nach oben

Die Dermatologie

Erschienen in:

01.06.2010 | Leitthema

Die Talgdrüse

verfasst von: Prof. Dr. C.C. Zouboulis

Erschienen in: Die Dermatologie | Ausgabe 6/2010

Einloggen, um Zugang zu erhalten

Zusammenfassung

In der Fetal- und Neugeborenenzeit werden Entwicklung und Funktion der Talgdrüse von maternalen Androgenen, endogenen Steroiden und anderen Morphogenen gesteuert. Die offensichtlichste Funktion der Talgdrüse ist die Sebumsekretion. Kurz nach der Geburt kommt es zu einem starken Anstieg der Sebumexkretion und einem Peak in der ersten Lebenswoche, danach zu einem allmählichen Abfall. Im Rahmen der Adrenarche im Alter von etwa 9 Jahren entsteht ein erneuter Anstieg, der bis etwa zum 17. Lebensjahr anhält, bis das Erwachsenenniveau erreicht ist. Die Talgdrüse ist Zielorgan, aber auch Bildungsort von Hormonen (v. a. aktiven Androgenen). Sebozyten weisen ein breites Spektrum von Hormonrezeptoren auf. Die Wirkung von Androgenen auf die Sebumexkretion ist bekannt, die Differenzierung terminaler Sebozyten wird von Peroxisom-Proliferator-aktivierenden Rezeptorliganden unterstützt. Auch Östrogene, Glukokortikoide und Prolaktin beeinflussen die Talgdrüsenfunktion. Zusätzlich induzieren Stress-sensible kutane Signale die Produktion und Freisetzung von CRH („corticotrohin releasing hormone“) mit nachfolgender dosisabhängiger Regulierung der neutralen Lipide. Ohne exogene Einflüsse synthetisieren Talgdrüsen neben anderen Lipidfragmenten erhebliche Mengen freier Fettsäuren. Atopische bzw. seborrhoische Dermatitis, Psoriasis und Akne vulgaris zählen zu den Krankheitsbildern, an deren Entstehung und Ausprägung Talgdrüsenlipide wahrscheinlich oder sicher beteiligt sind.

Montagna W (1963) Comparative aspects of sebaceous glands. In: Montagna W, Ellis RA, Silver AF (eds) Advances in biology of skin, vol IV. The sebaceous glands. Pergamon, Oxford, pp 32–45

Nikkari T (1974) Comparative chemistry of sebum. J Invest Dermatol 62:257–267CrossRefPubMed

Pochi P (1982) The sebaceous gland. In: Maibach HI, Boisits EK (eds) Neonatal skin structure and function. Marcel Dekker, New York, pp 67–80

Wheatley VR (1956) Sebum: its chemistry and biochemistry. Am Perfumer 68:37–47

Thody AJ, Shuster S (1989) Control and function of sebaceous glands. Physiol Rev 69:383–416PubMed

Mykytowycz R, Goodrich BS (1974) Skin glands as organs of communication in mammals. J Invest Dermatol 62:124–131CrossRefPubMed

Ebling FJG, Cunliffe WJ (1992) Disorders of the sebaceous glands. In: Champion RH, Burton JL, Ebling FJG (eds) Textbook of Dermatology. 5th edn. Blackwell, London, pp 1699–1744

Kligman AM (1963) The uses of sebum? In: Montagna W, Ellis RA, Silver AF (eds) Advances in biology of skin, vol IV. The sebaceous glands. Pergamon, Oxford, pp 110–112

Cunliffe WJ (1989) Acne. Martin Dunitz, London

10.

Zouboulis CC, Seltmann H, Neitzel H, Orfanos CE (1999) Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol 113:1011–1020CrossRefPubMed

11.

Zouboulis CC, Schagen S, Alestas T (2008) The sebocyte culture – a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne. Arch Dermatol Res 300:397–413CrossRefPubMed

12.

Zouboulis CC (2004) The human skin as a hormone target and an endocrine gland. Hormones 3:9–26PubMed

13.

Zouboulis CC (2005) Acne and sebaceous gland function. Clin Dermatol 22:360–366CrossRef

14.

Hong I, Lee M, Na T et al (2008) LXRα enhances lipid synthesis in SZ95 sebocytes. J Invest Dermatol 128:1266–1272CrossRefPubMed

15.

Zouboulis CC, Chen W, Thornton MJ et al (2007) Sexual hormones in human skin. Horm Metab Res 39:85–95CrossRefPubMed

16.

Reichrath J, Lehmann B, Carlberg C et al (2007) Vitamins as hormones. Horm Metab Res 39:71–84CrossRefPubMed

17.

Schmuth M, Watson REB, Deplewski D et al (2007) Nuclear hormone receptors in human skin. Horm Metab Res 39:96–105CrossRefPubMed

18.

Agache P, Blanc D, Barrand C, Laurent R (1980) Sebum levels during the first year of life. Br J Dermatol 103:643–649CrossRefPubMed

19.

Mesiano S, Jaffe RB (1997) Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev 18:378–403CrossRefPubMed

20.

Billich A, Rot A, Lam C et al (2000) Immunohistochemical localization of steroid sulfatase in acne lesions: Implications for the contribution of dehydroepiandrosterone sulfate to the pathogenesis of acne (abstract). Horm Res 53:99

21.

Fritsch M, Orfanos CE, Zouboulis CC (2001) Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol 116:793–800CrossRefPubMed

22.

Nicolaides N, Wells GC (1957) On the biogenesis of the free fatty acids in human skin surface fat. J Invest Dermatol 29:423–433PubMed

23.

Henderson CA, Taylor J, Cunliffe WJ (2000) Sebum excretion rates in mothers and neonates. Br J Dermatol 142:110–111CrossRefPubMed

24.

Ghodsi SZ, Orawa H, Zouboulis CC (2009) Prevalence, severity and severity risk factors of acne in high school pupils: A community-based study. J Invest Dermatol 129:2136–2141CrossRefPubMed

25.

Pochi PE, Strauss JS, Downing DT (1977) Sebum, acne and androgens in children (abstract). Clin Res Cardiol 25:531A

26.

Ramasastry P, Downing DT, Pochi PE, Strauss JS (1970) Chemical composition of human skin surface lipids from birth to puberty. J Invest Dermatol 54:139–144CrossRefPubMed

27.

Pappas A, Anthonavage M, Gordon J (2002) Metabolic fate and selective utilization of major fatty acids in human sebaceous gland. J Invest Dermatol 118:164–171CrossRefPubMed

28.

Sanders D, Philpott M, Nicolle F, Kealey T (1994) The isolation and maintenance of the human pilosebaceous unit. Br J Dermatol 131:166–176PubMed

29.

Zouboulis CC, Xia L, Akamatsu H et al (1998) The human sebocyte culture model provides new insights into development and management of seborrhoea and acne. Dermatology 196:21–31CrossRefPubMed

30.

Chen W, Yang C, Sheu H et al (2003) Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol 121:441–447CrossRefPubMed

31.

Deplewski D, Rosenfield R (1999) Growth hormone and insulin like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinology 140:4089–4094CrossRefPubMed

32.

Harrison WJ, Bull JJ, Seltmann H et al (2007) Expression of lipogenic factors galectin-12, resistin, SREBP-1 and SCD in human sebaceous glands and cultured sebocytes. J Invest Dermatol 127:1309–1317CrossRefPubMed

33.

Smith T, Cong Z, Gilliland K et al (2006) Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1. J Invest Dermatol 126:1226–1232CrossRefPubMed

34.

Lo Celso C, Berta M, Braun K et al (2008) Characterisation of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and β-catenin. Stem Cells 26:1241–1252CrossRef

35.

Ge L, Gordon J, Hsuan C et al (2003) Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. J Invest Dermatol 120:707–714CrossRefPubMed

36.

Downing D, Stewart M, Wertz P, Strauss J (1986) Essential fatty acids and acne. J Am Acad Dermatol 14:221–225CrossRefPubMed

37.

Chiba K, Yoshizawa K, Makino I et al (2000) Comedogenicity of squalene monohydroperoxide in the skin after topical application. J Toxicol Sci 25:77–83PubMed

38.

Stewart M, Grahek M, Cambier L et al (1986) Dilutional effect of increased sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in epidermal acylceramides. J Invest Dermatol 87:733–736CrossRefPubMed

39.

Ottaviani M, Alestas T, Flori E et al (2006) Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: A possible role in acne vulgaris. J Invest Dermatol 126:2430–2437CrossRefPubMed

40.

Nagai A, Sato T, Akimoto N et al (2005) Isolation and identification of histone H3 protein enriched in microvesicles secreted from cultured sebocytes. Endocrinology 146:2593–2601CrossRefPubMed

41.

Akimoto N, Sato T, Iwata C et al (2005) Expression of perilipin A on the surface of lipid droplets increases along with the differentiation of hamster sebocytes in vivo and in vitro. J Invest Dermatol 124:1127–1133CrossRefPubMed

42.

Schmuth M, Ortegon A, Mao-Qiang M et al (2005) Differential expression of fatty acid transport proteins in epidermis and skin appendages. J Invest Dermatol 125:1174–1181CrossRefPubMed

43.

Greenspan P, Mayer E, Fowler S (1985) Nile red: a selective fluorescent stain for intracellular lipid droplets. J Cell Biol 100:965–973CrossRefPubMed

44.

Wróbel A, Seltmann H, Fimmel S et al (2003) Differentiation and apoptosis in human immortalized sebocytes. J Invest Dermatol 120:175–181CrossRefPubMed

45.

Alestas T, Ganceviciene R, Fimmel S et al (2006) Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands. J Mol Med 84:75–87CrossRefPubMed

46.

Sato T, Imai N, Akimoto N et al (2001) Epidermal growth factor and 1alpha,25-dihydroxyvitamin D3 suppress lipogenesis in hamster sebaceous gland cells in vitro. J Invest Dermatol 117:965–970CrossRefPubMed

47.

Krause K, Schnitger A, Fimmel S et al (2007) Corticotropin-releasing hormone skin signalling is receptor-mediated and is predominant in the sebaceous glands. Horm Metab Res 39:166–170CrossRefPubMed

48.

Zouboulis CC, Seltmann H, Hiroi N et al (2002) Corticotropin releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A 99:7148–7153CrossRefPubMed

49.

Böhm M, Schiller M, Ständer S et al (2002) Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ. J Invest Dermatol 118:533–539CrossRefPubMed

50.

Ganceviciene R, Graziene V, Böhm M, Zouboulis CC (2007) Increased in situ expression of melanocortin-1 receptor in sebaceous glands of lesional skin of patients with acne vulgaris. Exp Dermatol 16:547–552CrossRefPubMed

51.

Zhang L, Li W, Anthonavage M, Eisinger M (2006) Melanocortin-5 receptor: A marker of human sebocyte differentiation. Peptides 27:413–420CrossRefPubMed

52.

Böhm M, Li Z, Ottaviani M et al (2004) Beta-endorphin modulates lipogenesis in human sebocytes (abstract). J Invest Dermatol 123:A10

53.

Seiffert K, Zouboulis CC, Seltmann H, Granstein R (2000) Expression of neuropeptide receptors by human sebocytes and stimulatory effect of their agonists on cytokine production (abstract). Horm Res 53:102

54.

Ständer S, Schmelz M, Metze D et al (2005) Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci 38:177–188CrossRefPubMed

55.

Dobrosi N, Tóth B, Nagy G et al (2008) Endocannabinoids enhance lipid synthesis in human sebocytes via cannabinoid receptor-2-mediated signaling. FASEB J 22:3685–3695CrossRefPubMed

56.

Pelle E, McCarthy J, Seltmann H et al (2008) Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes. J Invest Dermatol 128:1280–1285CrossRefPubMed

57.

Makrantonaki E, Adjaye J, Herwig R et al (2006) Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro. Aging Cell 5:331–344CrossRefPubMed

58.

Liang T, Hoyer S, Yu R et al (1993) Immunocytochemical localization of androgen receptors in human skin using monoclonal antibodies against the androgen receptor. J Invest Dermatol 100:663–666CrossRefPubMed

59.

Bläuer M, Vaalasti A, Pauli SL et al (1991) Location of androgen receptor in human skin. J Invest Dermatol 97:264–268CrossRefPubMed

60.

Fimmel S, Saborowski A, Térouanne B et al (2007) Inhibition of the androgen receptor by antisense oligonucleotides regulates the biological activity of androgens in SZ95 sebocytes. Horm Metab Res 39:149–156CrossRefPubMed

61.

Chen W, Zouboulis CC, Fritsch M et al (1998) Evidence of heterogeneity and quantitative differences of the type 1 5α-reductase expression in cultured human skin cells. Evidence of its presence in melanocytes. J Invest Dermatol 110:84–89CrossRefPubMed

62.

Akamatsu H, Zouboulis CC, Orfanos CE (1993) Spironolactone directly inhibits proliferation of cultured human facial sebocytes and acts antagonistically to testosterone and 5 alpha-dihydrotestosterone in vitro. J Invest Dermatol 100:660–662CrossRefPubMed

63.

Makrantonaki E, Zouboulis CC (2007) Testosterone metabolism to 5α-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferators-activated receptor ligand linoleic acid in human sebocytes. Br J Dermatol 156:428–432CrossRefPubMed

64.

Rosenfield R, Deplewski D, Kentsis A, Ciletti N (1998) Mechanisms of androgen induction of sebocyte differentiation. Dermatology 196:43–46CrossRefPubMed

65.

Pelletier G, Ren L (2004) Localization of sex steroid receptors in human skin. Histol Histopathol 19:629–636PubMed

66.

Thornton M, Nelson L, Taylor AH et al (2006) The modulation of aromatase and estrogen receptor alpha in cultured human dermal papilla cells by dexamethasone: a novel mechanism for selective action of estrogen via estrogen receptor beta? J Invest Dermatol 126:2010–2018CrossRefPubMed

67.

Thornton M, Taylor A, Mulligan K et al (2003) Oestrogen receptor-β is the predominant oestrogen receptor in human scalp skin. Exp Dermatol 12:181–190CrossRefPubMed

68.

Makrantonaki E, Vogel K, Fimmel S et al (2008) Interplay of IGF-I and 17ß-estradiol at age-specific levels in human sebocytes and fibroblasts in vitro. Exp Gerontol 43:939–946CrossRefPubMed

69.

Guy R, Green M, Kealey T (1996) Modeling acne in vitro. J Invest Dermatol 106:176–1782CrossRefPubMed

70.

Reichrath J, Mittmann M, Kamradt J, Müller S (1997) Expression of retinoid-X receptors (-alpha, -beta, -gamma) and retinoic acid receptors (-alpha, -beta, -gamma) in normal human skin: an immunohistological evaluation. Histochem J 29:127–133CrossRefPubMed

71.

Tsukada M, Schroder M, Roos T et al (2000) 13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J Invest Dermatol 115:321–327CrossRefPubMed

72.

Kim M, Deplewski D, Ciletti N et al (2001) Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and development. Mol Genet Metab 74:362–369CrossRefPubMed

73.

Reichrath J, Classen U, Meineke V et al (2000) Immunoreactivity of six monoclonal antibodies directed against 1,25-dihydroxyvitamin-D3 receptors in human skin. Histochem J 32:625–629CrossRefPubMed

74.

Krämer C, Seltmann H, Seifert M et al (2009) Characterization of the vitamin D endocrine system in human sebocytes in vitro. J Steroid Biochem Mol Biol 113:9–16CrossRefPubMed

75.

Russell L, Harrison W, Bahta A et al (2007) Characterization of liver X receptor expression and function in human skin and the pilosebaceous unit. Exp Dermatol 16:844–852CrossRefPubMed

76.

Tóth BI, Géczy T, Griger Z et al (2009) Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology. J Invest Dermatol 129:329–339CrossRefPubMed

77.

Melnik B, Schmitz G, Zouboulis CC (2009) Anti-acne agents attenuate FGFR2 signal transduction in acne. J Invest Dermatol 129:1868–1877CrossRefPubMed

78.

Nanney LB, Magid M, Stoscheck CM, King LE Jr (1984) Comparison of epidermal growth factor binding and receptor distribution in normal human epidermis and epidermal appendages. J Invest Dermatol 83:385–393CrossRefPubMed

79.

Saitoh K, Takahashi H, Sawada N, Parsons PG (1994) Detection of the c-met proto-oncogene product in normal skin and tumours of melanocytic origin. J Pathol 174:191–199CrossRefPubMed

80.

Oeff MK, Seltmann H, Hiroi N et al (2006) Differential regulation of Toll-like receptor and CD14 pathways by retinoids and corticosteroids in human sebocytes. Dermatology 213:266CrossRefPubMed

81.

Nagy I, Pivarcsi A, Kis K et al (2006) Propionibacterium acnes and lipopolysaccharide induce the expression of antibacterial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes Infect 8:2195–2205CrossRefPubMed

82.

Chen W, Tsai S-J, Sheu H-M et al (2010) Testosterone synthesized in cultured human SZ95 sebocytes mainly derives from dehydroepiandrosterone. Exp Dermatol 19:470–472CrossRefPubMed

83.

Kim MH, Herrmann WL (1969) In vitro metabolsim of dehydroepiandrosterone sulphate in foreskin, abdominal skin and vaginal mucosa. J Clin Endocrinol Metab 28:187–191CrossRef

84.

Deplewski D, Rosenfield RL (2000) Role of hormones in pilosebaceous unit development. Endocr Rev 21:363–392CrossRefPubMed

85.

Toh YC (1980) Effect of ovarectomy at birth on regulation of sebaceous glands in rats. J Endocrinol 86:179–182CrossRefPubMed

86.

Shuster S, Hinks WM, Thody AJ (1977) Effect of sex and age at gonadectomy on the sebaceous response to progesterone. J Endocrinol 73:67–70CrossRefPubMed

87.

Pochi PE, Strauss JS, Mescon H (1963) The role of adrenocortical steroids in the control of human sebaceous gland activity. J Invest Dermatol 41:391–399PubMed

88.

Leveque JL, Piecard-Franchimont C, Rigal J de et al (1991) Effects of topical coricosteroids on human sebum production assessed by two different methods. Arch Dermatol Res 283:372–376CrossRefPubMed

89.

Ahsan MK, Urano Y, Kato S et al (1998) Immunohistochemical localization of thyroid hormone nuclear receptors in human hair follicles and in vitro effect of l-trijodthyronine on cultured cells of hair follicles and skin. J Med Invest 44:179–184PubMed

90.

Billoni N, Buan B, Gautier B et al (2000) Thyroid hormone receptor β1 is expressed in the human hair follicle. Br J Dermatol 142:645–652CrossRefPubMed

91.

Orfanos CE, Adler YD, Zouboulis CC (2000) The SAHA syndrome. Horm Res 54:251–258CrossRefPubMed

92.

Burton JL, Libman LJ, Cunliffe WJ et al (1972) Sebum excretion in acromegaly. Br Med J 1:406–408CrossRefPubMed

93.

Ebling FJG, Ebling E, Randall V, Skinner J (1975) The effects of hypophysectomy and of bovine growth hormone on the responses to testosterone of prostate, preputial, Harderian and lacrymal glands and of brown adipose tissue in the rat. J Endocrinol 66:401–406CrossRefPubMed

94.

Ganceviciene R, Graziene V, Fimmel S, Zouboulis CC (2009) Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris. Br J Dermatol 160:345–352CrossRefPubMed

95.

Ebling FJG, Ebling E, Randall V, Skinner J (1975) The sebotrophic action of growth hormone (BGH) in the rat. Br J Dermatol 92:325–332CrossRefPubMed

96.

Glickman SP, Rosenfield RL, Bergenstal RM, Helke J (1982) Multiple androgenic abnormalities, including elevated free testosterone, in hyperprolactinemic women. J Clin Endocrinol Metab 55:251–257CrossRefPubMed

97.

Zouboulis CC, Böhm M (2004) Neuroendocrine regulation of sebocytes – a pathogenetic link between stress and acne. Exp Dermatol 13(Suppl 4):31–35CrossRefPubMed

98.

Schaich B, Korting HC, Hollmann J (1993) Hautlipide bei mit Seborrhoe- und Sebostase-assoziierten Hauterkrankungen. Hautarzt 44:75–80PubMed

99.

Ead RD, Fairbank RA, Cunliffe WJ (1977) Sebum excretion rate, surface lipid composition and constitutional eczema. Clin Exp Dermatol 2:361–364CrossRefPubMed

100.

Saint-Leger D, Francois AM, Leveque JL et al (1989) Stratum corneum lipids in skin xerosis. Dermatologica 178:151–155CrossRefPubMed

101.

Downing DT, Stewart ME, Strauss JS (1986) Changes in sebum secretion and the sebaceous gland. Dermatol Clin 4:419–423PubMed

102.

Headington JT, Gupta AK, Goldfarb MT et al (1989) A morphometric and histologic study of the scalp in psoriasis. Paradoxical sebaceous gland atrophy and decreased hair shaft diameters without alopecia. Arch Dermatol 125:639–642CrossRefPubMed

103.

Shahrad P, Marks R (1976) Hair follicle kinetics in psoriasis. Br J Dermatol 94:7–12CrossRefPubMed

104.

Nicolaides N, Fu HC, Ansari MNA, Rice GR (1972) The fatty acids of esters and sterol esters from vernix caseosa and from human surface lipid. Lipids 7:506–517CrossRefPubMed

105.

Katsambas AD, Katoulis AC, Stavropoulos P (1999) Acne neonatorum: a study of 22 cases. Int J Dermatol 38:128–130CrossRefPubMed

Titel: Die Talgdrüse
verfasst von: Prof. Dr. C.C. Zouboulis
Publikationsdatum: 01.06.2010
Verlag: Springer-Verlag
Erschienen in: Die Dermatologie / Ausgabe 6/2010
Print ISSN: 2731-7005
Elektronische ISSN: 2731-7013
DOI: https://doi.org/10.1007/s00105-009-1894-y

Leitlinien kompakt für die Dermatologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Dermatologie

Riesenzellarteriitis: 15% der Patienten sind von okkulter Form betroffen

16.05.2024 Riesenzellarteriitis Nachrichten

In einer retrospektiven Untersuchung haben Forschende aus Belgien und den Niederlanden die okkulte Form der Riesenzellarteriitis genauer unter die Lupe genommen. In puncto Therapie und Rezidivraten stellten sie keinen sehr großen Unterschied zu Erkrankten mit kranialen Symptomen fest.

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

16.05.2024 Pädiatrische Allergologie Nachrichten

Die große Mehrheit der vermeintlichen Penicillinallergien sind keine. Da das „Etikett“ Betalaktam-Allergie oft schon in der Kindheit erworben wird, kann ein frühzeitiges Delabeling lebenslange Vorteile bringen. Ein Team von Pädiaterinnen und Pädiatern aus Kanada stellt vor, wie sie dabei vorgehen.

Isotretinoin: Risiko für schwere Laboranomalien „marginal erhöht“

08.05.2024 Akne Nachrichten

Die Aknetherapie mit Isotretinoin kann einen Anstieg von Leberenzymen und Blutfetten verursachen. Das Risiko für schwere Störungen ist laut einer Forschungsgruppe der Universität Lübeck aber nur marginal erhöht und auf einen engen Zeitraum konzentriert.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Update Dermatologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2010

Asta von Mallinckrodt-Haupt, 1896–1960

Zur Bedeutung des Vitamin-D-Stoffwechsels in der humanen Haut

Hormone und Haarwachstum

Ungewöhnliche chronische sklerodermiforme Graft-versus-Host-Erkrankung

Dermatoendokrinologie