Erschienen in:
Open Access
01.02.2011 | Poster presentation
Danger signal uric acid is involved in ventilator-induced lung injury pathogenesis
verfasst von:
M Kuipers, H Aslami, T Van der Poll, M Schultz, C Wieland
Erschienen in:
Critical Care
|
Sonderheft 1/2011
Einloggen, um Zugang zu erhalten
Excerpt
Endogenous molecules released during tissue injury can trigger an innate immune response and are termed damage-associated molecular patterns (DAMPs). Uric acid is considered an important DAMP and causes acute lung inflammation when administered locally. The exact role of the innate immune response in ventilator-induced lung injury (VILI) is not yet completely understood. We hypothesized that uric acid is released during VILI and that reduction of uric acid levels attenuates lung injury induced by short-term mechanical ventilation (MV). …