Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
European Archives of Psychiatry and Clinical Neuroscience
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 5/2010

01.08.2010 | Original Paper

Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients

verfasst von: Susanne Karch, Tobias Thalmeier, Jürgen Lutz, Anja Cerovecki, Markus Opgen-Rhein, Bettina Hock, Gregor Leicht, Kristina Hennig-Fast, Thomas Meindl, Michael Riedel, Christoph Mulert, Oliver Pogarell

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 5/2010

Einloggen, um Zugang zu erhalten

Abstract

Deficits in executive functions, e.g. voluntary selection, are considered central to the attention-deficit/hyperactivity disorder (ADHD). The aim of this simultaneous EEG/fMRI study was to examine associated neural correlates in ADHD patients. Patients with ADHD and healthy subjects performed an adapted go/nogo task including a voluntary selection condition allowing participants to freely decide, whether to press the response button. Electrophysiologically, response inhibition and voluntary selection led to fronto-central responses. The fMRI data revealed increased medial/lateral frontal and parietal activity during the voluntary selection task. Frontal brain responses were reduced in ADHD patients compared to controls during free responses, whereas parietal brain functions seemed to be unaffected. These results may indicate that selection processes are related to dysfunctions, predominantly in frontal brain regions in ADHD patients.
Literatur
1.
Aron AR, Poldrack RA (2005) The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1285–1292CrossRefPubMed
2.
3.
Barkley RA (1997) Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121:65–94CrossRefPubMed
4.
Bartholow BD, Pearson MA, Dickter CL, Sher KJ, Fabiani M, Gratton G (2005) Strategic control and medial frontal negativity: beyond errors and response conflict. Psychophysiology 42:33–42CrossRefPubMed
5.
Bekker EM, Kenemans JL, Verbaten MN (2004) Electrophysiological correlates of attention, inhibition, sensitivity and bias in a continuous performance task. Clin Neurophysiol 115:2001–2013CrossRefPubMed
6.
Bekker EM, Overtoom CC, Kooij JJ, Buitelaar JK, Verbaten MN, Kenemans JL (2005) Disentangling deficits in adults with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 62:1129–1136CrossRefPubMed
7.
Botvinick MM, Braver TS, Barch DM, Carter CS, Cohen JD (2001) Conflict monitoring and cognitive control. Psychol Rev 108:624–652CrossRefPubMed
8.
Brass M, Derrfuss J, Forstmann B, von Cramon DY (2005) The role of the inferior frontal junction area in cognitive control. Trends Cogn Sci 9:314–316CrossRefPubMed
9.
Braver TS, Barch DM, Kelley WM, Buckner RL, Cohen NJ, Miezin FM et al (2001) Direct comparison of prefrontal cortex regions engaged by working and long-term memory tasks. Neuroimage 14:48–59CrossRefPubMed
10.
Bruin KJ, Wijers AA, van Staveren AS (2001) Response priming in a go/nogo task: do we have to explain the go/nogo N2 effect in terms of response activation instead of inhibition? Clin Neurophysiol 112:1660–1671CrossRefPubMed
11.
Bush G, Frazier JA, Rauch SL, Seidman LJ, Whalen PJ, Jenike MA et al (1999) Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop. Biol Psychiatry 45:1542–1552CrossRefPubMed
12.
Bush G, Valera EM, Seidman LJ (2005) Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions. Biol Psychiatry 57:1273–1284CrossRefPubMed
13.
Cabeza R, Nyberg L (2000) Imaging cognition II: an empirical review of 275 PET and fMRI studies. J Cogn Neurosci 12:1–47CrossRefPubMed
14.
Casey BJ, Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Schubert AB et al (1997) Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36:374–383CrossRefPubMed
15.
Casey BJ, Thomas KM, Welsh TF, Badgaiyan RD, Eccard CH, Jennings JR et al (2000) Dissociation of response conflict, attentional selection, and expectancy with functional magnetic resonance imaging. Proc Natl Acad Sci USA 97:8728–8733CrossRefPubMed
16.
Connors CK, Erhardt D, Sparrow E (1999) Conners’ Adult ADHD Rating Scales (CAARS). Multi-Health Systems, North Tonawanda, New York
17.
Debener S, Ullsperger M, Siegel M, Engel AK (2006) Single-trial EEG-fMRI reveals the dynamics of cognitive function. Trends Cogn Sci 10:558–563CrossRefPubMed
18.
Debener S, Ullsperger M, Siegel M, Fiehler K, von Cramon DY, Engel AK (2005) Trial-by-trial coupling of concurrent electroencephalogram and functional magnetic resonance imaging identifies the dynamics of performance monitoring. J Neurosci 25:11730–11737CrossRefPubMed
19.
Deiber MP, Passingham RE, Colebatch JG, Friston KJ, Nixon PD, Frackowiak RS (1991) Cortical areas and the selection of movement: a study with positron emission tomography. Exp Brain Res 84:393–402CrossRefPubMed
20.
Dickstein SG, Bannon K, Castellanos FX, Milham MP (2006) The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis. J Child Psychol Psychiatry 47:1051–1062CrossRefPubMed
21.
Donchin E, Coles MGH (1988) Is the P300 component a manifestation of context updating? Behav Brain Sci 11:355–372
22.
Donkers FC, van Boxtel GJ (2004) The N2 in go/no-go tasks reflects conflict monitoring not response inhibition. Brain Cogn 56:165–176PubMed
23.
Durston S, Thomas KM, Worden MS, Yang Y, Casey BJ (2002) The effect of preceding context on inhibition: an event-related fMRI study. Neuroimage 16:449–453CrossRefPubMed
24.
Eichele T, Specht K, Moosmann M, Jongsma ML, Quiroga RQ, Nordby H et al (2005) Assessing the spatiotemporal evolution of neuronal activation with single-trial event-related potentials and functional MRI. Proc Natl Acad Sci USA 102:17798–17803CrossRefPubMed
25.
Falkenstein M, Hoormann J, Hohnsbein J (1999) ERP components in Go/Nogo tasks and their relation to inhibition. Acta Psychol (Amst) 101:267–291CrossRef
26.
Fallgatter AJ, Ehlis AC, Seifert J, Strik WK, Scheuerpflug P, Zillessen KE et al (2004) Altered response control and anterior cingulate function in attention-deficit/hyperactivity disorder boys. Clin Neurophysiol 115:973–981CrossRefPubMed
27.
Fassbender C, Schweitzer JB (2006) Is there evidence for neural compensation in attention deficit hyperactivity disorder? A review of the functional neuroimaging literature. Clin Psychol Rev 26:445–465CrossRefPubMed
28.
Forstmann BU, Brass M, Koch I, von Cramon DY (2006) Voluntary selection of task sets revealed by functional magnetic resonance imaging. J Cogn Neurosci 18:388–398CrossRefPubMed
29.
Forstmann BU, Ridderinkhof KR, Kaiser J, Bledowski C (2007) At your own peril: an ERP study of voluntary task set selection processes in the medial frontal cortex. Cogn Affect Behav Neurosci 7:286–296CrossRefPubMed
30.
Frith CD, Friston K, Liddle PF, Frackowiak RS (1991) Willed action and the prefrontal cortex in man: a study with PET. Proc Biol Sci 244:241–246CrossRefPubMed
31.
Gajewski PD, Stoerig P, Falkenstein M (2008) ERP-correlates of response selection in a response conflict paradigm. Brain Res 1189:127–134CrossRefPubMed
32.
Garavan H, Ross TJ, Murphy K, Roche RA, Stein EA (2002) Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correction. Neuroimage 17:1820–1829CrossRefPubMed
33.
Garon N, Moore C, Waschbusch DA (2006) Decision making in children with ADHD only, ADHD-anxious/depressed, and control children using a child version of the Iowa Gambling Task. J Atten Disord 9:607–619CrossRefPubMed
34.
Geurts HM, Verte S, Oosterlaan J, Roeyers H, Sergeant JA (2004) How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? J Child Psychol Psychiatry 45:836–854CrossRefPubMed
35.
Goldberg II, Harel M, Malach R (2006) When the brain loses its self: prefrontal inactivation during sensorimotor processing. Neuron 50:329–339CrossRefPubMed
36.
Harvey PO, Fossati P, Pochon JB, Levy R, Lebastard G, Lehericy S et al (2005) Cognitive control and brain resources in major depression: an fMRI study using the n-back task. Neuroimage 26:860–869CrossRefPubMed
37.
Hyder F, Phelps EA, Wiggins CJ, Labar KS, Blamire AM, Shulman RG (1997) “Willed action”: a functional MRI study of the human prefrontal cortex during a sensorimotor task. Proc Natl Acad Sci USA 94:6989–6994CrossRefPubMed
38.
Iaboni F, Douglas VI, Baker AG (1995) Effects of reward and response costs on inhibition in ADHD children. J Abnorm Psychol 104:232–240CrossRefPubMed
39.
Ille N, Berg P, Scherg M (2002) Artifact correction of the ongoing EEG using spatial filters based on artifact and brain signal topographies. J Clin Neurophysiol 19:113–124CrossRefPubMed
40.
Jahanshahi M, Jenkins IH, Brown RG, Marsden CD, Passingham RE, Brooks DJ (1995) Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson’s disease subjects. Brain 118(Pt 4):913–933CrossRefPubMed
41.
Jueptner M, Stephan KM, Frith CD, Brooks DJ, Frackowiak RS, Passingham RE (1997) Anatomy of motor learning. I. Frontal cortex and attention to action. J Neurophysiol 77:1313–1324PubMed
42.
Kamarajan C, Porjesz B, Jones KA, Choi K, Chorlian DB, Padmanabhapillai A et al (2005) Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task. Biol Psychol 69:353–373CrossRefPubMed
43.
Karch S, Jager L, Karamatskos E, Graz C, Stammel A, Flatz W et al (2008) Influence of trait anxiety on inhibitory control in alcohol-dependent patients: simultaneous acquisition of ERPs and BOLD responses. J Psychiatr Res 42:734–745CrossRefPubMed
44.
Karch S, Mulert C, Thalmeier T, Lutz J, Leicht G, Meindl T et al (2009) The free choice whether or not to respond after stimulus presentation. Hum Brain Mapp 30:2971–2985CrossRefPubMed
45.
Kessler RC, Adler L, Ames M, Barkley RA, Birnbaum H, Greenberg P et al (2005) The prevalence and effects of adult attention deficit/hyperactivity disorder on work performance in a nationally representative sample of workers. J Occup Environ Med 47:565–572CrossRefPubMed
46.
Kessler RC, Adler LA, Barkley R, Biederman J, Conners CK, Faraone SV et al (2005) Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: results from the national comorbidity survey replication. Biol Psychiatry 57:1442–1451CrossRefPubMed
47.
Kim MS, Kim YY, Yoo SY, Kwon JS (2007) Electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder. Depress Anxiety 24:22–31CrossRefPubMed
48.
Konrad K, Gauggel S, Manz A, Scholl M (2000) Lack of inhibition: a motivational deficit in children with attention deficit/hyperactivity disorder and children with traumatic brain injury. Child Neuropsychol 6:286–296PubMed
49.
Kramer AF, Strayer DL (1988) Assessing the development of automatic processing: an application of dual-task and event-related brain potential methodologies. Biol Psychol 26:231–267CrossRefPubMed
50.
Krause KH, Krause J, Trott GE (1998) Hyperkinetic syndrome (attention deficit-hyperactivity disorder) in adulthood. Nervenarzt 69:543–556CrossRefPubMed
51.
Lau H, Rogers RD, Passingham RE (2006) Dissociating response selection and conflict in the medial frontal surface. Neuroimage 29:446–451CrossRefPubMed
52.
Lau HC, Rogers RD, Ramnani N, Passingham RE (2004) Willed action and attention to the selection of action. Neuroimage 21:1407–1415CrossRefPubMed
53.
Matsuda T, Matsuura M, Ohkubo T, Ohkubo H, Atsumi Y, Tamaki M et al (2002) Influence of arousal level for functional magnetic resonance imaging (fMRI) study: simultaneous recording of fMRI and electroencephalogram. Psychiatry Clin Neurosci 56:289–290CrossRefPubMed
54.
Menon V, Crottaz-Herbette S (2005) Combined EEG and fMRI studies of human brain function. Int Rev Neurobiol 66:291–321CrossRefPubMed
55.
Mulert C, Jager L, Schmitt R, Bussfeld P, Pogarell O, Moller HJ et al (2004) Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection. Neuroimage 22:83–94CrossRefPubMed
56.
Mulert C, Seifert C, Leicht G, Kirsch V, Ertl M, Karch S et al (2008) Single-trial coupling of EEG and fMRI reveals the involvement of early anterior cingulate cortex activation in effortful decision making. Neuroimage 42:158–168CrossRefPubMed
57.
Nachev P, Rees G, Parton A, Kennard C, Husain M (2005) Volition and conflict in human medial frontal cortex. Curr Biol 15:122–128CrossRefPubMed
58.
Nieuwenhuis S, Yeung N, van den Wildenberg W, Ridderinkhof KR (2003) Electrophysiological correlates of anterior cingulate function in a go/no-go task: effects of response conflict and trial type frequency. Cogn Affect Behav Neurosci 3:17–26CrossRefPubMed
59.
60.
Oosterlaan J, Sergeant JA (1998) Response inhibition and response re-engagement in attention-deficit/hyperactivity disorder, disruptive, anxious and normal children. Behav Brain Res 94:33–43CrossRefPubMed
61.
Passingham RE (1995) The frontal lobes and voluntary action. Oxford University Press, Oxford
62.
Playford ED, Jenkins IH, Passingham RE, Nutt J, Frackowiak RS, Brooks DJ (1992) Impaired mesial frontal and putamen activation in Parkinson’s disease: a positron emission tomography study. Ann Neurol 32:151–161CrossRefPubMed
63.
Polich J, Kok A (1995) Cognitive and biological determinants of P300: an integrative review. Biol Psychol 41:103–146CrossRefPubMed
64.
Retz-Junginger P, Retz W, Blocher D, Weijers HG, Trott GE, Wender PH et al (2002) Wender Utah rating scale. The short-version for the assessment of the attention-deficit hyperactivity disorder in adults. Nervenarzt 73:830–838CrossRefPubMed
65.
Ridderinkhof KR, Ullsperger M, Crone EA, Nieuwenhuis S (2004) The role of the medial frontal cortex in cognitive control. Science 306:443–447CrossRefPubMed
66.
Ritter W, Simson R, Vaughan HG Jr (1983) Event-related potential correlates of two stages of information processing in physical and semantic discrimination tasks. Psychophysiology 20:168–179CrossRefPubMed
67.
Ritter W, Simson R, Vaughan HG Jr, Macht M (1982) Manipulation of event-related potential manifestations of information processing stages. Science 218:909–911CrossRefPubMed
68.
Rubia K, Smith AB, Brammer MJ, Taylor E (2003) Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. Neuroimage 20:351–358CrossRefPubMed
69.
Rushworth MF, Buckley MJ, Behrens TE, Walton ME, Bannerman DM (2007) Functional organization of the medial frontal cortex. Curr Opin Neurobiol 17:220–227CrossRefPubMed
70.
Schachar R, Mota VL, Logan GD, Tannock R, Klim P (2000) Confirmation of an inhibitory control deficit in attention-deficit/hyperactivity disorder. J Abnorm Child Psychol 28:227–235CrossRefPubMed
71.
Schulz KP, Fan J, Tang CY, Newcorn JH, Buchsbaum MS, Cheung AM et al (2004) Response inhibition in adolescents diagnosed with attention deficit hyperactivity disorder during childhood: an event-related FMRI study. Am J Psychiatry 161:1650–1657CrossRefPubMed
72.
Sergeant JA, Geurts H, Huijbregts S, Scheres A, Oosterlaan J (2003) The top and the bottom of ADHD: a neuropsychological perspective. Neurosci Biobehav Rev 27:583–592CrossRefPubMed
73.
Sergeant JA, Geurts H, Oosterlaan J (2002) How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder? Behav Brain Res 130:3–28CrossRefPubMed
74.
Siniatchkin M, Boor R, Jacobs J, Wolff S, Jansen O, Stephani U et al (2006) Correction of ballistocardiogram artefacts from EEG acquired in the MRI scanner using spatial filters based on artefact and brain signal topographies. Neuroimage 31:S86
75.
Sirigu A, Daprati E, Ciancia S, Giraux P, Nighoghossian N, Posada A et al (2004) Altered awareness of voluntary action after damage to the parietal cortex. Nat Neurosci 7:80–84CrossRefPubMed
76.
Smith JL, Johnstone SJ, Barry RJ (2004) Inhibitory processing during the Go/NoGo task: an ERP analysis of children with attention-deficit/hyperactivity disorder. Clin Neurophysiol 115:1320–1331CrossRefPubMed
77.
Sonuga-Barke EJ, Dalen L, Daley D, Remington B (2002) Are planning, working memory, and inhibition associated with individual differences in preschool ADHD symptoms? Dev Neuropsychol 21:255–272CrossRefPubMed
78.
Tamm L, Menon V, Ringel J, Reiss AL (2004) Event-related FMRI evidence of frontotemporal involvement in aberrant response inhibition and task switching in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 43:1430–1440CrossRefPubMed
79.
Turken AU, Swick D (1999) Response selection in the human anterior cingulate cortex. Nat Neurosci 2:920–924CrossRefPubMed
80.
Vaidya CJ, Austin G, Kirkorian G, Ridlehuber HW, Desmond JE, Glover GH et al (1998) Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study. Proc Natl Acad Sci USA 95:14494–14499CrossRefPubMed
81.
Walton ME, Devlin JT, Rushworth MF (2004) Interactions between decision making and performance monitoring within prefrontal cortex. Nat Neurosci 7:1259–1265CrossRefPubMed
82.
Watanabe J, Sugiura M, Sato K, Sato Y, Maeda Y, Matsue Y et al (2002) The human prefrontal and parietal association cortices are involved in NO-GO performances: an event-related fMRI study. Neuroimage 17:1207–1216CrossRefPubMed
83.
Williams D, Stott CM, Goodyer IM, Sahakian BJ (2000) Specific language impairment with or without hyperactivity: neuropsychological evidence for frontostriatal dysfunction. Dev Med Child Neurol 42:368–375CrossRefPubMed
84.
Zametkin AJ, Nordahl TE, Gross M, King AC, Semple WE, Rumsey J et al (1990) Cerebral glucose metabolism in adults with hyperactivity of childhood onset. N Engl J Med 323:1361–1366PubMedCrossRef
85.
Zang YF, Jin Z, Weng XC, Zhang L, Zeng YW, Yang L et al (2005) Functional MRI in attention-deficit hyperactivity disorder: evidence for hypofrontality. Brain Dev 27:544–550CrossRefPubMed
Metadaten
Titel
Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients
verfasst von
Susanne Karch
Tobias Thalmeier
Jürgen Lutz
Anja Cerovecki
Markus Opgen-Rhein
Bettina Hock
Gregor Leicht
Kristina Hennig-Fast
Thomas Meindl
Michael Riedel
Christoph Mulert
Oliver Pogarell
Publikationsdatum
01.08.2010
Verlag
Springer-Verlag
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 5/2010
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-009-0089-y

Weitere Artikel der Ausgabe 5/2010

European Archives of Psychiatry and Clinical Neuroscience 5/2010 Zur Ausgabe

Original Paper

Pharmacogenetics of antidepressive treatment

Original Paper

Duration of untreated illness and suicide in bipolar disorder: a naturalistic study

Original Paper

Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia

Original Paper

The Munich 15-year follow-up study (MUFUSSAD) on first-hospitalized patients with schizophrenic or affective disorders: comparison of psychopathological and psychosocial course and outcome and prediction of chronicity

Original Paper

Sustainable effects on suicidality were found for the Nuremberg alliance against depression

Editorial

Affective disorders: the role of the duration of untreated illness, suicidality and pharmacogenetics

Neu im Fachgebiet Psychiatrie

23.04.2024 | Demenz | Nachrichten

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 | Depression antepartal oder postpartal | Nachrichten

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

22.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

22.04.2024 | DGIM 2024 | Nachrichten

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein
weitere anzeigen

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen