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Erschienen in: Japanese Journal of Radiology 6/2019

19.03.2019 | Original Article

Distinction between benign and malignant breast masses at breast ultrasound using deep learning method with convolutional neural network

verfasst von: Tomoyuki Fujioka, Kazunori Kubota, Mio Mori, Yuka Kikuchi, Leona Katsuta, Mai Kasahara, Goshi Oda, Toshiyuki Ishiba, Tsuyoshi Nakagawa, Ukihide Tateishi

Erschienen in: Japanese Journal of Radiology | Ausgabe 6/2019

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Abstract

Purpose

We aimed to use deep learning with convolutional neural network (CNN) to discriminate between benign and malignant breast mass images from ultrasound.

Materials and Methods

We retrospectively gathered 480 images of 96 benign masses and 467 images of 144 malignant masses for training data. Deep learning model was constructed using CNN architecture GoogLeNet and analyzed test data: 48 benign masses, 72 malignant masses. Three radiologists interpreted these test data. Sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (AUC) were calculated.

Results

The CNN model and radiologists had a sensitivity of 0.958 and 0.583–0.917, specificity of 0.925 and 0.604–0.771, and accuracy of 0.925 and 0.658–0.792, respectively. The CNN model had equal or better diagnostic performance compared to radiologists (AUC = 0.913 and 0.728–0.845, p = 0.01–0.14).

Conclusion

Deep learning with CNN shows high diagnostic performance to discriminate between benign and malignant breast masses on ultrasound.
Literatur
1.
2.
3.
Zurück zum Zitat Newell MS, Mahoney MC. Ultrasound-guided percutaneous breast biopsy. Tech Vasc Interv Radiol. 2014;17:23–31.CrossRefPubMed Newell MS, Mahoney MC. Ultrasound-guided percutaneous breast biopsy. Tech Vasc Interv Radiol. 2014;17:23–31.CrossRefPubMed
4.
Zurück zum Zitat D’Orsi C, Sickles E, Mendelson E, Morris E. Breast imaging reporting and data system. 5th ed. Reston: American College of Radiology; 2013. D’Orsi C, Sickles E, Mendelson E, Morris E. Breast imaging reporting and data system. 5th ed. Reston: American College of Radiology; 2013.
5.
Zurück zum Zitat Rao AA, Feneis J, Lalonde C, Ojeda-Fournier H. A pictorial review of changes in the BI-RADS fifth edition. Radiographics. 2016;36:623–39.CrossRefPubMed Rao AA, Feneis J, Lalonde C, Ojeda-Fournier H. A pictorial review of changes in the BI-RADS fifth edition. Radiographics. 2016;36:623–39.CrossRefPubMed
6.
Zurück zum Zitat Youk JH, Son EJ, Gweon HM, Kim H, Park YJ, Kim JA. Comparison of strain and shear wave elastography for the differentiation of benign from malignant breast lesions, combined with B-mode ultrasonography: qualitative and quantitative assessments. Ultrasound Med Biol. 2014;40:2336–44.CrossRefPubMed Youk JH, Son EJ, Gweon HM, Kim H, Park YJ, Kim JA. Comparison of strain and shear wave elastography for the differentiation of benign from malignant breast lesions, combined with B-mode ultrasonography: qualitative and quantitative assessments. Ultrasound Med Biol. 2014;40:2336–44.CrossRefPubMed
7.
Zurück zum Zitat Yasaka K, Akai H, Kunimatsu A, Kiryu S, Abe O. Deep learning with convolutional neural network in radiology. Jpn J Radiol. 2018;36:257–72.CrossRefPubMed Yasaka K, Akai H, Kunimatsu A, Kiryu S, Abe O. Deep learning with convolutional neural network in radiology. Jpn J Radiol. 2018;36:257–72.CrossRefPubMed
8.
Zurück zum Zitat Chartrand G, Cheng PM, Vorontsov E, Drozdzal M, Turcotte S, Pal CJ, et al. Deep learning: a primer for radiologists. Radiographics. 2017;37:2113–31.CrossRefPubMed Chartrand G, Cheng PM, Vorontsov E, Drozdzal M, Turcotte S, Pal CJ, et al. Deep learning: a primer for radiologists. Radiographics. 2017;37:2113–31.CrossRefPubMed
9.
Zurück zum Zitat Lakhani P, Sundaram B. Deep learning at chest radiography: automated classification of pulmonary tuberculosis by using convolutional neural networks. Radiology. 2017;284:574–82.CrossRefPubMed Lakhani P, Sundaram B. Deep learning at chest radiography: automated classification of pulmonary tuberculosis by using convolutional neural networks. Radiology. 2017;284:574–82.CrossRefPubMed
10.
Zurück zum Zitat Hamidinekoo A, Denton E, Rampun A, Honnor K, Zwiggelaar R. Deep learning in mammography and breast histology, an overview and future trends. Med Image Anal. 2018;47:45–67.CrossRefPubMed Hamidinekoo A, Denton E, Rampun A, Honnor K, Zwiggelaar R. Deep learning in mammography and breast histology, an overview and future trends. Med Image Anal. 2018;47:45–67.CrossRefPubMed
11.
Zurück zum Zitat Yasaka K, Akai H, Kunimatsu A, Kiryu S, Abe O. Deep learning with convolutional neural network in radiology. Jpn J Radiol. 2018;36:257–72.CrossRefPubMed Yasaka K, Akai H, Kunimatsu A, Kiryu S, Abe O. Deep learning with convolutional neural network in radiology. Jpn J Radiol. 2018;36:257–72.CrossRefPubMed
12.
Zurück zum Zitat Szegedy C, Liu W, Jia Y, Sermanet P, Reed S, Anguelov D, et al. Going deeper with convolutions. In: Proceeding of IEEE international conference on computer vision pattern recognition; 2015. p. 1–9. Szegedy C, Liu W, Jia Y, Sermanet P, Reed S, Anguelov D, et al. Going deeper with convolutions. In: Proceeding of IEEE international conference on computer vision pattern recognition; 2015. p. 1–9.
13.
Zurück zum Zitat Ioffe S, Szegedy C. Batch normalization: accelerating deep network training by reducing internal covariate shift. arXiv:1502.03167 (2015). Ioffe S, Szegedy C. Batch normalization: accelerating deep network training by reducing internal covariate shift. arXiv:​1502.​03167 (2015).
14.
Zurück zum Zitat Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.CrossRefPubMed Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.CrossRefPubMed
15.
Zurück zum Zitat Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.CrossRefPubMed Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.CrossRefPubMed
16.
Zurück zum Zitat Demircioğlu Ö, Uluer M, Arıbal E. How many of the biopsy decisions taken at inexperienced breast radiology units were correct? J Breast Health. 2017;13:23–6.CrossRefPubMedPubMedCentral Demircioğlu Ö, Uluer M, Arıbal E. How many of the biopsy decisions taken at inexperienced breast radiology units were correct? J Breast Health. 2017;13:23–6.CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Han S, Kang HK, Jeong JY, Park MH, Kim W, Bang WC, et al. A deep learning framework for supporting the classification of breast lesions in ultrasound images. Phys Med Biol. 2017;62:7714–28.CrossRefPubMed Han S, Kang HK, Jeong JY, Park MH, Kim W, Bang WC, et al. A deep learning framework for supporting the classification of breast lesions in ultrasound images. Phys Med Biol. 2017;62:7714–28.CrossRefPubMed
18.
Zurück zum Zitat Huang Q, Zhang F, Li X. Machine learning in ultrasound computer-aided diagnostic systems: a survey. Biomed Res Int. 2018;4(2018):5137904. Huang Q, Zhang F, Li X. Machine learning in ultrasound computer-aided diagnostic systems: a survey. Biomed Res Int. 2018;4(2018):5137904.
19.
Zurück zum Zitat Shin HC, Roth HR, Gao M, Lu L, Xu Z, Nogues I, et al. Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics and transfer learning. IEEE Trans Med Imaging. 2016;35:1285–98.CrossRefPubMed Shin HC, Roth HR, Gao M, Lu L, Xu Z, Nogues I, et al. Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics and transfer learning. IEEE Trans Med Imaging. 2016;35:1285–98.CrossRefPubMed
20.
Zurück zum Zitat Shi J, Zhou S, Liu X, Zhang Q, Lu M, Wang T. Stacked deep polynomial network based representation learning for tumor classification with small ultrasound image dataset. Neurocomputing. 2016;194:87–94.CrossRef Shi J, Zhou S, Liu X, Zhang Q, Lu M, Wang T. Stacked deep polynomial network based representation learning for tumor classification with small ultrasound image dataset. Neurocomputing. 2016;194:87–94.CrossRef
21.
Zurück zum Zitat Stoffel E, Becker AS, Wurnig MC, Marcon M, Ghafoor S, Berger N, et al. Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis. Eur J Radiol Open. 2018;24:165–70.CrossRef Stoffel E, Becker AS, Wurnig MC, Marcon M, Ghafoor S, Berger N, et al. Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis. Eur J Radiol Open. 2018;24:165–70.CrossRef
22.
Zurück zum Zitat Kumar V, Webb JM, Gregory A, Denis M, Meixner DD, Bayat M, et al. Automated and real-time segmentation of suspicious breast masses using convolutional neural network. PLoS ONE. 2018;16(13):e0195816.CrossRef Kumar V, Webb JM, Gregory A, Denis M, Meixner DD, Bayat M, et al. Automated and real-time segmentation of suspicious breast masses using convolutional neural network. PLoS ONE. 2018;16(13):e0195816.CrossRef
Metadaten
Titel
Distinction between benign and malignant breast masses at breast ultrasound using deep learning method with convolutional neural network
verfasst von
Tomoyuki Fujioka
Kazunori Kubota
Mio Mori
Yuka Kikuchi
Leona Katsuta
Mai Kasahara
Goshi Oda
Toshiyuki Ishiba
Tsuyoshi Nakagawa
Ukihide Tateishi
Publikationsdatum
19.03.2019
Verlag
Springer Japan
Erschienen in
Japanese Journal of Radiology / Ausgabe 6/2019
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-019-00831-5

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