trial

Konrad F. R. Schmidt, Jochen S. Gensichen, Maya Schroevers, Martina Kaufmann, Friederike Mueller, Gustav Schelling, Sabine Gehrke-Beck, Monique Boede, Christoph Heintze, Michel Wensing, Daniel Schwarzkopf

The protective effect of apolipoprotein H in paediatric sepsis

Zhicai Yu, Changxue Xiao, Rong Liu, Dandan Pi, Bian Jin, Zhen Zou, Feng Xu

Response to: the association between time definition of reintubation and patient outcomes in critically ill patients—several topics should be noticed

Aiko Tanaka, Tetsuhisa Kitamura, Akinori Uchiyama, Yusuke Enokidani, Yukiko Koyama, Takeshi Yoshida, Yuji Fujino

Combining proteins with n-3 PUFAs (EPA + DHA) and their inflammation pro-resolution mediators for preservation of skeletal muscle mass

Renée Blaauw, Philip C. Calder, Robert G. Martindale, Mette M. Berger

Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial

François Jardot, Robert G. Hahn, Dominique Engel, Christian M. Beilstein, Patrick Y. Wuethrich

Antibiotic definitive treatment in ventilator associated pneumonia caused by AmpC-producing Enterobacterales in critically ill patients: a prospective multicenter observational study

Matthieu Petit, Frank Bidar, Quentin Fosse, Lucie Lefevre, Marine Paul, Tomas Urbina, Paul Masi, Florent Bavozet, Jérémie Lemarié, Etienne de Montmollin, Chloé Andriamifidy-Berti, Julien Dessajan, Benjamin Zuber, Lara Zafrani, Edwige Peju, Paris Meng, Liliane Charrier, Loic Le Guennec, Marie Simon, Charles-Edouard Luyt, Luc Haudebourg, Guillaume Geri

Thiamine administration in septic shock: a post hoc analysis of two randomized trials

Jacob Vine, John H. Lee, Max S. Kravitz, Anne V. Grossestreuer, Lakshman Balaji, Shannon B. Leland, Noa Berlin, Ari Moskowitz, Michael W. Donnino

qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in the emergency department: a randomized controlled trial

Maria Evangelia Adami, Antigone Kotsaki, Nikolaos Antonakos, Efthymia Giannitsioti, Stamatios Chalvatzis, Maria Saridaki, Christina Avgoustou, Karolina Akinosoglou, Konstantina Dakou, Georgia Damoraki, Konstantina Katrini, Panagiotis Koufargyris, Vasileios Lekakis, Antonia Panagaki, Asimina Safarika, Jesper Eugen-Olsen, Evangelos J. Giamarellos-Bourboulis

Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study

Paul Gabarre, Cyrielle Desnos, Alexandra Morin, Louai Missri, Tomas Urbina, Vincent Bonny, Matthieu Turpin, Jean-Luc Baudel, Laurence Berard, Melissa Montil, Bertrand Guidet, Guillaume Voiriot, Jérémie Joffre, Eric Maury, Hafid Ait-Oufella

Procalcitonin for the diagnosis of postoperative bacterial infection after adult cardiac surgery: a systematic review and meta-analysis

Davide Nicolotti, Silvia Grossi, Valeria Palermo, Federico Pontone, Giuseppe Maglietta, Francesca Diodati, Matteo Puntoni, Sandra Rossi, Caterina Caminiti

Transforming research to improve therapies for trauma in the twenty-first century

Nicole P. Juffermans, Tarik Gözden, Karim Brohi, Ross Davenport, Jason P. Acker, Michael C. Reade, Marc Maegele, Matthew D. Neal, Philip C. Spinella

Administration of methylene blue in septic shock: pros and cons

Julian Arias-Ortiz, Jean-Louis Vincent

Trauma systems in Asian countries: challenges and recommendations

Dinesh Bagaria, Amila S. Ratnayake, Aireen Madrid, Tamara J. Worlton

Ketamine versus etomidate as an induction agent for tracheal intubation in critically ill adults: a Bayesian meta-analysis

Takatoshi Koroki, Yuki Kotani, Takahiko Yaguchi, Taisuke Shibata, Motoki Fujii, Stefano Fresilli, Mayuko Tonai, Toshiyuki Karumai, Todd C. Lee, Giovanni Landoni, Yoshiro Hayashi

Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies

Jayesh Dhanani, Jason A. Roberts, Antoine Monsel, Antoni Torres, Marin Kollef, Jean-Jacques Rouby, Kostoula Arvaniti, Mona Assefi, Matteo Bassetti, Stijn Blot, Matthieu Boisson, Adrien Bouglé, Jean-Michel Constantin, Jayesh Dhanani, George Dimopoulos, Jonathan Dugernier, Pauline Dureau, Timothy Felton, Marin Kollef, Antonia Koutsoukou, Anna Kyriakoudi, Pierre-François Laterre, Marc Leone, Victoria Lepère, Gianluigi Li Bassi, Xuelian Liao, Olivier Mimoz, Antoine Monsel, Girish B. Nair, Michael Niederman, Lucy B. Palmer, Paolo Pelosi, Jose Manuel Pereira, Konstantinos Pontikis, Garyphalia Poulakou, Jérôme Pugin, Chuanyun Qian, Jie-ming Qu, Jordi Rello, Jason Roberts, Jean-Jacques Rouby, Christina Routsi, Gerald C. Smaldone, Antoni Torres, Melda Türkoğlu, Tobias Welte, Michel Wolff, Xia Jing, Li Yang, Ting Yang, Ying-gang Zhu

Phenotype-specific therapeutic efficacy of ilofotase alfa in patients with sepsis-associated acute kidney injury

Niklas Bruse, Katerina Pardali, Maarten Kraan, Matthijs Kox, Peter Pickkers

The administration of four-factor prothrombin complex concentrate exacerbates thrombin generation in trauma patients at risk of massive transfusion: an ancillary study of the PROCOAG trial

Jules Greze, Raphael Marlu, Mariette Baud, Landry Seyve, Tobias Gauss, Pierre Bouzat

Coexistence of a fluid responsive state and venous congestion signals in critically ill patients: a multicenter observational proof-of-concept study

Felipe Muñoz, Pablo Born, Mario Bruna, Rodrigo Ulloa, Cecilia González, Valerie Philp, Roberto Mondaca, Juan Pablo Blanco, Emilio Daniel Valenzuela, Jaime Retamal, Francisco Miralles, Pedro D. Wendel-Garcia, Gustavo A. Ospina-Tascón, Ricardo Castro, Philippe Rola, Jan Bakker, Glenn Hernández, Eduardo Kattan

Cardiogenic shock: all hail the RCT, long live the registry

A. Warren, D. Morrow, Alastair G. Proudfoot

Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study

Nicolas Nesseler, Alexandre Mansour, Matthieu Schmidt, Marylou Para, Alizée Porto, Pierre-Emmanuel Falcoz, Nicolas Mongardon, Claire Fougerou, James T. Ross, Antoine Beurton, Lucie Gaide-Chevronnay, Pierre-Grégoire Guinot, Guillaume Lebreton, Erwan Flecher, André Vincentelli, Nicolas Massart, Olivier Fouquet, Marc Pierrot, Sidney Chocron, Guillaume Flicoteaux, Philippe Mauriat, Alexandre Ouattara, Hadrien Roze, Olivier Huet, Marc-Olivier Fischer, Raphel Bellaïche, Ophélie Constant, Quentin De Roux, L. Y. André, Arnaud Meffert, Jean-Claude Merle, Lucile Picard, Elena Skripkina, Thierry Folliguet, Antonio Fiore, Nicolas D’ostrevy, Marie-Catherine Morgan, Maxime Nguyen, Nicolas Terzi, Gwenhaël Colin, Olivier Fabre, Arash Astaneh, Justin Issard, Elie Fadel, Dominique Fabre, Julien Guihaire, Iolande Ion, Jean Baptiste Menager, Delphine Mitilian, Olaf Mercier, François Stephan, Jacques Thes, Jerôme Jouan, Thibault Duburcq, Valentin Loobuyck, Mouhammed Moussa, Sabrina Manganiello, Agnes Mugnier, Natacha Rousse, Olivier Desebbe, Jean-Luc Fellahi, Roland Henaine, Matteo Pozzi, Zakaria Riad, Christophe Guervilly, Sami Hraiech, Laurent Papazian, Matthias Castanier, Charles Chanavaz, Cyril Cadoz, Sebastien Gette, Guillaume Louis, Erick Portocarrero, Philippe Gaudard, Kais Brini, Nicolas Bischoff, Antoine Kimmoun, Bruno Levy, Pierre Perez, Alexandre Bourdiol, Yannick Hourmant, Pierre-Joachim Mahé, Bertrand Rozec, Mickaël Vourc’h, Stéphane Aubert, Florian Bazalgette, Claire Roger, Pierre Jaquet, Brice Lortat-Jacob, Pierre Mordant, Patrick Nataf, Juliette Patrier, Sophie Provenchere, Morgan Roué, Romain Sonneville, Alexy Tran-Dinh, Paul-Henri Wicky, Charles Al Zreibi, Bernard Cholley, Yannis Guyonvarch, Sophie Hamada, Claudio Barbanti, Astrid Bertier, Anatole Harrois, Jordi Matiello, Thomas Kerforne, Corentin Lacroix, Nicolas Brechot, Alain Combes, Juliette Chommeloux, Cosimo D’alessandro, Pierre Demondion, Alexandre Demoule, Martin Dres, Guillaume Fadel, Muriel Fartoukh, Guillaume Hekimian, Charles Juvin, Pascal Leprince, David Levy, Charles Edouard Luyt, Thibaut Schoell, Pierre Fillâtre, Nicolas Massart, Maud Jonas, Nicolas Allou, Salvatore Muccio, Dario Di Perna, Vito-Giovanni Ruggieri, Bruno Mourvillier, Amedeo Anselmi, Karl Bounader, Yoann Launey, Thomas Lebouvier, Alessandro Parasido, Florian Reizine, Maxime Esvan, Philippe Seguin, Emmanuel Besnier, Dorothée Carpentier, Thomas Clavier, Anne Olland, Marion Villard, Fanny Bounes, François Labaste, Vincent Minville, Antoine Guillon, Yannick Fedun

Evidence supports the use of hydrocortisone for patients with community-acquired pneumonia

De-En Lu, Cheng-Yi Chang, Sheng-Wei Cheng, Enoch Kang, Chih-Hsin Lee, Kee-Hsin Chen

Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial

Narges Alipanah-Lechner, James Hurst-Hopf, Kevin Delucchi, Lamorna Swigart, Andrew Willmore, Benjamin LaCombe, Robin Dewar, H. Clifford Lane, Perrine Lallemand, Kathleen D. Liu, Laura Esserman, Michael A. Matthay, Carolyn S. Calfee, Neil R. Aggarwal, Timothy Albertson, Sara Auld, Jeremy R. Beitler, Paul Berger, Ellen L. Burnham, Nathan Cobb, Alessio Crippa, Andrea Discacciati, Martin Eklund, D. Clark Files, Eliot Friedman, Sheetal Gandotra, Kashif Khan, Jonathan Koff, Santhi Kumar, Thomas R. Martin, Nuala J. Meyer, Timothy Obermiller, Philip Robinson, Derek Russell, Karl Thomas, Se Fum Wong, Richard G. Wunderink, Mark M. Wurfel, Albert Yen, Fady A. Youssef, Anita Darmanian, Amy L. Dzierba, Ivan Garcia, Katarzyna Gosek, Purnema Madahar, Aaron M. Mittel, Justin Muir, Amanda Rosen, John Schicchi, Alexis L. Serra, Romina Wahab, Kevin W. Gibbs, Leigha Landreth, Mary LaRose, Lisa Parks, Adina Wynn, Caroline A. G. Ittner, Nilam S. Mangalmurti, John P. Reilly, Donna Harris, Abhishek Methukupally, Siddharth Patel, Lindsie Boerger, John Kazianis, Carrie Higgins, Jeff McKeehan, Brian Daniel, Scott Fields, Alejandra Jauregui, Daniel Belvins, Catherine Nguyen, Alexis Suarez, Maged A. Tanios, Farjad Sarafian, Usman Shah, Max Adelman, Christina Creel-Bulos, Joshua Detelich, Gavin Harris, Katherine Nugent, Christina Spainhour, Philip Yang, Angela Haczku, Erin Hardy, Richart Harper, Brian Morrissey, Christian Sandrock, G. R. Scott Budinger, Helen K. Donnelly, Benjamin D. Singer, Ari Moskowitz, Melissa Coleman, Joseph Levitt, Ruixiao Lu, Paul Henderson, Adam Asare, Imogene Dunn, Alejandro Botello Barragan

Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis

Christopher Jer Wei Low, Ryan Ruiyang Ling, Kollengode Ramanathan, Ying Chen, Bram Rochwerg, Tetsuhisa Kitamura, Taku Iwami, Marcus Eng Hock Ong, Yohei Okada

Improving management of ARDS: uniting acute management and long-term recovery

Nicola Latronico, M. Eikermann, E. W. Ely, D. M. Needham

Reflections on epidemiological investigations of sepsis in the Asian Region

Mingqiang Wang, Lin Zhong

How often do we need to update PEEP setting during prone positioning in ARDS?

Ling Sang, Zhimin Lin, Zhanqi Zhao

Violence against healthcare professionals in intensive care units: a systematic review and meta-analysis of frequency, risk factors, interventions, and preventive measures

Sebastian Berger, Pascale Grzonka, Anja I. Frei, Sabina Hunziker, Sira M. Baumann, Simon A. Amacher, Caroline E. Gebhard, Raoul Sutter

The use of mechanical CPR for IHCA during the COVID-19 pandemic as compared to the pre-pandemic period

Conor Crowley, Justin Salciccioli, Yuxiu Lei, Christopher Hansen, Tomoyoshi Tamura, Edy Y. Kim, Ari Moskowitz, Anne Grossestreuer, Ari Moskowitz, Joseph Ornato, Matthew Churpek, Monique Anderson Starks, Paul Chan, Saket Girotra, Sarah Perman

Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia

Chel Hee Lee, Mohammad M. Banoei, Mariam Ansari, Matthew P. Cheng, Francois Lamontagne, Donald Griesdale, David E. Lasry, Koray Demir, Vinay Dhingra, Karen C. Tran, Terry Lee, Kevin Burns, David Sweet, John Marshall, Arthur Slutsky, Srinivas Murthy, Joel Singer, David M. Patrick, Todd C. Lee, John H. Boyd, Keith R. Walley, Robert Fowler, Greg Haljan, Donald C. Vinh, Alison Mcgeer, David Maslove, Puneet Mann, Kathryn Donohoe, Geraldine Hernandez, Genevieve Rocheleau, Uriel Trahtemberg, Anand Kumar, Ma Lou, Claudia dos Santos, Andrew Baker, James A. Russell, Brent W. Winston, J. A. Russell, K. R. Walley, J. Boyd, T. Lee, J. Singer, D. Sweet, K. Tran, S. Reynolds, G. Haljan, M. Cheng, D. Vinh, T. Lee, F. Lamontagne, B. Winston, O. Rewa, J. Marshall, A. Slutsky, A. McGeer, V. Sivanantham, R. Fowler, D. Maslove, S. Perez Patrigeon, K. D. Burns

Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial

Olivier Huet, Thomas Gargadennec, Jean-Ferréol Oilleau, Bertrand Rozec, Nicolas Nesseler, Adrien Bouglé, Thomas Kerforne, Sigismond Lasocki, Vedat Eljezi, Géraldine Dessertaine, Julien Amour, Xavier Chapalain, Grégoire Le Gac, Nima Djavidi, Emmanuel Rineau, Dauphou Eddi, Emmanuel Novak, Maëlys Consigny, Karim Ashenoune, Antoine Roquilly, Philippe Seguin, Claire Dayot-Fitzellier, Francis Remerand, Marc Laffon

Imatinib treatment improves hyperglycaemic dysregulation in severe COVID-19: a secondary analysis of blood biomarkers in a randomised controlled trial

Erik Duijvelaar, Xiaoke Pan, Harm Jan Bogaard, Etto C. Eringa, Jurjan Aman

Impact of hyperoxia on the gut during critical illnesses

Ninan Dai, Juan Gu, Yanhong Luo, Yuanfa Tao, Yuehting Chou, Ying He, Han Qin, Tao Chen, Xiaoyun Fu, Miao Chen, Zhouxiong Xing

The acute mesenteric ischaemia (AMESI) study: a matter of incidence

Lorenzo Garzelli, Mathieu Nacher

Toxicities, intensive care management, and outcome of chimeric antigen receptor T cells in adults: an update

Mathieu Bellal, Jolan Malherbe, Gandhi Damaj, Damien Du Cheyron

Accuracy of respiratory muscle assessments to predict weaning outcomes: a systematic review and comparative meta-analysis

Diego Poddighe, Marine Van Hollebeke, Yasir Qaiser Choudhary, Débora Ribeiro Campos, Michele R. Schaeffer, Jan Y. Verbakel, Greet Hermans, Rik Gosselink, Daniel Langer

Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis

Mairi Ziaka, Aristomenis Exadaktylos

Long-term outcome in new onset refractory status epilepticus: a retrospective study

Federica Stretti, Stefan Yu Bögli, Francesca Casagrande, Amanda Eisele, Marian Galovic, Emanuela Keller, Giovanna Brandi

Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial

Evdoxia Kyriazopoulou, Yehudit Hasin-Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vasiliki Tzavara, Sofia Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios Kotsis, Dionysios G. Tsoukalas, Carlo Selmi, Alexandra Konstantinou, Michael Samarkos, Michael Doumas, Aikaterini Masgala, Konstantinos Pagkratis, Aikaterini Argyraki, Karolina Akinosoglou, Styliani Symbardi, Mihai G. Netea, Periklis Panagopoulos, George N. Dalekos, Oliver Liesenfeld, Timothy E. Sweeney, Purvesh Khatri, Evangelos J. Giamarellos-Bourboulis

Mean arterial pressure during cardiopulmonary bypass: A modifiable risk factor for acute kidney injury in cardiac surgery patients?

Nikolaus Schreiber, Simon Orlob, Stephanie Fida, Christoph Klivinyi, Alexander H. Kirsch, Michael Kolland, Michael Schörghuber

Flow starvation during square-flow assisted ventilation detected by supervised deep learning techniques

Candelaria de Haro, Verónica Santos-Pulpón, Irene Telías, Alba Xifra-Porxas, Carles Subirà, Montserrat Batlle, Rafael Fernández, Gastón Murias, Guillermo M. Albaiceta, Sol Fernández-Gonzalo, Marta Godoy-González, Gemma Gomà, Sara Nogales, Oriol Roca, Tai Pham, Josefina López-Aguilar, Rudys Magrans, Laurent Brochard, Lluís Blanch, Leonardo Sarlabous, Laurent Brochard, Irene Telias, Felipe Damiani, Ricard Artigas, Cesar Santis, Tài Pham, Tommaso Mauri, Elena Spinelli, Giacomo Grasselli, Savino Spadaro, Carlo Alberto Volta, Francesco Mojoli, Dimitris Georgopoulos, Eumorfia Kondili, Stella Soundoulounaki, Tobias Becher, Norbert Weiler, Dirk Schaedler, Oriol Roca, Manel Santafe, Jordi Mancebo, Nuria Rodríguez, Leo Heunks, Heder de Vries, Chang-Wen Chen, Jian-Xin Zhou, Guang-Qiang Chen, Nuttapol Rit-tayamai, Norberto Tiribelli, Sebastian Fredes, Ricard Mellado Artigas, Carlos Ferrando Ortolá, François Beloncle, Alain Mercat, Jean-Michel Arnal, Jean-Luc Diehl, Alexandre Demoule, Martin Dres, Quentin Fossé, Sébastien Jochmans, Jonathan Chelly, Nicolas Terzi, Claude Guérin, E. Baedorf Kassis, Jeremy Beitler, Davide Chiumello, Erica Ferrari Luca Bol-giaghi, Arnaud W. Thille, Rémi Coudroy, Laurent Papazian

Real-time machine learning model to predict short-term mortality in critically ill patients: development and international validation

Leerang Lim, Ukdong Gim, Kyungjae Cho, Dongjoon Yoo, Ho Geol Ryu, Hyung-Chul Lee

Impact of COVID-19 on posttraumatic stress disorder in ICU survivors: a prospective observational comparative cohort study

Pierre Kalfon, Wissam El-Hage, Marie-Agnès Geantot, Constance Favier, Laetitia Bodet-Contentin, Khaldoun Kuteifan, Pierre-Yves Olivier, Didier Thévenin, Julien Pottecher, Jullien Crozon-Clauzel, Bénédicte Mauchien, Arnaud Galbois, Roland de Varax, Sabine Valera, Philippe Estagnasie, Audrey Berric, Martine Nyunga, Nathalie Revel, Georges Simon, Benjamin Kowalski, Achille Sossou, Thomas Signouret, Marc Leone, Charles Delalé, Aurélien Seemann, Sigismond Lasocki, Jean-Pierre Quenot, Antoine Monsel, Olivier Michel, Mathieu Page, René-Gilles Patrigeon, Walid Nicola, Arnaud W. Thille, Guillaume Hekimian, Pascal Auquier, Karine Baumstarck, Hortense Catry, Anne-Laure Dubus, Léa Laugery, Marion Lintaff, Mélanie Lourseyre, Lou Merigard, Lisa Michel, Nawal Ouhmad, Solenn Petit, Laurence Tricoche, Florent Beaumale, Anne-Sylvie Scholastique, Emmanuelle Mougenot, Céline Delerue, Marc Feller, Julien Grouille, Charles-Edouard Rochon, Juliette Audibert, Gaëtan Badre, Cécile Jourdain, Leslie Lehaie, Hasni Si Abdelkader, Emilie Henry, Marie Labruyere, Claire Boulle-Geronimi, Stéphanie Beaussard, Olivier Nigeon, Anthea Loiez, Valérie Cerro, Laetitia Marchand, Charlotte Arbelot, Karine Buzelier, Deborah Levy, Pascale Leloup, Karim Messaoudi, Camille Alzina, Lee Nguyen, Steve Nowak, Carole Ichai, Aminata Diop, Hélène Brisson, Jean-Michel Constantin, Samia Lakhal, Madjid Oudihat, Rémi Coudroy, Carole Guyon, Jean-Pierre Frat, René Robert, Nadine Lubango, Lisa Villequey, Stéphane Hecketsweiler, Nicolas Partouche, Laurent Ducros, Vincent Gardan, Julie Rivoire, Stéphanie Deparis-Dusautois, Lamia Lamri, Alexandra Lavalart

Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study

Alwyn Gomez, Logan Froese, Donald Griesdale, Eric P. Thelin, Rahul Raj, Levi van Iperenburg, Jeanette Tas, Marcel Aries, Kevin Y. Stein, Clare Gallagher, Francis Bernard, Andreas H. Kramer, Frederick A. Zeiler

Albumin for sepsis-related peripheral tissue hypoperfusion

Mingqiang Wang, Lin Zhong

Scrutinizing mechanical circulatory support in cardiogenic shock: Have we jumped the gun?

Enzo Lüsebrink, Hugo Lanz, Holger Thiele

Trends in pre-hospital volume resuscitation of blunt trauma patients: a 15-year analysis of the British (TARN) and German (TraumaRegister DGU®) National Registries

M. F. Bath, J. Schloer, J. Strobel, W. Rea, R. Lefering, M. Maegele, H. De’Ath, Z. B. Perkins

Effects of prone positioning on lung mechanical power components in patients with acute respiratory distress syndrome: a physiologic study

Christoph Boesing, Joerg Krebs, Alice Marguerite Conrad, Matthias Otto, Grietje Beck, Manfred Thiel, Patricia R. M. Rocco, Thomas Luecke, Laura Schaefer

The elusive relationship between cardiac filling and fluid responsiveness

Jon-Emile S. Kenny, Ross Prager, Korbin Haycock

Trauma systems in high socioeconomic index countries in 2050

Tobias Gauss, Mariska de Jongh, Marc Maegele, Elaine Cole, Pierre Bouzat

The incidences of acute mesenteric ischaemia vary greatly depending on the population and diagnostic activity

Annika Reintam Blaser, Kadri Tamme, Joel Starkopf, Alastair Forbes, Marko Murruste, Peep Talving, Stefan Acosta, Martin Björck

A comparison of extracorporeal and conventional cardiopulmonary resuscitation for cardiac arrest

Yang Zhao, Qian Wang, Bin Zang

Effect of a self-developed fixation device on preventing endotracheal intubation-related pressure injury: a randomised controlled trial

Xiaodong Zhang, Qibing Zhang, Jiqin You, Rong Xu, Zhaojie Zhang, Yunlan Shi, Chunrong Han, Shiyan Zhao, Bangtao Yao, Yan Geng, Songqiao Liu

Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response

Giuseppe G. F. Leite, Justin de Brabander, Erik H. A. Michels, Joe M. Butler, Olaf L. Cremer, Brendon P. Scicluna, Timothy E. Sweeney, Miguel Reyes, Reinaldo Salomao, Hessel Peters-Sengers, Tom van der Poll

Association between tranexamic acid administration and mortality based on the trauma phenotype: a retrospective analysis of a nationwide trauma registry in Japan

Jotaro Tachino, Shigeto Seno, Hisatake Matsumoto, Tetsuhisa Kitamura, Atsushi Hirayama, Shunichiro Nakao, Yusuke Katayama, Hiroshi Ogura, Jun Oda

Feasibility of 3D-EIT in identifying lung perfusion defect and V/Q mismatch in a patient with VA-ECMO

Yelin Gao, Ke Zhang, Maokun Li, Siyi Yuan, Qianlin Wang, Yi Chi, Yun Long, Zhanqi Zhao, Huaiwu He

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Adrian Ceccato, Carles Forne, Lieuwe D. Bos, Marta Camprubí-Rimblas, Aina Areny-Balagueró, Elena Campaña-Duel, Sara Quero, Emili Diaz, Oriol Roca, David De Gonzalo-Calvo, Laia Fernández-Barat, Anna Motos, Ricard Ferrer, Jordi Riera, Jose A. Lorente, Oscar Peñuelas, Rosario Menendez, Rosario Amaya-Villar, José M. Añón, Ana Balan-Mariño, Carme Barberà, José Barberán, Aaron Blandino-Ortiz, Maria Victoria Boado, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Nieves Franco, Cristóbal Galbán, Víctor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Ángel Estella, Elena Gallego, José Luis García-Garmendia, José Garnacho-Montero, José M. Gómez, Arturo Huerta, Ruth Noemí Jorge-García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, María Cruz Martin-Delgado, Ignacio Martínez-Varela, Juan Lopez Messa, Guillermo Muñiz-Albaiceta, María Teresa Nieto, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Felipe Pérez-García, Pilar Ricart, Ferran Roche-Campo, Alejandro Rodríguez, Victor Sagredo, Angel Sánchez-Miralles, Susana Sancho-Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suarez-Sipmann, Luis Tamayo-Lomas, José Trenado, Alejandro Úbeda, Luis Jorge Valdivia, Pablo Vidal, Jesus Bermejo, Jesica Gonzalez, Ferran Barbe, Carolyn S. Calfee, Antonio Artigas, Antoni Torres, Berta Adell-Serrano, María Aguilar Cabello, Luciano Aguilera, Victoria Alcaraz-Serrano, Cesar Aldecoa, Cynthia Alegre, Raquel Almansa, Sergio Álvarez, Antonio Álvarez Ruiz, Rosario Amaya Villar, Ruth Andrea, Mariana Andrea Novo, José Ángel, Jose Manuel Añon, Marta Arrieta, JIgnacio Ayestarán, Joan Ramon Badia, Mariona Badía, Orville Báez Pravia, Ana Balan Mariño, Begoña Balsera, Carme Barberà, José Barberán, Laura Barbena, Enric Barbeta, Tommaso Bardi, Patricia Barral Segade, Marta Barroso, José Ángel Berezo García, Jesús F. Bermejo-Martin, Belén Beteré, Judit Bigas, Aaron Blandino Ortiz, Rafael Blancas, María Luisa Blasco Cortés, María Boado, María Bodi Saera, Neus Bofill, María Teresa Bouza Vieiro, Leticia Bueno, Elena Bustamante-Munguira, Juan Bustamante-Munguira, Cecilia del Busto Martínez, Jesús Caballero, David Campi Hermoso, Sandra Campos Fernández, Cristina Carbajales, Iosune Cano, Maria Luisa Cantón-Bulnes, Nieves Carbonell, Pablo Cardina Fernández, Laura Carrión García, Sulamita Carvalho, Núria Casacuberta-Barberà, Manuel Castellà, Andrea Castellví, Pedro Castro, Mercedes Catalán-González, Ramon Cicuendez Ávila, Catia Cillóniz, Luisa Clar, Cristina Climent, Jordi Codina, Pamela Conde, Sofía Contreras, María Cruz Martin, Raul de Pablo Sánchez, Diego De Mendoza, Emili Díaz, Yolanda Díaz, María Digna Rivas Vilas, Cristina Dólera Moreno, Irene Dot, Pedro Enríquez Giraudo, Inés Esmorís Arijón, Angel Estella, Teresa Farre Monjo, Javier Fernández, Carlos Ferrando, Albert Figueras, Eva Forcadell-Ferreres, Lorena Forcelledo Espina, Nieves Franco, Enric Franquesa, Àngels Furro, Albert Gabarrus, Cristóbal Galbán, Elena Gallego, Felipe García, Beatriz García, José Luis García Garmendia, Dario Garcia-Gasulla, Emilio García Prieto, Carlos García Redruello, Amaia García Sagastume, José Garnacho-Montero, Maria Luisa Gascón Castillo, Gemma Gomà, José M. Gómez, Vanesa Gómez Casal, Silvia Gómez, Carmen Gómez Gonzalez, David de Gonzalo-Calvo, Jessica González, Federico Gordo, Maria Pilar Gracia, Víctor D. Gumucio-Sanguino, Alba Herraiz, Rubén Herrán-Monge, Arturo Huerta, Mercedes Ibarz, Silvia Iglesias, Maria Teresa Janer, Gabriel Jiménez, Ruth Noemí Jorge García, Mar Juan Díaz, Karsa Kiarostami, Juan ILazo Álvarez, Miguel León, Alexandre López-Gavín, Ana López Lago, Juan Lopez Messa, Esther López-Ramos, Ana Loza-Vázquez, Desire Macias Guerrero, Nuria Mamolar Herrera, Rafael Mañez Mendiluce, Cecilia L. Mantellini, Gregorio Marco Naya, Pilar Marcos, Judith Marin-Corral, Enrique Marmol Peis, Paula Martín Vicente, María Martínez, Carmen Eulalia Martínez Fernández, Amalia Martínez de la Gándara, Maria Dolores Martínez Juan, Basilisa Martínez Palacios, Ignacio Martínez Varela, Juan Fernando Masa Jimenez, Joan Ramon Masclans, Emilio Maseda, Eva María Menor Fernández, Mar Miralbés, Josman Monclou, Juan Carlos Montejo-González, Neus Montserrat, María Mora Aznar, Dulce Morales, Sara Guadalupe Moreno Cano, David Mosquera Rodríguez, Rosana Muñoz-Bermúdez, Guillermo Muñiz Albaiceta, José María Nicolás, Maria Teresa NIeto, Ramon Nogue Bou, Rafaela Nogueras Salinas, Marta Ocón, Ana Ortega, Sergio Ossa, Pablo Pagliarani, Francisco Parrilla, Jose Pedregosa-Díaz, Yhivian Peñasco, Oscar Peñuelas, Leire Pérez Bastida, Purificación Pérez, Felipe Pérez-García, Gloria Pérez Planelles, Eva Pérez Rubio, David Pestaña Laguna, Àngels Piñol-Tena, Javier Prados, Andrés Pujol, Juan Carlos Pozo, Núria Ramon Coll, Gloria Renedo Sanchez-Giron, Jordi Riera, Pilar Ricart, Ferran Roche-Campo, Alejandro Rodríguez, Laura Rodriguez, Felipe Rodríguez de Castro, Silvia Rodríguez, Covadonga Rodríguez Ruiz, Jorge Rubio, Alberto Rubio López, Ángela Leonor Ruiz-García, Miriam Ruiz Miralles, Pablo Ryan Murúa, Eva Saborido Paz, Victor Sagredo, Ana Salazar Degracia, Inmaculada Salvador-Adell, Miguel Sanchez, Ana Sánchez, Angel Sánchez-Miralles, Susana Sancho Chinesta, Bitor Santacoloma, Miguel Sanchez, Maria Teresa Sariñena, Marta Segura Pensado, Lidia Serra, Mireia Serra-Fortuny, Ainhoa Serrano Lázaro, Lluís Servià, Lorenzo Socias, Laura Soliva, Jordi Solé-Violan, Fernando Suarez Sipmann, Carla Speziale, Luis Tamayo Lomas, Adrián Tormos, Maria del Carmen de la Torre, Gerard Torres, Mateu Torres, Sandra Trefler, Josep Trenado, Javier Trujillano, Alejandro Úbeda, Luis Urrelo-Cerrón, Estela Val, Manuel Valledor, Luis Valdivia Ruiz, Montserrat Vallverdú, Maria Van der Hofstadt Martin-Montalvo, Sabela Vara Adrio, Nil Vázquez, Javier Vengoechea, Pablo Vidal, Clara Vilà-Vilardel, Judit Vilanova, Tatiana Villada Warrington, Hua Yang, Minlan Yang, Ana Zapatero

Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials

Matthieu Legrand, Sean M. Bagshaw, Pavan K. Bhatraju, Azra Bihorac, Ellen Caniglia, Ashish K. Khanna, John A. Kellum, Jay Koyner, Michael O. Harhay, Fernando G. Zampieri, Alexander Zarbock, Kevin Chung, Kathleen Liu, Ravindra Mehta, Peter Pickkers, Abigail Ryan, Juliane Bernholz, Laura Dember, Martin Gallagher, Patrick Rossignol, Marlies Ostermann

Intra-aortic balloon pump in patients undergoing VA-ECMO: an analysis of the Chinese Extracorporeal Life Support Registry

Liangshan Wang, Xing Hao, Chenglong Li, Haixiu Xie, Feng Yang, Hong Wang, Zhongtao Du, Xiaotong Hou

Correction : Selected articles from the annual update in intensive care and emergency medicine 2020

The long-term intercorrelation between post-burn pain, anxiety, and depression: a post hoc analysis of the “RE-ENERGIZE” double-blind, randomized, multicenter placebo-controlled trial

Adriana C. Panayi, Daren K. Heyland, Christian Stoppe, Marc G. Jeschke, Oliver Didzun, Dany Matar, Christian Tapking, Alen Palackic, Björn Bliesener, Leila Harhaus, Samuel Knoedler, Valentin Haug, Amir K. Bigdeli, Ulrich Kneser, Dennis P. Orgill, Gabriel Hundeshagen

Breath metabolomics for diagnosis of acute respiratory distress syndrome

Shiqi Zhang, Laura A. Hagens, Nanon F. L. Heijnen, Marry R. Smit, Paul Brinkman, Dominic Fenn, Tom van der Poll, Marcus J. Schultz, Dennis C. J. J. Bergmans, Ronny M. Schnabel, Lieuwe D. J. Bos, Lieuwe D. J. Bos, Laura A. Hagens, Marcus J. Schultz, Marry R. Smit, Dennis C. J. J. Bergmans, Nanon F. L. Heijnen, Ronny M. Schnabel, Inge Geven, Tamara M. E. Nijsen, Alwin R. M. Verschueren

Vascular leak in sepsis: physiological basis and potential therapeutic advances

Ross R. McMullan, Daniel F. McAuley, Cecilia M. O’Kane, Jonathan A. Silversides

Physical activity is associated with a lower risk of contracting and dying in infection and sepsis: a Swedish population-based cohort study

Karl Stattin, Mikael Eriksson, Robert Frithiof, Rafael Kawati, Michael Hultström, Miklos Lipcsey

Association between intensive care unit nursing grade and mortality in patients with cardiogenic shock and its cost-effectiveness

Ki Hong Choi, Danbee Kang, Jin Lee, Hyejeong Park, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Juhee Cho, Jeong Hoon Yang

Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review

Hang Ruan, Qin Zhang, You-ping Zhang, Shu-sheng Li, Xiao Ran

Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS

Antoine Guillon, Youenn Jouan, Arthur Kassa-Sombo, Christophe Paget, Pierre-François Dequin

Quality of life-related and non-quality of life-related issues in ICU survivors and non-ICU-treated controls: a multi-group exploratory factor analysis

Johan Malmgren, Stefan Lundin, Ann-Charlotte Waldenström, Christian Rylander, Elias Johannesson

Response to commentary “The importance of assessing left ventricular longitudinal function in presence of increased afterload”

Hugues de Courson, Alexandre Loiseau, Grégoire Chadefaux, Matthieu Biais

“NeuroVanguard”: a contemporary strategy in neuromonitoring for severe adult brain injury patients

Edith Elianna Rodriguez, Mario Zaccarelli, Elda Diletta Sterchele, Fabio Silvio Taccone

The management of heart failure cardiogenic shock: an international RAND appropriateness panel

Stefan Williams, Antonis Kalakoutas, Segun Olusanya, Benedict Schrage, Guido Tavazzi, Anthony P. Carnicelli, Santiago Montero, Christophe Vandenbriele, Adriana Luk, Hoong Sern Lim, Sai Bhagra, Sascha C. Ott, Marta Farrero, Marc D. Samsky, Jamie L. W. Kennedy, Sounok Sen, Richa Agrawal, Penelope Rampersad, Amanda Coniglio, Federico Pappalardo, Christopher Barnett, Alastair G. Proudfoot

Facial appearance associates with longitudinal multi-organ failure: an ICU cohort study

Eline G. M. Cox, Bas C. T. van Bussel, Nerea Campillo Llamazares, Jan-Willem E. M. Sels, Marisa Onrust, Iwan C. C. van der Horst, Jacqueline Koeze, Geert Koster, Jacqueline Koeze, Renske Wiersema, Frederik Keus, Iwan C. C. van der Horst, Willem Dieperink, Marisa Onrust, Nynke van der Veen, Alexander Irk, Arlinde Roelofs, Leonie Tijsma, Eline Cox, Nerea Campillo Llamazares, Lesley Holzhauer

Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients

Benjamin Coiffard, Jose Dianti, Irene Telias, Laurent J. Brochard, Arthur S. Slutsky, Jennifer Beck, Christer Sinderby, Niall D. Ferguson, Ewan C. Goligher

Vitamin D metabolism in critically ill patients with acute kidney injury: a prospective observational study

Lynda K. Cameron, Lesedi Ledwaba-Chapman, Kieran Voong, Geeta Hampson, Lui G. Forni, Nina Seylanova, Dominic J. Harrington, Rosario Lim, Aneta Bociek, Wang Yanzhong, Marlies Ostermann

GFAP point-of-care measurement for prehospital diagnosis of intracranial hemorrhage in acute coma

Sabina Zylyftari, Sebastian Luger, Kristaps Blums, Stephan Barthelmes, Sebastian Humm, Hannsjörg Baum, Stephan Meckel, Jörg Braun, Gregor Lichy, Andreas Heilgeist, Love-Preet Kalra, Christian Foerch

Correction: Selected articles from the annual update in Intensive Care and Emergency Medicine 2021

Volatile versus propofol sedation after cardiac valve surgery: a single-center prospective randomized controlled trial

Armin Niklas Flinspach, Florian Jürgen Raimann, Philipp Kaiser, Michaela Pfaff, Kai Zacharowski, Vanessa Neef, Elisabeth Hannah Adam

Effects of robotic-assisted early mobilization versus conventional mobilization in intensive care unit patients: prospective interventional cohort study with retrospective control group analysis

Lucas Huebner, Angelika Warmbein, Christina Scharf, Ines Schroeder, Kirsi Manz, Ivanka Rathgeber, Marcus Gutmann, Johanna Biebl, Amrei Mehler-Klamt, Jana Huber, Inge Eberl, Eduard Kraft, Uli Fischer, Michael Zoller

Use of artificial intelligence in critical care: opportunities and obstacles

Michael R. Pinsky, Armando Bedoya, Azra Bihorac, Leo Celi, Matthew Churpek, Nicoleta J. Economou-Zavlanos, Paul Elbers, Suchi Saria, Vincent Liu, Patrick G. Lyons, Benjamin Shickel, Patrick Toral, David Tscholl, Gilles Clermont

Anti-inflammatory therapies are associated with delayed onset of anemia and reduction in transfusion requirements in critically ill patients: results from two studies

Madelief Bolscher, Stephanie C. E. Koster, Matty Koopmans, Jelle L. G. Haitsma Mulier, Lennie P. G. Derde, Nicole P. Juffermans

Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study

Weizhuo Liu, Rongjiao Shao, Shen Zhang, Lei Jin, Rongchen Liu, Peidong Chen, Jintao Hu, Haocheng Ma, Bangwei Wu, Weiguo Liang, Xinping Luo, Jian Li, Weiming Chen, Nanqing Xiong, Bin He

Plasma glial fibrillary acidic protein and tau: predictors of neurological outcome after cardiac arrest

Isabelle Arctaedius, Helena Levin, Bergthóra Thorgeirsdóttir, Marion Moseby-Knappe, Tobias Cronberg, Martin Annborn, Niklas Nielsen, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Attila Frigyesi, Hans Friberg, Anna Lybeck, Niklas Mattsson-Carlgren

Correction: Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP) in patients with acute exacerbation of COPD: From the French OUTCOMEREA cohort

Louis‑Marie Galerneau, Sebastien Bailly, Nicolas Terzi, Stephane Ruckly, Maite Garrouste‑Orgeas, Johanna Oziel, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Jean‑Marie Forel, Anais Dartevel, Julien Dessajan, Christophe Adrie, Dany Goldgran‑Toledano, Virginie Laurent, Laurent Argaud, Jean Reignier, Jean‑Louis Pepin, Michael Darmon, Jean‑Francois Timsit

Outcome prediction of cardiac arrest with automatically computed gray-white matter ratio on computed tomography images

Hsinhan Tsai, Chien-Yu Chi, Liang-Wei Wang, Yu-Jen Su, Ya-Fang Chen, Min-Shan Tsai, Chih-Hung Wang, Cheyu Hsu, Chien-Hua Huang, Weichung Wang

Job description and perception of clinical research personnel working in a network of French intensive care units

Mireille Adda, Claire Dupuis, Gérald Gouby, Claude Dubray, Jean Reignier, Bertrand Souweine, Christian Dualé

Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study

YiWen Fan, Jill Moser, Matijs van Meurs, Dorien Kiers, Jannie Marie Bülow Sand, Diana Julie Leeming, Peter Pickkers, Janette K. Burgess, Matthijs Kox, Janesh Pillay

Correction to: Interventions to promote cost-effectiveness in adult intensive care units: consensus statement and considerations for best practice from a multidisciplinary and multinational eDelphi study

Amit Kansal, Jos M. Latour, Kay Choong See, Sumeet Rai, Maurizio Cecconi, Carl Britto, Andrew Conway Morris, Raymond Dominic Savio, Vinay M. Nadkarni, B. K. Rao, Rajesh Mishra

Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis

Lujia Zhang, Jiahuan Xu, Yue Li, Fanqi Meng, Wei Wang

Impact of attaining aggressive vs. conservative PK/PD target on the clinical efficacy of beta-lactams for the treatment of Gram-negative infections in the critically ill patients: a systematic review and meta-analysis

Milo Gatti, Pier Giorgio Cojutti, Federico Pea

Contribution of electrical impedance tomography to personalize positive end-expiratory pressure under ECCO2R

Benjamin Pequignot, Alain Combes, Mickael Lescroart, Bruno Levy, Matthieu Koszutski

Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation and immediate invasive assessment in refractory out-of-hospital cardiac arrest: a long-term follow-up of the Prague OHCA trial

Daniel Rob, Klaudia Farkasovska, Marketa Kreckova, Ondrej Smid, Petra Kavalkova, Jaromir Macoun, Michal Huptych, Petra Havrankova, Juraj Gallo, Jan Pudil, Milan Dusik, Stepan Havranek, Ales Linhart, Jan Belohlavek

Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: be aware of the temporal selection bias

Romain Jouffroy, Anne-Cécile Vie, Benoît Vivien

Significance of critical closing pressures (starling resistors) in arterial circulation

Michael R. Pinsky, M. Ignacio Monge García, Arnaldo Dubin

Policy framework for the utilization of generative AI

Kunming Cheng, Haiyang Wu

Time-dependent effect of prone position in ARDS: considerations for future research

Yuxian Wang, Ming Zhong

ACE inhibitors and angiotensin receptor blockers differentially alter the response to angiotensin II treatment in vasodilatory shock

Daniel E. Leisman, Damian R. Handisides, Laurence W. Busse, Mark C. Chappell, Lakhmir S. Chawla, Michael R. Filbin, Marcia B. Goldberg, Kealy R. Ham, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, Christopher D. Adams, Tony N. Hodges, Rinaldo Bellomo

Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis

Keyvan Razazi, Charles-Edouard Luyt, Guillaume Voiriot, Anahita Rouzé, Marc Garnier, Alexis Ferré, Laurent Camous, Nicholas Heming, Nathanaël Lapidus, Anais Charles-Nelson, Armand Mekontso-Dessap, Alain Mercat, Pierre Asfar, François Beloncle, Julien Demiselle, Tài Pham, Arthur Pavot, Xavier Monnet, Christian Richard, Alexandre Demoule, Martin Dres, Julien Mayaux, Alexandra Beurton, Cédric Daubin, Richard Descamps, Aurélie Joret, Damien Du Cheyron, Frédéric Pene, Jean-Daniel Chiche, Mathieu Jozwiak, Paul Jaubert, Guillaume Voiriot, Muriel Fartoukh, Marion Teulier, Clarisse Blayau, Erwen L’Her, Cécile Aubron, Laetitia Bodenes, Nicolas Ferriere, Johann Auchabie, Anthony Le Meur, Sylvain Pignal, Thierry Mazzoni, Jean-Pierre Quenot, Pascal Andreu, Jean-Baptiste Roudau, Marie Labruyère, Saad Nseir, Sébastien Preau, Julien Poissy, Daniel Mathieu, Sarah Benhamida, Rémi Paulet, Nicolas Roucaud, Martial Thyrault, Florence Daviet, Sami Hraiech, Gabriel Parzy, Aude Sylvestre, Sébastien Jochmans, Anne-Laure Bouilland, Mehran Monchi, Marc Danguy des Déserts, Quentin Mathais, Gwendoline Rager, Pierre Pasquier, Jean Reignier, Amélie Seguin, Charlotte Garret, Emmanuel Canet, Jean Dellamonica, Clément Saccheri, Romain Lombardi, Yanis Kouchit, Sophie Jacquier, Armelle Mathonnet, Mai-Ahn Nay, Isabelle Runge, Frédéric Martino, Laure Flurin, Amélie Rolle, Michel Carles, Rémi Coudroy, Arnaud W. Thille, Jean-Pierre Frat, Maeva Rodriguez, Pascal Beuret, Audrey Tientcheu, Arthur Vincent, Florian Michelin, Fabienne Tamion, Dorothée Carpentier, Déborah Boyer, Christophe Girault, Valérie Gissot, Stéphan Ehrmann, Charlotte Salmon Gandonniere, Djlali Elaroussi, Agathe Delbove, Yannick Fedun, Julien Huntzinger, Eddy Lebas, Grâce Kisoka, Céline Grégoire, Stella Marchetta, Bernard Lambermont, Laurent Argaud, Thomas Baudry, Pierre-Jean Bertrand, Auguste Dargent, Christophe Guitton, Nicolas Chudeau, Mickaël Landais, Cédric Darreau, Alexis Ferré, Antoine Gros, Guillaume Lacave, Fabrice Bruneel, Mathilde Neuville, Jérôme Devaquet, Guillaume Tachon, Richard Gallot, Riad Chelha, Arnaud Galbois, Anne Jallot, Ludivine Chalumeau Lemoine, Khaldoun Kuteifan, Valentin Pointurier, Louise-Marie Jandeaux, Joy Mootien, Charles Damoisel, Benjamin Sztrymf, Matthieu Schmidt, Alain Combes, Juliette Chommeloux, Charles Edouard Luyt, Frédérique Schortgen, Leon Rusel, Camille Jung, Florent Gobert, Damien Vimpere, Lionel Lamhaut, Bertrand Sauneuf, Liliane Charrrier, Julien Calus, Isabelle Desmeules, Benoît Painvin, Jean-Marc Tadie, Vincent Castelain, Baptiste Michard, Jean-Etienne Herbrecht, Mathieu Baldacini, Nicolas Weiss, Sophie Demeret, Clémence Marois, Benjamin Rohaut, Pierre-Henri Moury, Anne-Charlotte Savida, Emmanuel Couadau, Mathieu Série, Nica Alexandru, Cédric Bruel, Candice Fontaine, Sonia Garrigou, Juliette Courtiade Mahler, Maxime Leclerc, Michel Ramakers, Pierre Garçon, Nicole Massou, Ly Van Vong, Juliane Sen, Nolwenn Lucas, Franck Chemouni, Annabelle Stoclin, Alexandre Avenel, Henri Faure, Angélie Gentilhomme, Sylvie Ricome, Paul Abraham, Céline Monard, Julien Textoris, Thomas Rimmele, Florent Montini, Gabriel Lejour, Thierry Lazard, Isabelle Etienney, Younes Kerroumi, Claire Dupuis, Marine Bereiziat, Elisabeth Coupez, François Thouy, Clément Hofmann, Nicolas Donat, Anne Chrisment, Rose-Marie Blot, Antoine Kimmoun, Audrey Jacquot, Matthieu Mattei, Bruno Levy, Ramin Ravan, Loïc Dopeux, Jean-Mathias Liteaudon, Delphine Roux, Brice Rey, Radu Anghel, Deborah Schenesse, Vincent Gevrey, Jermy Castanera, Philippe Petua, Benjamin Madeux, Otto Hartman, Michael Piagnerelli, Anne Joosten, Cinderella Noel, Patrick Biston, Thibaut Noel, Gurvan L. E. Bouar, Messabi Boukhanza, Elsa Demarest, Marie-France Bajolet, Nathanaël Charrier, Audrey Quenet, Cécile Zylberfajn, Nicolas Dufour, Bruno Mégarbane, Sébastian Voicu, Nicolas Deye, Isabelle Malissin, François Legay, Matthieu Debarre, Nicolas Barbarot, Pierre Fillatre, Bertrand Delord, Thomas Laterrade, Tahar Saghi, Wilfried Pujol, Pierre Julien Cungi, Pierre Esnault, Mickael Cardinale, Vivien Hong Tuan Ha, Grégory Fleury, Marie-Ange Brou, Daniel Zafmahazo, David Tran-Van, Patrick Avargues, Lisa Carenco, Nicolas Robin, Alexandre Ouali, Lucie Houdou, Christophe Le Terrier, Noémie Suh, Steve Primmaz, Jérome Pugin, Emmanuel Weiss, Tobias Gauss, Jean-Denis Moyer, Catherine Paugam Burtz, Béatrice La Combe, Rolland Smonig, Jade Violleau, Pauline Cailliez, Jonathan Chelly, Antoine Marchalot, Cécile Saladin, Christelle Bigot, Pierre-Marie Fayolle, Jules Fatséas, Amr Ibrahim, Dabor Resiere, Rabih Hage, Clémentine Cholet, Marie Cantier, Pierre Trouiler, Philippe Montravers, Brice Lortat-Jacob, Sebastien Tanaka, Alexy Tran Dinh, Jacques Duranteau, Anatole Harrois, Guillaume Dubreuil, Marie Werner, Anne Godier, Sophie Hamada, Diane Zlotnik, Hélène Nougue, Armand Mekontso-Dessap, Guillaume Carteaux, Keyvan Razazi, Nicolas de Prost, Nicolas Mongardon, Nicolas Mongardon, Meriam Lamraoui, Claire Alessandri, Quentin de Roux, Charles de Roquetaillade, Benjamin G. Chousterman, Alexandre Mebazaa, Etienne Gayat, Marc Garnier, Emmanuel Pardo, Lea Satre-Buisson, Christophe Gutton, Elise Yvin, Clémence Marcault, Elie Azoulay, Michael Darmon, Hafid Ait Oufella, Geofroy Hariri, Tomas Urbina, Sandie Mazerand, Nicholas Heming, Francesca Santi, Pierre Moine, Djillali Annane, Adrien Bouglé, Edris Omar, Aymeric Lancelot, Emmanuelle Begot, Gaétan Plantefeve, Damien Contou, Hervé Mentec, Olivier Pajot, Stanislas Faguer, Olivier Cointault, Laurence Lavayssiere, Marie-Béatrice Nogier, Matthieu Jamme, Claire Pichereau, Jan Hayon, Hervé Outin, François Dépret, Maxime Coutrot, Maité Chaussard, Lucie Guillemet, Pierre Gofn, Romain Thouny, Julien Guntz, Laurent Jadot, Romain Persichini, Vanessa Jean-Michel, Hugues Georges, Thomas Caulier, Gaël Pradel, Marie-Hélène Hausermann, Thi My Hue Nguyen-Valat, Michel Boudinaud, Emmanuel Vivier, Sylvène Rosseli, Gaël Bourdin, Christian Pommier, Marc Vinclair, Simon Poignant, Sandrine Mons, Wulfran Bougouin, Franklin Bruna, Quentin Maestraggi, Christian Roth, Laurent Bitker, François Dhelft, Justine Bonnet-Chateau, Mathilde Filippelli, Tristan Morichau-Beauchant, Stéphane Thierry, Charlotte Le Roy, Mélanie Saint Jouan, Bruno Goncalves, Aurélien Mazeraud, Matthieu Daniel, Tarek Sharshar, Cyril Cadoz, Rostane Gaci, Sébastien Gette, Guillaune Louis, Sophie-Caroline Sacleux, Marie-Amélie Ordan, Aurélie Cravoisy, Marie Conrad, Guilhem Courte, Sébastien Gibot, Younès Benzidi, Claudia Casella, Laurent Serpin, Jean-Lou Setti, Marie-Catherine Besse, Anna Bourreau, Jérôme Pillot, Caroline Rivera, Camille Vinclair, Marie-Aline Robaux, Chloé Achino, Marie-Charlotte Delignette, Tessa Mazard, Frédéric Aubrun, Bruno Bouchet, Aurélien Frérou, Laura Muller, Charlotte Quentin, Samuel Degoul, Xavier Stihle, Claude Sumian, Nicoletta Bergero, Bernard Lanaspre, Hervé Quintard, Eve Marie Maiziere, Pierre-Yves Egreteau, Guillaume Leloup, Florin Berteau, Marjolaine Cottrel, Marie Bouteloup, Matthieu Jeannot, Quentin Blanc, Julien Saison, Isabelle Geneau, Romaric Grenot, Abdel Ouchike, Pascal Hazera, Anne-Lyse Masse, Suela Demiri, Corinne Vezinet, Elodie Baron, Deborah Benchetrit, Antoine Monsel, Grégoire Trebbia, Emmanuelle Schaack, Raphaël Lepecq, Mathieu Bobet, Christophe Vinsonneau, Thibault Dekeyser, Quentin Delforge, Imen Rahmani, Bérengère Vivet, Jonathan Paillot, Lucie Hierle, Claire Chaignat, Sarah Valette, Benoït Her, Jennifer Brunet, Mathieu Page, Fabienne Boiste, Anthony Collin, Florent Bavozet, Aude Garin, Mohamed Dlala, Kais Mhamdi, Bassem Beilouny, Alexandra Lavalard, Severine Perez, Benoit Veber, Pierre-Gildas Guitard, Philippe Gouin, Anna Lamacz, Fabienne Plouvier, Bertrand P. Delaborde, Aïssa Kherchache, Amina Chaalal, Jean-Damien Ricard, Marc Amouretti, Santiago Freita-Ramos, Damien Roux, Jean-Michel Constantin, Mona Assef, Marine Lecore, Agathe Selves, Florian Prevost, Christian Lamer, Ruiying Shi, Lyes Knani, Sébastien Pili Floury, Lucie Vettoretti, Michael Levy, Lucile Marsac, Stéphane Dauger, Sophie Guilmin-Crépon, Hadrien Winiszewski, Gael Piton, Thibaud Soumagne, Gilles Capellier, Jean-Baptiste Putegnat, Frédérique Bayle, Maya Perrou, Ghyslaine Thao, Guillaume Géri, Cyril Charron, Xavier Repessé, Antoine Vieillard-Baron, Mathieu Guilbart, Pierre-Alexandre Roger, Sébastien Hinard, Pierre-Yves Macq, Kevin Chaulier, Sylvie Goutte, Patrick Chillet, Anaïs Pitta, Barbara Darjent, Amandine Bruneau, Sigismond Lasocki, Maxime Leger, Soizic Gergaud, Pierre Lemarie, Nicolas Terzi, Carole Schwebel, Anaïs Dartevel, Louis-Marie Galerneau, Jean-Luc Diehl, Caroline Hauw-Berlemont, Nicolas Péron, Emmanuel Guérot, Abolfazl Mohebbi Amoli, Michel Benhamou, Jean-Pierre Deyme, Olivier Andremont, Diane Lena, Julien Cady, Arnaud Causeret, Arnaud De La Chapelle, Christophe Cracco, Stéphane Rouleau, David Schnell, Camille Foucault, Cécile Lory, Thibault Chapelle, Vincent Bruckert, Julie Garcia, Abdlazize Sahraoui, Nathalie Abbosh, Caroline Bornstain, Pierre Pernet, Florent Poirson, Ahmed Pasem, Philippe Karoubi, Virginie Poupinel, Caroline Gauthier, François Bouniol, Philippe Feuchere, Florent Bavozet, Anne Heron, Serge Carreira, Malo Emery, Anne Sophie Le Floch, Luana Giovannangeli, Nicolas Herzog, Christophe Giacardi, Thibaut Baudic, Chloé Thill, Said Lebbah, Jessica Palmyre, Florence Tubach, David Hajage, Nicolas Bonnet, Nathan Ebstein, Stéphane Gaudry, Yves Cohen, Julie Noublanche, Olivier Lesieur, Arnaud Sément, Isabel Roca-Cerezo, Michel Pascal, Nesrine Sma, Gwenhaël Colin, Jean-Claude Lacherade, Gauthier Bionz, Natacha Maquigneau, Pierre Bouzat, Michel Durand, Marie-Christine Hérault, Jean-Francois Payen

Rapidly improving ARDS differs clinically and biologically from persistent ARDS

Patricia L. Valda Toro, Andrew Willmore, Nelson E. Wu, Kevin L. Delucchi, Alejandra Jauregui, Pratik Sinha, Kathleen D. Liu, Carolyn M. Hendrickson, Aartik Sarma, Lucile P. A. Neyton, Aleksandra Leligdowicz, Charles R. Langelier, Hanjing Zhuo, Chayse Jones, Kirsten N. Kangelaris, Antonio D. Gomez, Michael A. Matthay, Carolyn S. Calfee

Lower airway microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndromes

Sébastien Imbert, Mathilde Revers, Raphaël Enaud, Arthur Orieux, Adrian Camino, Alexandre Massri, Laurent Villeneuve, Cédric Carrié, Laurent Petit, Alexandre Boyer, Patrick Berger, Didier Gruson, Laurence Delhaes, Renaud Prével

Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure

Kazuki Sudo, Mao Kinoshita, Ken Kawaguchi, Kohsuke Kushimoto, Ryogo Yoshii, Keita Inoue, Masaki Yamasaki, Tasuku Matsuyama, Kunihiko Kooguchi, Yasuo Takashima, Masami Tanaka, Kazumichi Matsumoto, Kei Tashiro, Tohru Inaba, Bon Ohta, Teiji Sawa

Transforming research to improve therapies for trauma in the twenty-first century: an alternative perspective

Geoffrey P. Dobson, Jodie L. Morris, Hayley L. Letson

Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome

Elias Baedorf-Kassis, Michael Murn, Amy L. Dzierba, Alexis L. Serra, Ivan Garcia, Emily Minus, Clarissa Padilla, Todd Sarge, Valerie M. Goodspeed, Michael A. Matthay, Michelle N. Gong, Deborah Cook, Stephen H. Loring, Daniel Talmor, Jeremy R. Beitler, Daniel Talmor, Todd Sarge, Valerie Goodspeed, Emily Fish, Sayuri Jinadasa, Ray Ritz, Joseph Previtera, Michelle N. Gong, Lawrence Lee, Jeremy R. Beitler, Deborah Cook, France Clarke, Tom Piraino, Joseph Levitt, Rosemary Vojnik, Pauline Park, Kristin Brierley, Carl Haas, Andrew Weirauch, Eddy Fan, Andrea Matte, R. Scott Harris, Mamary Kone, Stephen Heard, Karen Longtine, Franćois Lellouche, Pierre-Alexandre Bouchard, Lewis Rubinson, Jennifer McGrain, Donald E. G. Griesdale, Denise Foster, Richard Oeckler, Amy Amsbaugh, Edgar Jimenez, Valerie Danesh

Adapting NeuroVanguard to real-world challenges

Andres Giglio, Monserrat Pino, Andres Ferre, Andres Reccius

Quantitative analysis of apparent diffusion coefficients to predict neurological prognosis in cardiac arrest survivors: an observational derivation and internal–external validation study

Jung A Yoon, Changshin Kang, Jung Soo Park, Yeonho You, Jin Hong Min, Yong Nam In, Wonjoon Jeong, Hong Jun Ahn, Hye Seon Jeong, Yong Hwan Kim, Byung Kook Lee, Dongha Kim

Beta-blockade in V-V ECMO

Aravind K. Bommiasamy, Bishoy Zakhary, Ran Ran

Fluid responsiveness and venous congestion: unraveling the nuances of fluid status

Adrien Joseph, Matthieu Petit, Philippe Vignon, Antoine Vieillard-Baron