Erschienen in:
01.02.2012 | Letter
Duration of antibiotic therapy in bacteraemia
verfasst von:
Matt P Wise, Matt PG Morgan, Anton G Saayman
Erschienen in:
Critical Care
|
Ausgabe 1/2012
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Excerpt
Reducing duration of antibiotic therapy without a diminution in efficacy decreases cost, side effects, antibiotic related diarrhoea, and bacterial resistance. Havey and colleagues [
1] reported the results of a systematic review and meta-analysis of antibiotic duration in bacteraemia and deduced short course therapy (<7 days) might be as effective as longer treatments. It is surprising given the obvious benefits and the frequency with which bacteraemia is documented in critically ill patients that there is such a paucity of randomised clinical trials (RCTs) comparing duration of therapy. Only one RCT, in neonates, had been performed in patients solely with bacteraemia. Accordingly, Havey and colleagues concluded that duration of antibiotic therapy in bacteraemia is poorly studied and would benefit from a large RCT. …