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01.12.2015 | Case Report - Functional

Deep brain stimulation of the subthalamic nucleus: histological verification and 9.4-T MRI correlation

verfasst von: Othman Al-Helli, David L. Thomas, Luke Massey, Thomas Foltynie, Patricia Limousin, Janice L. Holton, Tarek A. Yousry, Ludvic Zrinzo

Erschienen in: Acta Neurochirurgica | Ausgabe 12/2015

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Abstract

Background

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) using an MRI-guided and MRI-verified technique without microelectrode recording is an effective and safe surgical treatment for patients with Parkinson’s disease (PD).

Objectives

To assess the anatomical accuracy of lead placement after MRI-guided, MRI-verified STN DBS using post-mortem histology and high-field MRI at 9.4 T.

Methods

We conducted post-mortem analysis of a patient’s brain who had had MRI-guided, MRI-verified STN DBS for PD, using 9.4-T MRI and histology. After death, the brain was retrieved and a block including the electrode tracks down to the mesencephalon was examined with high-field MRI at 9.4 T and histological analysis.

Results

High-field MRI images and corresponding histological examination showed that each electrode track ended within the intended target area, and that DBS did not cause significant neuroparenchymal tissue damage.

Conclusions

This study supports the anatomical accuracy of the MRI-guided and MRI-verified method of STN DBS.

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Titel: Deep brain stimulation of the subthalamic nucleus: histological verification and 9.4-T MRI correlation
verfasst von: Othman Al-Helli
David L. Thomas
Luke Massey
Thomas Foltynie
Patricia Limousin
Janice L. Holton
Tarek A. Yousry
Ludvic Zrinzo
Publikationsdatum: 01.12.2015
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 12/2015
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-015-2599-x

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Abstract

Background

Objectives

Methods

Results

Conclusions

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