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Neurotoxicity Research

Erschienen in:

01.01.2009

Disubstituted Diaryl Diselenides Inhibit [³H]-Serotonin Uptake in Rats

verfasst von: V. C. Borges, L. Savegnago, G. Dadalt, Cristina Wayne Nogueira

Erschienen in: Neurotoxicity Research | Ausgabe 1/2009

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Abstract

Diphenyl diselenide (PhSe)₂, the parent compound of disubstituted diaryl diselenides, produces significant antidepressant-like effect when evaluated in the forced swimming test (FST) in rats. The goal of this study was to investigate the effects of diphenyl diselenide (PhSe)₂, m-trifluoromethyl-diphenyl diselenide (F₃CPhSe)₂ and p-methoxy-diphenyl diselenide (CH₃OPhSe)₂ on [³H]-serotonin uptake in rat platelets and synaptosomes. At concentrations higher than 10 μM (PhSe)₂, and (F₃CPhSe)₂ inhibited about 20% [³H]-serotonin uptake in platelets. (CH₃OPhSe)₂ inhibited [³H]-serotonin uptake in platelets at concentrations higher than 1 μM. Similarly, (PhSe)₂, (F₃CPhSe)₂, and (CH₃OPhSe)₂ significantly inhibited [³H]-serotonin uptake (about 50%) in synaptosomes from rat brain at concentrations higher than 1 μM. The maximal inhibitory effects of (PhSe)₂, (F₃CPhSe)₂, and (CH₃OPhSe)₂ on [³H]-serotonin uptake from rat synaptosomes were 65%, 96%, and 80%, respectively. In conclusion, our results demonstrate that disubstituted diaryl diselenides altered monoaminergic system by interacting with monoamine uptake.

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Titel: Disubstituted Diaryl Diselenides Inhibit [3H]-Serotonin Uptake in Rats
verfasst von: V. C. Borges
L. Savegnago
G. Dadalt
Cristina Wayne Nogueira
Publikationsdatum: 01.01.2009
Verlag: Springer-Verlag
Erschienen in: Neurotoxicity Research / Ausgabe 1/2009
Print ISSN: 1029-8428
Elektronische ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-009-9005-5

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