Erschienen in:
Open Access
01.09.2012 | Meeting abstract
Dysregulation of the serine/threonine phosphatase PP2A contributes to autoimmunity
verfasst von:
JC Crispín
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2012
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Excerpt
Protein phosphatase 2A is a ubiquitously expressed serine/threonine phosphatase that regulates a large number of cellular processes. Levels of the catalytic subunit of PP2A (PP2Ac) are tightly controlled. T cells from patients with systemic lupus erythematosus (SLE) express abnormally high levels of PP2Ac. This is promoted by a lupus-associated SNP and by DNA hypomethylation that alters local transcription factor binding. PP2Ac regulates CREB, Elf-1, and SP1, and could thus contribute to several molecular abnormalities described in SLE T cells. In order to determine whether increased levels of PP2Ac in T cells play a role in the development and/or promotion of autoimmune disease, we genetically engineered a mouse to transgenically express high levels of PP2A in T cells. This isolated abnormality allowed us to evaluate the effects of PP2Ac dysregulation in an otherwise normal immune system. …