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Current Anesthesiology Reports
Erschienen in: Current Anesthesiology Reports 1/2015

01.03.2015 | Perioperative Delirium (JM Leung, Section Editor)

Delirium and Obstructive Sleep Apnea: Exploring the Molecular Link

verfasst von: Stephanie C. Patterson, Shawn G. Kwatra, Miles Berger, Madan M. Kwatra

Erschienen in: Current Anesthesiology Reports | Ausgabe 1/2015

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Abstract

Delirium is a common problem among the elderly. The incidence of delirium will increase considerably in the coming decades as the proportion of the population over age 65 increases. Given that an FDA-approved drug to treat delirium is not available, efforts geared toward prevention are paramount. Several risk factors that predispose/precipitate delirium have been identified. A recently described, reversible risk factor for postoperative delirium is obstructive sleep apnea (OSA). In this review, we focus on the molecular basis of delirium and its link to OSA. We present evidence that OSA modulates the levels of two factors, IGF-1 and cortisol, which both have been linked to postoperative delirium.
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Metadaten
Titel
Delirium and Obstructive Sleep Apnea: Exploring the Molecular Link
verfasst von
Stephanie C. Patterson
Shawn G. Kwatra
Miles Berger
Madan M. Kwatra
Publikationsdatum
01.03.2015
Verlag
Springer US
Erschienen in
Current Anesthesiology Reports / Ausgabe 1/2015
Elektronische ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-014-0092-3

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