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01.01.2012 | Urogenital

Detection of intrarenal microstructural changes with supersonic shear wave elastography in rats

verfasst von: Marc Derieppe, Yahsou Delmas, Jean-Luc Gennisson, Colette Deminière, Sandrine Placier, Mickaël Tanter, Christian Combe, Nicolas Grenier

Erschienen in: European Radiology | Ausgabe 1/2012

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Abstract

Objectives

To evaluate, in a rat model of glomerulosclerosis, whether ultrasonic shear wave elastography detects kidney cortex stiffness changes and predicts histopathological development of fibrosis.

Materials and methods

Three groups were studied transversally: a control group (n = 8), a group after 4 weeks of L-NAME administration (H4, n = 8), and a group after 6 weeks (H6, n = 15). A fourth group was studied longitudinally (n = 8) before, after 4 weeks and after 7 weeks of L-NAME administration. Shear modulus of renal cortex was quantified using supersonic shear imaging technique. Urine was analysed for dosage of protein/creatinine ratio. Kidneys were removed for histological quantification of fibrosis.

Results

Diseased rats showed an increased urinary protein/creatinine ratio. Cortical stiffness expressed as median (interquartile range) was 4.0 kPa (3.3–4.5) in control kidneys. It increased in all but one pathological groups: H4: 7.7 kPa (5.5–8.6) (p < 0.01); H6: 4.8 kPa (3.9–5.9) (not significant); in the longitudinal cohort, from 4.5 kPa (3.1–5.9) to 7.7 kPa (5.9–8.3) at week 4 (p < 0.05) and to 6.9 kPa (6.1–7.8) at week 7 (p < 0.05). Stiffness values were correlated with the proteinuria/creatininuria ratio (r = 0.639, p < 0.001).

Conclusions

Increased cortical stiffness is correlated with the degree of renal dysfunction. More experience in other models is necessary to understand its relationship with microstructural changes.

Key Points

Ultrasound elastography with supersonic shear wave imaging can predict parenchymal microstructural changes
In this rat model, cortical stiffness correlated with the proteinuria/creatininuria ratio
Quantification of cortical stiffness could be a useful biomarker for chronic renal disease
SSI should now be investigated in patients with native/transplanted renal disease

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Titel: Detection of intrarenal microstructural changes with supersonic shear wave elastography in rats
verfasst von: Marc Derieppe
Yahsou Delmas
Jean-Luc Gennisson
Colette Deminière
Sandrine Placier
Mickaël Tanter
Christian Combe
Nicolas Grenier
Publikationsdatum: 01.01.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 1/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2229-9

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Detection of intrarenal microstructural changes with supersonic shear wave elastography in rats

Abstract

Objectives

Materials and methods

Results

Conclusions

Key Points

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Springer Medizin

Abstract

Objectives

Materials and methods

Results

Conclusions

Key Points

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