Erschienen in:
01.12.2001 | Paper Report
Does elevated DR on RA B cells reveal cryptic epitopes?
verfasst von:
Robert Busch
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
Human leukocyte antigen (HLA)- DR molecules present antigens to CD4+ T cells. DR alleles sharing a common polymorphism at residues 67-74 of the DR? chain confer susceptibility to severe rheumatoid arthritis (RA). However, the biological role of HLA-DR remains poorly understood. The authors previously reported that expression of HLA-DM, a catalyst of DR/peptide binding, is decreased in B cells of RA patients, suggesting a role for antigen presentation defects (see Additional information). The aims of this study were to quantify DR expression in RA and to examine consequences of quantitative differences in DR levels for T-cell responses. …