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12.07.2022 | Neurology and Preclinical Neurological Studies - Original Article

Differences in aphasia syndromes between progressive supranuclear palsy–Richardson’s syndrome, behavioral variant frontotemporal dementia and Alzheimer’s dementia

verfasst von: Lucia Ransmayr, Alexandra Fuchs, Sibylle Ransmayr-Tepser, Romana Kommenda, Mariella Kögl, Petra Schwingenschuh, Franz Fellner, Michael Guger, Christian Eggers, Robert Darkow, Stephanie Mangesius, Gerhard Ransmayr

Erschienen in: Journal of Neural Transmission | Ausgabe 8/2022

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Abstract

Language impairments, hallmarks of speech/language variant progressive supranuclear palsy, also occur in Richardson’s syndrome (PSP-RS). Impaired communication may interfere with daily activities. Therefore, assessment of language functions is crucial. It is uncertain whether the Aachen Aphasia Test (AAT) is practicable in PSP-RS, behavioral variant frontotemporal dementia (bvFTD) and Alzheimer’s dementia (AD) and language deficits differ in these disorders. 28 PSP-RS, 24 AD, and 24 bvFTD patients were investigated using the AAT and the CERAD-Plus battery. 16–25% of all patients failed in AAT subtests for various reasons. The AAT syndrome algorithm diagnosed amnestic aphasia in 5 (23%) PSP-RS, 7 (36%) bvFTD and 6 (30%) AD patients, Broca aphasia in 1 PSP-RS and 1 bvFTD patient, Wernicke aphasia in 1 bvFTD and 3 (15%) AD patients. However, aphasic symptoms resembled non-fluent primary progressive aphasia in 14 PSP-RS patients. In up to 46% of PSP-RS patients, 61% of bvFTD and 64% of AD patients significant impairments were found in the AAT subtests spontaneous speech, written language, naming, language repetition, language comprehension and the Token subtest. The CERAD-Plus subtest semantic fluency revealed significant impairment in 81% of PSP-RS, 61% of bvFTD, 44% of AD patients, the phonemic fluency subtest in 31, 40 and 31%, respectively. In contrast to bvFTD and AD, severity of language impairment did not correlate with cognitive decline in PSP-RS. In summary, the patterns of aphasia differ between the diagnoses. Local frontal language networks might be impaired in PSP-RS, whereas in AD and bvFTD, more widespread neuropathology might underly language impairment.

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Titel: Differences in aphasia syndromes between progressive supranuclear palsy–Richardson’s syndrome, behavioral variant frontotemporal dementia and Alzheimer’s dementia
verfasst von: Lucia Ransmayr
Alexandra Fuchs
Sibylle Ransmayr-Tepser
Romana Kommenda
Mariella Kögl
Petra Schwingenschuh
Franz Fellner
Michael Guger
Christian Eggers
Robert Darkow
Stephanie Mangesius
Gerhard Ransmayr
Publikationsdatum: 12.07.2022
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 8/2022
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-022-02524-2

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