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Critical Care

Ausgabe 1/2021

Inhalt (448 Artikel)

Open Access Editorial

How I prescribe continuous renal replacement therapy

Emily J. See, Rinaldo Bellomo

Open Access Research

Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort study

Pablo Monedero, Alfredo Gea, Pedro Castro, Angel M. Candela-Toha, María L. Hernández-Sanz, Egoitz Arruti, Jesús Villar, Carlos Ferrando, Pablo Monedero, Alfredo Gea, Pedro Castro, Angel M. Candela-Toha, Marina Vendrell, Gerard Sánchez-Etayo, Amalia Alcón, Isabel Belda, Mercé Agustí, Albert Carramiñana, Isabel Gracia, Miriam Panzeri, Irene León, Jaume Balust, Ricard Navarro, María José Arguís, María José Carretero, Cristina Ibáñez, Juan Perdomo, Antonio López, Manuel López-Baamonde, Tomás Cuñat, Marta Ubré, Antonio Ojeda, Andrea Calvo, Eva Rivas, Paola Hurtado, Roger Pujol, Nuria Martín, Javier Tercero, Pepe Sanahuja, Marta Magaldi, Miquel Coca, Elena del Rio, Julia Martínez-Ocon, Paula Masgoret, Monserrat Tio, Angel Caballero, Raquel Risco, Raquel Bergé, Lidia Gómez, Nicolás de Riva, Ana Ruiz, Beatriz, Tena, Sebastián Jaramillo, José María Balibrea, Francisco Borja de Lacy, Ana Otero, Ainitze Ibarzabal, Raquel Bravo, Anna Carreras, Daniel Martín-Barreda, Alfonso Jesús Alias, Mariano Balaguer, Jorge Aliaga, Alex Almuedo, Joan Ramón Alonso, Rut Andrea, Gerard Sergi Angelès, Marilyn Arias, Fátima Aziz, Joan Ramon Badía, Enric Barbeta, Toni Torres, Guillem Batiste, Pau Benet, Xavi Borrat, María Borrell, Ernest Bragulat, Inmaculada Carmona, Manuel Castellà, Pedro Castro, Joan Ceravalls, Oscar Comino, Claudia Cucciniello, Clàudia De Deray, Oriol De Diego, Paula De la Matta, Marta Farrero, Javier Fernández, Sara Fernández, Anna Fernández, Miquel Ferrer, Ana Fervienza, María Tallo Forga, Daniel Forné, Clàudia Galán, Andrea Gómez, Eduard Guasch, María Hernández-Tejero, Adriana Jacas, Beltrán Jiménez, Pere Leyes, Teresa López, José Antonio Martínez, Graciela Martínez-Pallí, Jordi Mercadal, Guido Muñoz, José Muñoz, Ricard Navarro, Josep María Nicolás, José Tomás Ortiz, Anna Peiró, Manuel Pérez, Esteban Poch, Margarida Pujol, Eduard Quintana, Bartomeu Ramis, Enric Reverter, Irene Rovira, Pablo Ruiz, Elena Sandoval, Stefan Schneider, Oriol Sibila, Carla Solé, Alex Soriano, Dolors Soy, M. Suárez, Adrián Téllez, Néstor David Toapanta, Antoni Torres, Xavier Urra, César Aldecoa, Alicia Bordell, Silvia Martín, Judith Andrés, Alberto Martínez Ruiz, Gonzalo Tamayo Medel, Iñaki Bilbao Villasante, Fernando Iturri Clavero, Covadonga Peralta Álvarez, Julia T. Herrera Díez, Andrea García Trancho, Iñaki Sainz Mandiola, Carmen Ruano Suarez, Angela Ruiz Bocos, Eneritz Urrutia Izagirre, Pablo Ortiz de Urbina Fernández, Naiara Apodaka López, Leire Prieto Molano, Eunate Ganuza Martínez, Iratxe Vallinas Hidalgo, Karmele de Orte Sancho, Celia González Paniagua, Gemma Ortiz Labrador, Mireia Pérez Larrañaga, Marta López Miguelez, Estíbaliz Bárcena Andrés, Erik Urutxurtu Laureano, Maria Jesús Maroño Boedo, Blanca Escontrela Rodríguez, Aitziber Ereñozaga Camiruaga, Deiene Lasuen Aguirre, Ainhoa Zabal Maeztu, Ane Guereca Gala, Iker Castelo Korro, Andrés Álvarez Campo, Alejandro Carcelen Viana, Alejandro Alberdi Enríquez, Xabier Ormazábal Rementeria, Alberto Sánchez Campos, Rosa Gutiérrez Rico, Pablo Barbier Damborenea, Marta Guerenabarrena Momeñe, Borja Cuesta Ruiz, Alejandro López Rico, Ana Rojo Polo, Covadonga García Grijelmo, Mikel Celorrio Reta, Eneko Martín Arroyo, Leire Artaza Aparicio, Iñaki Ituarte Aspiazu, Ane Igeregi Basabe, Itxaso Merino Julian, Isabel Diaz Rico, Maria Paz Martínez, Ramón Adalia Bartolomé, Luigi Zattera, Irina Adalid Hernandez, Leire Larrañaga Altuna, Aina Serrallonga Castells, Adriana Vílchez Garcia, María Núñez, Lorena Román, Isabel Ramos Delgado, Adela Benítez-Cano Martínez, Mireia Chanzá Albert, Juan Carlos Álvarez García, Luis Aguilera Cuchillo, Sandra Beltrán de Heredia, Jesús Carazo Cordobés, Carlos Alberto García Bernedo, Fernando Escolano Villén, Francisco Javier Redondo Calvo, Rubén Villazala González, Victor Baladron González, Patricia Faba, Omar Montenegro, Natalia Bejarano Ramírez, Sergio Marcos Contreras, Alejandro Garcia Rodríguez, Saleta Rey Vázquez, Cristina Garcia Pérez, Eva Higuera Miguelez, Irene Pérez Blanco, David García Rivera, Ane Martín de la Fuente, Marta Pardo, Vanessa Rodriguez, Unai Bengoetxea, Fernando Ramasco, Sheila Olga Santidrián Bernal, Alvar Santa Cruz Hernando, Antonio Planas Roca, Carlos Figueroa Yusta, Esther García Villabona, Carmen Vallejo Lantero, Eva Patiño Rodriguez, Alvaro Esquivel Toledo, David Arribas Méndez, Mar Orts Rodriguez, Rosa Méndez Hernández, Jesús Nieves Alonso, Inés Imaz Artazcoz, Sonia Expósito Carazo, Carlos Román Guerrero, Elena Rojo Rodríguez, Ricardo Moreno González, Julia Hernando Santos, Jara Torrente Pérez, Esperanza Mata Mena, Manuel José Muñoz Martínez, Enrique Alday Muñoz, Patricia Martin Serrano, Laura Cotter Muñoz, Amadea Mjertan, Diego Gutierrez Martínez, Carmen Rodríguez García, Olaya Alonso Viejo, Juan Alvarez Pereira, Ana Carmona Bonet, Diana Parrado López, Eva de Dios Tomas, Rafael Martín Celemin, María Luisa Meilan Paz, Luis Quecedo Gutiérrez, Noemí Diaz Velasco, Gabriel Martin Hernández, Francisco Garcia del Corral, Gloria Hernandez Arias, David Rodriguez Cuesta, Ana Gómez Rice, Encarna Mateos Sevillano, Natalia Olmos Molpeceres, Beatriz Domínguez, Ana Vázquez Lima, Ángel Candela, Ismael AAcevedo Bambaren, Maria Isabel Albala Blanco, Paloma Alonso Montoiro, Fernando Álvarez Utrera, Juan Avellanosa Esteruelas, Amal Azzam López, Alberto José Balvis Balvis, Tommaso Bardi, María Beltrán Martín, Jacobo Benatar Haserfaty, Alberto Berruezo Camacho, Laura Betolaza Weimer, María del Mar Carbonell Soto, Cristina Carrasco Seral, Cristina Cerro Zaballos, Elizabeth Claros Llamas, Pilar Coleta Orduna, Ingrid P. Cortes Forero, Pascual Agustín Crespo Aliseda, María Angélica de Pablo Pajares, Yolanda Díez Remesal, Trinidad Dorado Díaz, Noemí Echevarría Blasco, María Elena Elías Martín, Javier Felices Triviño, Natalia Fernández López, Cristina Fernández Martín, Natalia Ferreiro Pozuelo, Luis Gajate Martín, Clara Gallego Santos, Diego Gil Mayo, María Gómez Rojo, Claudia González Cibrián, Elena Herrera López, Borja Hinojal Olmedillo, Berta Iglesias Gallego, Sassan Khonsari, María Nuria Mane Ruiz, María Manzanero Arroyo, Ana María Mariscal Ortega, Sara Martín Burcio, María del Carmen Martín González, Ascensión Martín Grande, Jose Juan Martín López, Cecilia Martín Rabes, Marcos Martínez Borja, Nilda Martínez Castro, Adolfo Martínez Pérez, Snejana Matcan, Cristina Medrano Viñas, Lisset Miguel Herrera, Adrián Mira Betancur, María Montiel Carbajo, Javier Moya Moradas, Lorena Muñoz Pérez, Mónica Nuñez Murias, Eva Ordiales González, Óscar Ordoñez Recio, Miguel Ángel Palomero Rodriguez, Diego Parise Roux, Lucia Pereira Torres, David Pestaña Lagunas, Juana María Pinto Corraliza, Marian Prieto Rodrigo, Inmaculada Rodriguez Diaz-Regaño, David Rodriguez Esteban, Víctor Rojas Pernia, Álvaro Ruigómez Saiz, Bárbara Saavedra Villarino, Noemí Samaranch Palero, Gloria Santos Pérez, Jaume Serna Pérez, Ana Belén Serrano Romero, Jesús Tercero López, Carlos Tiscar García, Marta de la Torre Concostrina, Eva María Ureta Mesa, Eva Velasco Olarte, Judith Villahoz Martínez, Raúl Villalaba Palacios, Gema Villanueva García, Cristina Vogel de Medeiros, Soraya Gholamian Ovejero, Marta Vicente Orgaz, Patricia Lloreda Herradon, Cristina Crespo Gómez, Tatiana Sarmiento-Trujillo, Noemí García Medina, María Martínez García, Carles Espinós Ramírez, Nabil Mouhaffel Rivero, Jose Antonio Bernia Gil, Sonsoles Martín, María Victoria Moral, Josefina Galán, Pilar Paniagua, Sergio Pérez, Albert Bainac, Ana Arias, Elsa Ramil, Jorge Escudero, Pablo Monedero, Carmen Cara, Andrea Lara, Elena Mendez Martínez, Jorge Mendoza, Íñigo Rubio Baines, Carmen Sala Trull, Pablo Montero López, Alfredo Gea, Alejandro Montero, Rocío Armero Ibañez, Juan Vicente Llau Pitarch, Fernando Rauer Alcóver, Cristina Álvarez Herreros, Cyntia Sánchez Martín, Lucía López Ocáriz Olmos, Marta Navas Moruno, Fernando García Montoto, M. F. Mirón Rodriguez, Laura Fuentes Coco, Cristina Hernández Gamito, Antonio Barba Orejudo, Luis Gerardo Smith Vielma, Yasmina González Marín, Francisco de Borja Amador Penco, Marta Donoso Domínguez, Silvia Esquivel Ramírez, José Antonio Carbonell, Berta Monleón López, Sara Martínez-Castro, Gerardo Aguilar, María Gestal, Pablo Casas, Angel Outeiro Rosato, Andrea Naveiro Pan, María Alonso Portela, Adrián García Romar, Eva Mosquera Rodríguez, Diego Ruanova Seijo, Pablo Rama Maceiras, Francisco Castro-Ceoane, Esther Moreno López, Sergio Gil, Julia Guillén Antón, Patricia García-Consuegra Tirado, Aurora Callau Calvo, Laura Forés Lisbona, María Carbonell Romero, Belén Albericio Gil, Laura Pradal Jarne, María Soria Lozano, Diego Loscos López, Andrea Patiño Abarca, Javier Pérez-Asenjo, Ángel Díez-Domínguez, Ion Zubizarreta, Jon Ramos, Iosu Fernández, Emilio Maseda, Alejandro Suárez de la Rica, Javier Veganzones, Itziar Insausti, Javier Sagra, Sofía Díaz Carrasco, Ana Montero Feijoo, Julio Yagüe, Ignacio Garutti, Javier Hortal, Patricia Piñeiro, Matilde Piñeiro, Matilde Zaballos, Jamil cedeño, Pablo García-Olivares, Alberto Garriido, Jose Eugenioi Guerrero, Eva Bassas Parga, Carmen Deiros Garcia, Elisenda Pujol Rosa, Ana Tejedor Navarro, Roser Font Gabernet, Maria José Bernat, Meritxell Serra Valls, Cristina Cobaleda Garcia-Bernalt, Jesus Fernanz Anton, Adriana Aponte Sierra, Lucia Gil Gomez, Olaia Guenaga Vaqueiro, Susana Hernandez Marin, Laura Pardo Pinzon, Sira Garcia Aranda, Carlos Briones Orejuela, Edgar Cortes Sánchez, Alejandro Romero Fernández, Esther Fernández SanJosé, Patricia Iglesias Garsabal, Guillermo Isidro Lopez, Ana Vicol, Sara Espejo Malagon, María Sanabra Loewe, Laura Grau Torradeflo, Lourdes Blanco Alcaide, Gloria Buenaventura Sanclemente, Pere Serra Pujol, Gustavo Cuadros Mendoza, Miroslawa Konarska, Fedra Bachs Almenara, Agnieszka Golska, Aleix Carmona Blesa, Arantxa Mas Serra, Javier Ripolles Melchor, Ana Nieto Moreno, Káteri Chao Novo, Sandra Gadín López, Elena Nieto Moreno, Bérénice Gutiérrez Tonal, Elena Lucena de Pablo, Barbara Algar Yañez, Beatriz Vázquez Rivero, Beatriz Nozal Mateo, Marina de Retes, Norma Aracil Escoda, Cristina Gallardo Mayo, Rosa Sanz González, Alicia Ruiz Escobar, Maria Laura Pelegrina López, Marina Valenzuela Peña, David Stolle Dueñas, Ane Abad Motos, Alfredo Abad-Gurumeta, Ana Tirado Errazquin, Elena Sáez Ruiz, Nerea Gómez Pérez, Francisco de Borja Bau González, Cesar Morcillo Serra, Jessica Souto Higueras, Rosario Vicente, Raquel Ferrandis, Silvia Polo Martín, Azucena Pajares Moncho, Ignacio Moreno Puigdollers, Juan Pérez Artacho Cortés, Ana Moret Calvo, Ana Pi Peña, María Catalán Fernández, Marina Varela, Pilar Díaz Parada, Raquel Rey Carlín, Sarra Barreiro Aragunde, María Isabel Forés Chiva, A. Javier Agulló, Antonio Pérez Ferrer, María Galiana, Antoni Margarit, Válerie Mourre del Rio, Eva Heras Muxella, Anna Vidal

Open Access Research Letter

Comparison between first and second wave among critically ill COVID-19 patients admitted to a French ICU: no prognostic improvement during the second wave?

Damien Contou, Megan Fraissé, Olivier Pajot, Jo-Anna Tirolien, Hervé Mentec, Gaëtan Plantefève

Open Access Research

Protective reactive thymus hyperplasia in COVID-19 acute respiratory distress syndrome

Pelagia Cuvelier, Hélène Roux, Anne Couëdel-Courteille, Jacques Dutrieux, Cécile Naudin, Bénédicte Charmeteau de Muylder, Rémi Cheynier, Pierre Squara, Stefano Marullo

Open Access Research

Accelerated versus standard initiation of renal replacement therapy for critically ill patients with acute kidney injury: a systematic review and meta-analysis of RCT studies

Heng-Chih Pan, Ying-Ying Chen, I-Jung Tsai, Chih-Chung Shiao, Tao-Min Huang, Chieh-Kai Chan, Hung-Wei Liao, Tai-Shuan Lai, Yvonne Chueh, Vin-Cent Wu, Yung-Ming Chen

Open Access Editorial

Clinical application of esophageal manometry: how I do it

Elias Baedorf Kassis, Daniel Talmor

Open Access Research Letter

Carboxyhemoglobin, a reliable diagnosis biomarker for hemolysis in intensive care unit: a retrospective study

Geoffroy Hariri, Kyann Hodjat Panah, Bénédicte Beneteau-Burnat, Michael Chaquin, Arsene Mekinian, Hafid Ait-Oufella

Open Access Research

Prevalence of burnout among intensivists in mainland China: a nationwide cross-sectional survey

Jing Wang, Bo Hu, Zhiyong Peng, Huimin Song, Shuhan Cai, Xin Rao, Lu Li, Jianguo Li

Open Access Research

Venoarterial extracorporeal membrane oxygenation induces early immune alterations

Aurélien Frerou, Mathieu Lesouhaitier, Murielle Gregoire, Fabrice Uhel, Arnaud Gacouin, Florian Reizine, Caroline Moreau, Aurélie Loirat, Adel Maamar, Nicolas Nesseler, Amedeo Anselmi, Erwan Flecher, Jean-Philippe Verhoye, Yves Le Tulzo, Michel Cogné, Mikael Roussel, Karin Tarte, Jean-Marc Tadié

Open Access Research

Problems in care and avoidability of death after discharge from intensive care: a multi-centre retrospective case record review study

Sarah Vollam, Owen Gustafson, J. Duncan Young, Benjamin Attwood, Liza Keating, Peter Watkinson

Open Access Research

Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates

Şerife Kurul, Sinno H. P. Simons, Christian R. B. Ramakers, Yolanda B. De Rijke, René F. Kornelisse, Irwin K. M. Reiss, H. Rob Taal

Open Access Research

Mechanical power during extracorporeal membrane oxygenation and hospital mortality in patients with acute respiratory distress syndrome

Li-Chung Chiu, Shih-Wei Lin, Li-Pang Chuang, Hsin-Hsien Li, Pi-Hua Liu, Feng-Chun Tsai, Chih-Hao Chang, Chen-Yiu Hung, Chung-Shu Lee, Shaw-Woei Leu, Han-Chung Hu, Chung-Chi Huang, Huang-Pin Wu, Kuo-Chin Kao

Open Access Research Letter

Endotracheal aspirates contain a limited number of lower respiratory tract immune cells

Marika Orlov, Eric D. Morrell, Victoria Dmyterko, Jessica A. Hamerman, Mark M. Wurfel, Carmen Mikacenic

Open Access Research

Mortality in septic patients treated with vitamin C: a systematic meta-analysis

Sean S. Scholz, Rainer Borgstedt, Nicole Ebeling, Leoni C. Menzel, Gerrit Jansen, Sebastian Rehberg

Open Access Research

Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis

Dominik Menges, Bianca Seiler, Yuki Tomonaga, Matthias Schwenkglenks, Milo A. Puhan, Henock G. Yebyo

Open Access Research

A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients

Etienne Macedo, Bethany Karl, Euyhyun Lee, Ravindra L. Mehta

Open Access Viewpoint

Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”

Daniel Agustin Godoy, Rafael Badenes, Paolo Pelosi, Chiara Robba

Open Access Research

The immune modulatory effects of mitochondrial transplantation on cecal slurry model in rat

Jung Wook Hwang, Min Ji Lee, Tae Nyoung Chung, Han A. Reum Lee, Jung Ho Lee, Seo Yoon Choi, Ye Jin Park, Chul Hee Kim, Isom Jin, Seong Hoon Kim, Hyo-Bum Kwak, Jun-Won Heo, Kwangmin Na, Sangchun Choi, Yong-Soo Choi, Kyuseok Kim

Open Access Research

Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study

Bruno Levy, Caroline Fritz, Caroline Piona, Kevin Duarte, Andrea Morelli, Philippe Guerci, Antoine Kimmoun, Nicolas Girerd

Open Access COVID-19 Review

Knowledge translation tools to guide care of non-intubated patients with acute respiratory illness during the COVID-19 Pandemic

David Leasa, Paul Cameron, Kimia Honarmand, Tina Mele, Karen J. Bosma, Rob Arntfield, John Basmaji, Karen J. Bosma (lead), Paul Cameron, Ian Dashnay, Rob Ducharme, Belinda Gougoulias, Jeff Granton, Wael Haddara, Ahmed F. Hegazy, Kimia Honarmand, Kendrah Krouskos, John Landau, David Leasa, Rob Leeper, Christine MacDonald, Claudio Martin, David McCormack, Rachelle McCready, Tina Mele, Brenda Morgan, Dave Nagpal, Ruediger Noppens, Allison Oldershaw, Marat Slessarev, Joanne Smith, Michelle Stephens, Ravi Taneja, Susan Whitehouse, Tim Winterburn

Open Access Research

Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS

Inès Bendib, Asma Beldi-Ferchiou, Frédéric Schlemmer, Mathieu Surenaud, Bernard Maitre, Anne Plonquet, Guillaume Carteaux, Keyvan Razazi, Veronique Godot, Sophie Hüe, Armand Mekontso Dessap, Nicolas de Prost

Open Access Research

Burden of pneumococcal pneumonia requiring ICU admission in France: 1-year prognosis, resources use, and costs

Claire Dupuis, Ayman Sabra, Juliette Patrier, Gwendoline Chaize, Amine Saighi, Céline Féger, Alexandre Vainchtock, Jacques Gaillat, Jean-François Timsit

Open Access COVID-19 Research

Ventilator-associated pneumonia in critically ill patients with COVID-19

Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar, Nicholas M. Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefin Bartholdson Scott, Andrew Conway Morris

Open Access Research

Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients

Michael Chaim Sklar, Fabiana Madotto, Annemijn Jonkman, Michela Rauseo, Ibrahim Soliman, L. Felipe Damiani, Irene Telias, Sebastian Dubo, Lu Chen, Nuttapol Rittayamai, Guang-Qiang Chen, Ewan C. Goligher, Martin Dres, Remi Coudroy, Tai Pham, Ricard M. Artigas, Jan O. Friedrich, Christer Sinderby, Leo Heunks, Laurent Brochard

Open Access Research

Incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients: data from two prospective cohort studies

Ruben J. Eck, Lisa Hulshof, Renske Wiersema, Chris H. L. Thio, Bart Hiemstra, Niels C. Gritters van den Oever, Reinold O. B. Gans, Iwan C. C. van der Horst, Karina Meijer, Frederik Keus

Open Access COVID-19 Letter

Hospital networks and patient transport capacity during the COVID-19 pandemic when intensive care resources become scarce

Alexander Supady, Dawid Staudacher, Christoph Bode, Guido Michels, Tobias Wengenmayer

Open Access Research

Development and validation of new poisoning mortality score system for patients with acute poisoning at the emergency department

Kap Su Han, Su Jin Kim, Eui Jung Lee, Joong Ho Shin, Ji Sung Lee, Sung Woo Lee

Open Access Research Letter

Can prone positioning be a safe procedure in patients with acute brain injury and moderate-to-severe acute respiratory distress syndrome?

Pauline Bernon, Ségolène Mrozek, Guillaume Dupont, Frédéric Dailler, Anne-Claire Lukaszewicz, Baptiste Balança

Open Access Research

Semi-elemental versus polymeric formula for enteral nutrition in brain-injured critically ill patients: a randomized trial

Laurent Carteron, Emmanuel Samain, Hadrien Winiszewski, Gilles Blasco, Anne-Sophie Balon, Camille Gilli, Gael Piton, Gilles Capellier, Sebastien Pili-Floury, Guillaume Besch

Open Access Research

Serum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study

Sabina Hunziker, Adrian Quinto, Maja Ramin-Wright, Christoph Becker, Katharina Beck, Alessia Vincent, Kai Tisljar, Giulio Disanto, Pascal Benkert, David Leppert, Hans Pargger, Stephan Marsch, Raoul Sutter, Nils Peters, Jens Kuhle

Open Access COVID-19 Research Letter

Rate control in atrial fibrillation using Landiolol is safe in critically ill Covid-19 patients

Geoffroy Hariri, Tomas Urbina, Sandie Mazerand, Naike Bige, Jean-Luc Baudel, Hafid Ait-Oufella

Open Access Research

Bedside POCUS during ward emergencies is associated with improved diagnosis and outcome: an observational, prospective, controlled study

Laurent Zieleskiewicz, Alexandre Lopez, Sami Hraiech, Karine Baumstarck, Bruno Pastene, Mathieu Di Bisceglie, Benjamin Coiffard, Gary Duclos, Alain Boussuges, Xavier Bobbia, Sharon Einav, Laurent Papazian, Marc Leone

Open Access COVID-19 Research Letter

Lung ultrasound can predict response to the prone position in awake non-intubated patients with COVID‑19 associated acute respiratory distress syndrome

Sergey N. Avdeev, Galina V. Nekludova, Natalia V. Trushenko, Natalia A. Tsareva, Andrey I. Yaroshetskiy, Djuro Kosanovic

Open Access Research

Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI

Elisabeth C. van der Slikke, Bastiaan S. Star, Matijs van Meurs, Robert H. Henning, Jill Moser, Hjalmar R. Bouma

Open Access COVID-19 Research Letter

Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19

Michael Hultström, Miklos Lipcsey, Ewa Wallin, Ing-Marie Larsson, Anders Larsson, Robert Frithiof

Open Access Research

Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs

Benjamin Friedrichson, Haitham Mutlak, Kai Zacharowski, Florian Piekarski

Open Access Research

Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study)

Nuttha Lumlertgul, Anna Hall, Luigi Camporota, Siobhan Crichton, Marlies Ostermann

Open Access COVID-19 Viewpoint

COVID-19: What we’ve done well and what we could or should have done better—the 4 Ps

Jean-Louis Vincent, Julia Wendon, Greg S. Martin, Nicole P. Juffermans, Jacques Creteur, Maurizio Cecconi

Open Access Research

Blood purification with a cytokine adsorber for the elimination of myoglobin in critically ill patients with severe rhabdomyolysis

Christina Scharf, Uwe Liebchen, Michael Paal, Michael Irlbeck, Michael Zoller, Ines Schroeder

Open Access Research

The feasibility and reliability of actigraphy to monitor sleep in intensive care patients: an observational study

L. J. Delaney, E. Litton, K. L. Melehan, H.-C. C. Huang, V. Lopez, F. Van Haren

Open Access Research

Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery

Antonio Messina, Chiara Robba, Lorenzo Calabrò, Daniel Zambelli, Francesca Iannuzzi, Edoardo Molinari, Silvia Scarano, Denise Battaglini, Marta Baggiani, Giacomo De Mattei, Laura Saderi, Giovanni Sotgiu, Paolo Pelosi, Maurizio Cecconi

Open Access Research

The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study

Qiao He, Wen Wang, Shichao Zhu, Mingqi Wang, Yan Kang, Rui Zhang, Kang Zou, Zhiyong Zong, Xin Sun

Open Access Research

Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study

Tomoko Fujii, Andrew A. Udy, Alistair Nichol, Rinaldo Bellomo, Adam M. Deane, Khaled El-Khawas, Naorungroj Thummaporn, Ary Serpa Neto, Hannah Bergin, Robert Short-Burchell, Chin-Ming Chen, Kuang-Hua Cheng, Kuo-Chen Cheng, Clemente Chia, Feng-Fan Chiang, Nai-Kuan Chou, Timothy Fazio, Pin-Kuei Fu, Victor Ge, Yoshiro Hayashi, Jennifer Holmes, Ting-Yu Hu, Shih-Feng Huang, Naoya Iguchi, Sarah L. Jones, Toshiyuki Karumai, Shinshu Katayama, Shih-Chi Ku, Chao-Lun Lai, Bor-Jen Lee, Wen-Jinn Liaw, Chelsea T. W. Ong, Lisa Paxton, Chloe Peppin, Owen Roodenburg, Shinjiro Saito, John D. Santamaria, Yahya Shehabi, Aiko Tanaka, Ravindranath Tiruvoipati, Hsiao-En Tsai, An-Yi Wang, Chen-Yu Wang, Yu-Chang Yeh, Chong-Jen Yu, Kuo-Ching Yuan, Tomoko Fujii, Andrew A. Udy , Adam M. Deane , Alistair Nichol, Rinaldo Bellomo, Ary Serpa Neto, Khaled El-Khawas, Naorungroj Thummaporn, Lisa Paxton, Timothy Fazio, Robert Short-Burchell, Allison Bone, Hannah Bergin, Sarah Jones, Jennifer Holmes, John Santamaria, Chloe Peppin, Yahya Shehabi, Ravindranath Tiruvoipati, Victor Ge, Lee-Anne Clavarino, Chelsea Ong, Owen Roodenburg, Steven Hirth, Aiko Tanaka, Naoya Iguchi, Shinshu Katayama, Jun Shima, Fumie Takatsudo, Kumie Suzuki, Shinjiro Saito, Toshiyuki Karumai, Yoshiro Hayashi, Yu-Chang Yeh, Chong-Jen Yu, Shih-Chi Ku, Nai-Kuan Chou, Ting-Yu Hu, Kuang-Hua Cheng, Chao-Lun Lai, Hsiao-En Tsai, Kuo-Ching Yuan, An-Yi Wang, Shih-Feng Huang, Wen-Jinn Liaw, Kuo-Chen Cheng, Chin-Ming Chen, Bor-Jen Lee

Open Access Letter

Utility of AI models in critical care: union of man and the machine

Amos Lal, Vitaly Herasevich, Ognjen Gajic

Open Access COVID-19 Letter

Use of the lung ultrasound score in monitoring COVID-19 patients: it’s time for a reappraisal

Luigi Vetrugno, Daniele Orso, Cristian Deana, Flavio Bassi, Gianmaria Cammarota, Tiziana Bove

Open Access Research

Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure

Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache, Lorraine B. Ware

Open Access Research

Acute cholangitis in intensive care units: clinical, biological, microbiological spectrum and risk factors for mortality: a multicenter study

Jean-Rémi Lavillegrand, Emmanuelle Mercier-Des-Rochettes, Elodie Baron, Frédéric Pène, Damien Contou, Raphael Favory, Sébastien Préau, Arnaud Galbois, Chloé Molliere, Arnaud-Félix Miailhe, Jean Reignier, Mehran Monchi, Claire Pichereau, Sara Thietart, Thibault Vieille, Gael Piton, Gabriel Preda, Idriss Abdallah, Marine Camus, Eric Maury, Bertrand Guidet, Guillaume Dumas, Hafid Ait-Oufella

Open Access Research

Identification and characterization of neutrophil heterogeneity in sepsis

Xinxin Qi, Yao Yu, Ran Sun, Jiamin Huang, Lu Liu, Yunxi Yang, Tao Rui, Bingwei Sun

Open Access COVID-19 Research

Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Yue Zhang, Kai Han, Chunjing Du, Rui Li, Jingyuan Liu, Hui Zeng, Liuluan Zhu, Ang Li

Open Access COVID-19 Research

Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study

Benoit Vandenbunder, Stephan Ehrmann, Michael Piagnerelli, Bertrand Sauneuf, Nicolas Serck, Thibaud Soumagne, Julien Textoris, Christophe Vinsonneau, Nadia Aissaoui, Gauthier Blonz, Giuseppe Carbutti, Romain Courcelle, Alain D’hondt, Stephane Gaudry, Julien Higny, Geoffroy Horlait, Sami Hraiech, Laurent Lefebvre, Francois Lejeune, Andre Ly, Jean-Baptiste Lascarrou, David Grimaldi, Benoit Vandenbunder, Stephan Ehrmann, Michael Piagnerelli, Bertrand Sauneuf, Nicolas Serck, Thibaud Soumagne, Julien Textoris, Christophe Vinsonneau, Nadia Aissaoui, Gauthier Blonz, Giuseppe Carbutti, Romain Courcelle, Alain D’hondt, Stephane Gaudry, Julien Higny, Geoffroy Horlait, Sami Hraiech, Laurent Lefebvre, Francois Lejeune, Andre Ly, Jean‑Baptiste Lascarrou, David Grimaldi, Patrick Biston, Gwenhael Colin, Oriane de Maere, Nathan Ebstein, Frederic Foret, Thibault Helbert, Jean-Baptiste Mesland, Celine Monard, Nicolas Mongardon, Gregoire Ottavy, Thomas Pasau, Gael Piton, Zoe Pletschette, Ester Ponzetto, Caroline Sejourne, Piotr Szychowiak, Xavier Souloy, Aude Sylvestre, Nicolas Tartrat, Cedric Vanbrussel

Open Access COVID-19 Review

SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

Maria Clara Saad Menezes, Diego Vinicius Santinelli Pestana, Gustavo Rosa Gameiro, Luiz Fernando Ferraz da Silva, Ėlodie Baron, Jean-Jacques Rouby, José Otavio Costa Auler Jr

Open Access Letter

Septic shock, noradrenaline requirements and alpha-2 agonists: Fishing in the right pond?

Auguste Dargent, Luc Quintin, Jean-Pierre Quenot

Open Access Research

Renal dysfunction improves risk stratification and may call for a change in the management of intermediate- and high-risk acute pulmonary embolism: results from a multicenter cohort study with external validation

Romain Chopard, David Jimenez, Guillaume Serzian, Fiona Ecarnot, Nicolas Falvo, Elsa Kalbacher, Benjamin Bonnet, Gilles Capellier, François Schiele, Laurent Bertoletti, Manuel Monreal, Nicolas Meneveau

Open Access COVID-19 Research

High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure

Ricard Mellado-Artigas, Bruno L. Ferreyro, Federico Angriman, María Hernández-Sanz, Egoitz Arruti, Antoni Torres, Jesús Villar, Laurent Brochard, Carlos Ferrando, Ricard Mellado-Artigas, María Hernández-Sanz, Carlos Ferrando, Marina Vendrell, Gerard Sánchez-Etayo, Amalia Alcón, Isabel Belda, Mercé Agustí, Albert Carramiñana, Isabel Gracia, Miriam Panzeri, Irene León, Jaume Balust, Ricard Navarro, María José Arguís, María José Carretero, Cristina Ibáñez, Juan Perdomo, Antonio López, Manuel López-Baamonde, Tomás Cuñat, Marta Ubré, Antonio Ojeda, Andrea Calvo, Eva Rivas, Paola Hurtado, Roger Pujol, Nuria Martín, Javier Tercero, Pepe Sanahuja, Marta Magaldi, Miquel Coca, Elena del Rio, Julia Martínez-Ocon, Paula Masgoret, Monserrat Tio, Angel Caballero, Raquel Risco, Raquel Bergé, Lidia Gómez, Nicolás de Riva, Ana Ruiz, Beatriz Tena, Sebastián Jaramillo, José María Balibrea, Francisco Borja de Borja de Lacy, Ana Otero, Ainitze Ibarzabal, Raquel Bravo, Anna Carreras, Daniel Martín-Barreda, Alfonso Jesús Alias, Mariano Balaguer, Jorge Aliaga, Alex Almuedo, Joan Ramón Alonso, Rut Andrea, Gerard Sergi Angelès, Marilyn Arias, Fátima Aziz, Joan Ramon Badía, Enric Barbeta, Toni Torres, Guillem Batiste, Pau Benet, Xavi Borrat, María Borrell, Ernest Bragulat, Inmaculada Carmona, Manuel Castellà, Pedro Castro, Joan Ceravalls, Oscar Comino, Claudia Cucciniello, Clàudia De Deray, Oriol De Diego, Paula De la Matta, Marta Farrero, Javier Fernández, Sara Fernández, Anna Fernández, Miquel Ferrer, Ana Fervienza, María Tallo Forga, Daniel Forné, Clàudia Galán, Andrea Gómez, Eduard Guasch, María Hernández-Tejero, Adriana Jacas, Beltrán Jiménez, Pere Leyes, Teresa López, José Antonio Martínez, Graciela Martínez-Pallí, Jordi Mercadal, Guido Muñoz, José Muñoz, Ricard Navarro, Josep María Nicolás, José Tomás Ortiz, Anna Peiró, Manuel Pérez, Esteban Poch, Margarida Pujol, Eduard Quintana, Bartomeu Ramis, Enric Reverter, Irene Rovira, Pablo Ruiz, Elena Sandoval, Stefan Schneider, Oriol Sibila, Carla Solé, Alex Soriano, Dolors Soy, M. Suárez, Adrián Téllez, Néstor David Toapanta, Antoni Torres, Xavier Urra, César Aldecoa, Alicia Bordell, Silvia Martín, Judith Andrés, Alberto Martínez Ruiz, Gonzalo Tamayo Medel, Iñaki Bilbao Bilbao Villasante, Fernando Iturri Clavero, Covadonga Peralta Álvarez, Julia T. Herrera Díez, Andrea García Trancho, Iñaki Sainz Mandiola, Carmen Ruano Suarez, Angela Ruiz Bocos, Eneritz Urrutia Izagirre, Pablo Ortiz de Urbina Fernández, Naiara Apodaka López, Leire Prieto Molano, Eunate Ganuza Martínez, Iratxe Vallinas Hidalgo, Karmele de Orte Sancho, Celia González Paniagua, Gemma Ortiz Labrador, Mireia Pérez Larrañaga, Marta López Miguelez, Estíbaliz Bárcena Andrés, Erik Urutxurtu Laureano, Maria Jesús Maroño Boedo, Blanca Escontrela Rodríguez, Aitziber Ereñozaga Camiruaga, Deiene Lasuen Aguirre, Ainhoa Zabal Maeztu, Ane Guereca Gala, Iker Castelo Korro, Andrés Álvarez Campo, Alejandro Carcelen Viana, Alejandro Alberdi Enríquez, Xabier Ormazábal Rementeria, Alberto Sánchez Campos, Rosa Gutiérrez Rico, Pablo Barbier Damborenea, Marta Guerenabarrena Momeñe, Borja Cuesta Ruiz, Alejandro López Rico, Ana Rojo Polo, Covadonga García Grijelmo, Mikel Celorrio Reta, Eneko Martín Arroyo, Leire Artaza Aparicio, Iñaki Ituarte Aspiazu, Ane Igeregi Basabe, Itxaso Merino Julian, Isabel Diaz Rico, Maria Paz Martínez, Ramón Adalia Bartolomé, Luigi Zattera, Irina Adalid Hernandez, Leire Larrañaga Altuna, Aina Serrallonga Castells, Adriana Vílchez Garcia, María Núñez, Lorena Román, Isabel Ramos Delgado, Adela Benítez-Cano Martínez, Mireia Chanzá Albert, Juan Carlos Álvarez García, Luis Aguilera Cuchillo, Sandra Beltrán de Heredia, Jesús Carazo Cordobés, Carlos Alberto García Bernedo, Fernando Escolano Villén, Francisco Javier Redondo Calvo, Rubén Villazala González, Victor Baladron González, Patricia Faba, Omar Montenegro, Natalia Bejarano Ramírez, Sergio Marcos Contreras, Alejandro Garcia Rodríguez, Saleta Rey Vázquez, Cristina Garcia Pérez, Eva Higuera Miguelez, Irene Pérez Blanco, David García Rivera, Ane Martín de la Fuente, Marta Pardo, Vanessa Rodriguez, Unai Bengoetxea, Fernando Ramasco, Sheila Olga Santidrián Bernal, Alvar Santa Cruz Hernando, Antonio Planas Roca, Carlos Figueroa Yusta, Esther García Villabona, Carmen Vallejo Lantero, Eva Patiño Rodriguez, Alvaro Esquivel Toledo, David Arribas Méndez, Mar Orts Rodriguez, Rosa Méndez Hernández, Jesús Nieves Alonso, Inés Imaz Artazcoz, Sonia Expósito Carazo, Carlos Román Guerrero, Elena Rojo Rodríguez, Ricardo Moreno González, Julia Hernando Santos, Jara Torrente Pérez, Esperanza Mata Mena, Manuel José Muñoz Martínez, Enrique Alday Muñoz, Patricia Martin Serrano, Laura Cotter Muñoz, Amadea Mjertan, Diego Gutierrez Martínez, Carmen Rodríguez García, Olaya Alonso Viejo, Juan Alvarez Pereira, Ana Carmona Bonet, Diana Parrado López, Eva de Dios Tomas, Rafael Martín Celemin, María Luisa Meilan Paz, Luis Quecedo Gutiérrez, Noemí Diaz Velasco, Gabriel Martin Hernández, Francisco Garcia del Corral, Gloria Hernandez Arias, David Rodriguez Cuesta, Ana Gómez Rice, Encarna Mateos Sevillano, Natalia Olmos Molpeceres, Beatriz Domínguez, Ana Vázquez Lima, Ángel Candela, Ismael A. Acevedo Bambaren, Maria Isabel Albala Blanco, Paloma Alonso Montoiro, Fernando Álvarez Utrera, Juan Avellanosa Esteruelas, Amal Azzam López, Alberto José Balvis, Balvis Tommaso Bardi, María Beltrán Martín, Jacobo Benatar Haserfaty, Alberto Berruezo Camacho, Laura Betolaza Weimer, María del Mar Carbonell Soto, Cristina Carrasco Seral, Cristina Cerro Zaballos, Elizabeth Claros Llamas, Pilar Coleta Orduna, Ingrid P. Cortes Forero, Pascual Agustín Crespo Aliseda, María Angélica de Pablo Pajares, Yolanda Díez Remesal, Trinidad Dorado Díaz, Noemí Echevarría Blasco, María Elena Elías Martín, Javier Felices Triviño, Natalia Fernández López, Cristina Fernández Martín, Natalia Ferreiro Pozuelo, Luis Gajate Martín, Clara Gallego Santos, Diego Gil Mayo, María Gómez Rojo, Claudia González Cibrián, Elena Herrera López, Borja Hinojal Olmedillo, Berta Iglesias Gallego, Sassan Khonsari, María Nuria Mane Ruiz, María Manzanero Arroyo, Ana María Mariscal Ortega, Sara Martín Burcio, María del Carmen Martín González, Ascensión Martín Grande, Jose Juan Martín López, Cecilia Martín Rabes, Marcos Martínez Borja, Nilda Martínez Castro, Adolfo Martínez Pérez, Snejana Matcan, Cristina Medrano Viñas, Lisset Miguel Herrera, Adrián Mira Betancur, María Montiel Carbajo, Javier Moya Moradas, Lorena Muñoz Pérez, Mónica Nuñez Murias, Eva Ordiales González, Óscar Ordoñez Recio, Miguel Ángel Palomero Rodriguez, Diego Parise Roux, Lucia Pereira Torres, David Pestaña Lagunas, Juana María Pinto Corraliza, Marian Prieto Rodrigo, Inmaculada Rodriguez Diaz-Regaño, David Rodriguez Esteban, Víctor Rojas Pernia, Álvaro Ruigómez Saiz, Bárbara Saavedra Villarino, Noemí Samaranch Palero, Gloria Santos Pérez, Jaume Serna Pérez, Ana Belén Serrano Romero, Jesús Tercero López, Carlos Tiscar García, Marta de la Torre Concostrina, Eva María Ureta Mesa, Eva Velasco Olarte, Judith Villahoz Martínez, Raúl Villalaba Palacios, Gema Villanueva García, Cristina Vogel de Medeiros, Soraya Gholamian Ovejero, Marta Vicente Orgaz, Patricia Lloreda Herradon, Cristina Crespo Gómez, Tatiana Sarmiento-Trujillo, Noemí García Medina, María Martínez García, Carles Espinós Ramírez, Nabil Mouhaffel Rivero, Jose Antonio Bernia Gil, Sonsoles Martín, María Victoria Moral, Josefina Galán, Pilar Paniagua, Sergio Pérez, Albert Bainac, Ana Arias, Elsa Ramil, Jorge Escudero, Pablo Monedero, Carmen Cara, Andrea Lara, Elena Mendez Martínez, Jorge Mendoza, Íñigo Rubio Baines, Carmen Sala Trull, Pablo Montero López, Alfredo Gea, Alejandro Montero, Rocío Armero Ibañez, Juan Vicente Llau Pitarch, Fernando Rauer Alcóver, Cristina Álvarez Herreros, Cyntia Sánchez Martín, Lucía López Ocáriz Olmos, Marta Navas Moruno, Fernando García Montoto, M. F. Mirón Rodriguez, Laura Fuentes Coco, Cristina Hernández Gamito, Antonio Barba Orejudo, Luis Gerardo Smith Vielma, Yasmina González Marín Francisco de Borja Amador Penco, Marta Donoso Domínguez, Silvia Esquivel Ramírez, José Antonio Carbonell, Berta Monleón López, Sara Martínez-Castro, Gerardo Aguilar, María Gestal Pablo Casas, Angel Outeiro Rosato, Andrea Naveiro Pan, María Alonso Portela, Adrián García Romar, Eva Mosquera Rodríguez, Diego Ruanova Seijo, Pablo Rama Maceiras, Francisco Castro-Ceoane, Esther Moreno López, Sergio Gil, Julia Guillén Antón, Patricia García-Consuegra Tirado, Aurora Callau Calvo, Laura Forés Lisbona, María Carbonell Romero, Belén Albericio Gil, Laura Pradal Jarne, María Soria Lozano, Diego Loscos López, Andrea Patiño Abarca, Jordi Serrano, Javier Pérez-Asenjo Ángel Díez-Domínguez, Ion Zubizarreta, Jon Ramos, Iosu Fernández, Emilio Maseda Alejandro Suárez de la Rica, Javier Veganzones, Itziar Insausti Javier Sagra, Sofía Díaz Carrasco, Ana Montero Feijoo, Julio Yagüe, Ignacio Garutti Javier Hortal, Patricia Piñeiro, Matilde Piñeiro, Matilde Zaballos, Jamil cedeño, Pablo García-Olivares, Alberto Garriido, Jose Eugenioi Guerrero, Eva Bassas Parga, Carmen Deiros Garcia Elisenda Pujol Rosa, Ana Tejedor Navarro, Roser Font Gabernet, Maria José Bernat, Meritxell Serra Valls, Cristina Cobaleda Garcia-Bernalt, Jesus Fernanz Anton, Adriana Aponte Sierra, Lucia Gil Gomez, Olaia Guenaga Vaqueiro, Susana Hernandez Marin, Laura Pardo Pinzon, Sira Garcia Aranda Carlos Briones Orejuela, Edgar Cortes Sánchez, Alejandro Romero Fernández, Esther Fernández SanJosé, Patricia Iglesias Garsabal, Guillermo Isidro Lopez, Ana Vicol, Sara Espejo Malagon, María Sanabra Loewe, Laura Grau Torradeflo Lourdes Blanco Alcaide, Gloria Buenaventura Sanclemente, Pere Serra Pujol Gustavo Cuadros Mendoza, Miroslawa Konarska, Fedra Bachs Almenara Agnieszka Golska, Aleix Carmona Blesa, Arantxa Mas Serra, Javier Ripolles Melchor, Ana Nieto Moreno, Káteri Chao Novo, Sandra Gadín López, Elena Nieto Moreno, Bérénice Gutiérrez Tonal, Elena Lucena de Pablo, Barbara Algar Yañez, Beatriz Vázquez Rivero, Beatriz Nozal Mateo, Marina de Retes, Norma Aracil Escoda, Cristina Gallardo Mayo, Rosa Sanz González, Alicia Ruiz Escobar, Maria Laura Pelegrina López Marina Valenzuela Peña, David Stolle Dueñas, Ane Abad Motos, Alfredo Abad-Gurumeta, Ana Tirado Errazquin, Elena Sáez Ruiz, Nerea Gómez Pérez, Francisco de Borja Bau González, Cesar Morcillo Serra Jessica Souto Higueras, Rosario Vicente Raquel Ferrandis, Silvia Polo Martín, Azucena Pajares Moncho, Ignacio Moreno Puigdollers, Juan Pérez Artacho Cortés, Ana Moret Calvo, Ana Pi Peña, María Catalán Fernández, Marina Varela Pilar Díaz Parada, Raquel Rey Carlín, Sarra Barreiro Aragunde, María Isabel Forés Chiva, A. Javier Agulló, Antonio Pérez Ferrer, María Galiana, Antoni Margarit Válerie Mourre del Rio, Eva Heras Muxella, Anna Vidal

Open Access Research

Airway Pseudomonas aeruginosa density in mechanically ventilated patients: clinical impact and relation to therapeutic efficacy of antibiotics

Yohei Migiyama, Shinya Sakata, Shinji Iyama, Kentaro Tokunaga, Koichi Saruwatari, Yusuke Tomita, Sho Saeki, Shinichiro Okamoto, Hidenori Ichiyasu, Takuro Sakagami

Open Access Research

Automated detection and quantification of reverse triggering effort under mechanical ventilation

Tài Pham, Jaume Montanya, Irene Telias, Thomas Piraino, Rudys Magrans, Rémi Coudroy, L. Felipe Damiani, Ricard Mellado Artigas, Matías Madorno, Lluis Blanch, Laurent Brochard, Tài Pham, Jaume Montanya, Irene Telias, Thomas Piraino, Rudys Magrans, Rémi Coudroy, L. Felipe Damiani, Ricard Mellado Artigas, Matías Madorno, Lluis Blanch, Laurent Brochard, Cesar Santis, Tommaso Mauri, Elena Spinelli, Giacomo Grasselli, Savino Spadaro, Carlo Alberto Volta, Francesco Mojoli, Dimitris Georgopoulos, Eumorfia Kondili, Stella Soundoulounaki, Tobias Becher, Norbert Weiler, Dirk Schaedler, Oriol Roca, Manel Santafe, Jordi Mancebo, Leo Heunks, Heder de Vries, Chang-Wen Chen, Jian-Xin Zhou, Guang-Qiang Chen, Nuttapol Rittayamai, Norberto Tiribelli, Sebastian Fredes, Ricard Mellado Artigas, Carlos Ferrando Ortolá, François Beloncle, Alain Mercat, J. M. Arnal, J. L. Diehl, A. Demoule, M. Dres, S. Jochmans, J. Chelly, Nicolas Terzi, Claude Guérin, E. Baedorf Kassis, J. Beitler, Davide Chiumello, Erica Ferrari Luca Bolgiaghi, V. Fanelli, J. E. Alphonsine, Arnaud W. Thille, Laurent Papazian

Open Access Research

Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study

Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier, Feriel Azibani, Xavier Wittebole, Benjamin G. Chousterman, Etienne Gayat, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye, Salvatore Di Somma, Thierry Dugernier, Bruno François, Stephane Gaudry, Vincent Huberlant, Jean-Baptiste Lascarrou, Gernot Marx, Emmanuelle Mercier, Haikel Oueslati, Peter Pickkers, Romain Sonneville, Matthieu Legrand, Pierre-François Laterre, Alexandre Mebazaa, Laterre, Dugernier, Huberlant, Marx, Hohn, Meier-Hellmann, Jaschinski, Kortgen, Francois, Lascarrou, Mercier, Desachy, Lasocki, Mebazaa, Mebazaa, Jacob, Gaudry, Pottecher, Constantin, Sonneville, Disomma, Antonelli, Beishuizen, Pickkers

Open Access Research

Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial

Sigismond Lasocki, Pierre Asfar, Samir Jaber, Martine Ferrandiere, Thomas Kerforne, Karim Asehnoune, Philippe Montravers, Philippe Seguin, Katell Peoc’h, Soizic Gergaud, Nicolas Nagot, Thibaud Lefebvre, Sylvain Lehmann, Sigismond Lasocki, Pierre Asfar, Samir Jaber, Martine Ferrandiere, Thomas Kerforne, Karim Asehnoune, Philippe Montravers, Philippe Seguin, Katell Peoc’h, Soizic Gergaud, Nicolas Nagot, Thibaud Lefebvre, Sylvain Lehmann, François Beloncle, Alain Mercat, Thomas Gaillard, Maxime Leger, Emmanuel Rineau, Cyril Sargentini, Claire Geneve, Herve Puy, Grégoire Mercier, Gregory Marin, Constance Delaby, Christophe Hirtz, Gerald Chanques, Antoine Roquilly, Matthieu Boisson, Claire Dahyot-Fizelier, Olivier Mimoz, Sonia Isslame, Yoann Launey, Mathilde Barbaz

Open Access COVID-19 Research

Deploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain

Alejandro Rodríguez, Manuel Ruiz-Botella, Ignacio Martín-Loeches, María Jimenez Herrera, Jordi Solé-Violan, Josep Gómez, María Bodí, Sandra Trefler, Elisabeth Papiol, Emili Díaz, Borja Suberviola, Montserrat Vallverdu, Eric Mayor-Vázquez, Antonio Albaya Moreno, Alfonso Canabal Berlanga, Miguel Sánchez, María del Valle Ortíz, Juan Carlos Ballesteros, Lorena Martín Iglesias, Judith Marín-Corral, Esther López Ramos, Virginia Hidalgo Valverde, Loreto Vidaur Vidaur Tello, Susana Sancho Chinesta, Francisco Javier Gonzáles de Molina, Sandra Herrero García, Carmen Carolina Sena Pérez, Juan Carlos Pozo Laderas, Raquel Rodríguez García, Angel Estella, Ricard Ferrer, Ana Loza, Diego Matallana Zapata, Isabel Díaz Torres, Sonia Ibañez Cuadros, María Recuerda Nuñez, Maria Luz Carmona Pérez, Jorge Gómez Ramos, Alba Villares Casas, María Luisa Cantón, José Javier González Contreras, Helena Pérez Chomón, Nerissa Alvarez Chicote, Alberto Sousa González, María De Alba Aparicio, Juan Carlos Pozo Laderas, Angel Estella, Sara Moreno Cano, Diego Matallana Zapata, Ruth Jorge García, Laura Sánchez Montori, Sandra Herrero García, Paula Abanses Moreno, Carlos Mayordomo García, Tomás Mallor Bonet, Paula Omedas Bonafonte, Enric Franquesa Gonzalez, Nestor Bueno Vidales, Paula Ocabo Buil, Carlos Serón Arbeloa, Isabel Sancho, Pablo Guerrero Ibañez, Pablo Gutierrez, María Concepción Valdovinos, Raquel Canto, Ana Luz Balán Mariño, María José Gutiérrez Fernández, Marta Martín Cuadrado, Belén García Arias, Lorena Forcelledo Espina, Lucía Viña Soria, Lorena Martín Iglesias, Lucía López Amor, Elisabet Fernández Rey, Emilio García Prieto, Débora Fernández Ruíz, Carla Martínez González, Lorenzo Socias, Marcio Borges-Sá, María Aranda Pérez, Antonia Socias, José Ma Bonell Goytisolo, Inmaculada Alcalde Mayayo, Carlos Corradini, Isabel Ceniceros, Edwin Rodríguez, Jose Ignacio Ayestarán Rota, Mariana Andrea Novo Novo, Joaquim Colomina Climent, Albert Figueras Castilla, Tomàs Leal Rullan, Maria Magdalena Garcias Sastre, Rossana Pérez Senoff, Ramón Fernández-Cid Bouza, Juan Carlos Martín González, Carmen Pérez Ortiz, José Luciano Cabrera Santana, Juan José Cáceres Agra, Domingo González Romero, Ana Casamitjana Ortega, Luis Alberto Ramos Gómez, Jordi Solé-Violán, Alejandro Rodríguez, María Bodí, Gerard Moreno, Sandra Trefler, Laura Claverias, Raquel Carbonell, Erika Esteve, Montserrat Olona, Xavier Teixidó, Monserrat Vallverdú Vidal, Begoña Balsera Garrido, Elisabeth Papiol Gallofré, Raquel Albertos Martell, Rosa Alcaráz Peñarrocha, Xavier Nuvials Casals, Ricard Ferrer Roca, Eric Adrián Mayor Vázquez, Ferrán Roche Campo, Pablo Concha Martínez, Diego Franch Llasat, Joan Ramón Masclanz, Judith Marín-Corral, Purificación Pérez, Rosana Muñoz, Clara Vila, Francisco Javier González de Molina, Elisabeth Navas Moya, Josep Trenado, Imma Vallverdú, Eric Castañé, Emili Díaz Santos, Gemma Goma, Edgar Moglia, Borja Suberviola, Antonio Albaya Moreno, Carlos Marian Crespo, Carmen Carolina Sena Pérez, Francisca Arbol Linde, Diana Monge Donaire, Vega Losada Martínez, Nuria Rodrigo Castroviejo, Gerardo Ferrigno, Reyes Beltrán, Carolina Sanmartino, Concepción Tarancón Maján, Alfredo Marcos Gutiérrez, Virginia Hidalgo Valverde, Caridad Martín López, Oihane Badallo, María del Valle Ortiz, Rebeca Vara Arlanzón, David Iglesias Posadilla, María Teresa Recio, Juan Carlos Ballesteros, Enrique Laza Laza, Elena Gallego Curto, Ma Carmen Sánchez García, Miguel Díaz-Tavora, Rosa Mancha, Ana Ortega Montes, Isabel Gallego Barbachano, Eva Sanmartín Mantiñán, María Lourdes Cordero, Raquel María Rodríguez García, Jorge Gámez Zapata, María Gestal Vázquez, María José Castro Orjales, María Isabel Álvarez Diéguez, Carmen Rivero Velasco, Beatriz Lence Massa, María Gestal Vázquez, Ignacio Martínez Varela, Diego Matallana Zapata, Alberto Hernández Tejedor, Esther Ma López Ramos, Laura Alcázar Sánchez Elvira, Rocío Molina Montero, Ma Consuelo Pintado Delgado, María Trascasa MuñozMuñoz de la Peña, Yaiza Betania Ortiz de Zárate Ansotegui, Alejandra Acha Aranda, Juan Higuera Lucas, Juan Antonio Sanchez Giralt, Marta Chicot Llano, Nuria Arevalillo Fernández, Marta Sánchez Galindo, Ricardo Andino Ruiz, Alfonso Canabal Berlanga, Miguel Sánchez, Mercedes Nieto, Eduardo Arias Sarmiento, Adoración Bueno Blázquez, Rosa María de la Casa, Fátima Martín, Samuel González López, Elena Martínez Q uintana, Bernardo Gil Rueda, Áurea Higon Cañigral, Laura López Gómez, Pablo Safwat Bayoumi Delis, Augusto Montenegro Muore, Ángel Andrés Agamez Luengas, Enriqueta Andreu Soler, Ana Beatriz Pérez Pérez, José Higinio de Gea García, Rubén Jara Rubio, Silvia Sánchez Cámara, Alba Moreno Flores, José Moya Sánchez, Daniel Francisco Pérez Martínez, Ma Desamparados del Rey Carrión, María José Rico Lledó, Juana María Serrano Navarro, Juan Francisco Martín Ruíz, Julián Triviño Hidalgo, África López Ferrer, Isabel Cremades Navalón, Josefa Murcia Payá, JM Allegre Gallego, María del Carmen Lorente, Marta Gonsalvez, Ruth González Natera, Raquel Garrido López de Murillo, Tania Ojuel Gros, Raquel Flecha Viguera, Isabel López González, Adriana García Herrera, Loreto Vidaur Tello, Maialen Aseguinolaza, Itziar Eguibar, María Luisa Cantón Bulnes, Jose Javier González Contreras, Helena Pérez Chomón, Nerissa Álvarez Chicote, Alberto Sousa González, Asunción Marqués Parra, Sergio García Marti, Alberto Lorenzo Aguilar, Laura Bellver Bosch, Victor Gascón Sanchez, Sonia De la Guía Ortega, Martín Parejo Montell, Alberto Belenguer Muncharaz, Hector Hernández Garces, Victor Ramírez Montero, Mónica Crespo Gómez, Verónica Martí Algarra, Susana Sancho Chinesta, Joaquin Arguedas Cervera, Faustino Álvarez Cebrian, Begoña Balerdi Pérez, Rosa Jannone Fores, Javier Botella de Maglia, Nieves Carbonell Monleón, Jose Ferreres Franco, Ainhoa Serrano Lazaro, Mar Juan Díaz, María Luisa Blasco Cortés, Laura Fayos, Julia Giménez, Gaspar Soriano, Ricardo Navarro, Sonia Mas, Elena Bisbal, Laura Albert, Johncard Romero, Juan Fernández Cabreara, Andrea Ortíz, Antonio Margarit Ribas

Open Access Research

Diaphragm echodensity in mechanically ventilated patients: a description of technique and outcomes

Benjamin Coiffard, Stephen Riegler, Michael C. Sklar, Martin Dres, Stefannie Vorona, W. Darlene Reid, Laurent J. Brochard, Niall D. Ferguson, Ewan C. Goligher

Open Access Research

The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis

Arno Téblick, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Tim Van Oudenhove, Lies Langouche, Greet Van den Berghe

Open Access COVID-19 Research Letter

YKL-40 as a new promising prognostic marker of severity in COVID infection

Lauranne Schoneveld, Aurélie Ladang, Monique Henket, Anne-Noëlle Frix, Etienne Cavalier, Julien Guiot, L. Schoneveld, A. Ladang, M. Henket, A. Frix, E. Cavalier, J. Guiot, A. Ancion, J. Berg, O. Bonhomme, A. Bouquegneau, C. Bovy, S. Bruls, G. Darcis, J. O. Defraigne, A. Ghuysen, A. Gilbert, V. Heinen, B. Lambermont, R. Louis, O. Malaise, M. Martin, B. Misset, M. Moutschen, D. Nguyen Dang, J. Piazza, D. Szecel, J. Szecel, H. Van Cauwenberge, C. Von Frenckell, L. Vroonen

Open Access Research

Prevalence of post-intensive care syndrome among Japanese intensive care unit patients: a prospective, multicenter, observational J-PICS study

Daisuke Kawakami, Shigeki Fujitani, Takeshi Morimoto, Hisashi Dote, Mumon Takita, Akihiro Takaba, Masaaki Hino, Michitaka Nakamura, Hiromasa Irie, Tomohiro Adachi, Mami Shibata, Jun Kataoka, Akira Korenaga, Tomoya Yamashita, Tomoya Okazaki, Masatoshi Okumura, Takefumi Tsunemitsu

Open Access COVID-19 Research

Surge effects and survival to hospital discharge in critical care patients with COVID-19 during the early pandemic: a cohort study

Christopher R. Dale, Rachael W. Starcher, Shu Ching Chang, Ari Robicsek, Guilford Parsons, Jason D. Goldman, Andre Vovan, David Hotchkin, Tyler J. Gluckman

Open Access Research Letter

Factors influencing local signs at catheter insertion site regardless of catheter-related bloodstream infections

Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Olivier Mimoz, Bertrand Souweine, Jean-François Timsit

Open Access COVID-19 Research

Epidemiology and microbiology of ventilator-associated pneumonia in COVID-19 patients: a multicenter retrospective study in 188 patients in an un-inundated French region

Gauthier Blonz, Achille Kouatchet, Nicolas Chudeau, Emmanuel Pontis, Julien Lorber, Anthony Lemeur, Lucie Planche, Jean-Baptiste Lascarrou, Gwenhael Colin

Open Access COVID-19 Research

Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients

Savino Spadaro, Alberto Fogagnolo, Gianluca Campo, Ottavio Zucchetti, Marco Verri, Irene Ottaviani, Tanushree Tunstall, Salvatore Grasso, Valentina Scaramuzzo, Francesco Murgolo, Elisabetta Marangoni, Francesco Vieceli Dalla Sega, Francesca Fortini, Rita Pavasini, Paola Rizzo, Roberto Ferrari, Alberto Papi, Carlo Alberto Volta, Marco Contoli

Open Access Review

Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps

Daniele De Luca, Paola Cogo, Martin C. Kneyber, Paolo Biban, Malcolm Grace Semple, Jesus Perez-Gil, Giorgio Conti, Pierre Tissieres, Peter C. Rimensberger

Open Access Research

Role of endothelial microRNA 155 on capillary leakage in systemic inflammation

Valerie Etzrodt, Temitayo O. Idowu, Heiko Schenk, Benjamin Seeliger, Antje Prasse, Kristina Thamm, Thorben Pape, Janina Müller-Deile, Matijs van Meurs, Thomas Thum, Ankita Garg, Robert Geffers, Klaus Stahl, Samir M. Parikh, Hermann Haller, Sascha David

Open Access Research

Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis

Jilske A. Huijben, Abhishek Dixit, Nino Stocchetti, Andrew I. R. Maas, Hester F. Lingsma, Mathieu van der Jagt, David Nelson, Giuseppe Citerio, Lindsay Wilson, David K. Menon, Ari Ercole, Andrew I. R. Maas, Nino Stocchetti, Hester F. Lingsma, Giuseppe Citerio, David K. Menon, Ari Ercole, Cecilia Åkerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Ana M. Castaño León, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Mark Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Dula Dilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Dulière, Erzsébet Ezer, Martin Fabricius, Kelly Foks, Shirin Frisvold, Alex Furmanov, Damien Galanaud, Pedro A. Gomez, Francesca Grossi, Deepak Gupta, Iain Haitsma, Eirik Helseth, Peter J. Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, Angelos G. Kolias, Daniel Kondziella, Evgenios Koraropoulos, Lars Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Steven Laureys, Didier Ledoux, Aurelie Lejeune, Roger Lightfoot, Alex Manara, Costanza Martino, Hugues Maréchal, Julia Mattern, Catherine McMahon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, Virginia Newcombe, József Nyirádi, Fabrizio Ortolano, Jean François Payen, Vincent Perlbarg, Paolo Persona, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey V. Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oddrun Sandrød, Oliver Sakowitz, Renan Sanchez-Porras, Kari Schirmer-Mikalsen, Rico Frederik Schou, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Nina Sundström, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Olli Tenovuo, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Peter Vajkoczy, Shirley Vallance, Egils Valeinis, Zoltán Vámos, Gregory Van der Steen, Roel P. J. van Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Petar Vulekovic, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick A. Zeiler, Agate Ziverte Hans Clusmann, Daphne Voormolen, Jeroen T. J. M. van Dijck, Thomas A. van Essen

Open Access COVID-19 Research Letter

Causes and timing of death in critically ill COVID-19 patients

Damien Contou, Radj Cally, Florence Sarfati, Paul Desaint, Megan Fraissé, Gaëtan Plantefève

Open Access COVID-19 Research

Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak

Andrea Coppadoro, Annalisa Benini, Robert Fruscio, Luisa Verga, Paolo Mazzola, Giuseppe Bellelli, Marco Carbone, Giacomo Mulinacci, Alessandro Soria, Beatrice Noè, Eduardo Beck, Riccardo Di Sciacca, Davide Ippolito, Giuseppe Citerio, Maria Grazia Valsecchi, Andrea Biondi, Alberto Pesci, Paolo Bonfanti, Davide Gaudesi, Giacomo Bellani, Giuseppe Foti

Open Access COVID-19 Research

Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia

Lorenzo Ball, Chiara Robba, Lorenzo Maiello, Jacob Herrmann, Sarah E. Gerard, Yi Xin, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia R. M. Rocco, Maurizio Cereda, Lucio Castellan, Nicolò Patroniti, Paolo Pelosi, Lorenzo Ball, Chiara Robba, Lorenzo Maiello, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Lucio Castellan, Nicolò Patroniti, Paolo Pelosi, Angelo Gratarola, Maurizio Loconte, Alexandre Molin, Giulia Orefice, Francesca Iannuzzi, Federico Costantino, Dario Battioni, Giulio Bovio, Gerolama Buconte, Alessandro Casaleggio, Giuseppe Cittadini, Luca Dogliotti, Veronica Giasotto, Maria Pigati, Elena Santacroce, Federico Zaottini, Chiara Dentone, Lucia Taramasso, Laura Magnasco, Alberto Valbusa, Matilde Bastianello

Open Access Research

Long-term health-related quality of life and burden of disease after intensive care: development of a patient-reported outcome measure

Johan Malmgren, Ann-Charlotte Waldenström, Christian Rylander, Elias Johannesson, Stefan Lundin

Open Access Research

Predicting neurological outcome after out-of-hospital cardiac arrest with cumulative information; development and internal validation of an artificial neural network algorithm

Peder Andersson, Jesper Johnsson, Ola Björnsson, Tobias Cronberg, Christian Hassager, Henrik Zetterberg, Pascal Stammet, Johan Undén, Jesper Kjaergaard, Hans Friberg, Kaj Blennow, Gisela Lilja, Matt P. Wise, Josef Dankiewicz, Niklas Nielsen, Attila Frigyesi

Open Access Research

Frailty status among older critically ill patients with severe acute kidney injury

William Beaubien-Souligny, Alan Yang, Gerald Lebovic, Ron Wald, Sean M. Bagshaw

Open Access Letter

Closed-loop circuit for reduce oxygen waste on hollow-fiber oxygenators during extracorporeal technologies

Ignazio Condello, Flavio Rimmaudo, Giuseppe Speziale

Open Access COVID-19 Research

Long-term outcome after intensive care for COVID-19: differences between men and women—a nationwide cohort study

Erik Zettersten, Lars Engerström, Max Bell, Gabriella Jäderling, Johan Mårtensson, Linda Block, Emma Larsson

Open Access Research

Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts

Yasser Sakr, Bruno François, Jordi Solé-Violan, Katarzyna Kotfis, Ulrich Jaschinski, Angel Estella, Marc Leone, Stephan M. Jakob, Xavier Wittebole, Luis E. Fontes, Miguel de Melo Gurgel, Thais Midega, Jean-Louis Vincent, V. Marco Ranieri, Georg Delle Karth, Volker Draxler, Gottfried Filzwieser, Werner Heindl, Gerhard Kellner, Thomas Bauer, Kurt Lenz, Edmund Rossmann, Christian Wiedermann, Patrick Biston, Didier Chochrad, Vincent Collin, Pierre Damas, Johan Decruyenaere, Eric Hoste, Jacques Devriendt, Benoît Espeel, Vincent Fraipont, Etienne Installe, Manu Malbrain, Guy Nollet, Jean-Charles Preiser, Jan Raemaekers, Alain Roman, Marc Simon, Herbert Spapen, Walter Swinnen, Frédéreic Vallot, Jean-Louis Vincent, Ivan Chytra, Lukas Dadak, Ivan Herold, Ferdinand Polak, Martin Sterba, Morten Bestle, Kurt Espersen, Henrik Guldager, Karen-Liese Welling, Dag Nyman, Esko Ruokonen, Kari Saarinen, Djillali Annane, Philippe Catogni, Gabriel Colas, François Coulomb, Rene Dorne, Maite Garrouste, Christian Isetta, Jérôme Larché, Jean-Roger Le Gall, Henry Lessire, Yannick Malledant, Philippe Mateu, Michel Ossart, Didier Payen, Pascal Schlossmacher, Jean-François Timsit, Stéphane Winnock, Jean-Pierre Sollet, Laurent Mallet, Peter Maurer, Jean-Michel Sab, Gueclue Aykut, Frank Brunkhorst, Axel Nierhaus, Michael Lauterbach, Max Ragaller, Rainer Gatz, Herwig Gerlach, Deitrich Henzler, Hand-Bernd Hopf, Hilmar Hueneburg, Waheed Karzai, Ansgar Keller, Uwe Kuhlmann, Julia Langgartner, Cornelia Manhold, B. Reith, Tobias Schuerholz, Claudia Spies, Reimund Stögbauer, J. Unterburger, Phyllis-Maria Clouva-Molyvdas, George Giokas, Eleni Ioannidou, Alexandra Lahana, Alexandros Liolios, Katerina Marathias, George Nakos, Antonia Tasiou, Hercules Tsangaris, Peter Tamasi, Brian Marsh, Michael Power, Charles Sprung, Bonizella Biagioli, Franco Bobbio Pallavicini, Antonio Pesenti, Carlo Capra, Francesco Della Corte, Pierpaulo Donadio, Abele Donati, Antonino Giarratano, Tulli Giorgio, Daniela Giudici, Stefano Greco, Alberto Guadagnucci, Gaetano Lapichino, Sergio Livigni, Gabriella Moise, Giuseppe Nardi, Eltore Panascia, M. Pizzamiglio, V. M. Ranieri, Ranieri Rosi, Alberto Sicignano, Maurizio Solca, G. Vignali, Italo Volpe Rinonapoli, Michel Barnas, Ernst E. De Bel, Anne-Cornelie De Pont, Johan Groeneveld, Maarten Nijsten, Liang-Hai Sie, Durk F. Zandstra, Svein Harboe, Svante Lindén, Renata Z. Lovstad, Harald Moen, Nils Smith-Erichsen, Andrjej Piotrowski, Ewa Karpel, Eduardo Almeida, Rui Moreno, Antonio Pais-De-Lacerda, Jose A. Paiva, Isabel Serra, Jorge M. Pimentel, Daniela Filipescu, Krsta Jovanovic, Peter Malik, Kosec Lucka, Gorazd Voga, Cesar Aldecoa Alvarez-Santullano, Antonio Artigas, Elizabeth Zavala, Angels Escorsell, Jose Nicolas, José JIzura Cea, Luis Marina, Juan Montejo, Eduardo Palencia, Francisco Santos, Rafael Sierra-Camerino, Fernando Sipmann, Keld Brodersen, Jan Haggqvist, Dan Hermansson, Hans Hjelmqvist, Kuno Heer, Giorgio Loderer, Marco Maggiorini, Hervé Zender, Peter Andrews, Balraj Appadu, Casiano Barrera Groba, Jeremy Bewley, Ken Burchett, Philip Chambers, John Coakley, Doris Doberenz, Nigel Eastwood, Andrew Ferguson, Jonathan Fielden, Jacqueline Gedney, Kevin Gunning, David Harling, Stas Jankowski, David Jayson, Andrew Kilner, Venketachalam Krishna-Kumar, K. Lei, S. Mackenzie, Peter Macnaughton, Gernot Marx, C. McCulloch, Paul Morgan, Andrew Rhodes, Chris Roberts, Mark Russell, Darell Tupper-Carey, Maggie Wright, Linda Twohey, James Watts, Rae Webster, Dewi Williams, Philipp Urbanek, Joachim Schlieber, Johann Reisinger, Johann Auer, Andreas Hartjes, Andreas Lerche, Thomas Janous, Eveline Kink, Walter Krahulec, Karl-Heinz Smolle, Marc Van Der Schueren, Patrick Thibo, Marc Vanhoof, Ibis Ahmet, Philippe Gadisseux, Philippe Dufaye, Olivier Jacobs, Alain Dive, Yves Bouckaert, Eric Gilbert, Benjamin Gressens, Eric Pinck, Jan J. De Waele, Rocio Rimachi, Dan Gusu, Koen De Decker, Kakisidi Mandianga, Luc Heytens, Xavier Wittebole, Olivier Van Collie, Wout Vandenheede, Peter Rogiers, Pavel Pavlik, Jan Manak, Eva Kieslichova, Radovan Turek, Michal Fischer, Radka Valkova, Pavel Dostal, Jan Malaska, Roman Hajek, Alexandra Židková, Pavel Lavicka, Piotr Kolodzeike, Mary Kruse, Torben Andersen, Veli-Pekka Harjola, Marc Leone, Alain Durocher, Serge Moulront, Alain Lepape, Marie-Reine Losser, Philippe Cabaret, Evangelos Kalaitzis, Elie Zogheib, Philippe Charve, Bruno François, Jean-Yves Lefrant, Bassam Beilouny, Xavier Forceville, Benoit Misset, Frederic Jacobs, Bernard Floccard, Alain Wynckel, Vincent Castelain, Alexandre Faure, Pierre Lavagne, Thierry Lepoivre, Mouhamed D. Moussa, Antoine Vieillard-Baron, Michel Durand, Marc Gainnier, Carole Ichai, Stefan Arens, Clemens Hoffmann, Magnus Kaffarnik, Claus-Jorg Scharnofske, Ingo Voigt, Claus Peckelsen, Matthias Weber, Jochen Gille, Andreas Lange, Georg Schoser, Armin Sablotzki, Ulrich Jaschinski, Andreas Bluethgen, Frank Vogel, Andreas Tscheu, Thomas Fuchs, Michael Wattenberg, Torsten Helmes, Stefan Scieszka, Matthias Heintz, Samir Sakka, Johannes Kohler, Fritz Fiedler, Matthias Danz, Yasser Sakr, Reimer Riessen, Thomas Kerz, Alexander Kersten, Frank Tacke, Gernot Marx, Thomas Volkert, Axel Schmutz, Stefan Kluge, Peter Abel, Rolf A. Janosi, Stefan Utzolino, Hendrik Bracht, Susanne Toussaint, Maria Giannakou Peftoulidou, Pavlos Myrianthefs, Apostolos Armaganidis, Christina Routsi, Angela Xini, Eleni Mouloudi, Ioannis Kokoris, George Kyriazopoulos, Sawas Vlachos, Athena Lavrentieva, Panagio Partala, Laszlo Medve, Agnes Sarkany, Ildiko Kremer, Zsuzsa Marjanek, Joan Barry, Ruth A. O’Leary, Catherine Motherway, Mohammad Faheem, Eimhin Dunne, Maria Donnelly, Torsten Konrad, Jonathan Cohen, Oded Sold, Eleonora Bonora, Carola Achilli, Sandra Rossi, Giacomo Castiglione, Adriano Peris, Daniela Albanese, Nino Stocchetti, Giuseppe Citerio, Lorella Mozzoni, Erminio Sisillo, Pasquale De Negri, Monica Savioli, Pietro Vecchiarelli, Florin Puflea, Vladimir Stankovic, Giulio Minoja, Silvia Montibeller, Plinio Calligaro, Raffaella Sorrentino, Marco Feri, Massimo Zambon, Elena Colombaroli, Tommaso Pellis, Massimo Antonelli, Antonino Gullo, Cosimo Chelazzi, Antonella De Capraris, Nicolo Patroniti, Massimo Girardis, Frederico Franchi, Giorgio Berlot, Hubert Ponssen, Julia Ten Cate, Laura Bormans, Satria Husada, Marc Buise, Ben Van Der Hoven, Auke Reidinga, Michael Kuiper, Peter Pickkers, Georg Kluge, Sylvia Den Boer, Jozef Kesecioglu, Henk Van Leeuwen, Hans Flaatten, Skule Mo, Julia Kolbusz, Andrzej Kübler, Beata Mielczarek, Malgorzata Mikaszewska-Sokolewicz, Katarzyna Kotfis, Barbara Tamowicz, Wiktor Sulkowski, Piotr Smuszkiewicz, Andrzej Pihowicz, Ewa Trejnowska, Vitor Branco, Fernando Rua, Estevao Lafuente, Marta Sousa, Nuno Catorze, Maria Barros, Luis Pereira, Ana Vintém De Oliveira, Jose Gomes, Isable Gaspar, Maria F. Pereira, Maria Cymbron, Antonio Dias, Sofia Beirao, Rosa Ribeiro, Pedro Povoa, Filomena Faria, Zelia Costa-E-Silva, Jose J. Nóbrega, Fatima Fernandes, Natalia Hagau, Gabriela Droc, Mary Nicoleta Lupu, Alexandru Nica, Radu Stoica, Dana Rodica Tomescu, Dacia Laurentia Constantinescu, Georgica MValcoreanu Zbaganu, Adriana Slavcovici, Ljiljana Soskic, Ivan Palibrk, Radmilo Jankovic, Bojan Jovanovic, Milena Pandurovic, Vesna Bumbasirevic, Boris Uljarevic, Maja Surbatovic, Nebojsa Ladjevic, Garri Slobodianiuk, Viliam Sobona, Andrea Cikova, Andrea Gebhardtova, Erik Rupnik, Lucka Kosec, Milena Kerin Povšic, Irena Osojnik, Viktorija Tomic, Javier González, Jesus Pérez Valenzuela, Pablo Vidal-Cortés, Pilar Posada, Ignacio Martin-Loeches, Noelia Muñoz Guillén, Mercedes Palomar, Jordi Sole-Violan, Antoni Torres, Miguel AGonzalez Gallego, Gerardo Aguilar, Raquel Montoiro Allué, Monica Argüeso, Martin Parejo, Manuel Palomo Navarro, Anton Jose, Nicholas Nin, Francisco Alvarez Lerma, Oscar Martinez, Eva Tenza Lozano, Sara Arenal López, Maria JPerez Granda, Salvador Moreno, Clara Llubia, Carmen De La Fuente Martos, Paloma Gonzalez-Arenas, Noemi Llamas Fernández, Bernard Gil Rueda, Isabel Estruch Pons, Nieves Cruza, Fernando Maroto, Angel Estella, Ana Ferrer, Lisardo Iglesias Fraile, Brigida Quindos, Amaia Quintano, Maria T. Tebar, Pablo Cardinal, Antonio Reyes, Alejandro Rodríguez, Ana Abella, Santiago García Del Valle, Santiago Yus, Emilio Maseda, Jose A. Berezo, Armando Tejero Pedregosa, Clara Laplaza, Ricard Ferrer, Jesus Rico-Feijoo, Marina Rodríguez, Pablo Monedero, Karin Eriksson, David Chabanel, Bernd Frankenberger, Stephan Jakob, Shiju Matthew, Robert Downes, Andrew Johnston, Roseanne Meacher, Rick Keays, Philip Haji-Michael, Chris Tyler, Simon Jones, David Tyl, Andrew Ball, John Vogel, Malcolm Booth, Paul Downie, Malcolm Watters, Stephen Brett, Marc Garfield, Lynn Everett, Sarah Heenen, Sandeep Dhir, Zoe Beardow, Marthinus Mostert, Steve Brosnan, Nuno Pinto, Stephen Harris, Andy Summors, Andrew Norton, Alastair Rose, Rebecca Appelboam, Omubo Davies, Emma Vickers, Banwari Agarwal, Tamas Szakmany, Stephen Wimbush, Ingeborg Welters, Rupert Pearse, Robin Hollands, Justin Kirk-Bayley, Nick Fletcher, Barbara Bray, David Brealey, Peter Alexander, Steven Henderson, Chris Hargreaves, Heather Black, Kiran Gowda

Open Access Research

Energy delivery guided by indirect calorimetry in critically ill patients: a systematic review and meta-analysis

Jing-Yi Duan, Wen-He Zheng, Hua Zhou, Yuan Xu, Hui-Bin Huang

Open Access Research Letter

Effects of surgical masks on droplet dispersion under various oxygen delivery modalities

Takahiro Takazono, Kazuko Yamamoto, Ryuta Okamoto, Shimpei Morimoto, Koichi Izumikawa, Hiroshi Mukae

Open Access COVID-19 Research Letter

Survival after extracorporeal membrane oxygenation in severe COVID-19 ARDS: results from an international multicenter registry

Alexander Supady, Fabio Silvio Taccone, Philipp M. Lepper, Stephan Ziegeler, Dawid L. Staudacher, Alexander Supady, Fabio Silvio Taccone, Philipp M. Lepper, Stephan Ziegeler, Dawid L. Staudacher, Jeff DellaVolpe, Dominik Scharpf, Matthias Ulmer, Maximilian Halbe, Alexander Vogt, Raj Ramanan, David Boldt, Stephanie-Susanne Stecher, Andrea Montisci, Tobias Spangenberg, Olivier Marggraf, Chandra Kunavarapu, Lorenzo Peluso, Sebastian Muenz, Monica Buerle, Naveen G. Nagaraj, Sebastian Nuding, Catalin Toma, Vadim Gudzenko, Hans Joachim Stemmler, Federico Pappalardo, Georg Trummer, Christoph Benk, Guido Michels, Christoph Bode, Daniel Duerschmied, Constantin von zur Muehlen, Klaus Kaier, Daniel Brodie, Tobias Wengenmayer

Open Access COVID-19 Research Letter

Renin–angiotensin system dysregulation in critically ill patients with acute respiratory distress syndrome due to COVID-19: a preliminary report

Davide Eleuteri, Luca Montini, Salvatore Lucio Cutuli, Cristina Rossi, Francesca Alcaro, Massimo Antonelli

Open Access Letter

Towards use of POCUS to evaluate hemodynamics in critically ill neonates: caution before adoption in this population

Patrick J. McNamara, Piers Barker, Amish Jain, Wyman W. Lai

Open Access Research

Complete percutaneous angio-guided approach using preclosing for venoarterial extracorporeal membrane oxygenation implantation and explantation in patients with refractory cardiogenic shock or cardiac arrest

Anne-Sophie Martin-Tuffreau, François Bagate, Madjid Boukantar, Gabriel Saiydoun, Andrea Mangiameli, Laura Rostain, Gauthier Mouillet, Antonio Fiore, Olivier Langeron, Armand Mekontso-Dessap, Nicolas Mongardon, Thierry Folliguet, Emmanuel Teiger, Romain Gallet

Open Access COVID-19 Letter

Early rehabilitation in ICU for COVID-19: what about FES-cycling?

Gaëlle Deley, Davy Laroche, Jean-Pierre Quenot

Open Access Research

Diuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study

Raphaël Cinotti, Jean-Baptiste Lascarrou, Marie-Ange Azais, Gwenhaël Colin, Jean-Pierre Quenot, Pierre-Joachim Mahé, Antoine Roquilly, Aurélie Gaultier, Karim Asehnoune, Jean Reignier

Open Access Review

Systematic review of cognitive impairment and brain insult after mechanical ventilation

Thiago G. Bassi, Elizabeth C. Rohrs, Steven C. Reynolds

Open Access Letter

Prone mechanical ventilation in acute brain injury

Varun Suresh, Saurabh Sharma

Open Access Letter

D-dimer specificity and clinical context: an old unlearned story

Matteo Marin, Daniele Orso, Nicola Federici, Luigi Vetrugno, Tiziana Bove

Open Access Research Letter

Impact of withholding early parenteral nutrition in adult critically ill patients on ketogenesis in relation to outcome

Astrid De Bruyn, Lies Langouche, Sarah Vander Perre, Jan Gunst, Greet Van den Berghe

Open Access Research

Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study

Caroline Lindblad, Elisa Pin, David Just, Faiez Al Nimer, Peter Nilsson, Bo-Michael Bellander, Mikael Svensson, Fredrik Piehl, Eric Peter Thelin

Open Access Letter

Letter to the Editor: Stroke volume is the key measure of fluid responsiveness

Jon-Emile S. Kenny, Igor Barjaktarevic

Open Access Letter

Goal-directed therapy in the perioperative management: is a complete hemodynamics bundle of care better?

Nicolas Herzog, Jean-Baptiste Dablin, Christophe Giacardi, Marc Danguy des Déserts

Open Access COVID-19 Research

Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method

Prashant Nasa, Elie Azoulay, Ashish K. Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M. Arabi, Jan Bakker, Laurent J. Brochard, Adam M. Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M. Galvagno Jr., Claude Guérin, Samir Jaber, Gopi C. Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R. Machado, Manu L. N. G. Malbrain, Jordi Mancebo, Michael T. McCurdy, Brendan A. McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K. Park, Paolo Pelosi, John V. Peter, Jason Phua, David V. Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J. Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A. Udy, Tobias Welte, Sheila N. Myatra

Open Access Research

Neurological complications during veno-venous extracorporeal membrane oxygenation: Does the configuration matter? A retrospective analysis of the ELSO database

Roberto Lorusso, Mirko Belliato, Michael Mazzeffi, Michele Di Mauro, Fabio Silvio Taccone, Orlando Parise, Ayat Albanawi, Veena Nandwani, Paul McCarthy, Zachary Kon, Jay Menaker, Daniel M. Johnson, Sandro Gelsomino, Daniel Herr

Open Access Viewpoint

Long-term outcomes after critical illness: recent insights

Anne-Françoise Rousseau, Hallie C. Prescott, Stephen J. Brett, Björn Weiss, Elie Azoulay, Jacques Creteur, Nicola Latronico, Catherine L. Hough, Steffen Weber-Carstens, Jean-Louis Vincent, Jean-Charles Preiser

Open Access Research

Galectin-3 in septic acute kidney injury: a translational study

Haibing Sun, Huiping Jiang, Amity Eliaz, John A. Kellum, Zhiyong Peng, Isaac Eliaz

Open Access COVID-19 Research

Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational study

Chiara Robba, Lorenzo Ball, Denise Battaglini, Danilo Cardim, Emanuela Moncalvo, Iole Brunetti, Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Nicolò Patroniti, Patricia R. M. Rocco, Basil F. Matta, Paolo Pelosi, Pasquale Anania, Chiara Berri, Elena Ciaravolo, Chiara Dentone, Pietro Fiaschi, Paolo Frisoni, Angelo Gratarola, Laura Magnasco, Francesco Marramao, Marco Sottano, Lucia Taramasso, Fabio Tarantino, Gianluigi Zona

Open Access Research

Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study

Alexandros Rovas, Jan Sackarnd, Jan Rossaint, Stefanie Kampmeier, Hermann Pavenstädt, Hans Vink, Philipp Kümpers

Open Access Research

Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

Arianna Piotti, Deborah Novelli, Jennifer Marie Theresia Anna Meessen, Daniela Ferlicca, Sara Coppolecchia, Antonella Marino, Giovanni Salati, Monica Savioli, Giacomo Grasselli, Giacomo Bellani, Antonio Pesenti, Serge Masson, Pietro Caironi, Luciano Gattinoni, Marco Gobbi, Claudia Fracasso, Roberto Latini, Paola Bruzzone, Francesca Pagan, Riccarda Russo, Andrea Confalonieri, Chiara Abbruzzese, Beatrice Vergnano, Stefano Faenza, Antonio Siniscalchi, Elisabetta Pierucci, Andrea Noto, Angelo Pezzi, Paolo Spanu, Vieri Parrini, Roberto Oggioni, Giovanni Stefano Pasetti, Maria Cinzia Casadio, Rosa Buontempo, Sara Carrer, Francesca Piccoli, Tatiana Rizzi, Anselmo Caricato, Monica La Sala, Alessandra Antonaci, Paola Fassini, Silvia Paganini, Virginia Porta, Gabriella Moise, Silvia Marell, Mirella Furia, Maria Cristina Urbano, Roberta Carobbi, Simona Poleni, Hassan Kandil, Andrea Ballotta, Fabrizio Bettini, Manlio Sanseverino, Alessandro Gatta, Francesca Cecchini, Luca Guatteri, Gabriella Ciceri, Ferdinando Raimondi, Roberto Colombo, Sandra Ferraris, Massimo Borelli, Valentina Bellato, Franco Cancellieri, Silvia Senni, Ester Bertocchi, Paola Ferri, Gianpietro Moioli, Andrea Fedele, Alexandra Molin, Giovanni Salati, Pierpaolo Salsi, Emanuela Brunori, Daniele Elisei, Giuseppe Maggio, Federico Guardia Nicola, Marco Cavana, Giacomo Morelli, Arturo Guarino, Michele Isetta, Giorgio Tulli, Valerio Mangani, Nicola Rossi, Marta Ferrari, Francesco Bona, Monica Vay, Teresa Bartoli, Mauro Gallo, Katiuscia Vettoretto, Mauro Della Morte, Enrico Boselli, Daniela Puscio, Monia Bovo, Antonio Galzerano, Manuela Carli, Giovanni Zagara

Open Access Research

Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies

Daisuke Kudo, Tadahiro Goto, Ryo Uchimido, Mineji Hayakawa, Kazuma Yamakawa, Toshikazu Abe, Atsushi Shiraishi, Shigeki Kushimoto

Open Access COVID-19 Review

Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review

Giacomo Grasselli, Emanuele Cattaneo, Gaetano Florio, Mariachiara Ippolito, Alberto Zanella, Andrea Cortegiani, Jianbo Huang, Antonio Pesenti, Sharon Einav

Open Access Commentary

“I AM THOR/DUST DAHO”: mnemonic devices used by the Paris Fire Brigade to teach initial measures in undertaking a CBRN event

Louise Giaume, Yann Daniel, Franck Calamai, Clément Derkenne, Romain Kedzierewicz, Aude Demeny, Kilian Bertho, Stéphane Travers, Bertrand Prunet, Fréderic Dorandeu

Open Access Research

Comparison of clinical outcomes between nurse practitioner and registrar-led medical emergency teams: a propensity-matched analysis

Sachin Gupta, Mayurathan Balachandran, Gaby Bolton, Naomi Pratt, Jo Molloy, Eldho Paul, Ravindranath Tiruvoipati

Open Access Correction

Correction to: Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease

Keyvan Razazi, Romain Arrestier, Anne Fleur Haudebourg, Brice Benelli, Guillaume Carteaux, Jean‑Winoc Decousser, Slim Fourati, Paul Louis Woerther, Frederic Schlemmer, Anais Charles-Nelson, Francoise Botterel, Nicolas de Prost, Armand Mekontso Dessap

Open Access Research

Urinary metabolites predict mortality or need for renal replacement therapy after combat injury

Sarah Gisewhite, Ian J. Stewart, Greg Beilman, Elizabeth Lusczek

Open Access COVID-19 Letter

Lung compartmentalization of inflammatory biomarkers in COVID-19-related ARDS

Youenn Jouan, Thomas Baranek, Mustapha Si-Tahar, Christophe Paget, Antoine Guillon

Open Access COVID-19 Research

Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies

Eleni Papoutsi, Vassilis G. Giannakoulis, Eleni Xourgia, Christina Routsi, Anastasia Kotanidou, Ilias I. Siempos

Open Access Letter

Re: Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs (Friedrichson et al., Critical Care, January 2021)

Alex Warren, Luigi Camporota, Stephane Ledot, Ian Scott, Alain Vuylsteke

Open Access Research

Agreement between continuous and intermittent pulmonary artery thermodilution for cardiac output measurement in perioperative and intensive care medicine: a systematic review and meta-analysis

Karim Kouz, Frederic Michard, Alina Bergholz, Christina Vokuhl, Luisa Briesenick, Phillip Hoppe, Moritz Flick, Gerhard Schön, Bernd Saugel

Open Access Research Letter

Noninvasive sampling of the distal airspace via HME-filter fluid is not useful to detect SARS-CoV-2 in intubated patients

Joerg Reifart, Christoph Liebetrau, Christian Troidl, Katharina Madlener, Andreas Rolf

Open Access Research

Anti-Xa activity and hemorrhagic events under extracorporeal membrane oxygenation (ECMO): a multicenter cohort study

Richard Descamps, Mouhamed D. Moussa, Emmanuel Besnier, Marc-Olivier Fischer, Sébastien Preau, Fabienne Tamion, Cédric Daubin, Nicolas Cousin, André Vincentelli, Julien Goutay, Damien Du Cheyron

Open Access COVID-19 Research

Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients

Thomas Langer, Matteo Brioni, Amedeo Guzzardella, Eleonora Carlesso, Luca Cabrini, Gianpaolo Castelli, Francesca Dalla Corte, Edoardo De Robertis, Martina Favarato, Andrea Forastieri, Clarissa Forlini, Massimo Girardis, Domenico Luca Grieco, Lucia Mirabella, Valentina Noseda, Paola Previtali, Alessandro Protti, Roberto Rona, Francesca Tardini, Tommaso Tonetti, Fabio Zannoni, Massimo Antonelli, Giuseppe Foti, Marco Ranieri, Antonio Pesenti, Roberto Fumagalli, Giacomo Grasselli, Angela Berselli, Tiziana Bove, Plinio Calligari, Irene Coloretti, Antonio Coluccello, Elena Costantini, Vito Fanelli, Giuseppe Gagliardi, Federico Longhini, Federica Mariani, Annalisa Mascarello, Luca Menga, Irene Ottaviani, Daniela Pasero, Matteo Pedeferri, Angelo Pezzi, Giuseppe Servillo, Paolo Severgnini, Savino Spadaro, Vanessa Zambelli

Open Access Editorial

Beyond survival: identifying what matters to survivors of critical illness

Somnath Bose, Benjamin Hoenig, Maria Karamourtopoulos, Valerie Banner-Goodspeed, Samuel Brown

Open Access COVID-19 Correction

Correction to: Ventilator-associated pneumonia in critically ill patients with COVID-19

Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar, Nicholas M. Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefn Bartholdson Scott, Andrew Conway Morris

Open Access COVID-19 Letter

Fast recovery of cardiac function in PIMS-TS patients early using intravenous anti-IL-1 treatment

Maria Vincenza Mastrolia, Edoardo Marrani, Giovanni Battista Calabri, Manuela L’Erario, Ilaria Maccora, Silvia Favilli, Pier Paolo Duchini, Ilaria Pagnini, Gabriele Simonini

Open Access Letter

The prone position must accommodate changes in IAP in traumatic brain injury patients

Wojciech Dabrowski, Dorota Siwicka-Gieroba, Chiara Robba, Rafael Badenes, Manu L. N. G. Malbrain

Open Access Research

FDG-PET/CT in intensive care patients with bloodstream infection

Jordy P. Pijl, Mark Londema, Thomas C. Kwee, Maarten W. N. Nijsten, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Peter H. J. van der Voort, Andor W. J. M. Glaudemans, Janesh Pillay

Open Access Research

A 5G-powered robot-assisted teleultrasound diagnostic system in an intensive care unit

Shaobo Duan, Luwen Liu, Yongqing Chen, Long Yang, Ye Zhang, Shuaiyang Wang, Liuwei Hao, Lianzhong Zhang

Open Access Research

Post-extubation oxygenation strategies in acute respiratory failure: a systematic review and network meta-analysis

Hideto Yasuda, Hiromu Okano, Takuya Mayumi, Chihiro Narita, Yu Onodera, Masaki Nakane, Nobuaki Shime

Open Access COVID-19 Research Letter

Cerebral venous sinus thrombosis associated with thrombocytopenia post-vaccination for COVID-19

Gian Paolo Castelli, Claudio Pognani, Carlo Sozzi, Massimo Franchini, Luigi Vivona

Open Access Research Letter

Necrotizing soft-tissue infections in pediatric intensive care: a prospective multicenter case-series study

Stéphane Dauger, Renaud Blondé, Olivier Brissaud, Marie-Odile Marcoux, François Angoulvant, Michael Levy, Laurent Balu, Hélène Gatti, Etienne Javouhey, Nicolas Joram, Fabrice Lesage, Christophe Milesi, Marie-Hélène Perez, Isabelle Wroblewski, Marc-André Dugas, Etienne Javouhey, Nicolas Joram, Fabrice Lesage

Open Access COVID-19 Research

Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome

Fabienne Venet, Martin Cour, Thomas Rimmelé, Sebastien Viel, Hodane Yonis, Remy Coudereau, Camille Amaz, Paul Abraham, Céline Monard, Jean-Sebastien Casalegno, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurent Argaud, Guillaume Monneret, Remi Pescarmona, Lorna Garnier, Christine Lombard, Magali Perret, Marine Villard, Valérie Cheynet, Filippo Conti, Marie Groussaud, Marielle Buisson, Laetitia Itah, Inesse Boussaha, Françoise Poitevin-Later, Christophe Malcus, Morgane Gossez, Florent Wallet, Marie-Charlotte Delignette, Frederic Dailler, Marie Simon, Auguste Dargent, Pierre-Jean Bertrand, Neven Stevic, Marion Provent, Laurie Bignet, Valérie Cerro, Jean-Christophe Richard, Laurent Bitker, Mehdi Mezidi, Loredana Baboi

Open Access Research

Negative drift of sedation depth in critically ill patients receiving constant minimum alveolar concentration of isoflurane, sevoflurane, or desflurane: a randomized controlled trial

Adrian-Iustin Georgevici, Theodoros Kyprianou, Jennifer Herzog-Niescery, Livia Procopiuc, Sivakkanan Loganathan, Thomas Peter Weber, Martin Bellgardt

Open Access Research

Validation of the Critical-Care Pain Observation Tool-Neuro in brain-injured adults in the intensive care unit: a prospective cohort study

Céline Gélinas, Mélanie Bérubé, Kathleen A. Puntillo, Madalina Boitor, Melissa Richard-Lalonde, Francis Bernard, Virginie Williams, Aaron M. Joffe, Craig Steiner, Rebekah Marsh, Louise Rose, Craig M. Dale, Darina M. Tsoller, Manon Choinière, David L. Streiner

Open Access COVID-19 Correction

Correction to: CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS

Mathieu Blot, Marine Jacquier, Ludwig-Serge Aho Glele, Guillaume Beltramo, Maxime Nguyen, Philippe Bonniaud, Sebastien Prin, Pascal Andreu, Belaid Bouhemad, Jean-Baptiste Bour, Christine Binquet, Lionel Piroth, Jean-Paul Pais de Barros, David Masson, Jean-Pierre Quenot, Pierre-Emmanuel Charles

Open Access Research

Death in hospital following ICU discharge: insights from the LUNG SAFE study

Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G. Laffey, Giacomo Bellani, Antonio Pesenti, John G. Laffey, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Frank van Haren, Marco Ranieri, Gordon Rubenfeld, Gordon Rubenfeld, B. Taylor Thompson, Arthur S. Slutsky, Fernando Rios, Frank van Haren, Mohammad Omar Faruq, T. Sottiaux, P. Depuydt, Fredy S. Lora, Cesar Cesar Azevedo, Eddy Fan, Guillermo Bugedo, Haibo Qiu, Marcos Gonzalez, Juan Silesky, Vladimir Cerny, Jonas Nielsen, Manuel Jibaja, Tài Pham, Hermann Wrigge, Dimitrios Matamis, Jorge Luis Ranero, Charles Gomersall, Pravin Amin, S. M. Hashemian, Kevin Clarkson, Giacomo Bellani, Kiyoyasu Kurahashi, Younsuck Koh, Asisclo Villagomez, Amine Ali Zeggwagh, Leo M. Heunks, Jon Henrik Laake, Waqar Kashif, Jorge Synclair, Jose Emmanuel Palo, Antero do Vale Fernandes, Dorel Sandesc, Yaasen Arabi, Vesna Bumbasierevic, Nicolas Nin, Jose A. Lorente, Anders Larsson, Lise Piquilloud, Boonsong Patjanasoontorn, Fekri Abroug, Daniel F. McAuley, Lia McNamee, Javier Hurtado, Ed Bajwa, Gabriel Démpaire, Guy M. Francois, Francesca Rabboni, Fabiana Madotto, Sara Conti, Hektor Sula, Lordian Nunci, Alma Cani, Alan Zazu, Christian Dellera, Carolina S. Insaurralde, Risso V. Alejandro, Julio Daldin, Mauricio Vinzio, Ruben O. Fernandez, Luis P. Cardonnet, Lisandro R. Bettini, Mariano Carboni Bisso, Emilio M. Osman, Mariano G. Setten, Pablo Lovazzano, Javier Alvarez, Veronica Villar, Norberto C. Pozo, Nicolas Grubissich, Gustavo A. Plotnikow, Daniela N. Vasquez, Santiago Ilutovich, Norberto Tiribelli, Ariel Chena, Carlos A. Pellegrini, María G. Saenz, Elisa Estenssoro, Matias Brizuela, Hernan Gianinetto, Pablo E. Gomez, Valeria I. Cerrato, Marco G. Bezzi, Silvina A. Borello, Flavia A. Loiacono, Adriana M. Fernandez, Serena Knowles, Claire Reynolds, Deborah M. Inskip, Jennene J. Miller, Jing Kong, Christina Whitehead, Shailesh Bihari, Aylin Seven, Amanda Krstevski, Helen J. Rodgers, Rebecca T. Millar, Toni E. Mckenna, Irene M. Bailey, Gabrielle C. Hanlon, Anders Aneman, Joan M. Lynch, Raman Azad, John Neal, Paul W. Woods, Brigit L. Roberts, Mark R. Kol, Helen S. Wong, Katharina C. Riss, Thomas Staudinger, Xavier Wittebole, Caroline Berghe, Pierre A. Bulpa, Alain M. Dive, Rik Verstraete, Herve Lebbinck, Pieter Depuydt, Joris Vermassen, Philippe Meersseman, Helga Ceunen, Jonas I. Rosa, Daniel O. Beraldo, Claudio Piras, Adenilton M. Rampinelli, ñ P. Nassar Jr., Sergio Mataloun, Marcelo Moock, Marlus M. Thompson, Claudio H. Gonçalves, Ana Carolina P. Antônio, Aline Ascoli, Rodrigo S. Biondi, Danielle C. Fontenele, Danielle Nobrega, Vanessa M. Sales, Suresh Shindhe, Dk Maizatul Aiman, BPg Hj Ismail, John Laffey, Francois Beloncle, Kyle G. Davies, Rob Cirone, Venika Manoharan, Mehvish Ismail, Ewan C. Goligher, Mandeep Jassal, Niall D. Ferguson, Erin Nishikawa, Areej Javeed, Gerard Curley, Nuttapol Rittayamai, Matteo Parotto, Sangeeta Mehta, Jenny Knoll, Antoine Pronovost, Sergio Canestrini, Alejandro R. Bruhn, Patricio H. Garcia, Felipe A. Aliaga, Pamela A. Farías, Jacob S. Yumha, Claudia A. Ortiz, Javier E. Salas, Alejandro A. Saez, Luis D. Vega, Eduardo F. Labarca, Felipe T. Martinez, Nicolás G. Carreño, Pilar Lora, Haitao Liu, Haibo Qiu, Ling Liu, Rui Tang, Xiaoming Luo, Youzhong An, Huiying Zhao, Yan Gao, Zhe Zhai, Zheng L. Ye, Wei Wang, Wenwen Li, Qingdong Li, Ruiqiang Zheng, Wenkui Yu, Juanhong Shen, Xinyu Li, Tao Yu, Weihua Lu, Ya Q. Wu, Xiao B. Huang, Zhenyang He, Yuanhua Lu, Hui Han, Fan Zhang, Renhua Sun, Hua X. Wang, Shu H. Qin, Bao H. Zhu, Jun Zhao, Jian Liu, Bin Li, Jing L. Liu, Fa C. Zhou, Qiong J. Li, Xing Y. Zhang, Zhou Li-Xin, Qiang Xin-Hua, Liangyan Jiang, Yuan N. Gao, Xian Y. Zhao, Yuan Y. Li, Xiao L. Li, Chunting Wang, Qingchun Yao, Rongguo Yu, Kai Chen, Huanzhang Shao, Bingyu Qin, Qing Q. Huang, Wei H. Zhu, Ai Y. Hang, Ma X. Hua, Yimin Li, Yonghao Xu, Yu D. Di, Long L. Ling, Tie H. Qin, Shou H. Wang, Junping Qin, Yi Han, Suming Zhou, Monica P. Vargas, Juan I. Silesky Jimenez, Manuel A. González Rojas, Jaime E. Solis-Quesada, Christian M. Ramirez-Alfaro, Jan Máca, Peter Sklienka, Jakob Gjedsted, Aage Christiansen, Jonas Nielsen, Boris G. Villamagua, Miguel Llano, Philippe Burtin, Gautier Buzancais, Pascal Beuret, Nicolas Pelletier, Satar Mortaza, Alain Mercat, Jonathan Chelly, Sébastien Jochmans, Nicolas Terzi, Cédric Daubin, Guillaume Carteaux, Nicolas de Prost, Jean-Daniel Chiche, Fabrice Daviaud, Tài Pham, Muriel Fartoukh, Guillaume Barberet, Jerome Biehler, Jean Dellamonica, Denis Doyen, Jean-Michel Arnal, Anais Briquet, Fanny Klasen, Laurent Papazian, Arnaud Follin, Damien Roux, Jonathan Messika, Evangelos Kalaitzis, Laurence Dangers, Alain Combes, Siu-Ming Au, Gaetan Béduneau, Dorothée Carpentier, Elie H. Zogheib, Herve Dupont, Sylvie Ricome, Francesco L. Santoli, Sebastien L. Besset, Philippe Michel, Bruno Gelée, Pierre-Eric Danin, Bernard Goubaux, Philippe J. Crova, Nga T. Phan, Frantz Berkelmans, Julio C. Badie, Romain Tapponnier, Josette Gally, Samy Khebbeb, Jean-Etienne Herbrecht, Francis Schneider, Pierre-Louis M. Declercq, Jean-Philippe Rigaud, Jacques Duranteau, Anatole Harrois, Russell Chabanne, Julien Marin, Jean-Michel Constantin, Sandrine Thibault, Mohammed Ghazi, Messabi Boukhazna, Salem Ould Zein, Jack R. Richecoeur, Daniele M. Combaux, Fabien Grelon, Charlene Le Moal, Elise P. Sauvadet, Adrien Robine, Virginie Lemiale, Danielle Reuter, Martin Dres, Alexandre Demoule, Dany Goldgran-Toledano, Loredana Baboi, Claude Guérin, Ralph Lohner, Jens Kraßler, Susanne Schäfer, Kai D. Zacharowski, Patrick Meybohm, Andreas W. Reske, Philipp Simon, Hans-Bernd F. Hopf, Michael Schuetz, Thomas Baltus, Metaxia N. Papanikolaou, Theonymfi G. Papavasilopoulou, Giannis A. Zacharas, Vasilis Ourailogloy, Eleni K. Mouloudi, Eleni V. Massa, Eva O. Nagy, Electra E. Stamou, Ellada V. Kiourtzieva, Marina A. Oikonomou, Luis E. Avila, Cesar A. Cortez, Johanna E. Citalán, Sameer A. Jog, Safal D. Sable, Bhagyesh Shah, Mohan Gurjar, Arvind K. Baronia, Mohammedfaruk Memon, Radhakrishnan Muthuchellappan, Venkatapura J. Ramesh, Anitha Shenoy, Ramesh Unnikrishnan, Subhal B. Dixit, Rachana V. Rhayakar, Nagarajan Ramakrishnan, Vallish K. Bhardwaj, Heera L. Mahto, Sudha V. Sagar, Vijayanand Palaniswamy, Deeban Ganesan, Seyed Mohammadreza Hashemian, Hamidreza Jamaati, Farshad Heidari, Edel A. Meaney, Alistair Nichol, Karl M. Knapman, Donall O’Croinin, Eimhin S. Dunne, Dorothy M. Breen, Kevin P. Clarkson, Rola F. Jaafar, Rory Dwyer, Fahd Amir, Olaitan O. Ajetunmobi, Aogan C. O’Muircheartaigh, Colin S. Black, Nuala Treanor, Daniel V. Collins, Wahid Altaf, Gianluca Zani, Maurizio Fusari, Savino Spadaro, Carlo A. Volta, Romano Graziani, Barbara Brunettini, Salvatore Palmese, Paolo Formenti, Michele Umbrello, Andrea Lombardo, Elisabetta Pecci, Marco Botteri, Monica Savioli, Alessandro Protti, Alessia Mattei, Lorenzo Schiavoni, Andrea Tinnirello, Manuel Todeschini, Policlinico P. Giaccone, Antonino Giarratano, Andrea Cortegiani, Sara Sher, Anna Rossi, Massimo M. Antonelli, Luca M. Montini, Paolo Casalena, Sergio Scafetti, Giovanna Panarello, Giovanna Occhipinti, Nicolò Patroniti, Matteo Pozzi, Roberto R. Biscione, Michela M. Poli, Ferdinando Raimondi, Daniela Albiero, Giulia Crapelli, Eduardo Beck, Vincenzo Pota, Vincenzo Schiavone, Alexandre Molin, Fabio Tarantino, Giacomo Monti, Elena Frati, Lucia Mirabella, Gilda Cinnella, Tommaso Fossali, Riccardo Colombo, Pierpaolo Terragni Ilaria Pattarino, Francesco Mojoli, Antonio Braschi, Erika E. Borotto, Andrea N. Cracchiolo, Daniela M. Palma, Francesco Raponi, Giuseppe Foti, Ettore R. Vascotto, Andrea Coppadoro, Luca Brazzi, Leda Floris, Giorgio A. Iotti, Aaron Venti, Osamu Yamaguchi, Shunsuke Takagi, Hiroki N. Maeyama, Eizo Watanabe, Yoshihiro Yamaji, Kazuyoshi Shimizu, Kyoko Shiozaki, Satoru Futami, Sekine Ryosuke, Koji Saito, Yoshinobu Kameyama, Keiko Ueno, Masayo Izawa, Nao Okuda, Hiroyuki Suzuki, Tomofumi Harasawa, Michitaka Nasu, Tadaaki Takada, Fumihito Ito, Shin Nunomiya, Kansuke Koyama, Toshikazu Abe, Kohkichi Andoh, Kohei Kusumoto, Akira Hirata, Akihiro Takaba, Hiroyasu Kimura, Shuhei Matsumoto, Ushio Higashijima, Hiroyuki Honda, Nobumasa Aoki, Hiroshi Imai, Yasuaki Ogino, Ichiko Mizuguchi, Kazuya Ichikado, Kenichi Nitta, Katsunori Mochizuki, Tomoaki Hashida, Hiroyuki Tanaka, Tomoyuki Nakamura, Daisuke Niimi, Takeshi Ueda, Yozo Kashiwa, Akinori Uchiyama, Olegs Sabelnikovs, Peteris Oss, Youssef Haddad, Kong Y. Liew, Silvio A. Ñamendys-Silva, Yves D. Jarquin-Badiola, Luis A. Sanchez-Hurtado, Saira S. Gomez-Flores, Maria C. Marin, Asisclo J. Villagomez, Jordana S. Lemus, Jonathan M. Fierro, Mavy Ramirez Cervantes, Francisco Javier Flores Mejia, Dulce Dector, Dulce M. Dector, Daniel R. Gonzalez, Claudia R. Estrella, Jorge R. Sanchez-Medina, Alvaro Ramirez-Gutierrez, Fernando G. George, Janet S. Aguirre, Juan A. Buensuseso, Manuel Poblano, Mohammed V. University, Tarek Dendane, Amine Ali Zeggwagh, Hicham Balkhi, Mina Elkhayari, Nacer Samkaoui, Hanane Ezzouine, Abdellatif Benslama, Mourad Amor, Wajdi Maazouzi, Nedim Cimic, Oliver Beck, Monique M. Bruns, Jeroen A. Schouten, Myra Rinia, Monique Raaijmakers, Leo M. Heunks, Hellen M. Van Wezel, Serge J. Heines, Ulrich Strauch, Marc P. Buise, Fabienne D. Simonis, Marcus J. Schultz, Jennifer C. Goodson, Troy S. Browne, Leanlove Navarra, Anna Hunt, Robyn A. Hutchison, Mathew B. Bailey, Lynette Newby, Colin Mcarthur, Michael Kalkoff, Alex Mcleod, Jonathan Casement, Danielle J. Hacking, Finn H. Andersen, Merete S. Dolva, Jon H. Laake, Andreas Barratt-Due, Kim Andre L. Noremark, Eldar Søreide, Brit Å. Sjøbø, Anne B. Guttormsen, Hector H. Leon Yoshido, Ronald Zumaran Aguilar, Fredy A. Montes Oscanoa, Alain U. Alisasis, Joanne B. Robles, Rossini Abbie B. Pasanting-Lim, Beatriz C. Tan, Pawel Andruszkiewicz, Karina Jakubowska, Cristina M. Coxo, António M. Alvarez, Bruno S. Oliveira, Gustavo M. Montanha, Nelson C. Barros, Carlos S. Pereira, António M. Messias, Jorge M. Monteiro, Ana M. Araujo, Nuno T. Catorze, Susan M. Marum, Maria J. Bouw, Rui M. Gomes, Vania A. Brito, Silvia Castro, Joana M. Estilita, Filipa M. Barros, Isabel M. Serra, Aurelia M. Martinho, Dana R. Tomescu, Alexandra Marcu, Ovidiu H. Bedreag, Marius Papurica, Dan E. Corneci, Silvius Ioan Negoita, Evgeny Grigoriev, Alexey I. Gritsan, Andrey A. Gazenkampf, Ghaleb Almekhlafi, Mohamad M. Albarrak, Ghanem M. Mustafa, Khalid A. Maghrabi, Nawal Salahuddin, Tharwat M. Aisa, Ahmed S. Al Jabbary, Edgardo Tabhan, Yaseen M. Arabi, Olivia A. Trinidad, Hasan M. Al Dorzi, Edgardo E. Tabhan, Stefan Bolon, Oliver Smith, Jordi Mancebo, Hernan Aguirre-Bermeo, Juan C. Lopez-Delgado, Francisco Esteve, Gemma Rialp, Catalina Forteza, Candelaria De Haro, Antonio Artigas, Guillermo M. Albaiceta, Sara De Cima-Iglesias, Leticia Seoane-Quiroga, Alexandra Ceniceros-Barros, Antonio L. Ruiz-Aguilar, Luis M. Claraco-Vega, Juan Alfonso Soler, Maria del Carmen Lorente, Cecilia Hermosa, Federico Gordo, Miryam Prieto-González, Juan B. López-Messa, Manuel P. Perez, Cesar P. Perez, Raquel Montoiro Allue, Ferran Roche-Campo, Marcos Ibañez-Santacruz, Susana Temprano, Maria C. Pintado, Raul De Pablo, Pilar Ricart Aroa Gómez, Silvia Rodriguez Ruiz, Silvia Iglesias Moles, Mª Teresa Jurado, Alfons Arizmendi, Enrique A. Piacentini, Nieves Franco, Teresa Honrubia, Meisy Perez Cheng, Elena Perez Losada, Javier Blanco, Luis J. Yuste, Cecilia Carbayo-Gorriz, Francisca G. Cazorla-Barranquero, Javier G. Alonso, Rosa S. Alda, Ángela Algaba, Gonzalo Navarro, Enrique Cereijo, Esther Diaz-Rodriguez, Diego Pastor Marcos, Laura Alvarez Montero, Luis Herrera Para, Roberto Jimenez Sanchez, Miguel Angel Blasco Navalpotro, Ricardo Diaz Abad, Raquel Montiel Gonz á lez, Dácil Parrilla Toribio, Alejandro G. Castro, Maria Jose D. Artiga, Oscar Penuelas, Tomas P. Roser, Moreno F. Olga, Elena Gallego Curto, Rocío Manzano Sánchez, Vallverdu P. Imma, Garcia M. Elisabet, Laura Claverias, Monica Magret, Ana M. Pellicer, Lucia L. Rodriguez, Jesús Sánchez-Ballesteros, Ángela González-Salamanca, Antonio G. Jimenez, Francisco P. Huerta, Juan Carlos J. Sotillo Diaz, Esther Bermejo Lopez, David D. Llinares Moya, Alec A. Tallet Alfonso, Palazon Sanchez Eugenio Luis, Palazon Sanchez Cesar, Sánchez I. Rafael, Corcoles G. Virgilio, Noelia N. Recio, Richard O. Adamsson, Christian C. Rylander, Bernhard Holzgraefe, Lars M. Broman, Joanna Wessbergh, Linnea Persson, Fredrik Schiöler, Hans Kedelv, Anna Oscarsson Tibblin, Henrik Appelberg, Lars Hedlund, Johan Helleberg, Karin E. Eriksson, Rita Glietsch, Niklas Larsson, Ingela Nygren, Silvia L. Nunes, Anna-Karin Morin, Thomas Kander, Anne Adolfsson, Lise Piquilloud, Hervé O. Zender, Corinne Leemann-Refondini, Souheil Elatrous, Slaheddine Bouchoucha, Imed Chouchene, Islem Ouanes, La Marsa, Asma Ben Souissi, Salma Kamoun, Oktay Demirkiran, Mustafa Aker, Emre Erbabacan, Ilkay Ceylan, Nermin Kelebek Girgin, Menekse Ozcelik, Necmettin Ünal, Basak Ceyda Meco, Onat O. Akyol, Suleyman S. Derman, Barry Kennedy, Ken Parhar, Latha Srinivasa, Lia McNamee, Danny McAuley, Phil Hopkins, Clare Mellis, Vivek Kakar, Dan Hadfield, Andre Vercueil, Kaushik Bhowmick, Sally K. Humphreys, Andrew Ferguson, Raymond Mckee, Ashok S. Raj, Danielle A. Fawkes, Philip Watt, Linda Twohey, Rajeev R. JhaMatthew Thomas, Alex Morton, Varsha Kadaba, Mark J. Smith, Anil P. Hormis, Santhana G. Kannan, Miriam Namih, Henrik Reschreiter, Julie Camsooksai, Alek Kumar, Szabolcs Rugonfalvi, Christopher Nutt, Orla Oneill, Colette Seasman, Ged Dempsey, Christopher J. Scott, Helen E. Ellis, Stuart Mckechnie, Paula J. Hutton, Nora N. Di Tomasso, Michela N. Vitale, Ruth O. Griffin, Michael N. Dean, Julius H. Cranshaw, Emma L. Willett, Nicholas Ioannou, Sarah Gillis, Peter Csabi, Rosaleen Macfadyen, Heidi Dawson, Pieter D. Preez, Alexandra J. Williams, Owen Boyd, Laura Ortiz-Ruiz De Gordoa, Jon Bramall, Sophie Symmonds, Simon K. Chau, Tim Wenham, Tamas Szakmany, Piroska Toth-Tarsoly, Katie H. Mccalman, Peter Alexander, Lorraine Stephenson, Thomas Collyer, Rhiannon Chapman, Raphael Cooper, Russell M. Allan, Malcolm Sim, David W. Wrathall, Donald A. Irvine, Kim S. Zantua, John C. Adams, Andrew J. Burtenshaw, Gareth P. Sellors, Ingeborg D. Welters, Karen E. Williams, Robert J. Hessell, Matthew G. Oldroyd, Ceri E. Battle, Suresh Pillai, Istvan Kajtor, Mageswaran Sivashanmugavel, Sinead C. Okane, Adrian Donnelly, Aniko D. Frigyik, Jon P. Careless, Martin M. May, Richard Stewart, T. John Trinder, Samantha J. Hagan, Matt P. Wise, Jade M. Cole, Caroline C. MacFie, Anna T. Dowling, Javier Hurtado, Nicolás Nin, Javier Hurtado, Edgardo Nuñez, Gustavo Pittini, Ruben Rodriguez, María C. Imperio, Cristina Santos, Alberto Deicas, Carolina Serra, Aditya Uppalapati, Ghassan Kamel, Valerie M. Banner-Goodspeed, Jeremy R. Beitler, Satyanarayana Reddy Mukkera, Shreedhar Kulkarni, Jarone Lee, Tomaz Mesar, John O. Shinn Iii, Dina Gomaa, Christopher Tainter, Jarone Lee, Tomaz Mesar, Jarone Lee, Dale J. Yeatts, Jessica Warren, Michael J. Lanspa, Russel R. Miller, Colin K. Grissom, Samuel M. Brown, Philippe R. Bauer, Ryan J. Gosselin, Barrett T. Kitch, Jason E. Cohen, Scott H. Beegle, Renaud M. Gueret, Aiman Tulaimat, Shazia Choudry, William Stigler, Hitesh Batra, Nidhi G. Huff, Keith D. Lamb, Trevor W. Oetting, Nicholas M. Mohr, Claine Judy, Shigeki Saito, Fayez M. Kheir, Fayez Kheir, Adam B. Schlichting, Angela Delsing, Daniel R. Crouch, Mary Elmasri, Daniel R. Crouch, Dina Ismail, Kyle R. Dreyer, Thomas C. Blakeman, Kyle R. Dreyer, Dina Gomaa, Rebecca M. Baron, Carolina Quintana Grijalba, Peter C. Hou, Raghu Seethala, Imo Aisiku, Galen Henderson, Gyorgy Frendl, Sen-Kuang Hou, Robert L. Owens, Ashley Schomer, Vesna Bumbasirevic, Bojan Jovanovic, Maja Surbatovic, Milic Veljovic, John G. Laffey, Giacomo Bellani, Antonio Pesenti

Open Access COVID-19 Research Letter

A practical integrated radiomics model predicting intensive care hospitalization in COVID-19

Chiara Giraudo, Giovanni Frattin, Giulia Fichera, Raffaella Motta, Roberto Stramare

Open Access Research

Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis

Victoria S. Owen, Brianna K. Rosgen, Stephana J. Cherak, Andre Ferland, Henry T. Stelfox, Kirsten M. Fiest, Daniel J. Niven

Open Access Viewpoint

Addressing gender imbalance in intensive care

Jean-Louis Vincent, Nicole P. Juffermans, Karen E. A. Burns, V. Marco Ranieri, Chryssa Pourzitaki, Francesca Rubulotta

Open Access COVID-19 Research

Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study

Pavan K. Bhatraju, Eric D. Morrell, Leila Zelnick, Neha A. Sathe, Xin-Ya Chai, Sana S. Sakr, Sharon K. Sahi, Anthony Sader, Dawn M. Lum, Ted Liu, Neall Koetje, Ashley Garay, Elizabeth Barnes, Jonathan Lawson, Gail Cromer, Mary K. Bray, Sudhakar Pipavath, Bryan R. Kestenbaum, W. Conrad Liles, Susan L. Fink, T. Eoin West, Laura Evans, Carmen Mikacenic, Mark M. Wurfel

Open Access COVID-19 Research

The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study

Christian Jung, Hans Flaatten, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten, Bernhard Wernly, Antonio Artigas, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Muhammed Elhadi, Tilemachos Zafeiridis, Rui Moreno, Maurizio Cecconi, Ariane Boumendil, Hazem Maarouf Abosheaishaa, Enas M. Y. Abualqumboz, Abdullah Khudhur Ahmed, Hazem Ahmed, Zoi Aidoni, Cesar Aldecoa, Nica Alexandru, Yasmin Khairy NasrEldin Mohamed Ali, Mohammed Al-Sadawi, Kasper Andersen, Finn H. Andersen, Rui Assis, Mohammed A. Azab, Ahmed Y. Azzam, Mohamed Raafat Badawy, Ida Riise Balleby, Eberhard Barth, Eberhard Barth, Nawfel Ben-HAmouda, Guillaume Besch, Sebastien Besset, Anders Thais Bjerregaard, Helene Brix, Raphael Romano Bruno, Jens Brushoej, Helle Bundgaard, Philippe Burtin, Anais Caillard, Isabel Canas-Perez, Cyril Charron, Evangelia Chrisanthopoulou, Vittoria Comellini, Alex Cornet, Patricia Jimeno Cubero, Miroslaw Czuczwar, Stéphane Dauger, Cristina Diaz-Rodriguez, Willem Dieperink, Zouhir Dindane, Michel Djibré, Tom Dormans, Alexander Dullenkopf, Guillaume Dumas, Yumna A. Elgazzar, Philipp Eller, Ahmed Elsaka, Mirjam Evers, Andreas Faltlhauser, Aida Fernández Ferreira, Jesper Fjølner, Yvan Fleury, Arnaud Galbois, Pierre Garcon, Marc Garnier, Ryszard Gawda, Abdelilah Ghannam, Ulrich Goebel, Gemma Gomà, Bruno Goncalves, André Gordinho, Martijn Groenendijk, Emmanuel Guerot, Bertrand Guidet, Mohan Gurjar, Hendrik Haake, Lenneke Haas, Ayman Abdelmawgoad Habib, Michael Hahn, Maria Aagaard Hansen, Momin Majed Yousuf Hilles, Aliae A. R. Mohamed Hussein, David Iglesias, Michael Joannidis, Christian Jung, Igor Jurcisin, Hans-Joachim Kabitz, Malte Kelm, Detlef Kindgen-Milles, Jakub Klimkiewicz, Karl Friedrich Kuhn, Anselm Kunstein, Muhammed Kurt, Dylan W. De Lange, Susannah Leaver, Matthias Lutz, Ata Mahmoodpoor, Julien Maizel, Nathalie Marin, Brian Marsh, Buno Megarbane, Dieter Mesotten, Patrick Meybohm, Christian Meyer, Angela Prado Mira, Silvio a Namendys-Silva, Helene Korvenius Nedergaard, Saad Nseir, Sandra Oeyen, Theresa Olasveengen, Ana Isabel Pinho Oliveira, Johanna Oziel, Antonios Papadogoulas, David Perez-Torres, Bernardo Bollen Pinto, Gaël Piton, Gaëtan Plantefeve, Tudor Poerner, Jesús Priego, Ahmed Rabha, Winfried Randerath, Jean-herlé Raphaelen, Pascal Reper, Jean-Philippe Rigaud, Susana Arias Rivera, Andrea Roberti, Luis Romundstad, Nikoletta Rovina, Rehab Salah, Mahmoud Saleh, Susana Sancho, Maria de Lurdes Campos Santos, Henrique Santos, Stefan Schaller, Joerg C. Schefold, Michael Schuster, Gonxhe Shala, Britt Sjøbø, Stephan Steiner, Hans Frank Strietzel, Sigal Sviri, Walter Swinnen, Luis Tamayo-Lomas, Samar Tharwat, Teresa Tomasa, Stine Uhrenholt, Marie Vaissiere, Arnaud Valent, Xavier Valette, Thierry Vanderlinden, Eric Mayor Vázquez, Mercedes Ibarz Villamayor, Maja Villefrance, Ingo Voigt, Kyrillos Wassim, Martin Welte, Georg Wolff, Jakob Wollborn, Begoña Zalba-Etayo, Marieke Zegers

Open Access Research

Novel criteria to classify ARDS severity using a machine learning approach

Mohammed Sayed, David Riaño, Jesús Villar

Open Access Research

Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

Jérôme Pugin, Thomas Daix, Jean-Luc Pagani, Davide Morri, Angelo Giacomucci, Pierre-François Dequin, Christophe Guitton, Yok-Ai Que, Gianluca Zani, David Brealey, Alain Lepape, Ben Creagh-Brown, Duncan Wyncoll, Daniela Silengo, Irina Irincheeva, Laurie Girard, Fabien Rebeaud, Iwan Maerki, Philippe Eggimann, Bruno François

Open Access COVID-19 Research Letter

Toward the personalized and integrative management of voriconazole dosing during COVID-19-associated pulmonary aspergillosis

Brendan Le Daré, Christelle Boglione-Kerrien, Florian Reizine, Jean-Pierre Gangneux, Astrid Bacle

Open Access COVID-19 Editorial

Ventilator-associated pneumonia in the era of COVID-19 pandemic: How common and what is the impact?

Paul-Henri Wicky, Michael S. Niedermann, Jean-François Timsit

Open Access Research

Latent class analysis to predict intensive care outcomes in Acute Respiratory Distress Syndrome: a proposal of two pulmonary phenotypes

Pedro D. Wendel Garcia, Alessio Caccioppola, Silvia Coppola, Tommaso Pozzi, Arianna Ciabattoni, Stefano Cenci, Davide Chiumello

Open Access COVID-19 Research

Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients during the first wave of the pandemic: observational report from 28 European intensive care units

Andrea Lavinio, Ari Ercole, Denise Battaglini, Sandra Magnoni, Rafael Badenes, Fabio Silvio Taccone, Raimund Helbok, William Thomas, Paolo Pelosi, Chiara Robba, Nicole Innerhofer, Sara Miori, Alberto Librizzi, Rita Bertuetti, Nicolas Figueiredo Faria, Lorenzo Peluso, Giorgia Montrucchio, Gabriele Sales, Luca Brazzi, Daniela Alampi, Maria Beatrice Manca, Lilia Sepe, Giuseppe Natalini, Antonio Bellino, Maria Grazia Bocci, Chiara Mattana, Francesco Corradi, Francesco Forfori, Francesco Cundari, Emilio Bonvecchio, Zara Busani, Andrea Bianchin, Carla Federico, Anna Santoro, Federico Bilotta, Giorgio Rajani, Berta Moleon Lopez, Raffaele Aspide, Merola Raffaele, Luca Cabrini, Alessandro Motta, Lara Frattini, Alexandre Godon, Pierre Bouzat, Elena Grappa, Alberto Bonvecchio, Nicole Innerhofer, Dietmar Fries, Christian Preuss Hernandez, Claudius Thomé, Sebastian Klein, Michael Joannidis, Paolo Pelosi, Lorenzo Ball, Nicolo’ Patroniti, Iole Brunetti, Matteo Bassetti, Daniele Roberto Giacobbe, Antonio Vena, Alberto Valbusa, Italo Porto, Roberta Della Bona

Open Access Research

Day-to-day progression of vital-sign circadian rhythms in the intensive care unit

Shaun Davidson, Mauricio Villarroel, Mirae Harford, Eoin Finnegan, João Jorge, Duncan Young, Peter Watkinson, Lionel Tarassenko

Open Access Review

Bedside voluntary and evoked forces evaluation in intensive care unit patients: a narrative review

Djahid Kennouche, Eric Luneau, Thomas Lapole, Jérome Morel, Guillaume Y. Millet, Julien Gondin

Open Access COVID-19 Research

Implications of cardiac markers in risk-stratification and management for COVID-19 patients

Pengping Li, Wei Wu, Tingting Zhang, Ziyu Wang, Jie Li, Mengyan Zhu, Yuan Liang, Wenhua You, Kening Li, Rong Ding, Bin Huang, Lingxiang Wu, Weiwei Duan, Yi Han, Xuesong Li, Xin Tang, Xin Wang, Han Shen, Qianghu Wang, Hong Yan, Xinyi Xia, Yong Ji, Hongshan Chen

Open Access Research Letter

Elevated carboxyhaemoglobin as a novel indicator for extracorporeal membrane haemolysis and oxygenator exchange

Kenneth R. Hoffman, Aidan J. C. Burrell, Arne Diehl, Warwick Butt

Open Access Research

Argatroban versus heparin in patients without heparin-induced thrombocytopenia during venovenous extracorporeal membrane oxygenation: a propensity-score matched study

Christoph Fisser, Maren Winkler, Maximilian V. Malfertheiner, Alois Philipp, Maik Foltan, Dirk Lunz, Florian Zeman, Lars S. Maier, Matthias Lubnow, Thomas Müller

Open Access Research

Trajectories of depression in sepsis survivors: an observational cohort study

Monique Boede, Jochen S. Gensichen, James C. Jackson, Fiene Eißler, Thomas Lehmann, Sven Schulz, Juliana J. Petersen, Florian P. Wolf, Tobias Dreischulte, Konrad F. R. Schmidt

Open Access COVID-19 Editorial

COVID-19: spot urine rather than bronchoalveolar lavage fluid analysis?

Faeq Husain-Syed, Claudio Ronco, Thorsten Wiech, Matthias Hecker, Werner Seeger

Open Access COVID-19 Letter

PEEP-induced alveolar recruitment in patients with COVID-19 pneumonia: take the right time!

Gianmaria Cammarota, Rachele Simonte, Edoardo De Robertis

Open Access Research Letter

Extracorporeal membrane oxygenation in non-intubated immunocompromised patients

Klaus Stahl, Heiko Schenk, Christian Kühn, Olaf Wiesner, Marius M. Hoeper, Sascha David

Open Access Research

Temporal patterns of organ dysfunction after severe trauma

Jesper Eriksson, David Nelson, Anders Holst, Elisabeth Hellgren, Ola Friman, Anders Oldner

Open Access COVID-19 Research Letter

A high blood endocan profile during COVID-19 distinguishes moderate from severe acute respiratory distress syndrome

Tiffany Pascreau, Colas Tcherakian, Benjamin Zuber, Eric Farfour, Marc Vasse, Philippe Lassalle

Open Access Research

Comparison of culture-negative and culture-positive sepsis or septic shock: a systematic review and meta-analysis

Yuting Li, Jianxing Guo, Hongmei Yang, Hongxiang Li, Yangyang Shen, Dong Zhang

Open Access Research Letter

Blind placement of postpyloric feeding tubes at the bedside in intensive care

Qianwen Wang, Yongbo Xuan, Cuiping Liu, Mei Lu, Zhanguo Liu, Ping Chang

Open Access COVID-19 Research Letter

Distinct temporal characteristics of circulating alveolar epithelial and endothelial injury markers in ARDS with COVID-19

Kentaro Tojo, Natsuhiro Yamamoto, Takahiro Mihara, Miyo Abe, Takahisa Goto

Open Access COVID-19 Research Letter

Non-intubated COVID-19 patients despite high levels of supplemental oxygen

Samuel Chosidow, Gaëtan Plantefève, Megan Fraissé, Hervé Mentec, Radj Cally, Damien Contou

Open Access COVID-19 Research

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

Luis Morales-Quinteros, Ary Serpa Neto, Antonio Artigas, Lluis Blanch, Michela Botta, David A. Kaufman, Marcus J. Schultz, Anissa M. Tsonas, Frederique Paulus, Lieuwe D. Bos, Luis Morales-Quinteros, Ary Serpa Neto, Antonio Artigas, Lluis Blanch, Michela Botta, David A. Kaufman, Marcus J. Schultz, Anissa M. Tsonas, Frederique Paulus, Lieuwe D. Bos, A. G. Algera, L. S. Boers, L. D. J. Bos, J. Pillay, D. A. Dongelmans, M. W. Hollmann, J. Horn, A. P. Vlaar, J. P. van Akkeren, A. G. Algera, C. K. Algoe, R. B. van Amstel, O. L. Baur, P. van de Berg, A. E. van den Berg, D. C. J. J. Bergmans, D. I. van den Bersselaar, F. A. Bertens, A. J. G. H. Bindels, M. M. de Boer, S. den Boer, L. S. Boers, M. Bogerd, J. S. Breel, H. de Bruin, S. de Bruin, C. L. Bruna, L. A. Buiteman–Kruizinga, O. Cremer, R. M. Determann, W. Dieperink, D. A. Dongelmans, H. S. Franke, M. S. Galek–Aldridge, M. J. de Graaff, L. A. Hagens, J. J. Haringman, S. T. van der Heide, P. L. J. van der Heiden, N. F. L. Heijnen, S. J. P. Hiel, L. L. Hoeijmakers, L. Hol, M. W. Hollmann, M. E. Hoogendoorn, J. Horn, R. van der Horst, E. L. K. Ie, D. Ivanov, N. P. Juffermans, E. Kho, E. S. de Klerk, A. W. M. M. Koopman-van Gemert, M. Koopmans, S. Kucukcelebi, M. A. Kuiper, D. W. de Lange, N. van Mourik, S. G. Nijbroek, M. Onrust, E. A. N. Oostdijk, C. J. Pennartz, J. Pillay, L. Pisani, I. M. Purmer, T. C. D. Rettig, J. P. Roozeman, M. T. U. Schuijt, M. E. Sleeswijk, M. R. Smit, P. E. Spronk, W. Stilma, A. C. Strang, P. R. Tuinman, C. M. A. Valk, F. L. Veen-Schra, L. I. Veldhuis, P. van Velzen, W. H. van der Ven, A. P. J. Vlaar, P. van Vliet, P. H. J. van der Voort, L. van Welie, H. J. F. T. Wesselink, H. H. van der Wier-Lubbers, B. van Wijk, T. Winters, W. Y. Wong, A. R. H. van Zanten

Open Access Research

The impact of right ventricular injury on the mortality in patients with acute respiratory distress syndrome: a systematic review and meta-analysis

Ryota Sato, Siddharth Dugar, Wisit Cheungpasitporn, Mary Schleicher, Patrick Collier, Saraschandra Vallabhajosyula, Abhijit Duggal

Open Access Letter

Timing of Intubation in Covid-19 ARDS: What “time” really matters?

Vasiliki Tsolaki, George E. Zakynthinos

Open Access Research

Mechanical circulatory support for refractory out-of-hospital cardiac arrest: a Danish nationwide multicenter study

Sivagowry Rasalingam Mørk, Carsten Stengaard, Louise Linde, Jacob Eifer Møller, Lisette Okkels Jensen, Henrik Schmidt, Lars Peter Riber, Jo Bønding Andreasen, Sisse Anette Thomassen, Helle Laugesen, Phillip Michael Freeman, Steffen Christensen, Jacob Raben Greisen, Mariann Tang, Peter Hasse Møller-Sørensen, Lene Holmvang, Emilie Gregers, Jesper Kjaergaard, Christian Hassager, Hans Eiskjær, Christian Juhl Terkelsen

Open Access COVID-19 Research

Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort

Pedro D. Wendel Garcia, Hernán Aguirre-Bermeo, Philipp K. Buehler, Mario Alfaro-Farias, Bernd Yuen, Sascha David, Thomas Tschoellitsch, Tobias Wengenmayer, Anita Korsos, Alberto Fogagnolo, Gian-Reto Kleger, Maddalena A. Wu, Riccardo Colombo, Fabrizio Turrini, Antonella Potalivo, Emanuele Rezoagli, Raquel Rodríguez-García, Pedro Castro, Arantxa Lander-Azcona, Maria C. Martín-Delgado, Herminia Lozano-Gómez, Rolf Ensner, Marc P. Michot, Nadine Gehring, Peter Schott, Martin Siegemund, Lukas Merki, Jan Wiegand, Marie M. Jeitziner, Marcus Laube, Petra Salomon, Frank Hillgaertner, Alexander Dullenkopf, Hatem Ksouri, Sara Cereghetti, Serge Grazioli, Christian Bürkle, Julien Marrel, Isabelle Fleisch, Marie-Helene Perez, Anja Baltussen Weber, Samuele Ceruti, Katharina Marquardt, Tobias Hübner, Hermann Redecker, Michael Studhalter, Michael Stephan, Daniela Selz, Urs Pietsch, Anette Ristic, Antje Heise, Friederike Meyer zu Bentrup, Marilene Franchitti Laurent, Patricia Fodor, Tomislav Gaspert, Christoph Haberthuer, Elif Colak, Dorothea M. Heuberger, Thierry Fumeaux, Jonathan Montomoli, Philippe Guerci, Reto A. Schuepbach, Matthias P. Hilty, Ferran Roche-Campo, Pedro D. Wendel Garcia, Hernán Aguirre-Bermeo, Philipp K. Buehler, Mario Alfaro-Farias, Bernd Yuen, Sascha David, Thomas Tschoellitsch, Tobias Wengenmayer, Anita Korsos, Alberto Fogagnolo, Gian-Reto Kleger, Maddalena A. Wu, Riccardo Colombo, Fabrizio Turrini, Antonella Potalivo, Emanuele Rezoagli, Raquel Rodríguez-García, Pedro Castro, Arantxa Lander-Azcona, Maria C. Martín-Delgado, Herminia Lozano-Gómez, Rolf Ensner, Marc P. Michot, Nadine Gehring, Peter Schott, Martin Siegemund, Lukas Merki, Jan Wiegand, Marie M. Jeitziner, Marcus Laube, Petra Salomon, Frank Hillgaertner, Alexander Dullenkopf, Hatem Ksouri, Sara Cereghetti, Serge Grazioli, Christian Bürkle, Julien Marrel, Isabelle Fleisch, Marie-Helene Perez, Anja Baltussen Weber, Samuele Ceruti, Katharina Marquardt, Tobias Hübner, Hermann Redecker, Michael Studhalter, Michael Stephan, Daniela Selz, Urs Pietsch, Anette Ristic, Antje Heise, Friederike Meyer zu Bentrup, Marilene Franchitti Laurent, Patricia Fodor, Tomislav Gaspert, Christoph Haberthuer, Elif Colak, Dorothea M. Heuberger, Thierry Fumeaux, Jonathan Montomoli, Philippe Guerci, Reto A. Schuepbach, Matthias P. Hilty, Ferran Roche-Campo, Angela Algaba-Calderon, Janina Apolo, Theodoros Aslanidis, Barna Babik, Filippo Boroli, Jan Brem, Mirko Brenni, Silvio D. Brugger, Giovanni Camen, Emanuele Catena, Roberto Ceriani, Ivan Chau, Andreas Christ, Chiara Cogliati, Pablo Concha, Gauthier Delahaye, Iris Drvaric, Jesús Escós-Orta, Silvia Fabbri, Francesca Facondini, Miodrag Filipovic, Jorge Gámez-Zapata, Peter Gerecke, Diederik Gommers, Thomas Hillermann, Can Ince, Beatrice Jenni-Moser, Marija Jovic, Geoffrey Jurkolow, Alexander Klarer, Adriana Lambert, Jean-Christophe Laurent, Jerome Lavanchy, Barbara Lienhardt-Nobbe, Pascal Locher, Marie-Reine Losser, Roger F. Lussman, Aurora Magliocca, Antoni Margarit, Alberto Martínez, Romano Mauri, Eric Mayor-Vázquez, Jens Meier, Mallory Moret-Bochatay, Martina Murrone, Didier Naon, Thomas Neff, Emmanuel Novy, Lina Petersen, Jerome Pugin, Anne-Sylvie Ramelet, Jonathan Rilinger, Peter C. Rimensberger, Michael Sepulcri, Karim Shaikh, Marianne Sieber, Maria Sole Simonini, Savino Spadaro, Govind Oliver Sridharan, Klaus Stahl, Dawid L. Staudacher, Xiana Taboada-Fraga, Adrian Tellez, Severin Urech, Giovanni Vitale, Gerardo Vizmanos-Lamotte, Tobias Welte, Begoña Zalba-Etayo, Nuria Zellweger

Open Access Research

Clinical outcomes and safety of passive leg raising in out-of-hospital cardiac arrest: a randomized controlled trial

Youcef Azeli, Alfredo Bardají, Eneko Barbería, Vanesa Lopez-Madrid, Jordi Bladé-Creixenti, Laura Fernández-Sender, Gil Bonet, Elena Rica, Susana Álvarez, Alberto Fernández, Christer Axelsson, Maria F. Jiménez-Herrera

Open Access COVID-19 Research

Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort

Saad Nseir, Ignacio Martin-Loeches, Pedro Povoa, Matthieu Metzelard, Damien Du Cheyron, Fabien Lambiotte, Fabienne Tamion, Marie Labruyere, Demosthenes Makris, Claire Boulle Geronimi, Marc Pinetonde Chambrun, Martine Nyunga, Olivier Pouly, Bruno Mégarbane, Anastasia Saade, Gemma Gomà, Eleni Magira, Jean-François Llitjos, Antoni Torres, Iliana Ioannidou, Alexandre Pierre, Luis Coelho, Jean Reignier, Denis Garot, Louis Kreitmann, Jean-Luc Baudel, Guillaume Voiriot, Damien Contou, Alexandra Beurton, Pierre Asfar, Alexandre Boyer, Arnaud W. Thille, Armand Mekontso-Dessap, Vassiliki Tsolaki, Christophe Vinsonneau, Pierre-Edouard Floch, Loïc Le Guennec, Adrian Ceccato, Antonio Artigas, Mathilde Bouchereau, Julien Labreuche, Alain Duhamel, Anahita Rouzé, Raphaël Favory, Sébastien Préau, Mercé Jourdain, Julien Poissy, Piehr Saint Leger, Thierry Van der Linden, Anne Veinstein, Elie Azoulay, Frédéric Pene, Maelle Martin, Keyvan Razazi, Gaëtan Plantefeve, Muriel Fartoukh, Didier Thevenin, Bertrand Guidet, Nicolas Weiss, Achille Kouatchet, Charlotte Salmon, Guillaume Brunin, Safaa Nemlaghi, David Meguerditchian, Laurent Argaud, Sebastian Voicu, Charles-Edouard Luyt, Benjamin Kowalski, Edgar Moglia, Luis Morales, Antonia Koutsoukou, Spyros D. Mentzelopoulos, David Nora, Sean Boyd, Julien Maizel, Pierre Cuchet, Quentin Delforge, Jean-Pierre Quenot, Déborah Boyer, Catia Cilloniz

Open Access COVID-19 Viewpoint

Tailored modulation of the inflammatory balance in COVID-19 patients admitted to the ICU?—a viewpoint

Marnix Kuindersma, Rocio Ramos Diaz, Peter E. Spronk

Open Access Editorial

Slicing and dicing ARDS: we almost forgot the lungs

Marry R. Smit, Lieuwe D. J. Bos

Open Access Research Letter

Factors associated with death in children with purpura fulminans: a French national prospective cohort study

Fouad Madhi, Naim Ouldali, Corinne Levy, Muhamed-Kheir Taha, Robert Cohen, Abdelhadi, Aberrane, Abi Warde, Abou Tara, Abrudan, Adam, Adamon, Akitani, Alba-Sauviat, Al Chaar, Albertini, Aljazayri, Aljumaidi, Allali, Allia, Al Mazini, Amama, Amara, Amira, Amirault, Andriantahina, Ansoborlo, Arlet, Armengaud, Armouche, Arnault, Asensio, Aubert, Auburtin, Audry, Aujard, Autret, Azemar, Bachelier, Badran, Bajolle, Baleine, Bandin, Banegas, Banerjee, Banige, Barbier, Bardou, Baret, Barnaud, Baron-Joly, Barrans, Barraud, Barré, Barrey, Barsotti, Barthez, Bartizel, Baruteau, Basmaci, Bassil, Battaglini, Bayle, Bednarek, Belgaid, Belivier, Bellulo, Benabdelmalek, Benchekroun, Benezech, Bengrina, Benmahammed, Benmoulai, Benoist, Benoit, Bensaid, Benseddik, Benzaim, Berche, Berrahma, Beretta-Salaun, Bergounioux, Berrahma, Berterottiere, Berthier, Bertrou, Besson-Leaud, Biendo, Biessy, Billaud, Billion, Bina, Bineau, Biran, Bitar-Obeid, Blanc, Blasquez, Blondel, Blondin, Boileau, Boivin, Boize, Bolot, Bonacorsi, Boniface, Bongo Boina, Bonnin, Boquet, Bordes, Born, Bosdure, Bosi, Bost-Bru, Bouainane, Bouderlique, Boukezia, Boulard, Bour, Bourennane, Bourgeois-Nicolaos, Boussadia, Boussicault, Boutros, Boutte, Bouvet, Bouziges, Bovero, Boyer, Branca, Branger, Bresson, Breton, Breuil, Briand, Brieu, Brizard, Brocard, Brouard, Bruna, Brunel, Bruno, Bruyas, Bucher, Bucur, Buisson-Touati, Bulteau-Cowan, Cabaret, Cadot, Caillon, Callamand, Calvez, Cambonie, Campet, Canis, Canzi, Capdeville, Carbajal, Carbonnelle, Carre, Carre-Cavellier, Carrer, Carriere, Carroger, Cartier, Cartier-Riviere, Cascarigny, Castella, Castelnau, Cathenoz, Cattoen, Cattoir, Cau, Cavalier, Cecille, Chabrol, Chace, Chaix, Chale, Chalumeau, Chalvon Demersay, Chami, Chamouilli, Chamoux, Champion, Chandesris, Chantelat, Chantepie, Chaplain, Chappet, Charachon, Charbonneau, Chardon, Charras, Chenaud, Chenel, Cheron, Cheuret, Chevallier, Chevrel, Chomienne, Chrisment, Ciupek, Clair, Claris, Cloix, Coche, Coinde, Cointin, Colin Gorski, Collignon, Colombani, Combe, Constanty, Cordier, Cormier, Corniau, Cosson, Costa, Cottin, Coumenges, Coupe, Courcol, Courdavault, Courouble, Courtade, Craiu, Crepet, Croizé, Cuzzi, D’albignac, Dagorne, Dalmon, Daltroff, Danan, Danekova, Danjean-Deguin, Danjoux, Dao-Dubremptz, Daoud, Daoudi, Darai, Darras, Dassieu, Dauger, Debriel, Dechamps, Decobert, Decoster, Decousser, Deforche, Degas, Degrange, Delacour, Delamare, Delaporte, Delarbre, Delattre, Delavelle, Delbeke, Delesalle, Deligne, Delisle, Delvart, Delorme, Deluca, Demachy, Demarcq, Demarque, Demay-Legros, Demersay, Demonchy, De Barbentane, De Champs, De Decker, De Montclos, De Mongolfier, De Pontual, Denis, De Ricaud, Desbois, Desfrere, Desprez, Dessein, Dessioux, Desvigne, Deutscher, Devictor, Deville, Devouge, Dhaoui, Dieckmann, Dit Dinard, Djafari, Djaghri, Doit, Dolfi Fiette, Dolhem, Dommergues, Dorangeon, Doucet, Doucet-Populaire, Douchain, Dubois, Dubos, Dubourdieu, Dubus, Duchaine, Duchene, Ducrocq, Dufillot, Dufour, Dugain, Dumont, Dumoulard, Dupre, Duquesne, Durand, Duthilly, Dutron, Duval, Duval Arnould, Eb, Eicher, Eitenschenck, El Hamri, Elbez, Elharrif, Elias, Emond, Enchery, Enoch, Epaud, Escarguel, Estapa, Esteve, Estournet Mathiaud, Estrangin, Etienne, Evers, Evrard, Evreux, Eyer, Eyssette-Gayraud, Ezzedine, Fabbro, Faibis, Fargeot, Farges, Farhat, Farrugia, Fasquelle, Faul, Favaretto, Faye, Feldmann, Ferey, Ferroni, Fevre, Fieschi, Fiette, Fihman, Filippi, Fischbach, Flevin, Flipo, Flurin, Forget, Fortin, Fos, Foskett, Foucaud, Franc, Francois-Chervet, Francoise, Frey, Gagliardone, Gaillard, Gallet, Gallou, Ganivala, Garandeau, Garbarg-Chenon, Garcera, Garnier, Garrec, Gaschet, Gaschignard, Gaudelus, Gauduchon, Gaugler, Gavignet, Gbadamassi, Geffroy, Gendrel, Geniez, Georget, Geraudel, Gerony-Laffitte, Gilles, Gillet, Giorgi, Girard, Gire, Girier, Glastre, Glatz, Gleize, Goguelin, Goissen, Goldstein, Goudeau, Gougeon, Goumy, Gouraud, Gouriet, Goux, Graber, Graff, Grailles, Graine, Grancher, Grando, Granier, Granry, Greco, Gremeaux, Gremillet, Gressier, Grimprel, Grise, Grollmuss, Guerin, Guibert, Guichard, Guiet, Guigonis, Guilbert, Guillaume Baudet, Guillermet Fromentin, Guillois, Guillot, Guilluy, Guitton, Guyon, Haas, Hachani, Hachart, Hachem, Haegy-Doehring, Hage, Halfatuhi, Hallage, Hallalel, Halna, Halphen, Hamdad, Haouisee, Harchaoui, Hasselmann, Hautefort, Hedjem, Hees, Heidt, Hentgen, Heraud, Herve, Heurte, Heusse, Hevin Martin, Heyman, Hidri, Hochart, Hoffmann, Hombrouck-Alet, Honore, Horea, Hubert, Hudebine, Huet, Huguet, Huin, Hureaux, Huvenne, Ikounga, Issa-Brunet, Izopet, Jacob, Jalloul, Jan, Jaouen, Jarlier, Jarreau, Jaulhac, Javouhey, Jeannoel, Jeannot, Jehan, Jensen, Jeny, Jeudy, Jokic, Joly-Guillou, Joly-Sanchez, Joram, Jorion, Julienne, Jullian, Juvin, Kalach, Kalkas, Kayal, Kayemba, Khaled, Khalfi, Khazaal, Khorsi, Kitzis, Klein, Klink, Klosowski, Kone-Paut, Kouame, Kovacs, Kozisek, Kretz, Kucerova, Kuntzel, Labarthe, Labbe, Labenne, Laborie, Labrune, Lafargue, Lafendi, Lagier, Lagree, Lahrach, Laidj, Laisney, Lakhdari, Lamarcq, Lambert, Lamoureux, Landragin, Lanotte, Lapeyre, Larchet, Laugel, Launay, Lavigne, Layadi, Lazarro, Le Bail, Le Bideau, Le Coustumier, Le Galloudec, Le Luyer, Leblanc, Leboucher, Lebrun, Lecarpentier, Lecine, Leclerc, Leclercq, Lecomte, Ledru, Lefevre, Lefrand-Crepin, Legagneur, Legros, Leheup, Lehnert, Lehours, Lejri, Lelioux, Lelorier, Leluan, Lemarié, Lemble, Lemeland, Lemonnier, Lenclen, Leneveu, Leotard, Lepage, Leret, Lesage, Lescanne, Letellier, Leturdu, Levy, Lienhardt, Lorrot, Louf, Lounis, Loznewski, Lureau, M’bamba, Maakaroun-Vermesse, Macchi, Madhi, Mager, Magrhraoui, Mahisatra, Maisonneuve, Malbrunot, Malige, Mallet, Mammeri, Mammes, Mancini, Mandjee, Mangeol, Manin, Mansir, Manteau, Marani, Marchand, Marcou, Marguet, Mariette, Marin, Marmonier, Marmouset, Marret, Martha, Martin, Martinat, Martinez Ozenda, Martinot, Marty, Mathieu, Matray, Maugard, Maurage, Maurin, May, Mazataud, Mellier, Melon, Menager, Menget, Menouar, Menouni-Foray, Merlot, Mermet Jeanvoine, Meslin, Meunier, Meyer, Mezgueldi, Micaelo, Mignard, Mignot, Mikail, Milcent, Milh, Milleret-Proyart, Mitanchez, Mondaud, Monier, Monin, Montagnon, Moquet, Morales-Gineste, Moreigne, Morice, Moriette, Morin, Morisot, Morville, Motte, Mougin-Joubert, Moulene, Moulin, Mouly, Mounzer, Mselati, Muller, Muller, Murbach, Nacer, Naudion, Naudot, Navarro, Nelson, Nerl Schiavini, Nerome, Netter, Neuwirth, Nevine, Nguyen, Nicola, Nordmann, Noulard, Nsimba, Oprea, Orzechowski, Osman, Ould Hocine, Oules, Ozanne, Pages, Paget, Palette, Pancher, Pangon, Pannecouck, Paon, Parisi Duchene, Pateyron, Patoz, Paul, Paut, Pejoan, Pellerin, Pelloux, Penaud, Penel-Capelle, Peralta, Pere, Perez, Perrin, Perroud, Pesenti, Petit, Petitboulanger, Phan, Philippon, Picherot, Pierre, Pina, Pierrejean, Pietrement, Pigeon, Pina, Pinchi, Pindi, Pinquier, Pinturier, Pladys, Planchenault, Plassart, Plasse, Plouvier, Poilane, Poilly, Pollet, Pons, Popelard, Porcheret, Poulain, Poyard, Poynard, Pradeaux, Prere, Priqueler, Prudent, Py, Queinnec, Questiaux, Quinet, Raber, Rafin, Raignoux, Raoult, Rault, Raymond, Raynaud, Rebaud, Renault, Renaud Vialet, Rennes, Renolleau, Retali, Retornaz, Rey, Reynaud, Richardin, Rimet, Rimpici, Rio, Rivaux, Riviere, Roche, Rodiere, Rolland, Romain, Romeo, Rosellini, Rossignol, Roth, Rottman, Roubin, Roudaut, Roudière, Rougeoreille, Rougier, Roullaud, Rousseau, Roussellier, Roux, Roybet, Roze, Sachs, Sadik, Sadki, Saf, Said-Menthon, Sakr, Saliba, Salomon, Sanchez, Santerne, Sanyas, Sarlangue, Sarthou, Sartre, Saumureau, Saunier, Savoy, Scanvic, Scat, Schaefer, Schneider, Seaume, Sebag, Secher, See, Sevin, Sfez, Simonin, Siouala, Sirot, Sivadon-Tardy, Smati, Smets, Sommabere, Soto, Soustelle, Spicq, Stefaniuk, Stephan, Sweertvaegher, Tahiri, Tarral, Tchanga, Terki, Texier, Therond, Thevenot, Thibault, Thiriez, Thore, Thouvenin, Tiry, Tixier, Tommasi, Toubiana, Touroult-Jupin, Tourrand, Tran, Trioche, Troller, Tronc, Trouilloud, Tuypens, Tytgat, Ursulescu, Uzan, Vachee, Vaillant, Valade, Valayer, Valensi, Vallee, Vallet, Vandenesch, Van de Perre, Vanel Contamin, Varengue, Vasselon-Raina, Vaucel, Venot, Verdan, Verdet, Vergerond, Vergnaud, Vergne, Vernet-Garnier, Vervel, Viala, Vialette, Vic, Vignaud, Vigneron, Villeneuve, Violette, Vittecoq, Vodoff, Vogt, Vorlet, Vray, Vrillon, Vu Thien, Warin, Wasels, Weber, Weisse, Wemeau, Worcel, Yang Ting, Ygout, Youssef, Ythier, Zaoui, Zarzour, Zehani, Zelinsky-Gurung, Zenkhri, Zimmermann, Zitvogel, Zumbo

Open Access Research

Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis

Josef Prazak, Irina Irincheeva, Martin J. Llewelyn, Daiana Stolz, Luis García de Guadiana Romualdo, Rolf Graf, Theresia Reding, Holger J. Klein, Philippe Eggimann, Yok-Ai Que

Open Access Viewpoint

Optimising the timing of renal replacement therapy in acute kidney injury

Matthew E. Cove, Graeme MacLaren, Daniel Brodie, John A. Kellum

Open Access Research

External validation of urinary C–C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury

Sean M. Bagshaw, Ali Al-Khafaji, Antonio Artigas, Danielle Davison, Michael Haase, Matthew Lissauer, Kai Zacharowski, Lakhmir S. Chawla, Thomas Kwan, J. Patrick Kampf, Paul McPherson, John A. Kellum

Open Access COVID-19 Research

COVID-19 ARDS is characterized by higher extravascular lung water than non-COVID-19 ARDS: the PiCCOVID study

Rui Shi, Christopher Lai, Jean-Louis Teboul, Martin Dres, Francesca Moretto, Nello De Vita, Tài Pham, Vincent Bonny, Julien Mayaux, Rosanna Vaschetto, Alexandra Beurton, Xavier Monnet

Open Access Research

Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials

Rosanna Vaschetto, Alessandro Pecere, Gavin D. Perkins, Dipesh Mistry, Gianmaria Cammarota, Federico Longhini, Miguel Ferrer, Renata Pletsch-Assunção, Michele Carron, Francesca Moretto, Haibo Qiu, Francesco Della Corte, Francesco Barone-Adesi, Paolo Navalesi

Open Access COVID-19 Research Letter

Hemofiltration with the Seraph® 100 Microbind® Affinity filter decreases SARS-CoV-2 nucleocapsid protein in critically ill COVID-19 patients

Jan T. Kielstein, Dan-Nicolae Borchina, Thomas Fühner, Soyoon Hwang, Dawn Mattoon, Andrew J. Ball

Open Access Viewpoint

Why and how to open intensive care units to family visits during the pandemic

Giovanni Mistraletti, Alberto Giannini, Giuseppe Gristina, Paolo Malacarne, Davide Mazzon, Elisabetta Cerutti, Alessandro Galazzi, Ilaria Giubbilo, Marco Vergano, Vladimiro Zagrebelsky, Luigi Riccioni, Giacomo Grasselli, Silvia Scelsi, Maurizio Cecconi, Flavia Petrini

Open Access Research

Unmatched ventilation and perfusion measured by electrical impedance tomography predicts the outcome of ARDS

Elena Spinelli, Michael Kircher, Birgit Stender, Irene Ottaviani, Maria C. Basile, Ines Marongiu, Giulia Colussi, Giacomo Grasselli, Antonio Pesenti, Tommaso Mauri

Open Access COVID-19 Letter

Timing of intubation in COVID-19: Not just location, location, location?

David A. Thomson, Gregory L. Calligaro

Open Access Research

Flow Index: a novel, non-invasive, continuous, quantitative method to evaluate patient inspiratory effort during pressure support ventilation

Filippo Albani, Luigi Pisani, Gianni Ciabatti, Federica Fusina, Barbara Buizza, Anna Granato, Valeria Lippolis, Eros Aniballi, Francesco Murgolo, Antonio Rosano, Nicola Latronico, Massimo Antonelli, Salvatore Grasso, Giuseppe Natalini

Open Access COVID-19 Research

Staphylococcus aureus ventilator-associated pneumonia in patients with COVID-19: clinical features and potential inference with lung dysbiosis

Gennaro De Pascale, Flavio De Maio, Simone Carelli, Giulia De Angelis, Margherita Cacaci, Luca Montini, Giuseppe Bello, Salvatore Lucio Cutuli, Gabriele Pintaudi, Eloisa Sofia Tanzarella, Rikardo Xhemalaj, Domenico Luca Grieco, Mario Tumbarello, Maurizio Sanguinetti, Brunella Posteraro, Massimo Antonelli

Open Access Research

Effect of intra-arrest trans-nasal evaporative cooling in out-of-hospital cardiac arrest: a pooled individual participant data analysis

Fabio Silvio Taccone, Jacob Hollenberg, Sune Forsberg, Anatolij Truhlar, Martin Jonsson, Filippo Annoni, Dan Gryth, Mattias Ringh, Jerome Cuny, Hans-Jörg Busch, Jean-Louis Vincent, Leif Svensson, Per Nordberg, Maaret Castren, Frank Eichwede, Pierre Mols, Tilmann Schwab, Michel Vergnion, Christian Storm, Antonio Pesenti, Jan Pachl, Fabien Guerisse, Thomas Elste, Markus Roessler, Harald Fritz, Pieterjan Durnez, Patrick Goldstein, Nick Vermeersch, Adeline Higuet, Francisco Carmona Jiménes, Fernando Rosell Ortiz, Julia Williams, Didier Desruelles, Jacques Creteur, Emelie Dillenbeck, Caroline Busche, David Konrad, Johan Peterson

Open Access COVID-19 Research

An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

Gianluigi Li Bassi, Jacky Y. Suen, Heidi J. Dalton, Nicole White, Sally Shrapnel, Jonathon P. Fanning, Benoit Liquet, Samuel Hinton, Aapeli Vuorinen, Gareth Booth, Jonathan E. Millar, Simon Forsyth, Mauro Panigada, John Laffey, Daniel Brodie, Eddy Fan, Antoni Torres, Davide Chiumello, Amanda Corley, Alyaa Elhazmi, Carol Hodgson, Shingo Ichiba, Carlos Luna, Srinivas Murthy, Alistair Nichol, Pauline Yeung Ng, Mark Ogino, Antonio Pesenti, Huynh Trung Trieu, John F. Fraser, Tala Al-Dabbous, Huda Alfoudri, Mohammed Shamsah, Subbarao Elapavaluru, Ashley Berg, Christina Horn, Stephan Schroll, Jorge Velazco, Wanda Fikes, Ludmyla Ploskanych, Dan Meyer, Maysoon Shalabi-McGuire, Trent Witt, Ashley Ehlers, Lorenzo Grazioli, E. Wilson Grandin, Jose Nunez, Tiago Reyes, Mark Joseph, Brook Mitchell, Martha Tenzer, Ryuzo Abe, Yosuke Hayashi, Hwa Jin Cho, In Seok Jeong, Nicolas Brozzi, Jaime Hernandez-Montfort, Omar Mehkri, Stuart Houltham, Jerónimo Graf, Rodrigo Perez, Roderigo Diaz, Camila Delgado, Joyce González, Maria Soledad Sanchez, Diego Fernando Bautista Rincón, Melissa Bustamante Duque, Angela Maria Marulanda Yanten, Dan Brodie, Desy Rusmawatiningtyas, Gabrielle Ragazzo, Azhari Taufik, Margaretha Gunawan, Vera Irawany, Muhammad Rayhan, Elizabeth Yasmin Wardoyo, Mauro Panigada, Silvia Coppola, Sebastiano Colombo, Giacomo Grasselli, Michela Leone, Alberto Zanella, Massimo Antonelli, Simone Carelli, Domenico L. Grieco, Motohiro Asaki, Kota Hoshino, Leonardo Salazar, Laura Duarte, Joseph McCaffrey, Allison Bone, David Thomson, Christel Arnold-Day, Jerome Cupido, Zainap Fanie, Malcom Miller, Lisa Seymore, Dawid van Straaten, Ibrahim Hassan, Ali Ait Hssain, Jeffrey Aliudin, Al-Reem Alqahtani, Khoulod Mohamed, Ahmed Mohamed, Darwin Tan, Joy Villanueva, Ahmed Zaqout, Ethan Kurtzman, Arben Ademi, Ana Dobrita, Khadija El Aoudi, Juliet Segura, Gezy Giwangkancana, Shinichiro Ohshimo, Koji Hoshino, Saito Hitoshi, Yuka Uchinami, Javier Osatnik, Anne Joosten, Antoni Torres, Ana Motos, Minlan Yang, Carlos Luna, Francisco Arancibia, Virginie Williams, Alexandre Noel, Nestor Luque, Trieu Huynh Trung, Sophie Yacoub, Marina Fantini, Ruth Noemi Jorge García, Enrique Chicote Alvarez, Anna Greti, Oscar Lomeli, Adrian Ceccato, Angel Sanchez, Ana Loza Vazquez, Ferran Roche-Campo, Divina Tuazon, Toni Duculan, Hiroaki Shimizu, Marcelo Amato, Luciana Cassimiro, Flavio Pola, Francis Ribeiro, Guilherme Fonseca, Heidi Dalton, Mehul Desai, Erik Osborn, Hala Deeb, Antonio Arcadipane, Claudia Bianco, Raffaele Cuffaro, Gennaro Martucci, Giovanna Occhipinti, Matteo Rossetti, Chiara Vitiello, Sung-Min Cho, Kate Calligy, Glenn Whitman, Hiroaki Shimizu, Naoki Moriyama, Jae-Burm Kim, Nobuya Kitamura, Takashi Shimazui, Abdullah Al-Hudaib, Alyaa Elhazmi, Johannes Gebauer, Toshiki Yokoyama, Abdulrahman Al-Fares, Esam Alamad, Fatma Alawadhi, Kalthoum Alawadi, Sarah Buabbas, Hiro Tanaka, Satoru Hashimoto, Masaki Yamazaki, Tak-Hyuck Oh, Mark Epler, Cathleen Forney, Jared Feister, Katherine Grobengieser, Louise Kruse, Joelle Williamson, Eric Gnall, Mara Caroline, Sasha Golden, Colleen Karaj, Sherry McDermott, Lynn Sher, Timothy Shapiro, Lisa Thome, Mark Vanderland, Mary Welch, Luca Brazzi, Tawnya Ogston, Dave Nagpal, Karlee Fischer, Roberto Lorusso, Maria de Piero, Mariano Esperatti, Diarmuid O’Briain, Edmund G. Carton, Ayan Sen, Amanda Palacios, Deborah Rainey, Cassandra Seefeldt, Lucia Durham, Octavio Falcucci, Amanda Emmrich, Jennifer Guy, Carling Johns, Emily Neumann, Nina Buchtele, Michael Schwameis, Stephanie-Susanne Stecher, Delila Singh, Michaela Barnikel, Lukas Arenz, Akram Zaaqoq, Lan Anh Galloway, Caitlin Merley, Marc Csete, Luisa Quesada, Isabela Saba, Daisuke Kasugai, Hiroaki Hiraiwa, Taku Tanaka, Eva Marwali, Yoel Purnama, Santi Rahayu Dewayanti, Ardiyan, Debby Siagian, Yih-Sharng Chen, John Laffey, Bairbre McNicholas, David Cosgrave, Marlice VanDyk, Sarah MacDonald, Ian Seppelt, Indrek Ratsep, Lauri Enneveer, Kristo Erikson, Getter Oigus, Andra-Maris Post, Piret Sillaots, Frank Manetta, Mamoru Komats, S. Veena Satyapriya, Amar Bhatt, Marco Echeverria, Juan Fiorda, Alicia Gonzalez, Nahush A. Mokadam, Johnny McKeown, Joshua Pasek, Haixia Shi, Alberto Uribe, Rita Moreno, Bishoy Zakhary, Hannah Johnson, Nolan Pow, Marco Cavana, Alberto Cucino, Giuseppe Foti, Marco Giani, Vincenzo Russotto, Davide Chiumello, Valentina Castagna, Andrea Dell’Amore, Hoi-Ping Shum, Alain Vuysteke, Asad Usman, Andrew Acker, Blake Mergler, Nicolas Rizer, Federico Sertic, Benjamin Smood, Alexandra Sperry, Madhu Subramanian, Navy Lolong, Ernita Akmal, Erlina Burhan, Menaldi Rasmin, Bhat Naivedh, Faya Sitompu, Peter Barrett, Julia Daugherty, David Dean, Antonio Loforte, Irfan Khan, Olivia DeSantis, Mohammed Abraar Quraishi, Gavin Salt, Dominic So, Darshana Kandamby, Jose M. Mandei, Hans Natanael, Eka YudhaLantang, Anastasia Lantang, Anna Jung, Terese Hammond, George Ng, Wing Yiu Ng, Pauline Yeung, Shingo Adachi, Pablo Blanco, Ana Prieto, Jesús Sánchez, Meghan Nicholson, Michael Farquharson, Warwick Butt, Alyssa Serratore, Carmel Delzoppo, Pierre Janin, Elizabeth Yarad, Richard Totaro, Jennifer Coles, Robert Balk, Samuel Fox, James Hays, Esha Kapania, Pavel Mishin, Andy Vissing, Garrett Yantosh, Saptadi Yuliarto, Kohar Hari Santoso, Susanthy Djajalaksana, Arie Zainul Fatoni, Masahiro Fukuda, Keibun Liu, Paolo Pelosi, Denise Battaglini, Juan Fernando Masa Jiménez, Sérgio Gaião, Roberto Roncon-Albuquerque, Jessica Buchner, Young-Jae Cho, Sang Min Lee, Su Hwan Lee, Tatsuya Kawasaki, Pranya Sakiyalak, Prompak Nitayavardhana, Tamara Seitz, Rakesh Arora, David Kent, Swapnil Parwar, Andrew Cheng, Jennene Miller, Daniel Marino, Jillian E. Deacon, Shigeki Fujitani, Naoki Shimizu, Jai Madhok, Clark Owyang, Hergen Buscher, Claire Reynolds, Olavi Maasikas, Aleksandr Beljantsev, Vladislav Mihnovits, Takako Akimoto, Mariko Aizawa, Kanako Horibe, Ryota Onodera, Carol Hodgson, Meredith Young, Timothy Smith, Cheryl Bartone, Timothy George, Kiran Shekar, Niki McGuinness, Lacey Irvine, Brigid Flynn, Abigail Houchin, Keiki Shimizu, Jun Hamaguchi, Leslie Lussier, Grace Kersker, John Adam Reich, Gösta Lotz, Maximilian Malfertheiner, Esther Dreier, Lars Maier, Neurinda Permata Kusumastuti, Colin McCloskey, Al-Awwab Dabaliz, Tarek B. Elshazly, Josiah Smith, Konstanty S. Szuldrzynski, Piotr Bielański, Yusuff Hakeem, Keith Wille, Rebecca Holt, Ken Kuljit S. Parhar, Kirsten M. Fiest, Cassidy Codan, Anmol Shahid, Mohamed Fayed, Timothy Evans, Rebekah Garcia, Ashley Gutierrez, Hiroaki Shimizu, Tae Song, Rebecca Rose, Suzanne Bennett, Denise Richardson, Giles Peek, Dalia Lopez-Colon, Lovkesh Arora, Kristina Rappapport, Kristina Rudolph, Zita Sibenaller, Lori Stout, Alicia Walter, Daniel Herr, Nazli Vedadi, Lace Sindt, Cale Ewald, Julie Hoffman, Sean Rajnic, Shaun Thompson, Ryan Kennedy, Matthew Griffee, Anna Ciullo, Yuri Kida, Ricard Ferrer Roca, Cynthia Alegre, Sofia Contreras, JordI Riera, Christy Kay, Irene Fischer, Elizabeth Renner, Hayato Taniguci, Gabriella Abbate, Halah Hassan, Silver Heinsar, Varun A. Karnik, Katrina Ki, Hollier F. O’Neill, Nchafatso Obonyo, Leticia Pretti Pimenta, Janice D. Reid, Kei Sato, Kiran Shekar, Aapeli Vuorinen, Karin S. Wildi, Emily S. Wood, Stephanie Yerkovich

Open Access Letter

Proportional assist ventilation versus pressure support ventilation for weaning from mechanical ventilation in adults: weaning success and mortality

Ioannis Pantazopoulos, Georgios Mavrovounis, Maria Mermiri, Christos Kampolis

Open Access Research

Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup

Josée Bouchard, Greene Shepherd, Robert S. Hoffman, Sophie Gosselin, Darren M. Roberts, Yi Li, Thomas D. Nolin, Valéry Lavergne, Marc Ghannoum, Josée Bouchard, Greene Shepherd, Robert S. Hoffman, Sophie Gosselin, Darren M. Roberts, Yi Li, Thomas D. Nolin, Valéry Lavergne, Marc Ghannoum, Badria Alhatali, Kurt Anseeuw, Steven Bird, Ingrid Berling, Timothy E Bunchman, Diane P Calello, Paul K Chin, Kent Doi, Tais Galvao, David S Goldfarb, Hossein Hassanian-Moghaddam, Lotte CG Hoegberg, Siba Kallab, Sofia Kebede, Jan T Kielstein, Andrew Lewington, Etienne M Macedo, Rob MacLaren, Bruno Megarbane, James B Mowry, Thomas D Nolin, Marlies E Ostermann, Ai Peng, Jean-Philippe Roy, Anitha Vijayan, Steven J Walsh, Anselm Wong, David M Wood, Christopher Yates

Open Access COVID-19 Research

Comparison of renal histopathology and gene expression profiles between severe COVID-19 and bacterial sepsis in critically ill patients

Meint Volbeda, Daniela Jou-Valencia, Marius C. van den Heuvel, Marjolein Knoester, Peter J. Zwiers, Janesh Pillay, Stefan P. Berger, Peter H. J. van der Voort, Jan G. Zijlstra, Matijs van Meurs, Jill Moser

Open Access Editorial

Palliative, palliative or palliative?

René Robert, Michel Goldberg

Open Access Research

Feasibility of achieving different protein targets using a hypocaloric high-protein enteral formula in critically ill patients

Pierre Singer, Itai Bendavid, Ilana BenArie, Liran Stadlander, Ilya Kagan

Open Access Research

Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery

Antonio Messina, Chiara Robba, Lorenzo Calabrò, Daniel Zambelli, Francesca Iannuzzi, Edoardo Molinari, Silvia Scarano, Denise Battaglini, Marta Baggiani, Giacomo De Mattei, Laura Saderi, Giovanni Sotgiu, Paolo Pelosi, Maurizio Cecconi

Open Access COVID-19 Research Letter

Predictors of weaning from helmet CPAP in patients with COVID-19 pneumonia

Dejan Radovanovic, Stefano Pini, Marina Saad, Luca Perotto, Fabio Giuliani, Pierachille Santus

Open Access COVID-19 Research

Breath-holding as a novel approach to risk stratification in COVID-19

Ludovico Messineo, Elisa Perger, Luciano Corda, Simon A. Joosten, Francesco Fanfulla, Leonardo Pedroni, Philip I. Terrill, Carolina Lombardi, Andrew Wellman, Garun S. Hamilton, Atul Malhotra, Guido Vailati, Gianfranco Parati, Scott A. Sands

Open Access COVID-19 Research

Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial

Jacob Rosén, Erik von Oelreich, Diddi Fors, Malin Jonsson Fagerlund, Knut Taxbro, Paul Skorup, Ludvig Eby, Francesca Campoccia Jalde, Niclas Johansson, Gustav Bergström, Peter Frykholm, Anna Gradin, Mustafa Ali, Ulrica Lennborn, Darko Bogdanovic, Andreas Roos, Matilda Modie, Julia Giesecke

Open Access Letter

Anti-Xa activity and hemorrhagic event: isn’t it time to consider time ?

Sébastien Redant, Xavier Beretta-Piccoli, Patrick M. Honore, David De Bels, Dominique Biarent

Open Access COVID-19 Research

Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis

Kollengode Ramanathan, Kiran Shekar, Ryan Ruiyang Ling, Ryan P. Barbaro, Suei Nee Wong, Chuen Seng Tan, Bram Rochwerg, Shannon M. Fernando, Shinhiro Takeda, Graeme MacLaren, Eddy Fan, Daniel Brodie

Open Access COVID-19 Research

Serum uric acid, disease severity and outcomes in COVID-19

Inès Dufour, Alexis Werion, Leila Belkhir, Anastazja Wisniewska, Marie Perrot, Julien De Greef, Gregory Schmit, Jean Cyr Yombi, Xavier Wittebole, Pierre-François Laterre, Michel Jadoul, Ludovic Gérard, Johann Morelle, Christophe Beauloye, Christine Collienne, Mélanie Dechamps, Florence Dupriez, Philippe Hantson, Luc-Marie Jacquet, Benoit Kabamba, Fatima Larbaoui, Virginie Montiel, Andrea Penaloza, Lucie Pothen, Hector Rodriguez-Villalobos, Anais Scohy, Maximilien Thoma, Olivier Van Caeneghem, Halil Yildiz

Open Access Research Letter

A systemic ultrasound positioning protocol for nasointestinal tube in critically ill patients

Ruizhong Ye, Xuping Cheng, Huihui Chai, Chengzhong Peng, Jingquan Liu, Jiyong Jing

Open Access COVID-19 Research

Lung distribution of gas and blood volume in critically ill COVID-19 patients: a quantitative dual-energy computed tomography study

Lorenzo Ball, Chiara Robba, Jacob Herrmann, Sarah E. Gerard, Yi Xin, Maura Mandelli, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Giulio Bovio, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia R. M. Rocco, Maurizio Cereda, Rahim R. Rizi, Lucio Castellan, Nicolò Patroniti, Paolo Pelosi, Mattia Bixio, Angelo Gratarola, Paolo Frisoni, Maurizio Loconte, Alexandre Molin, Giulia Orefice, Elena Ciaravolo, Federico Costantino, Dario Battioni, Gerolama Buconte, Alessandro Casaleggio, Giuseppe Cittadini, Luca Dogliotti, Veronica Giasotto, Sara Perissi, Maria Pigati, Elena Santacroce, Federico Zaottini, Chiara Dentone, Lucia Taramasso, Laura Magnasco, Matilde Bastianello

Open Access Research

SARS-COV-2 colonizes coronary thrombus and impairs heart microcirculation bed in asymptomatic SARS-CoV-2 positive subjects with acute myocardial infarction

Raffaele Marfella, Pasquale Paolisso, Celestino Sardu, Luciana Palomba, Nunzia D’Onofrio, Arturo Cesaro, Michelangela Barbieri, Maria Rosaria Rizzo, Ferdinando Carlo Sasso, Lucia Scisciola, Fabrizio Turriziani, Massimiliano Galdiero, Danilo Pignataro, Fabio Minicucci, Maria Consiglia Trotta, Michele D’Amico, Ciro Mauro, Paolo Calabrò, Maria Luisa Balestrieri, Giuseppe Signioriello, Emanuele Barbato, Marilena Galdiero, Giuseppe Paolisso

Open Access COVID-19 Research Letter

Psychological evaluation and support in COVID-19 critically ill patients: a feasibility study

Renaud Prével, Julien Coelho, Arthur Orieux, Pierre Philip, Didier Gruson, Stéphanie Bioulac

Open Access Research

Diaphragm thickening fraction predicts noninvasive ventilation outcome: a preliminary physiological study

Giovanna Mercurio, Sonia D’Arrigo, Rossana Moroni, Domenico Luca Grieco, Luca Salvatore Menga, Anna Romano, Maria Giuseppina Annetta, Maria Grazia Bocci, Davide Eleuteri, Giuseppe Bello, Luca Montini, Mariano Alberto Pennisi, Giorgio Conti, Massimo Antonelli

Open Access Research Letter

Evaluation of right ventricular function and driving pressure with blood gas analysis could better select patients eligible for VV ECMO in severe ARDS

Matthieu Petit, Armand Mekontso-Dessap, Paul Masi, Annick Legras, Philippe Vignon, Antoine Vieillard-Baron

Open Access Research

Non-invasive ventilation versus high-flow nasal oxygen for postextubation respiratory failure in ICU: a post-hoc analysis of a randomized clinical trial

Arnaud W. Thille, Grégoire Monseau, Rémi Coudroy, Mai-Anh Nay, Arnaud Gacouin, Maxens Decavèle, Romain Sonneville, François Beloncle, Christophe Girault, Laurence Dangers, Alexandre Lautrette, Quentin Levrat, Anahita Rouzé, Emmanuel Vivier, Jean-Baptiste Lascarrou, Jean-Damien Ricard, Keyvan Razazi, Guillaume Barberet, Christine Lebert, Stephan Ehrmann, Alexandre Massri, Jeremy Bourenne, Gael Pradel, Pierre Bailly, Nicolas Terzi, Jean Dellamonica, Guillaume Lacave, René Robert, Stéphanie Ragot, Jean-Pierre Frat, Florence Boissier, Delphine Chatellier, Céline Deletage, Carole Guignon, Florent Joly, Morgane Olivry, Anne Veinstein, Dalila Benzekri-Lefevre, Thierry Boulain, Grégoire Muller, Yves Le Tulzo, Jean-Marc Tadié, Adel Maamar, Suela Demiri, Julien Mayaux, Alexandre Demoule, Lila Bouadma, Claire Dupuis, Pierre Asfar, Marc Pierrot, Gaëtan Béduneau, Déborah Boyer, Benjamin Delmas, Bérénice Puech, Konstantinos Bachoumas, Edouard Soum, Séverin Cabasson, Marie-Anne Hoppe, Saad Nseir, Olivier Pouly, Gaël Bourdin, Sylvène Rosselli, Anthony Le Meur, Charlotte Garret, Maelle Martin, Guillaume Berquier, Abirami Thiagarajah, Guillaume Carteaux, Armand Mekontso-Dessap, Antoine Poidevin, Anne-Florence Dureau, Marie-Ange Azais, Gwenhaël Colin, Emmanuelle Mercier, Marlène Morisseau, Caroline Sabatier, Walter Picard, Marc Gainnier, Thi-My-Hue Nguyen, Gwenaël Prat, Carole Schwebel, Matthieu Buscot

Open Access Research

Neurally adjusted ventilatory assist as a weaning mode for adults with invasive mechanical ventilation: a systematic review and meta-analysis

Xueyan Yuan, Xinxing Lu, Yali Chao, Jennifer Beck, Christer Sinderby, Jianfeng Xie, Yi Yang, Haibo Qiu, Ling Liu

Open Access COVID-19 Research

Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study

Khalid Al Sulaiman, Ohoud Aljuhani, Maram Al Dossari, Asma Alshahrani, Aisha Alharbi, Rahmah Algarni, Majed Al Jeraisy, Shmeylan Al Harbi, Abdulmalik Al Katheri, Fahad Al Eidan, Abdulkareem M. Al Bekairy, Nouf Al Qahtani, Mashael Al Muqrin, Ramesh Vishwakarma, Ghassan Al Ghamdi

Open Access COVID-19 Research

Timing and causes of death in severe COVID-19 patients

Charles de Roquetaillade, Swann Bredin, Jean-Baptiste Lascarrou, Thibaud Soumagne, Mariana Cojocaru, Benjamin Glenn Chousterman, Maxime Leclerc, Albin Gouhier, Gaël Piton, Frédéric Pène, Annabelle Stoclin, Jean-François Llitjos

Open Access Research

Increased time from physiological derangement to critical care admission associates with mortality

Stephen F. Whebell, Emma J. Prower, Joe Zhang, Megan Pontin, David Grant, Andrew T. Jones, Guy W. Glover

Open Access Research

Monocyte distribution width (MDW) performance as an early sepsis indicator in the emergency department: comparison with CRP and procalcitonin in a multicenter international European prospective study

Pierre Hausfater, Neus Robert Boter, Cristian Morales Indiano, Marta Cancella de Abreu, Adria Mendoza Marin, Julie Pernet, Dolores Quesada, Iris Castro, Diana Careaga, Michel Arock, Liliana Tejidor, Laetitia Velly

Open Access Letter

Success rate of naso-jejunal tube placement influenced by CRRT: possible removal of metoclopramide

Patrick M. Honore, Sebastien Redant, Thierry Preseau, Sofie Moorthamers, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Evolution of inspiratory muscle function in children during mechanical ventilation

Benjamin Crulli, Atsushi Kawaguchi, Jean-Paul Praud, Basil J. Petrof, Karen Harrington, Guillaume Emeriaud

Open Access Research

Early individualized positive end-expiratory pressure guided by electrical impedance tomography in acute respiratory distress syndrome: a randomized controlled clinical trial

Huaiwu He, Yi Chi, Yingying Yang, Siyi Yuan, Yun Long, Pengyu Zhao, Inéz Frerichs, Feng Fu, Knut Möller, Zhanqi Zhao

Open Access Research

Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study

Jakub Fronczek, Kamil Polok, Dylan W. de Lange, Christian Jung, Michael Beil, Andrew Rhodes, Jesper Fjølner, Jacek Górka, Finn H. Andersen, Antonio Artigas, Maurizio Cecconi, Steffen Christensen, Michael Joannidis, Susannah Leaver, Brian Marsh, Alessandro Morandi, Rui Moreno, Sandra Oeyen, Christina Agvald-Öhman, Bernardo Bollen Pinto, Joerg C. Schefold, Andreas Valentin, Sten Walther, Ximena Watson, Tilemachos Zafeiridis, Sigal Sviri, Peter Vernon van Heerden, Hans Flaatten, Bertrand Guidet, Wojciech Szczeklik, R. Schmutz, F. Wimmer, P. Eller, M. Joannidis, P. De Buysscher, N. De Neve, S. Oeyen, W. Swinnen, B. Bollen Pinto, P. Abraham, L. Hergafi, J. C. Schefold, E. Biskup, P. Piza, I. Taliadoros, J. Fjølner, N. Dey, C. Sølling, B. S. Rasmussen, S. Christensen, X. Forceville, G. Besch, H. Mentec, P. Michel, P. Mateu, P. Michel, L. Vettoretti, J. Bourenne, N. Marin, M. Guillot, N. Aissaoui, C. Goulenok, N. Thieulot-Rolin, J. Messika, L. Lamhaut, B. Guidet, C. Charron, A. Lauten, A. L. Sacher, T. Brenner, M. Franz, F. Bloos, H. Ebelt, S. J. Schaller, K. Fuest, C. Rabe, T. Dieck, S. Steiner, T. Graf, A. M. Nia, C. Jung, R. A. Janosi, P. Meybohm, P. Simon, S. Utzolino, T. Rahmel, E. Barth, C. Jung, M. Schuster, Z. Aidoni, S. Aloizos, P. Tasioudis, K. Lampiri, V. Zisopoulou, I. Ravani, E. Pagaki, A. Antoniou, T. A. Katsoulas, A. Kounougeri, G. Marinakis, F. Tsimpoukas, A. Spyropoulou, P. Zygoulis, A. Kyparissi, M. Gupta, M. Gurjar, I. M. Maji, I. Hayes, B. Marsh, Y. Kelly, A. Westbrook, G. Fitzpatrick, D. Maheshwari, C. Motherway, G. Negri, S. Spadaro, G. Nattino, M. Pedeferri, A. Boscolo, S. Rossi, G. Calicchio, L. Cubattoli, G. Di Lascio, M. Barbagallo, F. Berruto, D. Codazzi, A. Bottazzi, P. Fumagalli, G. Negro, G. Lupi, F. Savelli, G. A. Vulcano, R. Fumagalli, A. Marudi, U. Lefons, R. Lembo, M. Babini, A. Paggioro, V. Parrini, M. Zaccaria, S. Clementi, C. Gigliuto, F. Facondini, S. Pastorini, S. Munaron, I. Calamai, A. Bocchi, A. Adorni, M. G. Bocci, A. Cortegiani, T. Casalicchio, S. Mellea, E. Graziani, M. Barattini, E. Brizio, M. Rossi, M. Hahn, H. Flaatten, N. Kemmerer, H. F. Strietzel, K. Dybwik, T. Legernaes, P. Klepstad, E. B. Olaussen, K. I. Olsen, O. M. Brresen, G. Bjorsvik, F. H. Andersen, S. Maini, L. Fehrle, M. Czuczwar, P. Krawczyk, M. Ziętkiewicz, Ł. R. Nowak, K. Kotfis, K. Cwyl, R. Gajdosz, J. Biernawska, R. Bohatyrewicz, R. Gawda, P. Grudzień, P. Nasiłowski, N. Popek, W. Cyrankiewicz, K. Wawrzyniak, M. Wnuk, D. Maciejewski, D. Studzińska, M. Żukowski, S. Bernas, M. Piechota, W. Szczeklik, I. Nowak-Kózka, J. Fronczek, M. Serwa, W. Machała, J. Stefaniak, M. Wujtewicz, P. Maciejewski, M. Szymkowiak, B. Adamik, K. Polok, J. Górka, N. Catorze, M. C. Branco, N. Barros, I. Barros, A. Krystopchuk, T. Honrado, C. Sousa, F. Munoz, M. Rebelo, R. Gomes, J. Nunes, C. Dias, A. M. Fernandes, C. Petrisor, B. Constantin, V. Belskiy, B. Boskholov, E. Rodriguez, G. Aguilar, G. Masdeu, M. I. Jaimes, A. P. Mira, M. A. Bodi, J. A. B. Mendoza, S. López-Cuenca, M. H. Guzman, J. Rico-Feijoo, M. Ibarz, J. Trenado Alvarez, R. Kawati, J. Sivik, J. Nauska, D. Smole, F. Parenmark, J. Lyrén, K. Rockstroh, S. Rydén, M. Spångfors, M. Strinnholm, S. Walther, L. De Geer, P. Nordlund, S. Pålsson, H. Zetterquist, A. Nilsson, K. Thiringer, M. Jungner, B. Bark, B. Nordling, H. Sköld, C. Brorsson, S. Persson, A. Bergström, J. Berkius, J. Holmström, I. van Dijk, L. E. M. van Lelyveld-Haas, T. Jansen, F. Nooteboom, P. H. J. van der Voort, D. de Lange, W. Dieperink, M. C. de Waard, A. G. E. de Smet, L. Bormans, T. Dormans, G. Dempsey, S. J. Mathew, A. S. Raj, I. Grecu, J. Cupitt, T. Lawton, R. Clark, M. Popescu, N. Spittle, M. Faulkner, A. Cowton, P. Williams, E. Elloway, M. Reay, S. Chukkambotla, R. Kumar, N. Al-Subaie, L. Kent, T. Tamm, I. Kajtor, K. Burns, R. Pugh, M. Ostermann, E. Kam, H. Bowyer, N. Smith, M. Templeton, J. Henning, K. Goffin, R. Kapoor, S. Laha, P. Chilton, W. Khaliq, A. Crayford, S. Coetzee, M. Tait, W. Stoker, M. Gimenez, A. Pope, J. Camsooksai, D. Pogson, K. Quigley, J. Ritzema, A. Hormis, C. Boulanger, M. Balasubramaniam, L. Vamplew, K. Burt, D. Martin, I. Grecu, J. Craig, J. Prowle, N. Doyle, J. Shelton, C. Scott, P. Donnison, S. Shelton, C. Frey, C. Ryan, D. Spray, C. Ryan, V. Barnes, K. Barnes, S. Ridgway, R. Saha, L. Kent, T. Clark, J. Wood, C. Bolger, C. Bassford, A. Cowton, J. Lewandowski, X. Zhao, S. Humphreys, S. Dowling, N. Richardson, A. Burtenshaw, C. Stevenson, D. Wilcock, Y. Nalapko, M. Joannidis, P. Eller, R. Helbok, R. Schmutz, J. Nollet, N. de Neve, P. De Buysscher, S. Oeyen, W. Swinnen, M. Mikačić, A. Bastiansen, A. Husted, B. E. S. Dahle, C. Cramer, C. Sølling, D. Ørsnes, J. Edelberg Thomsen, J. J. Pedersen, M. Hummelmose Enevoldsen, T. Elkmann, A. Kubisz-Pudelko, A. Pope, A. Collins, A. S. Raj, C. Boulanger, C. Frey, C. Hart, C. Bolger, D. Spray, G. Randell, H. Filipe, I. D. Welters, I. Grecu, J. Evans, J. Cupitt, J. Lord, J. Henning, J. Jones, J. Ball, J. North, K. Salaunkey, L. Ortiz-Ruiz De Gordoa, L. Bell, M. Balasubramaniam, M. Vizcaychipi, M. Faulkner, M. Mupudzi, M. Lea-Hagerty, M. Reay, M. Spivey, N. Love, N. Spittle, N. White, P. Williams, P. Morgan, P. Wakefield, R. Savine, R. Jacob, R. Innes, R. Kapoor, S. Humphreys, S. Rose, S. Dowling, S. Leaver, T. Mane, T. Lawton, V. Ogbeide, W. Khaliq, Y. Baird, A. Romen, A. Galbois, B. Guidet, C. Vinsonneau, C. Charron, D. Thevenin, E. Guerot, G. Besch, G. Savary, H. Mentec, J. L. Chagnon, J. P. Rigaud, J. P. Quenot, J. Castaneray, J. Rosman, J. Maizel, K. Tiercelet, L. Vettoretti, M. M. Hovaere, M. Messika, M. Djibré, N. Rolin, P. Burtin, P. Garcon, S. Nseir, X. Valette, C. Rabe, E. Barth, H. Ebelt, K. Fuest, M. Franz, M. Horacek, M. Schuster, P. Meybohm, R. Romano Bruno, S. Allgäuer, S. Dubler, S. J. Schaller, S. Schering, S. Steiner, T. Dieck, T. Rahmel, T. Graf, A. Koutsikou, A. Vakalos, B. Raitsiou, E. N. Flioni, E. Neou, F. Tsimpoukas, G. Papathanakos, G. Marinakis, I. Koutsodimitropoulos, K. Aikaterini, N. Rovina, S. Kourelea, T. Polychronis, V. Zidianakis, V. Konstantinia, Z. Aidoni, B. Marsh, C. Motherway, C. Read, I. Martin-Loeches, A. Neville Cracchiolo, A. Morigi, I. Calamai, S. Brusa, A. Elhadi, A. Tarek, A. Khaled, H. Ahmed, W. Ali Belkhair, A. D. Cornet, D. Gommers, D. de Lange, E. van Boven, J. Haringman, L. Haas, L. van den Berg, O. Hoiting, P. de Jager, R. T. Gerritsen, T. Dormans, W. Dieperink, A. Breidablik, A. Slapgard, A. K. Rime, B. Jannestad, B. Sjøbøe, E. Rice, F. H. Andersen, H. F. Strietzel, J. P. Jensen, J. Langørgen, K. Tøien, K. Strand, M. Hahn, P. Klepstad, A. Biernacka, A. Kluzik, B. Kudlinski, D. Maciejewski, D. Studzińska, H. Hymczak, J. Stefaniak, J. Solek-Pastuszka, J. Zorska, K. Cwyl, Ł. J. Krzych, M. Zukowski, M. Lipińska-Gediga, M. Pietruszko, M. Piechota, M. Serwa, M. Czuczwar, M. Ziętkiewicz, N. Kozera, P. Nasiłowski, P. Sendur, P. Zatorski, P. Galkin, R. Gawda, U. Kościuczuk, W. Cyrankiewicz, W. Gola, A. F. Pinto, A. M. Fernandes, A. R. Santos, C. Sousa, I. Barros, I. A. Ferreira, J. B. Blanco, J. T. Carvalho, J. Maia, N. Candeias, N. Catorze, V. Belskiy, A. Lores, A. P. Mira, C. Cilloniz, D. Perez-Torres, E. Maseda, E. Rodriguez, E. Prol-Silva, G. Eixarch, G. Gomà, G. Aguilar, G. Navarro Velasco, M. Irazábal Jaimes, M. Ibarz Villamayor, N. Llamas Fernández, P. Jimeno Cubero, S. López-Cuenca, T. Tomasa, A. Sjöqvist, C. Brorsson, F. Schiöler, H. Westberg, J. Nauska, J. Sivik, J. Berkius, K. Kleiven Thiringer, L. De Geer, S. Walther, F. Boroli, J. C. Schefold, L. Hergafi, P. Eckert, I. Yıldız, I. Yovenko, Y. Nalapko, R. Pugh

Open Access Letter

Bedside voluntary and evoked forces evaluation in intensive care unit patients, not only force evaluation: a letter to the Editor

Paulo Eugênio Silva, João Luiz Quaglioti Durigan, Nicolas Babault

Open Access Research

The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019

Runzhi Huang, Tong Meng, Qiongfang Zha, Kebin Cheng, Xin Zhou, Junhua Zheng, Dingyu Zhang, Ruilin Liu

Open Access COVID-19 Research Letter

Risk factors and outcomes of ventilator-associated pneumonia in COVID-19 patients: a propensity score matched analysis

María Martínez-Martínez, Erika P. Plata-Menchaca, Francesc X. Nuvials, Oriol Roca, Ricard Ferrer

Open Access COVID-19 Review

Infectious disease-associated encephalopathies

Maria C. Barbosa-Silva, Maiara N. Lima, Denise Battaglini, Chiara Robba, Paolo Pelosi, Patricia R. M. Rocco, Tatiana Maron-Gutierrez

Open Access COVID-19 Letter

The chicken or the egg: low testosterone predisposes for COVID-19 or COVID-19 induces a decrease in testosterone?

Roeland F. Stolk, Henk J. van Leeuwen, Matthijs Kox, Marcel van Borren, Hans de Boer, Peter Pickkers

Open Access Research

Tracheostomy management in patients with severe acute respiratory distress syndrome receiving extracorporeal membrane oxygenation: an International Multicenter Retrospective Study

Matthieu Schmidt, Christoph Fisser, Gennaro Martucci, Darryl Abrams, Thomas Frapard, Konstantin Popugaev, Antonio Arcadipane, Bianca Bromberger, Giovanni Lino, Alexis Serra, Sacha Rozencwajg, Matthias Lubnow, Sergey Petrikov, Thomas Mueller, Alain Combes, Tài Pham, Daniel Brodie

Open Access Editorial

Gender imbalance in intensive care: High time for action and evaluation!

Caroline Hauw-Berlemont, Charlotte Salmon Gandonnière, Florence Boissier, Nadia Aissaoui, Laetitia Bodet-Contentin, Muriel Sarah Fartoukh, Mercedes Jourdain, Julien Le Marec, Fabienne Tamion, Olfa Hamzaoui, Cécile Aubron, Caroline Hauw-Berlemont, Charlotte Salmon Gandonnière, Florence Boissier, Nadia Aissaoui, Laetitia Bodet-Contentin, Muriel Sarah Fartoukh, Mercedes Jourdain, Julien Le Marec, Fabienne Tamion, Olfa Hamzaoui, Cécile Aubron

Open Access Research

Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness

Marie Smedberg, Johan Helleberg, Åke Norberg, Inga Tjäder, Olav Rooyackers, Jan Wernerman

Open Access Research

Diagnostic yield of routine daily blood culture in patients on veno-arterial extracorporeal membrane oxygenation

Quentin de Roux, Marie Renaudier, Wulfran Bougouin, Johanna Boccara, Vincent Fihman, Raphaël Lepeule, Chamsedine Cherait, Antonio Fiore, François Hemery, Jean-Winoc Decousser, Olivier Langeron, Nicolas Mongardon

Open Access Research

Individualized resuscitation strategy for septic shock formalized by finite mixture modeling and dynamic treatment regimen

Penglin Ma, Jingtao Liu, Feng Shen, Xuelian Liao, Ming Xiu, Heling Zhao, Mingyan Zhao, Jing Xie, Peng Wang, Man Huang, Tong Li, Meili Duan, Kejian Qian, Yue Peng, Feihu Zhou, Xin Xin, Xianyao Wan, ZongYu Wang, Shusheng Li, Jianwei Han, Zhenliang Li, Guolei Ding, Qun Deng, Jicheng Zhang, Yue Zhu, Wenjing Ma, Jingwen Wang, Yan Kang, Zhongheng Zhang

Open Access Review

Emerging SARS-CoV-2 variants of concern and potential intervention approaches

Jasmin Khateeb, Yuchong Li, Haibo Zhang

Open Access Research Letter

Variation in central venous oxygen saturation to assess volume responsiveness in hemodynamically unstable patients under mechanical ventilation: a prospective cohort study

Mohamed Hassene Khalil, Adel Sekma, Wafa Zhani, Asma Zorgati, Houda Ben Soltane, Semir Nouira

Open Access Research

Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysis

Ryan Ruiyang Ling, Kollengode Ramanathan, Wynne Hsing Poon, Chuen Seng Tan, Nicolas Brechot, Daniel Brodie, Alain Combes, Graeme MacLaren

Open Access Research

Higher versus lower positive end-expiratory pressure in patients without acute respiratory distress syndrome: a meta-analysis of randomized controlled trials

Tommaso Pettenuzzo, Annalisa Boscolo, Alessandro De Cassai, Nicolò Sella, Francesco Zarantonello, Paolo Persona, Laura Pasin, Giovanni Landoni, Paolo Navalesi

Open Access COVID-19 Research

Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndrome

François Beloncle, Antoine Studer, Valérie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat, Ferhat Meziani

Open Access COVID-19 Research Letter

Impact of dexamethasone use to prevent from severe COVID-19-induced acute kidney injury

Arthur Orieux, Pierre Khan, Renaud Prevel, Didier Gruson, Sébastien Rubin, Alexandre Boyer

Open Access Review

Personalized mechanical ventilation in acute respiratory distress syndrome

Paolo Pelosi, Lorenzo Ball, Carmen S. V. Barbas, Rinaldo Bellomo, Karen E. A. Burns, Sharon Einav, Luciano Gattinoni, John G. Laffey, John J. Marini, Sheila N. Myatra, Marcus J. Schultz, Jean Louis Teboul, Patricia R. M. Rocco

Open Access Research

Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis

Renata Černá Pařízková, Jiřina Martínková, Eduard Havel, Petr Šafránek, Milan Kaška, David Astapenko, Jan Bezouška, Jaroslav Chládek, Vladimír Černý

Open Access Research

Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate

Chloë Goossens, Ruben Weckx, Sarah Derde, Sarah Vander Perre, Inge Derese, Paul P. Van Veldhoven, Bart Ghesquière, Greet Van den Berghe, Lies Langouche

Open Access Research

Treatment of the lung injury of drowning: a systematic review

Ogilvie Thom, Kym Roberts, Susan Devine, Peter A. Leggat, Richard C. Franklin

Open Access COVID-19 Research Letter

Analysis of top influencers in critical care medicine “twitterverse” in the COVID-19 era: a descriptive study

Ronny Munoz-Acuna, Akiva Leibowitz, Margaret Hayes, Somnath Bose

Open Access Letter

Letter to the editor

Folke Sjöberg, Lotti Orwelius, Michelle Chew, Sören Berg, Sten Walther

Open Access Review

Ethics in extracorporeal life support: a narrative review

Alexandra Schou, Jesper Mølgaard, Lars Willy Andersen, Søren Holm, Marc Sørensen

Open Access Review

Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review

Laura Drikite, Jonathan P. Bedford, Liam O’Bryan, Tatjana Petrinic, Kim Rajappan, James Doidge, David A. Harrison, Kathryn M. Rowan, Paul R. Mouncey, Duncan Young, Peter J. Watkinson, Mark Corbett

Open Access COVID-19 Research Letter

Inhaled iloprost improves gas exchange in patients with COVID-19 and acute respiratory distress syndrome

Natalia A. Tsareva, Sergey N. Avdeev, Djuro Kosanovic, Ralph Theo Schermuly, Natalia V. Trushenko, Galina V. Nekludova

Open Access COVID-19 Letter

Higher incidence of arrhythmia in COVID-19 than in other community-acquired pneumonia: possible role of concurrent therapies

Patrick M. Honore, Sebastien Redant, Thierry Preseau, Sofie Moorthamers, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials

Zheng-Yii Lee, Cindy Sing Ling Yap, M. Shahnaz Hasan, Julia Patrick Engkasan, Mohd Yusof Barakatun-Nisak, Andrew G. Day, Jayshil J. Patel, Daren K. Heyland

Open Access Research

Impact of a restrictive antibiotic policy on the acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an endemic region: a before-and-after, propensity-matched cohort study in a Caribbean intensive care unit

Christophe Le Terrier, Marco Vinetti, Paul Bonjean, Régine Richard, Bruno Jarrige, Bertrand Pons, Benjamin Madeux, Pascale Piednoir, Fanny Ardisson, Elain Elie, Frédéric Martino, Marc Valette, Edouard Ollier, Sébastien Breurec, Michel Carles, Guillaume Thiéry

Open Access Research Letter

What every intensivist should know about Tocilizumab

Daniel Andrea Hofmaenner, Pedro David Wendel Garcia , Christoph Camille Ganter, Silvio D. Brugger, Philipp Karl Buehler, Sascha David

Open Access COVID-19 Research

Static compliance and driving pressure are associated with ICU mortality in intubated COVID-19 ARDS

Annalisa Boscolo, Nicolò Sella, Giulia Lorenzoni, Tommaso Pettenuzzo, Laura Pasin, Chiara Pretto, Martina Tocco, Enrico Tamburini, Alessandro De Cassai, Paolo Rosi, Enrico Polati, Katia Donadello, Leonardo Gottin, Silvia De Rosa, Fabio Baratto, Fabio Toffoletto, V. Marco Ranieri, Dario Gregori, Paolo Navalesi, Ilaria Valeri, Giulio Andreatta, Leonardo Gandolfi, Alessandra Gadaldi, Nicolò Brumana, Edoardo Forin, Christelle Correale, Elisa Pesenti, Davide Fregolent, Pier Francesco Pirelli, Davide Marchesin, Matteo Perona, Nicola Franchetti, Michele Della Paolera, Caterina Simoni, Tatiana Falcioni, Alessandra Tresin, Chiara Schiavolin, Aldo Schiavi, Sonila Vathi, Daria Sartori, Alice Sorgato, Elisa Pistollato, Federico Linassi, Eugenio Serra, Demetrio Pittarello, Ivo Tiberio, Ottavia Bond, Elisa Michieletto, Luisa Muraro, Arianna Peralta, Paolo Persona, Enrico Petranzan, Francesco Zarantonello, Alessandro Graziano, Eleonora Piasentini, Lorenzo Bernardi, Roberto Pianon, Flavio Badii, Enrico Bosco, Moreno Agostini, Antonio Farnia, Mario Peta, Mauro Antonio Calò, Marco Meggiolaro, Francesco Lazzari, Ivan Martinello, Giorgio Fullin, Francesco Papaccio, Alfeo Bonato, Camilla Sgarabotto, Francesco Montacciani, Parnigotto Alessandra, Giuseppe Gagliardi, Gioconda Ferraro, Luigi Ongaro, Marco Baiocchi, Vinicio Danzi, Paolo Zanatta, Simonetta Marchiotto, Silvia Bassanini, Massimo Zamperini, Ivan Daroui

Open Access COVID-19 Review

Improving lung compliance by external compression of the chest wall

John J. Marini, Luciano Gattinoni

Open Access Review

Clinical practice recommendations on the management of perioperative cardiac arrest: A report from the PERIOPCA Consortium

Athanasios Chalkias, Nicolas Mongardon, Vladimir Boboshko, Vladimir Cerny, Anne-Laure Constant, Quentin De Roux, Gabriele Finco, Francesca Fumagalli, Eleana Gkamprela, Stéphane Legriel, Vladimir Lomivorotov, Aurora Magliocca, Panagiotis Makaronis, Ioannis Mamais, Iliana Mani, Theodoros Mavridis, Paolo Mura, Giuseppe Ristagno, Salvatore Sardo, Nikolaos Papagiannakis, Theodoros Xanthos, Athanasios Chalkias, Nicolas Mongardon, Vladimir Boboshko, Vladimir Cerny, Anne-Laure Constant, Quentin De Roux, Gabriele Finco, Francesca Fumagalli, Eleana Gkamprela, Stéphane Legriel, Vladimir Lomivorotov, Aurora Magliocca, Panagiotis Makaronis, Ioannis Mamais, Iliana Mani, Theodoros Mavridis, Paolo Mura, Giuseppe Ristagno, Salvatore Sardo, Nikolaos Papagiannakis, Theodoros Xanthos

Open Access Research

Association between the use of balanced fluids and outcomes in critically ill children: a before and after study

Matthew F. Barhight, Delphine Nelson, Thomas Moran, Jessica Christiano, L. Nelson Sanchez-Pinto

Open Access COVID-19 Research Letter

Pancreatic stone protein for early mortality prediction in COVID-19 patients

Mathias Van Singer, Thomas Brahier, Marie-Josée Brochu Vez, Hélène Gerhard Donnet, Olivier Hugli, Noémie Boillat-Blanco

Open Access COVID-19 Research

Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease: a systematic review and meta-analysis

Gianmaria Cammarota, Teresa Esposito, Danila Azzolina, Roberto Cosentini, Francesco Menzella, Stefano Aliberti, Andrea Coppadoro, Giacomo Bellani, Giuseppe Foti, Giacomo Grasselli, Maurizio Cecconi, Antonio Pesenti, Michele Vitacca, Tom Lawton, V. Marco Ranieri, Sandro Luigi Di Domenico, Onofrio Resta, Antonio Gidaro, Antonella Potalivo, Giuseppe Nardi, Claudia Brusasco, Simonetta Tesoro, Paolo Navalesi, Rosanna Vaschetto, Edoardo De Robertis

Open Access COVID-19 Research Letter

Blood volume and albumin transudation in critically ill COVID-19 patients

Jan Bakker, James M. Horowitz, Jackie Hagedorn, Sam Kozloff, David Kaufman, Ricardo Castro

Open Access Research

Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial

Ana Carolina Costa Monteiro, Heidi Flori, Mary K. Dahmer, Myung Shin Sim, Michael W. Quasney, Martha A. Q. Curley, Michael A. Matthay, Anil Sapru, Ana Carolina Costa Monteiro, Heidi Flori, Mary K. Dahmer, Myung Shin Sim, Michael W. Quasney, Martha A. Q. Curley, Michael A. Matthay, Anil Sapru, Scot T. Bateman, M. D. Berg, Santiago Borasino, G. Kris Bysani, Allison S. Cowl, Cindy Darnell Bowens, E. Vincent S. Faustino, Lori D. Fineman, A. J. Godshall, Ellie Hirshberg, Aileen L. Kirby, Gwenn E. McLaughlin, Shivanand Medar, Phineas P. Oren, James B. Schneider, Adam J. Schwarz, Thomas P. Shanley, Lauren R. Sorce, Edward J. Truemper, Michele A. Vander Heyden, Kim Wittmayer, Athena Zuppa, David Wypij

Open Access Correction

Correction to: Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials

Rosanna Vaschetto, Alessandro Pecere, Gavin D. Perkins, Dipesh Mistry, Gianmaria Cammarota, Federico Longhini, Miguel Ferrer, Renata Pletsch-Assunção, Michele Carron, Francesca Moretto, Haibo Qiu, Francesco Della Corte, Francesco Barone-Adesi, Paolo Navalesi

Open Access Letter

Letter to the Editor in response to “Find the real responders and improve the outcome of awake prone positioning”

Jacob Rosén, Erik von Oelreich, Diddi Fors, Malin Jonsson Fagerlund , Knut Taxbro, Peter Frykholm

Open Access Research Letter

Interleukin-34: an important modifier in the pathogenesis of influenza pneumonia

Banglao Xu, Xue Lin, Yi Gong, Xiaofei Lai, Lei Ren, Ju Cao

Open Access Commentary

Targeted temperature management and cardiac arrest after the TTM-2 study

Fabio Silvio Taccone, Jean-Baptiste Lascarrou, Markus B. Skrifvars

Open Access COVID-19 Research

A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography

Mariangela Pellegrini, Aleksandra Larina, Evangelos Mourtos, Robert Frithiof, Miklos Lipcsey, Michael Hultström, Monica Segelsjö, Tomas Hansen, Gaetano Perchiazzi

Open Access Research

The impact of prehospital tranexamic acid on mortality and transfusion requirements: match-pair analysis from the nationwide German TraumaRegister DGU®

Sebastian Imach, Arasch Wafaisade, Rolf Lefering, Andreas Böhmer, Mark Schieren, Victor Suárez, Matthias Fröhlich

Open Access Research

Association of cerebrospinal fluid protein biomarkers with outcomes in patients with traumatic and non-traumatic acute brain injury: systematic review of the literature

Carlos A. Santacruz, Jean-Louis Vincent, Andres Bader, Luis A. Rincón-Gutiérrez, Claudia Dominguez-Curell, David Communi, Fabio S. Taccone

Open Access Research

Feasibility of a home-based interdisciplinary rehabilitation program for patients with Post-Intensive Care Syndrome: the REACH study

Mel E. Major, Daniela Dettling-Ihnenfeldt, Stephan P. J. Ramaekers, Raoul H. H. Engelbert, Marike van der Schaaf

Open Access Review

Breathing variability—implications for anaesthesiology and intensive care

Oscar F. C. van den Bosch, Ricardo Alvarez-Jimenez, Harm-Jan de Grooth, Armand R. J. Girbes, Stephan A. Loer

Open Access COVID-19 Research

Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients

Emma J. Kooistra, Miranda van Berkel, Noortje F. van Kempen, Celine R. M. van Latum, Niklas Bruse, Tim Frenzel, Maarten J. W. van den Berg, Jeroen A. Schouten, Matthijs Kox, Peter Pickkers

Open Access Research

Course and predictors of posttraumatic stress-related symptoms among family members of deceased ICU patients during the first year of bereavement

Siew Tzuh Tang, Chung-Chi Huang, Tsung-Hui Hu, Wen-Chi Chou, Li-Pang Chuang, Ming Chu Chiang

Open Access COVID-19 Research

Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID study

Michiel T. U. Schuijt, Marcus J. Schultz, Frederique Paulus, Ary Serpa Neto, J. P. van Akkeren, A. G. Algera, C. K. Algoe, R. B. van Amstel, O. L. Baur, P. van de Berg, D. C. J. J. Bergmans, D. I. van den Bersselaar, F. A. Bertens, A. J. G. H. Bindels, M. M. de Boer, S.den Boer, L. S. Boers, M. Bogerd, L. D. J. Bos, M. Botta, J. S. Breel, H. de Bruin, S. de Bruin, C. L. Bruna, L. A. Buiteman-Kruizinga, O. Cremer, R. M. Determann, W. Dieperink, D. A. Dongelmans, H. S. Franke, M. S. Galek Aldridge, M. J. de Graaff, L. A. Hagens, J. J. Haringman, N. F. L. Heijnen, S. Hiel, S. T. van der Heide, P. L. J. van der Heiden, L. L. Hoeijmakers, L. Hol, M. W. Hollmann, M. E. Hoogendoorn, J. Horn, R. van der Horst, E. L. K. Ie, D. Ivanov, N. P. Juffermans, E. Kho, E. S. de Klerk, A. W. M. Koopman, M. Koopmans, S. Kucukcelebi, M. A. Kuiper, D. W. de Lange, D. M. van Meenen, Ignacio Martin-Loeches, Guido Mazzinari, N. van Mourik, S. G. Nijbroek, M. Onrust, E. A. N. Oostdijk, F. Paulus, C. J. Pennartz, J. Pillay, L. Pisani, I. M. Purmer, T. C. D. Rettig, J. P. Roozeman, M. T. U. Schuijt, M. J. Schultz, A. Serpa Neto, M. E. Sleeswijk, M. R. Smit, P. E. Spronk, W. Stilma, A. C. Strang, A. M. Tsonas, P. R. Tuinman, C. M. A. Valk, F. L. Veen, A. P. J. Vlaar, L. I. Veldhuis, P. van Velzen, W. H. van der Ven, P. van Vliet, P. van der Voort, H. H. van der Wier, L. van Welie, H. J. F. T. Wesselink, B. van Wijk, T. Winters, W. Y. Wong, A. R. H. van Zanten

Open Access COVID-19 Correction

Correction to: Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort

Saad Nseir, Ignacio Martin-Loeches, Pedro Povoa, Matthieu Metzelard, Damien Du Cheyron, Fabien Lambiotte, Fabienne Tamion, Marie Labruyere, Demosthenes Makris, Claire Boulle Geronimi, Marc Pinetonde Chambrun, Martine Nyunga, Olivier Pouly, Bruno Mégarbane, Anastasia Saade, Gemma Gomà, Eleni Magira, Jean-François Llitjos, Antoni Torres, Iliana Ioannidou, Alexandre Pierre, Luis Coelho, Jean Reignier, Denis Garot, Louis Kreitmann, Jean-Luc Baudel, Guillaume Voiriot, Damien Contou, Alexandra Beurton, Pierre Asfar, Alexandre Boyer, Arnaud W. Thille, Armand Mekontso-Dessap, Vassiliki Tsolaki, Christophe Vinsonneau, Pierre-Edouard Floch, Loïc Le Guennec, Adrian Ceccato, Antonio Artigas, Mathilde Bouchereau, Julien Labreuche, Alain Duhamel, Anahita Rouzé, Raphaël Favory, Sébastien Préau, Mercé Jourdain, Julien Poissy, Piehr Saint Leger, Thierry Van der Linden, Anne Veinstein, Elie Azoulay, Frédéric Pene, Maelle Martin, Keyvan Razazi, Gaëtan Plantefeve, Muriel Fartoukh, Didier Thevenin, Bertrand Guidet, Nicolas Weiss, Achille Kouatchet, Charlotte Salmon, Guillaume Brunin, Safaa Nemlaghi, David Meguerditchian, Laurent Argaud, Sebastian Voicu, Charles-Edouard Luyt, Benjamin Kowalski, Edgar Moglia, Luis Morales, Antonia Koutsoukou, Spyros D. Mentzelopoulos, David Nora, Sean Boyd, Julien Maizel, Pierre Cuchet, Quentin Delforge, Jean-Pierre Quenot, Déborah Boyer, Catia Cilloniz

Open Access COVID-19 Letter

Letter to the editor regarding Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis

Dominik Johannes Hoechter, Andrea Sabine Becker-Pennrich, Benjamin Peter Geisler, Bernhard Zwissler, Michael Irlbeck, Kollengode Ramanathan, Kiran Shekar, Ryan Ruiyang Ling, Ryan Barbaro, Graeme MacLaren, Eddy Fan, Daniel Brodie

Open Access Review

Management of severe trauma worldwide: implementation of trauma systems in emerging countries: China, Russia and South Africa

Jing Zhou, Tianbing Wang, Igor Belenkiy, Timothy Craig Hardcastle, Jean-Jacques Rouby, Baoguo Jiang, Demetrios Demetriades, Hans J. Oestern, Hiroaki Iwase, Mao Zhang, Pierre Bouzat, Timothy J. Coats, Tobias Gauss, Youzhong An

Open Access Research

Intensive care doctors and nurses personal preferences for Intensive Care, as compared to the general population: a discrete choice experiment

Matthew H. Anstey, Imogen A. Mitchell, Charlie Corke, Lauren Murray, Marion Mitchell, Andrew Udy, Vineet Sarode, Nhi Nguyen, Oliver Flower, Kwok M. Ho, Edward Litton, Bradley Wibrow, Richard Norman

Open Access Research

Machine learning model for early prediction of acute kidney injury (AKI) in pediatric critical care

Junzi Dong, Ting Feng, Binod Thapa-Chhetry, Byung Gu Cho, Tunu Shum, David P. Inwald, Christopher J. L. Newth, Vinay U. Vaidya

Open Access Research

Impact of baseline beta-blocker use on inotrope response and clinical outcomes in cardiogenic shock: a subgroup analysis of the DOREMI trial

Pietro Di Santo, Rebecca Mathew, Richard G. Jung, Trevor Simard, Stephanie Skanes, Brennan Mao, F. Daniel Ramirez, Jeffrey A. Marbach, Omar Abdel-Razek, Pouya Motazedian, Simon Parlow, Kevin E. Boczar, Gianni D’Egidio, Steven Hawken, Jordan Bernick, George A. Wells, Alexander Dick, Derek Y. So, Christopher Glover, Juan J. Russo, Caroline McGuinty, Benjamin Hibbert

Open Access Research

Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial

Jean-François Timsit, Jennifer A. Huntington, Richard G. Wunderink, Nobuaki Shime, Marin H. Kollef, Ülo Kivistik, Martin Nováček, Álvaro Réa-Neto, Ignacio Martin-Loeches, Brian Yu, Erin H. Jensen, Joan R. Butterton, Dominik J. Wolf, Elizabeth G. Rhee, Christopher J. Bruno

Open Access Research

Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis

Wynne Hsing Poon, Kollengode Ramanathan, Ryan Ruiyang Ling, Isabelle Xiaorui Yang, Chuen Seng Tan, Matthieu Schmidt, Kiran Shekar

Open Access Research

Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study

Alexander H. Flannery, Victor Ortiz-Soriano, Xilong Li, Fabiola G. Gianella, Robert D. Toto, Orson W. Moe, Prasad Devarajan, Stuart L. Goldstein, Javier A. Neyra

Open Access COVID-19 Research

Machine learning identifies ICU outcome predictors in a multicenter COVID-19 cohort

Harry Magunia, Simone Lederer, Raphael Verbuecheln, Bryant Joseph Gilot, Michael Koeppen, Helene A. Haeberle, Valbona Mirakaj, Pascal Hofmann, Gernot Marx, Johannes Bickenbach, Boris Nohe, Michael Lay, Claudia Spies, Andreas Edel, Fridtjof Schiefenhövel, Tim Rahmel, Christian Putensen, Timur Sellmann, Thea Koch, Timo Brandenburger, Detlef Kindgen-Milles, Thorsten Brenner, Marc Berger, Kai Zacharowski, Elisabeth Adam, Matthias Posch, Onnen Moerer, Christian S. Scheer, Daniel Sedding, Markus A. Weigand, Falk Fichtner, Carla Nau, Florian Prätsch, Thomas Wiesmann, Christian Koch, Gerhard Schneider, Tobias Lahmer, Andreas Straub, Andreas Meiser, Manfred Weiss, Bettina Jungwirth, Frank Wappler, Patrick Meybohm, Johannes Herrmann, Nisar Malek, Oliver Kohlbacher, Stephanie Biergans, Peter Rosenberger

Open Access Letter

Cholesterol and its association with muscle weakness in critical illness

Daniel A. Hofmaenner, Anna Kleyman, Mervyn Singer

Open Access Letter

Corticosteroids and RCTs against the supposed undervaluation of real data evidence

Alejandro Rodríguez, Gerard Moreno, Maria Bodi, Josep Gomez, Ignacio Martín-Loeches

Open Access COVID-19 Research Letter

Inhaled liposomal amphotericin-B as a prophylactic treatment for COVID-19-associated pulmonary aspergillosis/aspergillus tracheobronchitis

Sofie Van Ackerbroeck, Lynn Rutsaert, Ella Roelant, Kathleen Dillen, Joost Wauters, Niels Van Regenmortel

Open Access COVID-19 Research

Continuous renal replacement therapy in COVID-19—associated AKI: adding heparin to citrate to extend filter life—a retrospective cohort study

Eduardo de Oliveira Valle, Carla Paulina Sandoval Cabrera, Claudia Coimbra César de Albuquerque, Giovanio Vieira da Silva, Márcia Fernanda Arantes de Oliveira, Gabriel Teixeira Montezuma Sales, Igor Smolentzov, Bernardo Vergara Reichert, Lucia Andrade, Victor Faria Seabra, Paulo Ricardo Gessolo Lins, Camila Eleuterio Rodrigues

Open Access COVID-19 Research Letter

Elevated HbA1c remains a predominant finding in severe COVID-19 and may be associated with increased mortality in patients requiring mechanical ventilation

Sebastian J. Klein, Timo Mayerhöfer, Dietmar Fries, Christian Preuß Hernández, Michael Joannidis, Romuald Bellmann, Andreas Peer, Julia Haßlacher, Adelheid Ditlbacher, Georg F. Lehner, Fabian Perschinka, Walter Hasibeder, Christoph Krismer, Agnes Pechlaner, Stephan Eschertzhuber, Stefanie Zagitzer-Hofer, Eva Foidl, Isabella Weilguni, Stefanie Haslauer-Mariacher, Armin Kalenka, Alexandra Ribitsch, Andreas Mayr, Eugen Ladner, Bernhard Mayr-Hueber, Birgit Stögermüller, Lukas Kirchmair, Bruno Reitter, Miriam Potocnik, Simon Mathis, Anna Fiala, Jürgen Brunner, Claudius Thomé

Open Access Research

Outbreak of Pseudomonas aeruginosa producing VIM carbapenemase in an intensive care unit and its termination by implementation of waterless patient care

Gaud Catho, R. Martischang, F. Boroli, M. N. Chraïti, Y. Martin, Z. Koyluk Tomsuk, G. Renzi, J. Schrenzel, J. Pugin, P. Nordmann, D. S. Blanc, S. Harbarth

Open Access Research

Norepinephrine potentiates the efficacy of volume expansion on mean systemic pressure in septic shock

Imane Adda, Christopher Lai, Jean-Louis Teboul, Laurent Guerin, Francesco Gavelli, Xavier Monnet

Open Access COVID-19 Research

The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

Lucas M. Fleuren, Tariq A. Dam, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco Peters, Marlijn J. A. Kamps, Dharmanand Ramnarain, Ralph Nowitzky, Fleur G. C. A. Nooteboom, Wouter de Ruijter, Louise C. Urlings-Strop, Ellen G. M. Smit, D. Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P. C. de Jager, Stefaan H. A. Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C. Reidinga, Barbara Festen-Spanjer, Gert B. Brunnekreef, Alexander D. Cornet, Walter van den Tempel, Age D. Boelens, Peter Koetsier, Judith Lens, Harald J. Faber, A. Karakus, Robert Entjes, Paul de Jong, Thijs C. D. Rettig, Sesmu Arbous, Sebastiaan J. J. Vonk, Mattia Fornasa, Tomas Machado, Taco Houwert, Hidde Hovenkamp, Roberto Noorduijn-Londono, Davide Quintarelli, Martijn G. Scholtemeijer, Aletta A. de Beer, Giovanni Cina, Martijn Beudel, Willem E. Herter, Armand R. J. Girbes, Mark Hoogendoorn, Patrick J. Thoral, Paul W. G. Elbers

Open Access Research

Effect of awake prone position on diaphragmatic thickening fraction in patients assisted by noninvasive ventilation for hypoxemic acute respiratory failure related to novel coronavirus disease

Gianmaria Cammarota, Elisa Rossi, Leonardo Vitali, Rachele Simonte, Tiziano Sannipoli, Francesco Anniciello, Luigi Vetrugno, Elena Bignami, Cecilia Becattini, Simonetta Tesoro, Danila Azzolina, Angelo Giacomucci, Paolo Navalesi, Edoardo De Robertis

Open Access COVID-19 Research Letter

Role of endothelial miR-24 in COVID-19 cerebrovascular events

Jessica Gambardella, Antonietta Coppola, Raffaele Izzo, Giuseppe Fiorentino, Bruno Trimarco, Gaetano Santulli

Open Access Review

Initial antimicrobial management of sepsis

Michael S. Niederman, Rebecca M. Baron, Lila Bouadma, Thierry Calandra, Nick Daneman, Jan DeWaele, Marin H. Kollef, Jeffrey Lipman, Girish B. Nair

Open Access Review

Still a place for aortic counterpulsation in cardiac surgery and patients with cardiogenic shock?

Matthias Heringlake, Astrid Ellen Berggreen, Hauke Paarmann

Open Access Review

Measuring vitamin C in critically ill patients: clinical importance and practical difficulties—Is it time for a surrogate marker?

Sander Rozemeijer, Frans A. L. van der Horst, Angélique M. E. de Man

Open Access Review

Advanced management of intermediate-high risk pulmonary embolism

Tatiana Weinstein, Himanshu Deshwal, Shari B. Brosnahan

Open Access Review

Monitoring and modifying brain oxygenation in patients at risk of hypoxic ischaemic brain injury after cardiac arrest

Markus Benedikt Skrifvars, Mypinder Sekhon, Erik Anders Åneman

Open Access Review

Acute kidney injury in ECMO patients

Marlies Ostermann, Nuttha Lumlertgul

Open Access Review

To prone or not to prone ARDS patients on ECMO

Oriol Roca, Andrés Pacheco, Marina García-de-Acilu

Open Access COVID-19 Review

Tracheostomy for COVID-19: evolving best practice

Thomas Williams, Brendan A. McGrath

Open Access COVID-19 Review

Secondary infections in critically ill patients with COVID-19

Giacomo Grasselli, Emanuele Cattaneo, Gaetano Florio

Open Access Review

Pathophysiology and clinical implications of the veno-arterial PCO2 gap

Zied Ltaief, Antoine Guillaume Schneider, Lucas Liaudet

Open Access COVID-19 Research Letter

The application of an oxygen mask, without supplemental oxygen, improved oxygenation in patients with severe COVID-19 already treated with high-flow nasal cannula

Besarta Dogani, Fredrik Månsson, Fredrik Resman, Hannes Hartman, Johan Tham, Gustav Torisson

Open Access Research

Identification of distinct clinical phenotypes of acute respiratory distress syndrome with differential responses to treatment

Xiaowei Liu, Yusheng Jiang, Xiaonan Jia, Xiaohui Ma, Ci Han, Nana Guo, Yahui Peng, Haitao Liu, Yingnan Ju, Xiangfeng Luo, Xueting Li, Yue Bu, Jin Zhang, Yansong Liu, Yan Gao, Mingyan Zhao, Hongliang Wang, Ligang Luo, Kaijiang Yu, Changsong Wang

Open Access Research

Comprehensive versus standard care in post-severe acute kidney injury survivors, a randomized controlled trial

Peerapat Thanapongsatorn, Kamolthip Chaikomon, Nuttha Lumlertgul, Khanitha Yimsangyad, Akarathep Leewongworasingh, Win Kulvichit, Phatadon Sirivongrangson, Sadudee Peerapornratana, Weerachai Chaijamorn, Yingyos Avihingsanon, Nattachai Srisawat

Open Access Commentary

Ten strategies to optimize early mobilization and rehabilitation in intensive care

Carol L. Hodgson, Stefan J. Schaller, Peter Nydahl, Karina Tavares Timenetsky, Dale M. Needham

Open Access Research Letter

Seasonal trends of incidence and outcomes of cardiogenic shock : findings from a large, nationwide inpatients sample with 441,696 cases

Peter Moritz Becher, Benedikt Schrage, Alina Goßling, Nina Fluschnik, Moritz Seiffert, Alexander M. Bernhardt, Hermann Reichenspurner, Paulus Kirchhof, Stefan Blankenberg, Dirk Westermann, Alexander M. Bernhardt, Hermann Reichenspurner, Paulus Kirchhof, Stefan Blankenberg

Open Access COVID-19 Commentary

Isn’t it time to abandon ARDS? The COVID-19 lesson

L. Gattinoni, J. J. Marini

Open Access COVID-19 Review

The use of head helmets to deliver noninvasive ventilatory support: a comprehensive review of technical aspects and clinical findings

Andrea Coppadoro, Elisabetta Zago, Fabio Pavan, Giuseppe Foti, Giacomo Bellani

Open Access COVID-19 Research

Machine-learning-based COVID-19 mortality prediction model and identification of patients at low and high risk of dying

Mohammad M. Banoei, Roshan Dinparastisaleh, Ali Vaeli Zadeh, Mehdi Mirsaeidi

Open Access Research

Between-centre differences in care for in-hospital cardiac arrest: a prospective cohort study

B. Y. Gravesteijn, M. Schluep, H. F. Lingsma, R. J. Stolker, H. Endeman, S. E. Hoeks, Evert-Jan Wils, Cees Kuijs, Michiel Blans, Bas van den Bogaard, Ankie Koopman – van Gemert, Chris Hukshorn, Nardo van der Meer, Marco Knook, Trudy van Melsen, René Peters, Patrick Perik, Jan Assink, Gerben Spijkers, Wytze Vermeijden

Open Access Viewpoint

The management of multi-morbidity in elderly patients: Ready yet for precision medicine in intensive care?

Michael Beil, Hans Flaatten, Bertrand Guidet, Sigal Sviri, Christian Jung, Dylan de Lange, Susannah Leaver, Jesper Fjølner, Wojciech Szczeklik, Peter Vernon van Heerden

Open Access COVID-19 Research

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Antoni Torres, Anna Motos, Jordi Riera, Laia Fernández-Barat, Adrián Ceccato, Raquel Pérez-Arnal, Dario García-Gasulla, Oscar Peñuelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarrús, Rosario Menéndez, Jesús F. Bermejo-Martin, Ricard Ferrer, Rosario Amaya Villar, José M. Añón, Carme Barberà, José Barberán, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Cristóbal Galbán, Víctor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Díaz, Ángel Estella, Elena Gallego, José Luis García Garmendia, José Garnacho-Montero, José M. Gómez, Arturo Huerta, Ruth Noemí Jorge García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, Ignacio Martínez Varela, Juan López Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Pilar Ricart, Inmaculada Salvador-Adell, Angel Sánchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suares Sipmann, Luis Tamayo Lomas, José Trenado, Ferran Barbé, Berta Adell-Serrano, Alexander Agrifoglio, María Aguilar Cabello, Luciano Aguilera, Victoria Alcaraz-Serrano, Cesar Aldecoa, Cynthia Alegre, Sergio Álvarez, Antonjo Álvarez Ruiz, Rut Andrea, José Ángel, Marta Arrieta, J. Ignacio Ayestarán, Joan Ramon Badia, Mariona Badía, Orville Báez Pravia, Ana Balan Mariño, Begoña Balsera, Laura Barbena, Enric Barbeta, Tommaso Bardi, Patricia Barral Segade, Marta Barroso, José Ángel Berezo García, Judit Bigas, Rafael Blancas, María Luisa Blasco Cortés, María Boado, María Bodi Saera, Neus Bofill, María Teresa Bouza Vieiro, Leticia Bueno, Juan Bustamante-Munguira, Lucia Cachafeiro, David Campi Hermoso, Sandra Campos Fernández, Iosune Cano, Maria Luisa Cantón-Bulnes, Pablo Cardina Fernández, Laura Carrión García, Sula Carvalho, Núria Casacuberta-Barberà, Manuel Castellà, Andrea Castellví, Pedro Castro, Ramon Cicuendez Ávila, Catia Cillóniz, Luisa Clar, Cristina Climent, Jordi Codina, Pamela Conde, Sofía Contreras, María Cruz Martin, Raul de Pablo Sánchez, Diego De Mendoza, Cecilia del Busto Martínez, Yolanda Díaz, María Digna Rivas Vilas, Cristina Dólera Moreno, Irene Dot, Pedro Enríquez Giraudo, Inés Esmorís Arijón, Teresa Farre Monjo, Javier Fernández, Carlos Ferrando, Albert Figueras, Eva Forcadell-Ferreres, Lorena Forcelledo Espina, Nieves Franco, Àngels Furro, Felipe García, Beatriz García, Emilio García Prieto, Carlos García Redruello, Amaia García Sagastume, Maria Luisa Gascón Castillo, Gemma Gomà, Vanesa Gómez Casal, Silvia Gómez, Carmen Gómez Gonzalez, Jessica González, Federico Gordo, Maria Pilar Gracia, Alba Herraiz, Rubén Herrán-Monge, Mercedes Ibarz, Silvia Iglesias, Maria Teresa Janer, Gabriel Jiménez, Mar Juan Díaz, Karsa Kiarostami, Juan I. Lazo Álvarez, Miguel León, Alexandre López-Gavín, Ana López Lago, Desire Macias Guerrero, Nuria Mamolar Herrera, Rafael Mañez Mendiluce, Cecilia L. Mantellini, Gregorio Marco Naya, Pilar Marcos, Enrique Marmol Peis, Paula Martín Vicente, María Martínez, Carmen Eulalia Martínez Fernández, Maria Dolores Martínez Juan, Juan Fernando Masa Jimenez, Joan Ramon Masclans, Emilio Maseda, Eva María Menor Fernández, Mar Miralbés, Josman Monclou, Juan Carlos Montejo-González, Neus Montserrat, María Mora Aznar, Pedro Moral-Parras, Dulce Morales, Sara Guadalupe Moreno Cano, David Mosquera Rodríguez, Rosana Muñoz-Bermúdez, José María Nicolás, Ramon Nogue Bou, Rafaela Nogueras Salinas, Marta Ocón, Ana Ortega, Sergio Ossa, Pablo Pagliarani, Anna Parera Pous, Francisco Parrilla, Leire Pérez Bastida, Purificación Pérez, Gloria Pérez Planelles, Eva Pérez Rubio, David Pestaña Laguna, Àngels Piñol-Tena, Javier Prados, Andrés Pujol, Núria Ramon Coll, Gloria Renedo Sanchez-Giron, Ferran Roche-Campo, Laura Rodriguez, Felipe Rodríguez de Castro, Silvia Rodríguez, Covadonga Rodríguez Ruiz, Jorge Rubio, Alberto Rubio López, Miriam Ruiz Miralles, Pablo Ryan Murúa, Eva Saborido Paz, Ana Salazar Degracia, Miguel Sanchez, Ana Sánchez, Bitor Santacoloma, Maria Teresa Sariñena, Marta Segura Pensado, Lidia Serra, Mireia Serra-Fortuny, Ainhoa Serrano Lázaro, Lluís Servià, Laura Soliva, Carla Speziale, Daniel Tognetti, Adrián Tormos, Mateu Torres, Sandra Trefler, Javier Trujillano, Alejandro Úbeda, Luis Urrelo-Cerrón, Estela Val, Luis Valdivia Ruiz, Montserrat Vallverdú, Maria Van der Hofstadt Martin-Montalvo, Sabela Vara Adrio, Nil Vázquez, Javier Vengoechea, Pablo Vidal Cortes, Clara Vilà-Vilardel, Judit Vilanova, Tatiana Villada Warrington, Hua Yang, Minlan Yang, Ana Zapatero

Open Access Letter

Concern with reproducibility of rehabilitation after critical illness and hospital discharge

Kota Yamauchi, Shunsuke Kina, Shunsuke Taito

Open Access Research

Bedside estimates of dead space using end-tidal CO2 are independently associated with mortality in ARDS

Paola Lecompte-Osorio, Steven D. Pearson, Cole H. Pieroni, Matthew R. Stutz, Anne S. Pohlman, Julie Lin, Jesse B. Hall, Yu M. Htwe, Patrick G. Belvitch, Steven M. Dudek, Krysta Wolfe, Bhakti K. Patel, John P. Kress

Open Access Review

Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression

Emily M. L. Bowman, Emma L. Cunningham, Valerie J. Page, Daniel F. McAuley

Open Access COVID-19 Research

Antifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study

Stefan Hatzl, Alexander C. Reisinger, Florian Posch, Juergen Prattes, Martin Stradner, Stefan Pilz, Philipp Eller, Michael Schoerghuber, Wolfgang Toller, Gregor Gorkiewicz, Philipp Metnitz, Martin Rief, Florian Prüller, Alexander R. Rosenkranz, Thomas Valentin, Robert Krause, Martin Hoenigl, Gernot Schilcher

Open Access Research

Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts

Neha A. Sathe, Leila R. Zelnick, Carmen Mikacenic, Eric D. Morrell, Pavan K. Bhatraju, J. Brennan McNeil, Susanna Kosamo, Catherine L. Hough, W. Conrad Liles, Lorraine B. Ware, Mark M. Wurfel

Open Access COVID-19 Research Letter

Short and long-term outcomes of patients with COVID-19-associated acute respiratory distress syndrome and difficult veno-venous-ECMO weaning

Paul Masi, Samuel Tuffet, Laurent Boyer, Thierry Folliguet, Armand Mekontso Dessap, Nicolas de Prost

Open Access Research

Trends in the incidence and outcome of sepsis using data from a Japanese nationwide medical claims database-the Japan Sepsis Alliance (JaSA) study group-

Taro Imaeda, Taka-aki Nakada, Nozomi Takahashi, Yasuo Yamao, Satoshi Nakagawa, Hiroshi Ogura, Nobuaki Shime, Yutaka Umemura, Asako Matsushima, Kiyohide Fushimi

Open Access Research

Lung ultrasound in a tertiary intensive care unit population: a diagnostic accuracy study

Jasper M. Smit, Mark E. Haaksma, Michiel H. Winkler, Micah L. A. Heldeweg, Luca Arts, Erik J. Lust, Paul W. G. Elbers, Lilian J. Meijboom, Armand R. J. Girbes, Leo M. A. Heunks, Pieter R. Tuinman

Open Access COVID-19 Research

Early versus late awake prone positioning in non-intubated patients with COVID-19

Ramandeep Kaur, David L. Vines, Sara Mirza, Ahmad Elshafei, Julie A. Jackson, Lauren J. Harnois, Tyler Weiss, J. Brady Scott, Matthew W. Trump, Idrees Mogri, Flor Cerda, Amnah A. Alolaiwat, Amanda R. Miller, Andrew M. Klein, Trevor W. Oetting, Lindsey Morris, Scott Heckart, Lindsay Capouch, Hangyong He, Jie Li

Open Access Research

A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes

Faheem W. Guirgis, Lauren Page Black, Morgan Henson, Guillaume Labilloy, Carmen Smotherman, Charlotte Hopson, Ian Tfirn, Elizabeth L. DeVos, Christiaan Leeuwenburgh, Lyle Moldawer, Susmita Datta, Todd M. Brusko, Alexis Hester, Andrew Bertrand, Victor Grijalva, Alexander Arango-Esterhay, Frederick A. Moore, Srinivasa T. Reddy

Open Access Letter

The lonely glutamine tree in the middle of the infinite critically ill forest

Panagiotis Briassoulis, Stavroula Ilia, Efrossini Briassouli, Marianna Miliaraki, George Briassoulis

Open Access COVID-19 Research

Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe

Christian Jung, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Finn H. Andersen, Rui Moreno, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten, Philipp Eller, Michael Joannidis, Dieter Mesotten, Pascal Reper, Sandra Oeyen, Walter Swinnen, Helene Brix, Jens Brushoej, Maja Villefrance, Helene Korvenius Nedergaard, Anders Thais Bjerregaard, Ida Riise Balleby, Kasper Andersen, Maria Aagaard Hansen, Stine Uhrenholt, Helle Bundgaard, Jesper Fjølner, Aliae AR Hussein Mohamed, Rehab Salah, Yasmin Khairy NasrEldin Mohamed Ali, Kyrillos Wassim, Yumna A Elgazzar, Samar Tharwat, Ahmed Y Azzam, Ayman abdelmawgoad Habib, Hazem Maarouf Abosheaishaa, Mohammed A Azab, Susannah Leaver, Arnaud Galbois, Bertrand Guidet, Cyril Charron, Emmanuel Guerot, Guillaume Besch, Jean-Philippe Rigaud, Julien Maizel, Michel Djibré, Philippe Burtin, Pierre Garcon, Saad Nseir, Xavier Valette, Nica Alexandru, Nathalie Marin, Marie Vaissiere, Gaëtan Plantefeve, Thierry Vanderlinden, Igor Jurcisin, Buno Megarbane, Anais Caillard, Arnaud Valent, Marc Garnier, Sebastien Besset, Johanna Oziel, Jean-herlé Raphaelen, Stéphane Dauger, Guillaume Dumas, Bruno Goncalves, Gaël Piton, Christian Jung, Raphael Romano Bruno, Malte Kelm, Georg Wolff, Eberhard Barth, Ulrich Goebel, Eberhard Barth, Anselm Kunstein, Michael Schuster, Martin Welte, Matthias Lutz, Patrick Meybohm, Stephan Steiner, Tudor Poerner, Hendrik Haake, Stefan Schaller, Detlef Kindgen-Milles, Christian Meyer, Muhammed Kurt, Karl Friedrich Kuhn, Winfried Randerath, Jakob Wollborn, Zouhir Dindane, Hans-Joachim Kabitz, Ingo Voigt, Gonxhe Shala, Andreas Faltlhauser, Nikoletta Rovina, Zoi Aidoni, Evangelia Chrisanthopoulou, Antonios Papadogoulas, Mohan Gurjar, Ata Mahmoodpoor, Abdullah Khudhur Ahmed, Brian Marsh, Ahmed Elsaka, Sigal Sviri, Vittoria Comellini, Ahmed Rabha, Hazem Ahmed, Silvio a Namendys-Silva, Abdelilah Ghannam, Martijn Groenendijk, Marieke Zegers, Dylan de Lange, Alex Cornet, Mirjam Evers, Lenneke Haas, Tom Dormans, Willem Dieperink, Luis Romundstad, Britt Sjøbø, Finn H Andersen, Hans Frank Strietzel, Theresa Olasveengen, Michael Hahn, Miroslaw Czuczwar, Ryszard Gawda, Jakub Klimkiewicz, Maria Campos de LurdesSantos, André Gordinho, Henrique Santos, Rui Assis, Ana Isabel Pinho Oliveira, Mohamed Raafat Badawy, David Perez-Torres, Gemma Gomà, Mercedes Ibarz Villamayor, Angela Prado Mira, Patricia Jimeno Cubero, Susana Arias Rivera, Teresa Tomasa, David Iglesias, Eric Mayor Vázquez, Cesar Aldecoa, Aida Fernández Ferreira, Begoña Zalba-Etayo, Isabel Canas-Perez, Luis Tamayo-Lomas, Cristina Diaz-Rodriguez, Susana Sancho, Jesús Priego, Enas M.Y. Abualqumboz, Momin Majed Yousuf Hilles, Mahmoud Saleh, Nawfel Ben-HAmouda, Andrea Roberti, Alexander Dullenkopf, Yvan Fleury, Bernardo Bollen Pinto, Joerg C Schefold, Mohammed Al-Sadawi, Nicolas Serck, Elisabeth Dewaele, Pritpal Kumar, Camilla Bundesen, Richard Innes, James Gooch, Lenka Cagova, Elizabeth Potter, Michael Reay, Miriam Davey, Sally Humphreys, Caroline Hauw Berlemont, Benjamin Glenn Chousterman, François Dépret, Alexis Ferre, Lucie Vettoretti, Didier Thevenin, Andreas Faltlhauser, Milena Milovanovic, Philipp Simon, Marco Lorenz, Sandra Emily Stoll, Simon Dubler, Kristina Fuest, Francesk Mulita, Eumorifa Kondili, Ioannis Andrianopoulos, Iwan Meynaar, Alexander Daniel Cornet, Britt Sjøbøe, Anna Kluzik, Paweł Zatorski, Tomasz Drygalski, Wojciech Szczeklik, Joanna Solek-pastuszka, Dariusz Onichimowski, Jan Stefaniak, Karina Stefanska-Wronka, Ewa Zabul, Filipe Sousa Cardoso, Maria José Arche Banzo, Teresa Maria Tomasa-Irriguible, Ángela Prado Mira, Susana Arias-Rivera, Fernando Frutos-Vivar, Sonia Lopez-Cuenca, Pablo Ruiz de Gopegui, Nour Abidi, Ivan Chau, Richard Pugh, Sara Smuts

Open Access Research Letter

Feasibility of machine integrated point of care lung ultrasound automatic B-lines tool in the Corona-virus 2019 critical care unit

Gal Tsaban, Ori Galante, Yaniv Almog, Yuval Ullman, Lior Fuchs

Open Access COVID-19 Research Letter

Acute cor pulmonale in Covid-19 related acute respiratory distress syndrome

Pedro Cavaleiro, Paul Masi, François Bagate, Thomas d’Humières, Armand Mekontso Dessap

Open Access COVID-19 Research

Restricted visitation policies in acute care settings during the COVID-19 pandemic: a scoping review

Stephana J. Moss, Karla D. Krewulak, Henry T. Stelfox, Sofia B. Ahmed, Melanie C. Anglin, Sean M. Bagshaw, Karen E. A. Burns, Deborah J. Cook, Christopher J. Doig, Alison Fox-Robichaud, Robert Fowler, Laura Hernández, Michelle E. Kho, Maia Kredentser, Kira Makuk, Srinivas Murthy, Daniel J. Niven, Kendiss Olafson, Ken Kuljit S. Parhar, Scott B. Patten, Oleksa G. Rewa, Bram Rochwerg, Bonnie Sept, Andrea Soo, Krista Spence, Sean Spence, Sharon Straus, Andrew West, Jeanna Parsons Leigh, Kirsten M. Fiest

Open Access COVID-19 Research Letter

Pneumocystis pneumonia risk among viral acute respiratory distress syndrome related or not to COVID 19

Keyvan Razazi, Romain Arrestier, Anne Fleur Haudebourg, Francoise Botterel, Armand Mekontso Dessap, Slim Fourati, Brice Benelli, Frédérique Boquel, Nicolas de Prost, Guillaume Carteaux, Jeanne Tran Van Nhieu, Frederic Schlemmer

Open Access Research

Effectiveness of anisodamine for the treatment of critically ill patients with septic shock: a multicentre randomized controlled trial

Yuetian Yu, Cheng Zhu, Yucai Hong, Lin Chen, Zhiping Huang, Jiancang Zhou, Xin Tian, Dadong Liu, Bo Ren, Cao Zhang, Caibao Hu, Xinan Wang, Rui Yin, Yuan Gao, Zhongheng Zhang

Open Access Research

Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial

Johanna Laurikkala, Anders Aneman, Alexander Peng, Matti Reinikainen, Paul Pham, Pekka Jakkula, Johanna Hästbacka, Erika Wilkman, Pekka Loisa, Jussi Toppila, Thomas Birkelund, Kaj Blennow, Henrik Zetterberg, Markus B. Skrifvars

Open Access Research

The impact of wearable continuous vital sign monitoring on deterioration detection and clinical outcomes in hospitalised patients: a systematic review and meta-analysis

Carlos Areia, Christopher Biggs, Mauro Santos, Neal Thurley, Stephen Gerry, Lionel Tarassenko, Peter Watkinson, Sarah Vollam

Open Access Review

Oral health care for the critically ill: a narrative review

Lewis Winning, Fionnuala T. Lundy, Bronagh Blackwood, Daniel F. McAuley, Ikhlas El Karim

Open Access Research

Ceftolozane/tazobactam probability of target attainment and outcomes in participants with augmented renal clearance from the randomized phase 3 ASPECT-NP trial

Andrew F. Shorr, Christopher J. Bruno, Zufei Zhang, Erin Jensen, Wei Gao, Hwa-Ping Feng, Jennifer A. Huntington, Brian Yu, Elizabeth G. Rhee, Carisa De Anda, Sumit Basu, Marin H. Kollef

Open Access COVID-19 Research

Evolving outcomes of extracorporeal membrane oxygenation support for severe COVID-19 ARDS in Sorbonne hospitals, Paris

Matthieu Schmidt, Elise Langouet, David Hajage, Sarah Aissi James, Juliette Chommeloux, Nicolas Bréchot, Petra Barhoum, Lucie Lefèvre, Antoine Troger, Marc Pineton de Chambrun, Guillaume Hékimian, Charles-Edouard Luyt, Martin Dres, Jean-Michel Constantin, Muriel Fartoukh, Pascal Leprince, Guillaume Lebreton, Alain Combes

Open Access Research

Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Yang Jiao, Ti Zhang, Chengmi Zhang, Haiying Ji, Xingyu Tong, Ran Xia, Wei Wang, Zhengliang Ma, Xueyin Shi

Open Access Research

Bronchus-blocked ultrasound-guided percutaneous transthoracic needle biopsy (BUS-PTNB) for intubated patients with severe lung diseases

Yuean Zhao, Faming Jiang, He Yu, Ye Wang, Zhen Wang, Peng Sun, Zhong Ni, Weiya Wang, Lili Jiang, Junping Fan, Lanlan Zhang, Charles A. Powell, Zongan Liang

Open Access Review

Timing of antibiotic therapy in the ICU

Marin H. Kollef, Andrew F. Shorr, Matteo Bassetti, Jean-Francois Timsit, Scott T. Micek, Andrew P. Michelson, Jose Garnacho-Montero

Open Access Research Letter

Management of severe ARDS due to SARS-CoV-2 pneumonia using low-flow extracorporeal CO2 extraction

Rosario Molina Lobo, Beatriz Lobo-Valbuena, Federico Gordo

Open Access COVID-19 Research

Evaluation of zinc sulfate as an adjunctive therapy in COVID-19 critically ill patients: a two center propensity-score matched study

Khalid Al Sulaiman, Ohoud Aljuhani, Abdulrahman I. Al Shaya, Abdullah Kharbosh, Raed Kensara, Alhomaidi Al Guwairy, Aisha Alharbi, Rahmah Algarni, Shmeylan Al Harbi, Ramesh Vishwakarma, Ghazwa B. Korayem

Open Access Research

Lean mass as a risk factor for intensive care unit admission: an observational study

Matthew Thackeray, Mohammadreza Mohebbi, Neil Orford, Mark A. Kotowicz, Julie A. Pasco

Open Access COVID-19 Letter

Longitudinal ventilatory ratio monitoring for COVID-19: its potential in predicting severity and assessing treatment response

Natsuko Kaku, Yu Nakagama, Michinori Shirano, Sari Shinomiya, Kazuhiro Shimazu, Katsuaki Yamazaki, Yoshito Maehata, Ryo Morita, Yuko Nitahara, Hiromasa Yamamoto, Yasumitsu Mizobata, Yasutoshi Kido

Open Access Research

Cost impact of procalcitonin-guided decision making on duration of antibiotic therapy for suspected early-onset sepsis in neonates

A. J. L. M. Geraerds, Wendy van Herk, Martin Stocker, Salhab el Helou, Sourabh Dutta, Matteo S. Fontana, Frank A. B. A. Schuerman, Rita K. van den Tooren-de Groot, Jantien Wieringa, Jan Janota, Laura H. van der Meer-Kappelle, Rob Moonen, Sintha D. Sie, Esther de Vries, Albertine E. Donker, Urs Zimmerman, Luregn J. Schlapbach, Amerik C. de Mol, Angelique Hoffman-Haringsma, Madan Roy, Maren Tomaske, René F. Kornelisse, Juliette van Gijsel, Eline G. Visser, Annemarie M. C. van Rossum, Suzanne Polinder

Open Access Research

Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature

Daniel O. Thomas-Rüddel, Peter Hoffmann, Daniel Schwarzkopf, Christian Scheer, Friedhelm Bach, Marcus Komann, Herwig Gerlach, Manfred Weiss, Matthias Lindner, Hendrik Rüddel, Philipp Simon, Sven-Olaf Kuhn, Reinhard Wetzker, Michael Bauer, Konrad Reinhart, Frank Bloos, Gernot Marx, Achim Schindler, Tobias Schürholz, Heike Schlegel-Höfner, Gunther Lehmann, Annett Sander, Steffen Friese, Christian Scholz, Pia Fischer, Christina Fuchs, Lutz Becher, Norbert Salewsky, Torsten Schreiber, Anton Goldmann, Didier Keh, Katrin Schmid, Winfried Menning, Renate Steuckart, Robert Barz, Karin Dey, Meike Fahrenholz, Martin Müller, Herwig Gerlach, Susanne Toussaint, Jörg Brederlau, Friedhelm Bach, Dirk Buschmann, Ingo Gummelt, J. Hoeschen, Marion Klaproth, Ina Vedder, Ulrike Bachmann-Holdau, Jürgen Eiche, Rolf Hauschild, Martina Lange, Davia Herrmann-Karbaum, Annette Lubasch, Marcus Rücker, Christian Icke, Alexander Lucht, Andreas Meier-Hellmann, Jan Wagner, Olaf Arnold, Steffen Kästner, Tobias Clausen, Michael Sternkopf, Robert Voswinckel, T. Benndorf, Christel Eiserloh, Gerhard Kuhnle, Mathias Koch, Manuela Gerber, Matthias Gründling, Liane Guderian, Sven-Olaf Kuhn, Christian Scheer, Gerd Scheiber, Frank Bloos, Susann Christink, Martina Kortegast, Claudia Matthäus-Krämer, Marcel Mücke, Bernhard Poidinger, Hendrik Rüddel, Ulrike Redlich, Daniel Schwarzkopf, Daniel Thomas-Rüddel, Christel Volkmer, Stefanie D’Aria, Thees Lemke, Birgit Michaelsen, Dirk Schädler, Nina Schulz-Ruhtenberg, Norbert Weiler, Martin Anetseder, Zoran Textor, Udo Kaisers, Philipp Simon, Georg Braun, Nicole Jensen, Werner Gegenfurtner, Alexander Meinhardt, Robert Schmitt, Andrea Teichert, Klaus-Dieter Becker, Anja Diers, Florian Jelschen, Andreas Weyland, Frieder Knebel, Thomas Kupfer, Rüdinger Sinz, Petra Bautz, Annemarie Fischer, Armin Seibel, Christoph Fleischhacker, Helene Häberle, Philipp Henn, Friederike Mezger, Peter Rosenberger, Reimer Riessen, Silvia Ziegler, Eberhard Barth, Hendrik Bracht, I. Heymann, A. Hinder, R. Sens, Manfred Weiss, Christof Lascho, Henriette Micke, Falk Schmidt, Stefanie Schilling, Gabriele Wöbker

Open Access Research

Targeted high mean arterial pressure aggravates cerebral hemodynamics after extracorporeal resuscitation in swine

Yael Levy, Alice Hutin, Fanny Lidouren, Nicolas Polge, Rocio Fernandez, Matthias Kohlhauer, Pierre-Louis Leger, Guillaume Debaty, Keith Lurie, Lionel Lamhaut, Bijan Ghaleh, Renaud Tissier

Open Access Review

The effect of opioids on gastrointestinal function in the ICU

Yun Yan, Yu Chen, Xijing Zhang

Open Access Research Letter

Identification of focal ARDS using ventilatory ratio

Kay Choong See, Melanie Torres Estaras, Juvel Mabao Taculod

Open Access Research

Clinical spectrum and risk factors for mortality among seawater and freshwater critically ill drowning patients: a French multicenter study

Florian Reizine, Agathe Delbove, Alexandre Dos Santos, Laetitia Bodenes, Pierre Bouju, Pierre Fillâtre, Aurélien Frérou, Guillaume Halley, Olivier Lesieur, Maud Jonas, Florian Berteau, Jean Morin, David Luque-Paz, Rémy Marnai, Anthony Le Meur, Cécile Aubron, Jean Reignier, Jean-Marc Tadié, Arnaud Gacouin

Open Access Research

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients

Jan Gunst, Astrid De Bruyn, Michael P. Casaer, Sarah Vander Perre, Lies Langouche, Greet Van den Berghe

Open Access COVID-19 Correction

Correction to: Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis

Kollengode Ramanathan, Kiran Shekar, Ryan Ruiyang Ling, Ryan P. Barbaro, Suei Nee Wong, Chuen Seng Tan, Bram Rochwerg, Shannon M. Fernando, Shinhiro Takeda, Graeme MacLaren, Eddy Fan, Daniel Brodie

Open Access Research

The effect of the head-up position on cardiopulmonary resuscitation: a systematic review and meta-analysis

Cheng-Chieh Huang, Kuan-Chih Chen, Zih-Yang Lin, Yu-Hsuan Chou, Wen-Liang Chen, Tsung-Han Lee, Kun-Te Lin, Pei-You Hsieh, Cheng Hsu Chen, Chu-Chung Chou, Yan-Ren Lin

Open Access Research

The obesity paradox and hypoglycemia in critically ill patients

Drago Plečko, Nicolas Bennett, Johan Mårtensson, Rinaldo Bellomo

Open Access Letter

Study conclude that TXA in severely injured was associated with lower mortality: beware of potential confounders

Patrick M. Honore, Sebastien Redant, Thierry Preseau, Sofie Moorthamers, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani, Willem Boer, David De Bels

Open Access Research

Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis

Shuhei Murao, Hidekazu Nakata, Ian Roberts, Kazuma Yamakawa

Open Access COVID-19 Research

Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units

Jaume Mesquida, A. Caballer, L. Cortese, C. Vila, U. Karadeniz, M. Pagliazzi, M. Zanoletti, A. Pérez Pacheco, P. Castro, M. García-de-Acilu, R. C. Mesquita, D. R. Busch, T. Durduran, Turgut Durduran, Marco Pagliazzi, Lorenzo Cortese, Marta Zanoletti, Umut Karadeniz, Jaume Mesquida, Alba Caballer, Sara Nogales, Cristina Espinal, Guillem Gruartmoner, Puri Pérez Terán, Clara Vilà, Lucía Picazo, Ricard Ferrer, Marina García De Acilu, Luis Chiscano, Abraham Mera, Pedro Castro, Adrián Téllez, Sara Fernández, Ana Matas, Fernando Fuentes, Isabel Serra, David Romero, Francesc Font, Tim Myers, David R. Busch, Siddharth Dave, Sreekanth Cheruku, Christopher Choi, Peiman Lahsaei, DaiWai Olson, Argelia Pérez Pacheco, Rosa María Quispe Siccha, Eduardo Liceaga, Félix Jerandy Monte De Oca Hernández, Bruno Adler Maccagnan Pinheiro Besen, Leandro Utino Taniguchi, Pedro Vitale Mendes, Rickson Coelho Mesquita, Andrés Fabián Quiroga Soto, Italo Karmann Aventurato, Laís Bacchin de Oliveira, Lilian Elisabete Bernardes Delazari, Lígia dos Santos, Roceto Ratti, Antonio Luis Eiras Falcão, Judith Marin-Corral, Raúl Serrano-Loyola, Verónica Carbajal-Robles, Enrique Santillan-Aguayo, Melvin Parada-Guzmán, Rodrigo Menezes-Forti, Luis Bacchin, Gabriela Lívio-Emidio

Open Access COVID-19 Research

The impact of COVID-19 critical illness on new disability, functional outcomes and return to work at 6 months: a prospective cohort study

Carol L. Hodgson, Alisa M. Higgins, Michael J. Bailey, Anne M. Mather, Lisa Beach, Rinaldo Bellomo, Bernie Bissett, Ianthe J. Boden, Scott Bradley, Aidan Burrell, D. James Cooper, Bentley J. Fulcher, Kimberley J. Haines, Jack Hopkins, Alice Y. M. Jones, Stuart Lane, Drew Lawrence, Lisa van der Lee, Jennifer Liacos, Natalie J. Linke, Lonni Marques Gomes, Marc Nickels, George Ntoumenopoulos, Paul S. Myles, Shane Patman, Michelle Paton, Gemma Pound, Sumeet Rai, Alana Rix, Thomas C. Rollinson, Janani Sivasuthan, Claire J. Tipping, Peter Thomas, Tony Trapani, Andrew A. Udy, Christina Whitehead, Isabelle T. Hodgson, Shannah Anderson, Ary Serpa Neto, Nicola Burgess, Kirsty Hearn, David Brewster, Alyssa Waanders, Shannon Simpson, Yasmin de Silva, Jenna Lang, Sarah Burleigh, Elisha Killer, Michael Wang, Lauren O’Connor, Lauren Thomas, Lucy Dennis, Joanna Caruana, Wisam Al-Bassam, Morag Shealy, Marianne Chapman, Stephanie O’Connor, Janne Sheehan, Emily Alexander, Amanda Sukkar, Liesl Davis, Francis Bass, Naomi Hammond, Anne O’Connor, Elizabeth Yarad, Richard Totaro Heidi Buhr, Nazmeen Reddy, Wendy Chaseling, Kelvin Ip, Oystein Tronstad, Alison Mahoney, Cadi Fanning, Hariette Esterman, Alexia Kozary, Bronte Scott, Donna Urquhart

Open Access COVID-19 Research Letter

Prolonged time from intubation to cannulation in VV-ECMO for COVID-19: does it really matter?

Pierre-Yves Olivier, Gregoire Ottavy, Jerome Hoff, Johann Auchabie, Cedric Darreau, Marc Pierrot

Open Access Research Letter

Clinical phenotype and outcomes of pneumococcal versus meningococcal purpura fulminans: a multicenter retrospective cohort study

Damien Contou, Nicolas de Prost, Laurent Argaud, François Barbier, Amélie Bazire, Gaëtan Béduneau, Frédéric Bellec, Pascal Beuret, Pascal Blanc, Cédric Bruel, Christian Brun-Buisson, Gwenhaël Colin, Delphine Colling, Alexandre Conia, Rémi Coudroy, Martin Cour, Damien Contou, Fabrice Daviaud, Vincent Das, Jean Dellamonica, Nadège Demars, Stephan Ehrmann, Arnaud Galbois, Elodie Gelisse, Julien Grouille, Laurent Guérin, Emmanuel Guérot, Samir Jaber, Caroline Jannière, Sébastien Jochmans, Mathieu Jozwiak, Pierre Kalfon, Antoine Kimmoun, Alexandre Lautrette, Jérémie Lemarié, Charlène Le Moal, Christophe Lenclud, Nicolas Lerolle, Olivier Leroy, Antoine Marchalot, Bruno Mégarbane, Armand Mekontso Dessap, Etienne de Montmollin, Frédéric Pène, Claire Pichereau, Gaëtan Plantefève, Sébastien Préau, Gabriel Preda, Nicolas de Prost, Jean-Pierre Quenot, Sylvie Ricome, Damien Roux, Bertrand Sauneuf, Matthieu Schmidt, Guillaume Schnell, Romain Sonneville, Jean-Marc Tadié, Yacine Tandjaoui, Martial Tchir, Nicolas Terzi, Xavier Valette, Lara Zafrani, Benjamin Zuber

Open Access Research Letter

Association between longer duration of citrate accumulation and 90-day mortality of acute-on-chronic liver failure

Ming Wang, Yuanji Ma, Lingyao Du, Hong Tang, Lang Bai

Open Access Research

Early prediction of hemodynamic interventions in the intensive care unit using machine learning

Asif Rahman, Yale Chang, Junzi Dong, Bryan Conroy, Annamalai Natarajan, Takahiro Kinoshita, Francesco Vicario, Joseph Frassica, Minnan Xu-Wilson

Open Access Commentary

Why the renin–angiotensin–aldosterone system (RAAS) in critically ill patients can no longer be ignored

Alexander Zarbock, Lakhmir Chawla, Rinaldo Bellomo

Open Access Research

Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS

Jose Angel Lorente, Nicolas Nin, Palmira Villa, Dovami Vasco, Ana B. Miguel-Coello, Ignacio Rodriguez, Raquel Herrero, Oscar Peñuelas, Jesús Ruiz-Cabello, Jose L. Izquierdo-Garcia

Open Access Research

Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis

Flavia Torrini, Ségolène Gendreau, Johanna Morel, Guillaume Carteaux, Arnaud W. Thille, Massimo Antonelli, Armand Mekontso Dessap

Open Access Research

A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals

Dustin C. Krutsinger, Kuldeep N. Yadav, Michael O. Harhay, Karsten Bartels, Katherine R. Courtright

Open Access Research

The simple observational critical care studies: estimations by students, nurses, and physicians of in-hospital and 6-month mortality

Eline G. M. Cox, Marisa Onrust, Madelon E. Vos, Wolter Paans, Willem Dieperink, Jacqueline Koeze, Iwan C. C. van der Horst, Renske Wiersema, Tamar van der Aart, Amila Azdahic, Diede Benjamins, Anke Bergsma, Yorick Bergsma, Jeroen Boekema, Vera Braun, Berend Bremer, Jan-Paul de Bruin, Elisa Chen, Chantal Dankfort, Karin Delfsma, Isabel Dieleman, Allysa Dijkstra, Alma Dijkstra, Elsa Doornbos, Ruben Eck, Rebecca van Elst, Dajana Erceg, Koen Geertzen, Chris Govaerts, Dion Groothof, Elisabeth Hagenauw, Xantia Heeres, Bart Hiemstra, Jildou Hoogland, Gerben Horstink, Maike Huizenga, Alexander Irk, Astrid Jansen, Thibault de Jonge, Thomas Kaufmann, Britt Keuning, Eric Keus, Charlotte Koerts, Evelyn van der Kooi, Femia Koopmans, Lisa Koops, Geert Koster, Menno de Leeuw, Lothar Mastenbroek, Ahra Meetsma, Gwen Miedema, Hidde Pelsma, George Pijpstra, Sarah Pruckl, Arlinde Roelofs, Maaike Schagen, Carine Schilte, Kim Selles, Elma Sluiter, Anna Smit, Lou van der Starre, Paul van Stee, Tim Takkenkamp, Melanie Theunis, Leonie Tijsma, Kabir Tombat, Nymke Trouwborst, Fennie Uiterwijk, Nynke van der Veen, Dorje Meilink, Bart Vinke, Erin Anne Visser, Brenda Wiersma, Marleen Wijma, Hinse Wiltingh, Jelle Wolters

Open Access Letter

Continuous wireless postoperative monitoring using wearable devices: further device innovation is needed

William Xu, Armen A. Gharibans, Ian P. Bissett, Gregory O’Grady, Cameron I. Wells, Carlos Areia, Christopher Biggs, Mauro Santos, Neal Thurley, Stephen Gerry, Lionel Tarassenko, Peter Watkinson, Sarah Vollam

Open Access Research Letter

Effects of levosimendan on occurrence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a case–control study

Antoine Trinh-Duc, Marc-Antoine Labeyrie, Anaïs Caillard, Wagih Ben Hassen, Alexandre Mebazaa, Benjamin Glenn Chousterman

Open Access Editorial

Equilibrating SSC guidelines with individualized care

Jean-Louis Vincent, Mervyn Singer, Sharon Einav, Rui Moreno, Julia Wendon, Jean-Louis Teboul, Jan Bakker, Glenn Hernandez, Djillali Annane, Angélique M. E. de Man, Xavier Monnet, V. Marco Ranieri, Olfa Hamzaoui, Jukka Takala, Nicole Juffermans, Jean-Daniel Chiche, Sheila N. Myatra, Daniel De Backer

Open Access Research

Background frequency can enhance the prognostication power of EEG patterns categories in comatose cardiac arrest survivors: a prospective, multicenter, observational cohort study

Youn-Jung Kim, Min-Jee Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Dong Hoon Lee, Won Young Kim, Ji Hoon Kim, Kyu Nam Park, Won Jung Jeong, Seung Pill Choi, Mi Jin Lee, Jong-Seok Lee, Su Jin Kim, Tae Chang Jang, Inbyung Kim, Yong Hwan Kim, Won Young Kim, Jonghwan Shin, Ji Hwan Lee, Hyung Jun Moon, Giwoon Kim, Wook-jin Choi, Joo Suk Oh, Chul Han, Byung Kook Lee, Taeoh Jeong, Dong Hoon Lee, Min Jin Hong, Gyu Chong Cho, Young Hwan Lee, Youdong Sohn, In Soo Cho, Je Sung You, Changsun Kim, Kyoung-Chul Cha, Soo Hyung Cho

Open Access COVID-19 Research

In the eye of the storm: impact of COVID-19 pandemic on admission patterns to paediatric intensive care units in the UK and Eire

Hari Krishnan Kanthimathinathan, Hannah Buckley, Peter J. Davis, Richard G. Feltbower, Caroline Lamming, Lee Norman, Lyn Palmer, Mark J. Peters, Adrian Plunkett, Padmanabhan Ramnarayan, Barnaby R. Scholefield, Elizabeth S. Draper

Open Access Letter

AVDS should not dethrone ARDS

Yazine Mahjoub, Daniel Rodenstein, Vincent Jounieaux

Open Access Research Letter

Telomere shortening during human septic shock: influence of sepsis mediators, role in organ failures, and septic myocardial dysfunction

Keyvan Razazi, Elisabeth Marcos, Sophie Hüe, Laurent Boyer, Serge Adnot, Armand Mekontso Dessap

Open Access Research

Cardiogenic shock in Taiwan from 2003 to 2017 (CSiT-15 study)

Shih-Chieh Chien, Chien-Yi Hsu, Hung-Yi Liu, Chao-Feng Lin, Chung-Lieh Hung, Chun-Yao Huang, Li-Nien Chien

Open Access COVID-19 Research

The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study

Lauro Damonti, Andreas Kronenberg, Jonas Marschall, Philipp Jent, Rami Sommerstein, Marlieke E. A. De Kraker, Stephan Harbarth, Michael Gasser, Niccolò Buetti

Open Access COVID-19 Review

Promises and challenges of personalized medicine to guide ARDS therapy

Katherine D. Wick, Daniel F. McAuley, Joseph E. Levitt, Jeremy R. Beitler, Djillali Annane, Elisabeth D. Riviello, Carolyn S. Calfee, Michael A. Matthay

Open Access Research

Development and evaluation of the focused assessment of sonographic pathologies in the intensive care unit (FASP-ICU) protocol

Stefan Schmidt, Jana-Katharina Dieks, Michael Quintel, Onnen Moerer

Open Access Letter

Indirect calorimetry is the gold standard to assess REE in ICU patients: some limitations to consider

Patrick M. Honore, Sebastien Redant, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Research Letter

Role of MR-proADM in the risk stratification of COVID-19 patients assessed at the triage of the Emergency Department

Marilena Minieri, Vito N. Di Lecce, Maria Stella Lia, Massimo Maurici, Sergio Bernardini, Jacopo M. Legramante

Open Access Letter

Randomised trials of temperature management in cardiac arrest: Are we observing the Zeno’s paradox of the Tortoise and Achilles?

Tommaso Scquizzato, Paul J. Young, Giovanni Landoni, Luisa Zaraca, Alberto Zangrillo

Open Access Research

Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support

Jonathan Rilinger, Klara Krötzsch, Xavier Bemtgen, Markus Jäckel, Viviane Zotzmann, Corinna N. Lang, Klaus Kaier, Daniel Duerschmied, Alexander Supady, Christoph Bode, Dawid L. Staudacher, Tobias Wengenmayer

Open Access Research

Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry

Ryuta Nakae, Tetsuro Sekine, Takashi Tagami, Yasuo Murai, Eigo Kodani, Geoffrey Warnock, Hidetaka Sato, Akio Morita, Hiroyuki Yokota, Shoji Yokobori

Open Access Research Letter

Effects of intermittent hemodialysis on plasmatic levels of endocan

Maxence Hureau, Julien Poissy, Daniel Mathieu, Sylvain Dubucquoi, Alexandre Gaudet

Open Access Research Letter

Complete countrywide mortality in COVID patients receiving ECMO in Germany throughout the first three waves of the pandemic

Christian Karagiannidis, Arthur S. Slutsky, Thomas Bein, Wolfram Windisch, Steffen Weber-Carstens, Daniel Brodie

Open Access Research

Novel protocol combining physical and nutrition therapies, Intensive Goal-directed REhabilitation with Electrical muscle stimulation and Nutrition (IGREEN) care bundle

Hidehiko Nakano, Hiromu Naraba, Hideki Hashimoto, Masaki Mochizuki, Yuji Takahashi, Tomohiro Sonoo, Yasuhiro Ogawa, Yujiro Matsuishi, Nobutake Shimojo, Yoshiaki Inoue, Kensuke Nakamura

Open Access Research

Changes in carbon dioxide production and oxygen uptake evaluated using indirect calorimetry in mechanically ventilated patients with sepsis

Ichiro Hirayama, Toshifumi Asada, Miyuki Yamamoto, Naoki Hayase, Takahiro Hiruma, Kent Doi

Open Access COVID-19 Research

HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients

Antoine Meyer, Niccolò Buetti, Nadhira Houhou-Fidouh, Juliette Patrier, Moustafa Abdel-Nabey, Pierre Jaquet, Simona Presente, Tiphaine Girard, Faiza Sayagh, Stephane Ruckly, Paul-Henri Wicky, Etienne de Montmollin, Lila Bouadma, Romain Sonneville, Diane Descamps, Jean-Francois Timsit

Open Access Research

Clinical characteristics and risk factors associated with mortality in patients with severe community-acquired pneumonia and type 2 diabetes mellitus

Dong Huang, Dingxiu He, Linjing Gong, Wen Wang, Lei Yang, Zhongwei Zhang, Yujun Shi, Zongan Liang

Open Access Research

Development of a new score for early mortality prediction in trauma ICU patients: RETRASCORE

Luis Serviá, Juan Antonio Llompart-Pou, Mario Chico-Fernández, Neus Montserrat, Mariona Badia, Jesús Abelardo Barea-Mendoza, María Ángeles Ballesteros-Sanz, Javier Trujillano

Open Access COVID-19 Research

Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals

Matthieu Schmidt, Alexandre Demoule, David Hajage, Tài Pham, Alain Combes, Martin Dres, Said Lebbah, Antoine Kimmoun, Alain Mercat, Gaëtan Beduneau, Jessica Palmyre, Margot Prevost, Jean-Damien Ricard, Alexis Ferré, Pierre-Marie Fayolle, Christophe Girault, Gael Pradel, Alain Mercat, Pierre Asfar, François Beloncle, Julien Demiselle, Tài Pham, Arthur Pavot, Xavier Monnet, Christian Richard, Alexandre Demoule, Martin Dres, Julien Mayaux, Alexandra Beurton, Cédric Daubin, Richard Descamps, Aurélie Joret, Damien Du Cheyron, Frédéric Pene, Jean-Daniel Chiche, Mathieu Jozwiak, Paul Jaubert, Guillaume Voiriot, Muriel Fartoukh, Marion Teulier, Clarisse Blayau, Erwen L’Her, Cécile Aubron, Laetitia Bodenes, Nicolas Ferriere, Johann Auchabie, Anthony Le Meur, Sylvain Pignal, Thierry Mazzoni, Jean-Pierre Quenot, Pascal Andreu, Jean-Baptiste Roudau, Marie Labruyère, Saad Nseir, Sébastien Preau, Julien Poissy, Daniel Mathieu, Sarah Benhamida, Rémi Paulet, Nicolas Roucaud, Martial Thyrault, Florence Daviet, Sami Hraiech, Gabriel Parzy, Aude Sylvestre, Sébastien Jochmans, Anne-Laure Bouilland, Mehran Monchi, Marc Danguy des Déserts, Quentin Mathais, Gwendoline Rager, Pierre Pasquier, Reignier Jean, Seguin Amélie, Garret Charlotte, Canet Emmanuel, Jean Dellamonica, Clément Saccheri, Romain Lombardi, Yanis Kouchit, Sophie Jacquier, Armelle Mathonnet, Mai-Ahn Nay, Isabelle Runge, Frédéric Martino, Laure Flurin, Amélie Rolle, Michel Carles, Rémi Coudroy, Arnaud W. Thille, Jean-Pierre Frat, Maeva Rodriguez, Pascal Beuret, Audrey Tientcheu, Arthur Vincent, Florian Michelin, Fabienne Tamion, Dorothée Carpentier, Déborah Boyer, Christophe Girault, Valérie Gissot, Stéphan Ehrmann, Charlotte Salmon Gandonniere, Djlali Elaroussi, Agathe Delbove, Yannick Fedun, Julien Huntzinger, Eddy Lebas, Grâce Kisoka, Céline Grégoire, Stella Marchetta, Bernard Lambermont, Laurent Argaud, Thomas Baudry, Pierre-Jean Bertrand, Auguste Dargent, Christophe Guitton, Nicolas Chudeau, Mickaël Landais, Cédric Darreau, Alexis Ferre, Antoine Gros, Guillaume Lacave, Fabrice Bruneel, Mathilde Neuville, Jérôme Devaquet, Guillaume Tachon, Richard Gallot, Riad Chelha, Arnaud Galbois, Anne Jallot, Ludivine Chalumeau Lemoine, Khaldoun Kuteifan, Valentin Pointurier, Louise-Marie Jandeaux, Joy Mootien, Charles Damoisel, Benjamin Sztrymf, Matthieu Schmidt, Alain Combes, Juliette Chommeloux, Charles Edouard Luyt, Frédérique Schortgen, Leon Rusel, Camille Jung, Florent Gobert, Damien Vimpere, Lionel Lamhaut, Bertrand Sauneuf, Liliane Charrrier, Julien Calus, Isabelle Desmeules, Benoît Painvin, Jean-Marc Tadie, Vincent Castelain, Baptiste Michard, Jean-Etienne Herbrecht, Mathieu Baldacini, Nicolas Weiss, Sophie Demeret, Clémence Marois, Benjamin Rohaut, Pierre-Henri Moury, Anne-Charlotte Savida, Emmanuel Couadau, Mathieu Série, Nica Alexandru, Cédric Bruel, Candice Fontaine, Sonia Garrigou, Juliette Courtiade Mahler, Maxime Leclerc, Michel Ramakers, Pierre Garçon, Nicole Massou, Ly Van Vong, Juliane Sen, Nolwenn Lucas, Franck Chemouni, Annabelle Stoclin, Alexandre Avenel, Henri Faure, Angélie Gentilhomme, Sylvie Ricome, Paul Abraham, Céline Monard, Julien Textoris, Thomas Rimmele, Florent Montini, Gabriel Lejour, Thierry Lazard, Isabelle Etienney, Younes Kerroumi, Claire Dupuis, Marine Bereiziat, Elisabeth Coupez, François Thouy, Clément Hoffmann, Nicolas Donat, Anne Chrisment, Rose-Marie Blot, Antoine Kimmoun, Audrey Jacquot, Matthieu Mattei, Bruno Levy, Ramin Ravan, Loïc Dopeux, Jean-Mathias Liteaudon, Delphine Roux, Brice Rey, Radu Anghel, Deborah Schenesse, Vincent Gevrey, Jermy Castanera, Philippe Petua, Benjamin Madeux, Otto Hartman, Michael Piagnerelli, Anne Joosten, Cinderella Noel, Patrick Biston, Thibaut Noel, Gurvan L. E. Bouar, Messabi Boukhanza, Elsa Demarest, Marie-France Bajolet, Nathanaël Charrier, Audrey Quenet, Cécile Zylberfajn, Nicolas Dufour, Buno Mégarbane, Sqébastian Voicu, Nicolas Deye, Isabelle Malissin, François Legay, Matthieu Debarre, Nicolas Barbarot, Pierre Fillatre, Bertrand Delord, Thomas Laterrade, Tahar Saghi, Wilfried Pujol, Pierre Julien Cungi, Pierre Esnault, Mickael Cardinale, Vivien Hong Tuan Ha, Grégory Fleury, Marie-Ange Brou, Daniel Zafimahazo, David Tran-Van, Patrick Avargues, Lisa Carenco, Nicolas Robin, Alexandre Ouali, Lucie Houdou, Christophe Le Terrier, Noémie Suh, Steve Primmaz, Jérome Pugin, Emmanuel Weiss, Tobias Gauss, Jean-Denis Moyer, Catherine Paugam Burtz, Béatrice La Combe, Rolland Smonig, Jade Violleau, Pauline Cailliez, Jonathan Chelly, Antoine Marchalot, Cécile Saladin, Christelle Bigot, Pierre-Marie Fayolle, Jules Fatséas, Amr Ibrahim, Dabor Resiere, Rabih Hage, Clémentine Cholet, Marie Cantier, Pierre Trouiler, Philippe Montravers, Brice Lortat-Jacob, Sebastien Tanaka, Alexy Tran Dinh, Jacques Duranteau, Anatole Harrois, Guillaume Dubreuil, Marie Werner, Anne Godier, Sophie Hamada, Diane Zlotnik, Hélène Nougue, Armand Mekontso-Dessap, Guillaume Carteaux, Keyvan Razazi, Nicolas De Prost, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Arié Attias, Charles de Roquetaillade, Benjamin G. Chousterman, Alexandre Mebazaa, Etienne Gayat, Marc Garnier, Emmanuel Pardo, Lea Satre-Buisson, Christophe Gutton, Elise Yvin, Clémence Marcault, Elie Azoulay, Michael Darmon, Hafid Ait Oufella, Geoffroy Hariri, Tomas Urbina, Sandie Mazerand, Nicholas Heming, Francesca Santi, Pierre Moine, Djillali Annane, Adrien Bouglé, Edris Omar, Aymeric Lancelot, Emmanuelle Begot, Gaétan Plantefeve, Damien Contou, Hervé Mentec, Olivier Pajot, Stanislas Faguer, Olivier Cointault, Laurence Lavayssiere, Marie-Béatrice Nogier, Matthieu Jamme, Claire Pichereau, Jan Hayon, Hervé Outin, François Dépret, Maxime Coutrot, Maité Chaussard, Lucie Guillemet, Pierre Goffin, Romain Thouny, Julien Guntz, Laurent Jadot, Romain Persichini, Vanessa Jean-Michel, Hugues Georges, Thomas Caulier, Gaël Pradel, Marie-Hélène Hausermann, Thi My Hue Nguyen-Valat, Michel Boudinaud, Emmanuel Vivier, Sylvène Rosseli, Gaël Bourdin, Christian Pommier, Marc Vinclair, Simon Poignant, Sandrine Mons, Wulfran Bougouin, Franklin Bruna, Quentin Maestraggi, Christian Roth, Laurent Bitker, François Dhelft, Justine Bonnet-Chateau, Mathilde Filippelli, Tristan Morichau-Beauchant, Stéphane Thierry, Charlotte Le Roy, Mélanie Saint Jouan, Bruno Goncalves, Aurélien Mazeraud, Matthieu Daniel, Tarek Sharshar, Cyril Cadoz, Rostane Gaci, Sébastien Gette, Guillaune Louis, Sophe-Caroline Sacleux, Marie-Amélie Ordan, Aurélie Cravoisy, Marie Conrad, Guilhem Courte, Sébastien Gibot, Younès Benzidi, Claudia Casella, Laurent Serpin, Jean-Lou Setti, Marie-Catherine Besse, Anna Bourreau, Jérôme Pillot, Caroline Rivera, Camille Vinclair, Marie-Aline Robaux, Chloé Achino, Marie-Charlotte Delignette, Tessa Mazard, Frédéric Aubrun, Bruno Bouchet, Aurélien Frérou, Laura Muller, Charlotte Quentin, Samuel Degoul, Xavier Stihle, Claude Sumian, Nicoletta Bergero, Bernard Lanaspre, Hervé Quintard, Eve Marie Maiziere, Pierre-Yves Egreteau, Guillaume Leloup, Florin Berteau, Marjolaine Cottrel, Marie Bouteloup, Matthieu Jeannot, Quentin Blanc, Julien Saison, Isabelle Geneau, Romaric Grenot, Abdel Ouchike, Pascal Hazera, Anne-Lyse Masse, Suela Demiri, Corinne Vezinet, Elodie Baron, Deborah Benchetrit, Antoine Monsel, Grégoire Trebbia, Emmanuelle Schaack, Raphaël Lepecq, Mathieu Bobet, Christophe Vinsonneau, Thibault Dekeyser, Quentin Delforge, Imen Rahmani, Bérengère Vivet, Jonathan Paillot, Lucie Hierle, Claire Chaignat, Sarah Valette, Benoït Her, Jennifier Brunet, Mathieu Page, Fabienne Boiste, Anthony Collin, Florent Bavozet, Aude Garin, Mohamed Dlala, Kais Mhamdi, Bassem Beilouny, Alexandra Lavalard, Severine Perez, Benoit Veber, Pierre-Gildas Guitard, Philippe Gouin, Anna Lamacz, Fabienne Plouvier, Bertrand P. Delaborde, Aïssa Kherchache, Amina Chaalal, Jean-Damien Ricard, Marc Amouretti, Santiago Freita-Ramos, Damien Roux, Jean-Michel Constantin, Mona Assefi, Marine Lecore, Agathe Selves, Florian Prevost, Christian Lamer, Ruiying Shi, Lyes Knani, Sébastien Pili Floury, Lucie Vettoretti, Michael Levy, Lucile Marsac, Stéphane Dauger, Sophie Guilmin-Crépon, Hadrien Winiszewski, Gael Piton, Thibaud Soumagne, Gilles Capellier, Jean-Baptiste Putegnat, Frédérique Bayle, Maya Perrou, Ghyslaine Thao, Guillaume Géri, Cyril Charron, Xavier Repessé, Antoine Vieillard-Baron, Mathieu Guilbart, Pierre-Alexandre Roger, Sébastien Hinard, Pierre-Yves Macq, Kevin Chaulier, Sylvie Goutte, Patrick Chillet, Anaïs Pitta, Barbara Darjent, Amandine Bruneau, Sigismond Lasocki, Maxime Leger, Soizic Gergaud, Pierre Lemarie, Nicolas Terzi, Carole Schwebel, Anaïs Dartevel, Louis-Marie Galerneau, Jean-Luc Diehl, Caroline Hauw-Berlemont, Nicolas Péron, Emmanuel Guérot, Abolfazl Mohebbi Amoli, Michel Benhamou, Jean-Pierre Deyme, Olivier Andremont, Diane Lena, Julien Cady, Arnaud Causeret, Arnaud De La Chapelle, Christophe Cracco, Stéphane Rouleau, David Schnell, Camille Foucault, Cécile Lory, Thibault Chapelle, Vincent Bruckert, Julie Garcia, Abdlazize Sahraoui, Nathalie Abbosh, Caroline Bornstain, Pierre Pernet, Florent Poirson, Ahmed Pasem, Philippe Karoubi, Virginie Poupinel, Caroline Gauthier, François Bouniol, Philippe Feuchere, Florent Bavozet, Anne Heron, Serge Carreira, Malo Emery, Anne Sophie Le Floch, Luana Giovannangeli, Nicolas Herzog, Christophe Giacardi, Thibaut Baudic, Chloé Thill, Said Lebbah, Jessica Palmyre, Florence Tubach, David Hajage, Nicolas Bonnet, Nathan Ebstein, Stéphane Gaudry, Yves Cohen, Julie Noublanche, Olivier Lesieur, Arnaud Sément, Isabel Roca-Cerezo, Michel Pascal, Nesrine Sma, Gwenhaël Colin, Jean-Claude Lacherade, Gauthier Bionz, Natacha Maquigneau, Pierre Bouzat, Michel Durand, Marie-Christine Hérault, Jean-Francois Payen

Open Access COVID-19 Research

Lung histopathologic clusters in severe COVID-19: a link between clinical picture and tissue damage

Maddalena Alessandra Wu, Gianluca Lopez, Manuela Nebuloni, Davide Ottolina, Jonathan Montomoli, Luca Carsana, Tommaso Fossali, Antonio Castelli, Roberto Rech, Chiara Cogliati, Emanuele Catena, Riccardo Colombo

Open Access Review

A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice

Jean-Charles Preiser, Yaseen M. Arabi, Mette M. Berger, Michael Casaer, Stephen McClave, Juan C. Montejo-González, Sandra Peake, Annika Reintam Blaser, Greet Van den Berghe, Arthur van Zanten, Jan Wernerman, Paul Wischmeyer

Open Access Letter

Is endocan correlated to ARDS severity or an epiphenomenon of thrombo-embolic disease in COVID

Patrick M. Honore, Sebastien Redant, Thierry Preseau, Bogdan Vasile Cismas, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Letter

Collaborative intelligence for intensive care units

Kay Choong See

Open Access Research

Flow Index accurately identifies breaths with low or high inspiratory effort during pressure support ventilation

Filippo Albani, Federica Fusina, Gianni Ciabatti, Luigi Pisani, Valeria Lippolis, Maria Elena Franceschetti, Alessia Giovannini, Rossella di Mussi, Francesco Murgolo, Antonio Rosano, Salvatore Grasso, Giuseppe Natalini

Open Access Research

17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial

Andrew R. Mayer, Andrew B. Dodd, Julie G. Rannou-Latella, David D. Stephenson, Rebecca J. Dodd, Josef M. Ling, Carissa J. Mehos, Cidney R. Robertson-Benta, Sharvani Pabbathi Reddy, Rachel E. Kinsler, Meghan S. Vermillion, Andrew P. Gigliotti, Veronik Sicard, Amy L. Lloyd, Erik B. Erhardt, Jessica M. Gill, Chen Lai, Vivian A. Guedes, Irshad H. Chaudry

Open Access COVID-19 Research Letter

Orthodeoxia and its implications on awake-proning in COVID-19 pneumonia

Lorenzo Giosa, Didier Payen, Mattia Busana, Alessio Mattei, Luca Brazzi, Pietro Caironi

Open Access Research

Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness

Ilse Vanhorebeek, Inge Derese, Jan Gunst, Pieter J. Wouters, Greet Hermans, Greet Van den Berghe

Open Access COVID-19 Research

Positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome: the heterogeneous effects

Davide Chiumello, Matteo Bonifazi, Tommaso Pozzi, Paolo Formenti, Giuseppe Francesco Sferrazza Papa, Gabriele Zuanetti, Silvia Coppola

Open Access Research

Real-world corticosteroid use in severe pneumonia: a propensity-score-matched study

A. Ceccato, A. Russo, E. Barbeta, P. Oscanoa, G. Tiseo, A. Gabarrus, P. Di Giannatale, S. Nogas, C. Cilloniz, F. Menichetti, M. Ferrer, M. Niederman, M. Falcone, A. Torres

Open Access Letter

Anisodamine microcirulatory effects in septic shock: be aware of cardiac side effects

Patrick M. Honore, Sebastien Redant, Thierry Preseau, Bogdan Vasile Cismas, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Impact of rewarming rate on interleukin-6 levels in patients with shockable cardiac arrest receiving targeted temperature management at 33 °C: the ISOCRATE pilot randomized controlled trial

Jean-Baptiste Lascarrou, Elie Guichard, Jean Reignier, Amélie Le Gouge, Caroline Pouplet, Stéphanie Martin, Jean-Claude Lacherade, Gwenhael Colin, M. Azais, K. Bachoumas, A. Bailly, L. Camous, G. Colin, L. Crosby, M. Fiancette, M. Henry Lagarrigue, J. C. Lacherade, J. B. Lascarrou, C. Lebert, L. Martin Lefevre, C. Pouplet, J. Reignier, A. Seguin, I. Vinatier, A. Yehia

Open Access COVID-19 Correction

Correction to: The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Antoni Torres, Anna Motos, Jordi Riera, Laia Fernández-Barat, Adrián Ceccato, Raquel Pérez-Arnal, Dario García-Gasulla, Oscar Peñuelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarrús, Rosario Menéndez, Jesús F. Bermejo-Martin, Ricard Ferrer, Rosario Amaya Villar, José M. Añón, Carme Barberà, José Barberán, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Cristóbal Galbán, Víctor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Díaz, Ángel Estella, Elena Gallego, José Luis García Garmendia, José Garnacho-Montero, José M. Gómez, Arturo Huerta, Ruth Noemí Jorge García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, Ignacio Martínez Varela, Juan López Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Pilar Ricart, Inmaculada Salvador-Adell, Angel Sánchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suares Sipmann, Luis Tamayo Lomas, José Trenado, Ferran Barbé, Berta Adell-Serrano, Alexander Agrifoglio, María Aguilar Cabello, Luciano Aguilera, Victoria Alcaraz-Serrano, Cesar Aldecoa, Cynthia Alegre, Sergio Álvarez, Antonjo Álvarez Ruiz, Rut Andrea, José Ángel, Marta Arrieta, J. Ignacio Ayestarán, Joan Ramon Badia, Mariona Badía, Orville Báez Pravia, Ana Balan Mariño, Begoña Balsera, Laura Barbena, Enric Barbeta, Tommaso Bardi, Patricia Barral Segade, Marta Barroso, José Ángel Berezo García, Judit Bigas, Rafael Blancas, María Luisa Blasco Cortés, María Boado, María Bodi Saera, Neus Bofill, María Teresa Bouza Vieiro, Leticia Bueno, Juan Bustamante-Munguira, Lucia Cachafeiro, David Campi Hermoso, Sandra Campos Fernández, Iosune Cano, Maria Luisa Cantón-Bulnes, Pablo Cardina Fernández, Laura Carrión García, Sula Carvalho, Núria Casacuberta-Barberà, Manuel Castellà, Andrea Castellví, Pedro Castro, Ramon Cicuendez Ávila, Catia Cillóniz, Luisa Clar, Cristina Climent, Jordi Codina, Pamela Conde, Sofía Contreras, María Cruz Martin, Raul de Pablo Sánchez, Diego De Mendoza, Cecilia del Busto Martínez, Yolanda Díaz, María Digna Rivas Vilas, Cristina Dólera Moreno, Irene Dot, Pedro Enríquez Giraudo, Inés Esmorís Arijón, Teresa Farre Monjo, Javier Fernández, Carlos Ferrando, Albert Figueras, Eva Forcadell-Ferreres, Lorena Forcelledo Espina, Nieves Franco, Àngels Furro, Felipe García, Beatriz García, Emilio García Prieto, Carlos García Redruello, Amaia García Sagastume, Maria Luisa Gascón Castillo, Gemma Gomà, Vanesa Gómez Casal, Silvia Gómez, Carmen Gómez Gonzalez, Jessica González, Federico Gordo, Maria Pilar Gracia, Alba Herraiz, Rubén Herrán-Monge, Mercedes Ibarz, Silvia Iglesias, Maria Teresa Janer, Gabriel Jiménez, Mar Juan Díaz, Karsa Kiarostami, Juan I. Lazo Álvarez, Miguel León, Alexandre López-Gavín, Ana López Lago, Desire Macias Guerrero, Nuria Mamolar Herrera, Rafael Mañez Mendiluce, Cecilia L. Mantellini, Gregorio Marco Naya, Pilar Marcos, Enrique Marmol Peis, Paula Martín Vicente, María Martínez, Carmen Eulalia Martínez Fernández, Maria Dolores Martínez Juan, Juan Fernando Masa Jimenez, Joan Ramon Masclans, Emilio Maseda, Eva María Menor Fernández, Mar Miralbés, Josman Monclou, Juan Carlos Montejo-González, Neus Montserrat, María Mora Aznar, Pedro Moral-Parras, Dulce Morales, Sara Guadalupe Moreno Cano, David Mosquera Rodríguez, Rosana Muñoz-Bermúdez, José María Nicolás, Ramon Nogue Bou, Rafaela Nogueras Salinas, Marta Ocón, Ana Ortega, Sergio Ossa, Pablo Pagliarani, Anna Parera Pous, Francisco Parrilla, Leire Pérez Bastida, Purificación Pérez, Gloria Pérez Planelles, Eva Pérez Rubio, David Pestaña Laguna, Àngels Piñol-Tena, Javier Prados, Andrés Pujol, Núria Ramon Coll, Gloria Renedo Sanchez-Giron, Ferran Roche-Campo, Laura Rodriguez, Felipe Rodríguez de Castro, Silvia Rodríguez, Covadonga Rodríguez Ruiz, Jorge Rubio, Alberto Rubio López, Miriam Ruiz Miralles, Pablo Ryan Murúa, Eva Saborido Paz, Ana Salazar Degracia, Miguel Sanchez, Ana Sánchez, Bitor Santacoloma, Maria Teresa Sariñena, Marta Segura Pensado, Lidia Serra, Mireia Serra-Fortuny, Ainhoa Serrano Lázaro, Lluís Servià, Laura Soliva, Carla Speziale, Daniel Tognetti, Adrián Tormos, Mateu Torres, Sandra Trefler, Javier Trujillano, Alejandro Úbeda, Luis Urrelo-Cerrón, Estela Val, Luis Valdivia Ruiz, Montserrat Vallverdú, Maria Van der Hofstadt Martin-Montalvo, Sabela Vara Adrio, Nil Vázquez, Javier Vengoechea, Pablo Vidal Cortes, Clara Vilà-Vilardel, Judit Vilanova, Tatiana Villada Warrington, Hua Yang, Minlan Yang, Ana Zapatero

Open Access Research

Albumin and fibrinogen kinetics in sepsis: a prospective observational study

Keisuke Omiya, Hiroaki Sato, Tamaki Sato, Linda Wykes, Mengyin Hong, Roupen Hatzakorzian, Arnold S. Kristof, Thomas Schricker

Open Access Research

Patient discharge from intensive care: an updated scoping review to identify tools and practices to inform high-quality care

Kara M. Plotnikoff, Karla D. Krewulak, Laura Hernández, Krista Spence, Nadine Foster, Shelly Longmore, Sharon E. Straus, Daniel J. Niven, Jeanna Parsons Leigh, Henry T. Stelfox, Kirsten M. Fiest

Open Access Research Letter

How to monitor thiopental administration in the intensive care unit for refectory status epilepticus or intracranial hypertension?

Erika Dabricot, Inès Seqat, Frédéric Dailler, Sylvain Rheims, Sebastien Boulogne, Baptiste Balança

Open Access Review

Dangers of hyperoxia

Mervyn Singer, Paul J. Young, John G. Laffey, Pierre Asfar, Fabio Silvio Taccone, Markus B. Skrifvars, Christian S. Meyhoff, Peter Radermacher

Open Access Research

Surface EMG-based quantification of inspiratory effort: a quantitative comparison with Pes

Jan Graßhoff, Eike Petersen, Franziska Farquharson, Max Kustermann, Hans-Joachim Kabitz, Philipp Rostalski, Stephan Walterspacher

Open Access COVID-19 Commentary

Effect of chest wall loading during supine and prone position in a critically ill covid-19 patient: a new strategy for ARDS?

Sergio Lassola, Sara Miori, Andrea Sanna, Rocco Pace, Sandra Magnoni, Luigi Vetrugno, Michele Umbrello

Open Access Research

Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous haemodiafiltration (CVVHDF)

Marcus Kirwan, Reema Munshi, Hannah O’Keeffe, Conor Judge, Mary Coyle, Evelyn Deasy, Yvelynne P. Kelly, Peter J. Lavin, Maria Donnelly, Deirdre M. D’Arcy

Open Access COVID-19 Research Letter

Ventilator-associated pneumonia in critically-ill patients with COVID-19 in a setting of selective decontamination of the digestive tract

Sinta B. van der Meer, Grace Figaroa, Peter H. J. van der Voort, Maarten W. Nijsten, Janesh Pillay

Open Access Research

A pilot study of trained ICU doulas providing early psychological support to critically ill patients

Lioudmila V. Karnatovskaia, Katalin Varga, Alexander S. Niven, Phillip J. Schulte, Midhat Mujic, Ognjen Gajic, Brent A. Bauer, Matthew M. Clark, Roberto P. Benzo, Kemuel L. Philbrick

Open Access Letter

Demystifying machine learning for mortality prediction

J. M. Smit, M. E. van Genderen, M. J. T. Reinders, D. A. M. P. J. Gommers, J. H. Krijthe, J. Van Bommel

Open Access COVID-19 Research

Predictors for extubation failure in COVID-19 patients using a machine learning approach

Lucas M. Fleuren, Tariq A. Dam, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco Peters, Marlijn J. A. Kamps, Dharmanand Ramnarain, Ralph Nowitzky, Fleur G. C. A. Nooteboom, Wouter de Ruijter, Louise C. Urlings-Strop, Ellen G. M. Smit, D. Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P. C. de Jager, Stefaan H. A. Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C. Reidinga, Barbara Festen-Spanjer, Gert B. Brunnekreef, Alexander D. Cornet, Walter van den Tempel, Age D. Boelens, Peter Koetsier, Judith Lens, Harald J. Faber, A. Karakus, Robert Entjes, Paul de Jong, Thijs C. D. Rettig, Sesmu Arbous, Sebastiaan J. J. Vonk, Mattia Fornasa, Tomas Machado, Taco Houwert, Hidde Hovenkamp, Roberto Noorduijn Londono, Davide Quintarelli, Martijn G. Scholtemeijer, Aletta A. de Beer, Giovanni Cinà, Adam Kantorik, Tom de Ruijter, Willem E. Herter, Martijn Beudel, Armand R. J. Girbes, Mark Hoogendoorn, Patrick J. Thoral, Paul W. G. Elbers, Julia Koeter, Roger van Rietschote, M. C. Reuland, Laura van Manen, Leon Montenij, Jasper van Bommel, Roy van den Berg, Ellen van Geest, Anisa Hana, B. van den Bogaard, Peter Pickkers, Pim van der Heiden, Claudia van Gemeren, Arend Jan Meinders, Martha de Bruin, Emma Rademaker, Frits H. M. van Osch, Martijn de Kruif, Nicolas Schroten, Klaas Sierk Arnold, J. W. Fijen, Jacomar J. M. van Koesveld, Koen S. Simons, Joost Labout, Bart van de Gaauw, Michael Kuiper, Albertus Beishuizen, Dennis Geutjes, Johan Lutisan, Bart P. Grady, Remko van den Akker, Tom A. Rijpstra, W. G. Boersma, Daniel Pretorius, Menno Beukema, Bram Simons, A. A. Rijkeboer, Marcel Aries, Niels C. Gritters van den Oever, Martijn van Tellingen, Annemieke Dijkstra, Rutger van Raalte

Open Access Letter

Awake prone positioning on diaphragmatic function: Really bad or maybe good?

Basang Xiao, Yuntao Zhang, Zhuoga Ci, Dandan Shi, Hangyong He

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 Operationsvorbereitung Nachrichten

Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.

Update AINS

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