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European Archives of Psychiatry and Clinical Neuroscience
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 5/2010

01.08.2010 | Original Paper

Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia

verfasst von: Kathrin Koch, Gerd Wagner, Robert Dahnke, Claudia Schachtzabel, Christoph Schultz, Martin Roebel, Daniel Güllmar, Jürgen R. Reichenbach, Heinrich Sauer, Ralf G. M. Schlösser

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 5/2010

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Abstract

Evidence for white matter abnormalities in patients with schizophrenia is increasing. Decreased fractional anisotropy (FA) in interhemispheric commissural fibers as well as long-ranging fronto-parietal association fibers belongs to the most frequent findings. The present study used tract-based spatial statistics to investigate white matter integrity in 35 patients with schizophrenia and 35 healthy volunteers. We found that patients exhibited significantly decreased FA relative to healthy subjects in the corpus callosum, the cerebral peduncle, the left inferior fronto-occipital fasciculus, the anterior thalamic radiation, the right posterior corona radiata, the middle cerebellar peduncle, and the right superior longitudinal fasciculus. Increased FA was detectable in the inferior sections of the corticopontine-cerebellar circuit. Present data indicate extended cortical-subcortical alterations of white matter integrity in schizophrenia using advanced data analysis strategies. They corroborate preceding findings of white matter structural deficits in mainly long-ranging association fibers and provide first evidence for neuroplastic changes in terms of an increased directionality in more inferior fiber tracts.
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Metadaten
Titel
Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia
verfasst von
Kathrin Koch
Gerd Wagner
Robert Dahnke
Claudia Schachtzabel
Christoph Schultz
Martin Roebel
Daniel Güllmar
Jürgen R. Reichenbach
Heinrich Sauer
Ralf G. M. Schlösser
Publikationsdatum
01.08.2010
Verlag
Springer-Verlag
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 5/2010
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-009-0087-0

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