Erschienen in:
01.04.2008 | Poster presentation
Different tidal volumes induce similar elevation of lung injury markers in animals sensitized to injury by previous anesthesia and surgery
verfasst von:
P Dostal, V Cerny, M Senkerik, R Parizkova, H Zivna, P Zivny
Erschienen in:
Critical Care
|
Sonderheft 2/2008
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Excerpt
Large tidal volumes and transpulmonary pressures play a central role in pathogenesis of ventilator-induced lung injury. Moderate tidal volumes are considered safe in healthy lungs [
1]. Recent studies suggested that insults like endotoxin [
2] or surgery [
3] sensitize the lung to injury by priming for an exaggerated response to a second stimulus. Our aim was to investigate how animals sensitized to lung injury by previous anesthesia and surgery respond to mechanical ventilation (MV). …