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Abdominal Radiology

Erschienen in:

01.06.2015

Detection of liver metastases in patients with adenocarcinomas of the gastrointestinal tract: comparison of ¹⁸F-FDG PET/CT and MR imaging

verfasst von: Christian Maegerlein, Alexander A. Fingerle, Michael Souvatzoglou, Ernst J. Rummeny, Konstantin Holzapfel

Erschienen in: Abdominal Radiology | Ausgabe 5/2015

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Abstract

Purpose

Aim of our study was to compare the diagnostic performance of ¹⁸F-FDG PET/CT and MR imaging (MRI) in the detection of liver metastases in patients with adenocarcinomas of the gastrointestinal tract.

Methods

A total of 49 patients with adenocarcinomas of the gastrointestinal tract who had undergone ¹⁸F-FDG PET/CT and MRI of the liver were included in this study. The MRI protocol included diffusion-weighted imaging and dynamic contrast-enhanced MR imaging after intravenous injection of Gd-DTPA. PET and MR images were analyzed by two experienced radiologists. Imaging results were correlated with histopathological findings or imaging follow-up as available. Sensitivities of both modalities were compared using McNemar Test. Receiver operating characteristic (ROC) curves were calculated to determine the diagnostic performance in correctly identifying liver metastases.

Results

A total of 151 metastases were confirmed. For lesion detection, MRI was significantly superior to ¹⁸F-FDG PET/CT. Sensitivity of MRI in detecting metastases was 86.8% for Reader 1 (R1) and 87.4% for Reader 2 (R2), of PET/CT 66.2% for R1 and 68.2% for R2. Regarding only metastases with diameters of 10 mm or less, sensitivities of MRI were 66.7% for R1 and 75.0% for R2, and were significantly higher than those of PET/CT (17.9% for R1 and 20.5% for R2). ROC analysis showed superiority for lesion classification of MRI as compared to ¹⁸F-FDG PET/CT.

Conclusion

MRI is significantly superior to ¹⁸F-FDG PET/CT in the detection and classification of liver metastases in patients with adenocarcinomas of the gastrointestinal tract, especially in the detection of small metastases.

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Titel: Detection of liver metastases in patients with adenocarcinomas of the gastrointestinal tract: comparison of 18F-FDG PET/CT and MR imaging
verfasst von: Christian Maegerlein
Alexander A. Fingerle
Michael Souvatzoglou
Ernst J. Rummeny
Konstantin Holzapfel
Publikationsdatum: 01.06.2015
Verlag: Springer US
Erschienen in: Abdominal Radiology / Ausgabe 5/2015
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-014-0283-x

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Detection of liver metastases in patients with adenocarcinomas of the gastrointestinal tract: comparison of ¹⁸F-FDG PET/CT and MR imaging

Abstract

Purpose

Methods

Results

Conclusion

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